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Gates Foundation

Let's be honest: No one likes mosquitoes.

I try to avoid broad sweeping generalizations like that — but c'mon. Mosquitoes? Seriously? Gross. And unless you're a frog prince (in which case you're dealing with some other issues), you probably share my distaste for the little bloodsuckers.

Best-case scenario? They're just plain annoying.

They show up invited and ruin your picnic, leaving behind a wretched rash of itchy red bumps in their wake.


GIF via thegatesnotes/YouTube.

Worst case? They gift you some disease like malaria, West Nile virus, or the recently-relevant Zika virus. And if you thought bug bites were awful, try putting up with something called breakbone fever.

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Or, ya know, death. Did I mention that mosquito-borne illnesses kill more than half a million people every year, making them the deadliest creatures on the planet? And climate change is making it increasingly easier for them to spread their once-tropical sicknesses to the rest of the world.

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Not bad for a bug that only lives around 10 days and hardly travels the length of two football fields in its lifetime.

Just a chill mosquito infecting your blood stream with a horrible sickness. GIF via thegatesnotes/YouTube.

That's why we need more of them, and fast.

Wait — what?!?! How do more mosquitoes help anything?

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For that answer, you'll have to ask the folks at Oxford Insect Technologies, also known as Oxitec. Founded by Hadyn Parry in 2002, Oxitec is pioneering a sustainable and environmentally-conscious method of eradicating mosquito-borne illnesses.

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But instead of focusing on vaccinations for dengue, Zika, and other virus strains, Oxitec is focusing on the delivery method of these terrible diseases — the mosquitoes themselves.

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What better way to do that than to release thousands of weaponized mutant mosquitoes into the wild to breed?

♫ Do a little dance. Make a little love. Get down tonight. ♫ GIF cia thegatesnotes/YouTube.

Enter: SEXYTIME FRANKENSTEIN DEATH MOSQUITOES.

(That's what I call 'em, anyway. The folks at Oxitec call them OX513A, which is decidedly less catchy.) 

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As it turns out, there are more than 3,500 known species of mosquitoes on the planet, but only two of them — the Aedes aegypti and the Aedes albopictus — actually feed on human blood. And of those species, the females are the ones that actually do the biting, occasionally passing along some fatal viruses in the process.

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That's why the clever folks at Oxitec found a way to breed scientifically-modified male mosquitoes whose sole purpose is weaponized reproduction. 

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"Hello, ladies!" GIF from thegatesnotes/YouTube.

These lab-grown suckers have an altered gene that, without the antidote that's readily available in the Oxitec hatchery, will ultimately cause the bugs to break down and die. 

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This doesn't happen immediately of course. And once the infected mosquitoes are released into the world, they still follow their natural impulse to seek out the nearest female, do the midair humpty dance, and fertilize her eggs — both sides blissfully unaware that he just passed on that same self-destructive protein. 

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The unsuspecting larval mosquito babies are dead before they hatch, and whammo-blammo, problem solved!

That's what you get, ya little plague-bringin' creep! GIF from thegatesnotes/YouTube.

So if all it takes are a couple thousand mutant mosquitoes, then what's up with this Zika virus outbreak?

ICYMI, the CDC just announced a major U.S. travel ban.

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Specifically, they're warning anyone who is carrying, or is planning to carry, a baby to stay far, far away from South America and the Caribbean, where the Zika virus has been linked to a sudden meteoric increase in microcephaly — that is, children born with abnormally small heads, which can lead to lots of other problems and can severely affect brain development.

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In the 70 years or so since the virus was first discovered in the Ugandan jungle, the number of people affected by Zika was originally pretty small — somewhere around a hundred people, ever.

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But that all changed in the last few years. And like the spread of West Nile and dengue fever before it, there is no vaccine currently available to prevent the spread of Zika — and it could take a while before anyone figures one out.

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So, in the meantime, why not eradicate the virus at its source, before it has a chance to spread?

"Who, me? What? I didn't do anything. I'm just gonna go over here now..." GIF from thegatesnotes/Youtube

As it turns out, people aren't so keen on swarms of Sexytime Frankenstein Death Mosquitoes invading their communities.

After all, what happens if a female mosquito gets infected with this self-destructing protein and passes it on to a human before she dies? What happens if evolution and radical conditions eventually transform these weaponized genocidal mutant mosquitoes into, well, something worse? What kind of unforeseen damage will occur in the local ecosystem if neither of the human-biting mosquito species are present to fulfill their crucial ecological functions?

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To that last point, the answer is "almost certainly none." Yes, mosquitoes can assist in the spread of pollens, and they serve as meals for certain animals. But for the most part, they're selfish self-sustaining death machines designed to breed and kill.

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The rest of those questions, however, are totally valid.

Mosquitoes are basically the real-world equivalent of the xenomorph from "Aliens" (which is also where this GIF is from).

Unfortunately, those same concerns have also made it difficult for Oxitec to conduct the tests they would need to in order to produce satisfactory answers. The few controlled experiments they have conducted in Brazil and the Cayman Islands have both resulted in 80% reductions in the populations of disease-carrying mosquitoes in just a few months.

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While the science fiction fan in me is still terrified of the consequences, the rational human in me understands the math.

Eliminating 80% of the mosquitoes that deliver these diseases could save nearly half a million lives every year.

So what are we waiting for?

Here's a TED Talk with Oxitec founder Hadyn Parry about the real-life benefits of Sexytime Frankenstein Death Mosquitoes:

Joy

Nurse turns inappropriate things men say in the delivery room into ‘inspirational’ art

"Can you move to the birthing ball so I can sleep in the bed?"

Holly the delivery nurse.

After working six years as a labor and delivery nurse Holly, 30, has heard a lot of inappropriate remarks made by men while their partners are in labor. “Sometimes the moms think it’s funny—and if they think it’s funny, then I’ll laugh with them,” Holly told TODAY Parents. “But if they get upset, I’ll try to be the buffer. I’ll change the subject.”

Some of the comments are so wrong that she did something creative with them by turning them into “inspirational” quotes and setting them to “A Thousand Miles” by Vanessa Carlton on TikTok.

“Some partners are hard to live up to!” she jokingly captioned the video.

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All images provided by Adewole Adamson

It begins with more inclusive conversations at a patient level

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Adewole Adamson, MD, of the University of Texas, Austin, aims to create more equity in health care by gathering data from more diverse populations by using artificial intelligence (AI), a type of machine learning. Dr. Adamson’s work is funded by the American Cancer Society (ACS), an organization committed to advancing health equity through research priorities, programs and services for groups who have been marginalized.

Melanoma became a particular focus for Dr. Adamson after meeting Avery Smith, who lost his wife—a Black woman—to the deadly disease.

melanoma,  melanoma for dark skin Avery Smith (left) and Adamson (sidenote)

This personal encounter, coupled with multiple conversations with Black dermatology patients, drove Dr. Adamson to a concerning discovery: as advanced as AI is at detecting possible skin cancers, it is heavily biased.

To understand this bias, it helps to first know how AI works in the early detection of skin cancer, which Dr. Adamson explains in his paper for the New England Journal of Medicine (paywall). The process uses computers that rely on sets of accumulated data to learn what healthy or unhealthy skin looks like and then create an algorithm to predict diagnoses based on those data sets.

This process, known as supervised learning, could lead to huge benefits in preventive care.

After all, early detection is key to better outcomes. The problem is that the data sets don’t include enough information about darker skin tones. As Adamson put it, “everything is viewed through a ‘white lens.’”

“If you don’t teach the algorithm with a diverse set of images, then that algorithm won’t work out in the public that is diverse,” writes Adamson in a study he co-wrote with Smith (according to a story in The Atlantic). “So there’s risk, then, for people with skin of color to fall through the cracks.”

Tragically, Smith’s wife was diagnosed with melanoma too late and paid the ultimate price for it. And she was not an anomaly—though the disease is more common for White patients, Black cancer patients are far more likely to be diagnosed at later stages, causing a notable disparity in survival rates between non-Hispanics whites (90%) and non-Hispanic blacks (66%).

As a computer scientist, Smith suspected this racial bias and reached out to Adamson, hoping a Black dermatologist would have more diverse data sets. Though Adamson didn’t have what Smith was initially looking for, this realization ignited a personal mission to investigate and reduce disparities.

Now, Adamson uses the knowledge gained through his years of research to help advance the fight for health equity. To him, that means not only gaining a wider array of data sets, but also having more conversations with patients to understand how socioeconomic status impacts the level and efficiency of care.

“At the end of the day, what matters most is how we help patients at the patient level,” Adamson told Upworthy. “And how can you do that without knowing exactly what barriers they face?”

american cancer society, skin cacner treatment"What matters most is how we help patients at the patient level."https://www.kellydavidsonstudio.com/

The American Cancer Society believes everyone deserves a fair and just opportunity to prevent, find, treat, and survive cancer—regardless of how much money they make, the color of their skin, their sexual orientation, gender identity, their disability status, or where they live. Inclusive tools and resources on the Health Equity section of their website can be found here. For more information about skin cancer, visit cancer.org/skincancer.

The mesmerizing lost art of darning knit fabric.

For most of human history, people had to make their own clothing by hand, and sewing skills were subsequently passed down from generation to generation. Because clothing was so time-consuming and labor-intensive to make, people also had to know how to repair clothing items that got torn or damaged in some way.

The invention of sewing and knitting machines changed the way we acquire clothing, and the skills people used to possess have largely gone by the wayside. If we get a hole in a sock nowadays, we toss it and replace it. Most of us have no idea how to darn a sock or fix a hole in any knit fabric. It's far easier for us to replace than to repair.

But there are still some among us who do have the skills to repair clothing in a way that makes it look like the rip, tear or hole never happened, and to watch them do it is mesmerizing.

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Pop Culture

Artist uses AI to create ultra realistic portraits of celebrities who left us too soon

What would certain icons look like if nothing had happened to them?

Mercury would be 76 today.

Some icons have truly left this world too early. It’s a tragedy when anyone doesn’t make it to see old age, but when it happens to a well-known public figure, it’s like a bit of their art and legacy dies with them. What might Freddie Mercury have created if he were granted the gift of long life? Bruce Lee? Princess Diana?

Their futures might be mere musings of our imagination, but thanks to a lot of creativity (and a little tech) we can now get a glimpse into what these celebrities might have looked like when they were older.

Alper Yesiltas, an Istanbul-based lawyer and photographer, created a photography series titled “As If Nothing Happened,” which features eerily realistic portraits of long gone celebrities in their golden years. To make the images as real looking as possible, Yesiltas incorporated various photo editing programs such as Adobe Lightroom and VSCO, as well as the AI photo-enhancing software Remini.

“The hardest part of the creative process for me is making the image feel ‘real’ to me,” Yesiltas wrote about his passion project. “The moment I like the most is when I think the image in front of me looks as if it was taken by a photographer.”

Yesiltas’ meticulousness paid off, because the results are uncanny.

Along with each photo, Yesiltas writes a bittersweet message “wishing” how things might have gone differently … as if nothing happened.
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