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A drug discovered on Easter Island may help dogs live up to three years longer

Every dog owner is going to want this.

dog longevity, rapamycin, dog aging product
via Pixabay

A new drug could extend a dog's life by three years.

The tragedy of having pets is knowing that one day you’ll have to say goodbye to your loved ones. The average dog lives between 10 and 13 years, depending on its breed, but researchers believe that with the help of a drug called rapamycin, their lives can be extended by around three years.

Rapamycin was discovered nearly 50 years ago from soil that was found on Easter Island, an island in the South Pacific famous for its mysterious Moai statues. The drug was approved by the FDA for human use because it suppresses the immune system to prevent it from attacking donated organs.

"Rapamycin seems to have the ability to 'reset' immune function by reducing the increase in chronic inflammation that goes along with aging," Dr. Matt Kaeberlein of the Dog Aging Project says according to Yahoo. "This also seems to have benefits beyond the immune system in all sorts of tissues and organs."

Early tests on dogs, rats and mice show the drug is very effective at reducing the aging process. It was found to reduce age-related declines in mice, most notably in the heart, ovaries, brain and oral cavity. It was also found to boost the immune system's response to cancers and COVID-19.

The study found that rapamycin increased the mice's average life spans by up to 25%. If the same results are found in dogs, then a canine with a 12-year life span could presumably live to 15.

“You can take an old heart or an old immune system, treat a mouse with rapamycin for eight weeks, and see that function improve. I know it sounds a little bit like science fiction, but when you actually look at the data, it's quite remarkable," Kaeberlein says, according to KRTV.

The drug is found to have serious side effects in humans including cancer, diabetes and infections. However, Kaeberlein believes that they are partially the result of the drug being administered to people who already have health problems. Further, the drug will be administered in much smaller doses to dogs, compared to humans who have had organ transplants.

The University of Washington's Dog Aging Project is taking this research a step further by doing a nationwide study on almost 600 dogs.

Kaeberlein believes that a dog is just as likely as a mouse to benefit from the effects of rapamycin, although the reaction will differ by breed. He believes that when it becomes widely used by veterinarians it’ll be administered to larger dogs at around 6 or 7 years and smaller dogs at 9 or 10.

The drug is already approved for use in humans by the FDA, so further studies will help dog owners and veterinarians decide whether it’s a safe treatment. "If our trial shows compelling evidence for beneficial effects and little in the way of side effects, I suspect many veterinarians will become more comfortable prescribing it for owners who request it," Kaeberlein says.

There is never a right time to say goodbye to our beloved pets. But if these studies turn out as researchers predict, we may be able to have a few more years of memories with our dogs before they cross the Rainbow Bridge.

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Science

MIT’s trillion-frames-per-second camera can capture light as it travels

"There's nothing in the universe that looks fast to this camera."

Photo from YouTube video.

Photographing the path of light.

A new camera developed at MIT can photograph a trillion frames per second.

Compare that with a traditional movie camera which takes a mere 24. This new advancement in photographic technology has given scientists the ability to photograph the movement of the fastest thing in the Universe, light.

The actual event occurred in a nano second, but the camera has the ability to slow it down to twenty seconds.

time, science, frames per second, bounced light

The amazing camera.

Photo from YouTube video.

 For some perspective, according to New York Times writer, John Markoff, "If a bullet were tracked in the same fashion moving through the same fluid, the resulting movie would last three years."


In the video below, you'll see experimental footage of light photons traveling 600-million-miles-per-hour through water.

It's impossible to directly record light so the camera takes millions of scans to recreate each image. The process has been called femto-photography and according to Andrea Velten, a researcher involved with the project, "There's nothing in the universe that looks fast to this camera."

(H/T Curiosity)


This article originally appeared on 09.08.17

From Your Site Articles
science
Health

Her mother doesn't get why she's depressed. So she explains the best way she knows how.

Sabrina Benaim eloquently describes what it's like to be depressed.

via Button Poetry/YouTube

Sabrina Benaim's “Explaining My Depression to My Mother."

Sabrina Benaim's “Explaining My Depression to My Mother" is pretty powerful on its own.

But, in it, her mother exhibits some of the most common misconceptions about depression, and I'd like to point out three of them here.

Misconception #1: Depression is triggered by a single event or series of traumatic events.

empathy, human condition, humanity

Depression isn’t just over sleeping.

Most people think depression is triggered by a traumatic event: a loved one dying, a job loss, a national tragedy, some THING. The truth is that depression sometimes just appears out of nowhere. So when you think that a friend or loved one is just in an extended bad mood, reconsider. They could be suffering from depression.

Misconception #2: People with depression are only sad.

family, parents, mom, anxiety

The obligation of anxiety.

Most people who have never experienced depression think depression is just an overwhelming sadness. In reality, depression is a complex set of feelings and physical changes in the body. People who suffer from depression are sad, yes, but they can also be anxious, worried, apathetic, and tense, among other things.

Misconception #3: You can snap out of it.

button poetry, medical condition, biological factors

Making fun plans not wanting to have fun.

The thing with depression is that it's a medical condition that affects your brain chemistry. It has to do with environmental or biological factors first and foremost. Sabrina's mother seems to think that if her daughter would only go through the motions of being happy that then she would become happy. But that's not the case. Depression is a biological illness that leaks into your state of being.

Think of it this way: If you had a cold, could you just “snap out of it"?

No? Exactly.

empathy, misconceptions of depression, mental health

Mom doesn’t understand.

via Button Poetry/YouTube

These are only three of the misconceptions about depression. If you know somebody suffering from depression, you should take a look at this video here below to learn the best way to talk to them:

This article originally appeared on 11.24.15

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depression
Health

Persuasion expert shares how one word makes people 30% more likely to change their minds

This tactic can immediately get someone on your side.

via LinkedIn Sales Solutions/Unsplash

Here's how to be 30% more persuasive.

Everybody wants to see themselves in a positive light. That’s the key to understanding Jonah Berger’s simple tactic that makes people 30% more likely to do what you ask. Berger is a marketing professor at the Wharton School of the University of Pennsylvania and the bestselling author of “Magic Words: What to Say to Get Your Way.”

Berger explained the technique using a Stanford University study involving preschoolers. The researchers messed up a classroom and made two similar requests to groups of 5-year-olds to help clean up.

One group was asked, "Can you help clean?" The other was asked, “Can you be a helper and clean up?" The kids who were asked if they wanted to be a “helper” were 30% more likely to want to clean the classroom. The children weren’t interested in cleaning but wanted to be known as “helpers.”

Berger calls the reframing of the question as turning actions into identities.

"It comes down to the difference between actions and identities. We all want to see ourselves as smart and competent and intelligent in a variety of different things,” Berger told Big Think. “But rather than describing someone as hardworking, describing them as a hard worker will make that trait seem more persistent and more likely to last. Rather than asking people to lead more, tell them, 'Can you be a leader?' Rather than asking them to innovate, can you ask them to 'Be an innovator'? By turning actions into identities, you can make people a lot more likely to engage in those desired actions.”

Berger says that learning to reframe requests to appeal to people’s identities will make you more persuasive.

“Framing actions as opportunities to claim desired identities will make people more likely to do them,” Berger tells CNBC Make It. “If voting becomes an opportunity to show myself and others that I am a voter, I’m more likely to do it.”

This technique doesn’t just work because people want to see themselves in a positive light. It also works for the opposite. People also want to avoid seeing themselves being portrayed negatively.

“Cheating is bad, but being a cheater is worse. Losing is bad, being a loser is worse,” Berger says.

The same tactic can also be used to persuade ourselves to change our self-concept. Saying you like to cook is one thing, but calling yourself a chef is an identity. “I’m a runner. I’m a straight-A student. We tell little kids, ‘You don’t just read, you’re a reader,’” Berger says. “You do these things because that’s the identity you hold.”

Berger’s work shows how important it is to hone our communication skills. By simply changing one word, we can get people to comply with our requests more effectively. But, as Berger says, words are magic and we have to use thgem skillfully. “We think individual words don’t really matter that much. That’s a mistake,” says Berger. “You could have excellent ideas, but excellent ideas aren’t necessarily going to get people to listen to you.”


This article originally appeared on 2.11.24

From Your Site Articles
psychology
Pop Culture

A comic about wearing makeup goes from truthful to weird in 4 panels.

A hilariously truthful (and slightly weird) explanation of the "too much makeup" conundrum.

Image set by iri-draws/Tumblr, used with permission.

A comic shows the evolution or devolution from with makeup to without.

Even though I don't wear very much makeup, every few days or so SOMEONE...

(friends, family, internet strangers)

...will weigh in on why I "don't need makeup."

Now, I realize this is meant as a compliment, but this comic offers a hilariously truthful (and slightly weird) explanation of the "too much makeup" conundrum.

social norms, social pressure, friendship, self esteem

“Why do you wear so much makeup?"

Image set by iri-draws/Tumblr, used with permission.

passive aggressive, ego, confidence, beauty

“See, you look pretty without all that makeup on."

Image set by iri-draws/Tumblr, used with permission.

expectations, beauty products, mascara, lipstick

“Wow you look tired, are you sick?"

Image set by iri-draws/Tumblr, used with permission.

lizards, face-painting, hobbies, hilarious comic

When I shed my human skin...

Image set by iri-draws/Tumblr, used with permission.

Not everyone is able to turn into a badass lizard when someone asks about their face-painting hobbies. Don't you kinda wish you could? Just to drive this hilarious comic all the way home, here are four reasons why some women* wear makeup:

*Important side note: Anyone can wear makeup. Not just women. True story.

Four reasons some women* wear makeup:

1. Her cat-eye game is on point.

mascara, eyes, confidence

Her cat-eye game is on point.

Via makeupproject.

2. She has acne or acne scars.

acne, cover up, scarring, medical health

She has acne or acne scars.

Via Carly Humbert.

3. Pink lipstick.

lipstick, beauty products, basics, self-expression

Yes, pink lipstick.

Via Destiny Godley

4. She likes wearing makeup.

appearance, enhancement, creative expression

Happy to be going out and feeling good.

Happy Going Out GIF by Much.

While some people may think putting on makeup is a chore, it can be really fun! For some, makeup is an outlet for creativity and self-expression. For others, it's just a way to feel good about themselves and/or enhance their favorite features.

That's why it feels kinda icky when someone says something along the lines of "You don't need so much makeup!" Now, it's arguable that no one "needs" makeup, but everyone deserves to feel good about the way they look.

For some people, feeling good about their appearance includes wearing makeup. And that's totally OK.


This article originally appeared on 05.28.15

From Your Site Articles
Joy

Adorable 'Haka baby' dance offers a sweet window into Maori culture

Stop what you're doing and let this awesomeness wash over you.

@focuswithdan/TikTok

If you've never seen a Maori haka performed, you're missing out.

The Maori are the indigenous peoples of New Zealand, and their language and customs are an integral part of the island nation. One of the most recognizable Maori traditions outside of New Zealand is the haka, a ceremonial dance or challenge usually performed in a group. The haka represents the pride, strength, and unity of a tribe and is characterized by foot-stamping, body slapping, tongue protrusions, and rhythmic chanting.

Haka is performed at weddings as a sign of reverence and respect for the bride and groom and are also frequently seen before sports competitions, such as rugby matches.


The intensity of the haka is the point. It is meant to be a show of strength and elicit a strong response—which makes seeing a tiny toddler learning to do it all the more adorable.

Here's an example of a rugby haka:

Danny Heke, who goes by @focuswithdan on TikTok, shared a video of a baby learning haka and omigosh it is seriously the most adorable thing. When you see most haka, the dancers aren't smiling—their faces are fierce—so this wee one starting off with an infectious grin is just too much. You can see that he's already getting the moves down, facial expressions and all, though.

@focuswithdan When you grow up learning haka! #haka #teachthemyoung #maori #māori #focuswithdan #fyp #foryou #kapahaka ♬ original sound - 𝕱𝖔𝖈𝖚𝖘𝖂𝖎𝖙𝖍𝕯𝖆𝖓

As cute as this video is, it's part of a larger effort by Heke to use his TikTok channel to share and promote Maori culture. His videos cover everything from the Te Reo Maori language to traditional practices to issues of prejudice Maori people face.

Here he briefly goes over the different body parts that make up haka:

@focuswithdan

♬ Ngati - Just2maori

This video explains the purerehua, or bullroarer, which is a Maori instrument that is sometimes used to call rains during a drought.

@focuswithdan Reply to @illumi.is.naughty Some tribes used this to call the rains during drought 🌧 ⛈ #maori #māori #focuswithdan #fyp ♬ Pūrerehua - 𝕱𝖔𝖈𝖚𝖘𝖂𝖎𝖙𝖍𝕯𝖆𝖓

This one shares a demonstration and explanation of the taiaha, a traditional Maori weapon.

@focuswithdan Reply to @shauncalvert Taiaha, one of the most formidable of the Māori Weaponry #taiaha #maori #māori #focuswithdan #fyp #foryou ♬ original sound - 𝕱𝖔𝖈𝖚𝖘𝖂𝖎𝖙𝖍𝕯𝖆𝖓

For another taste of haka, check out this video from a school graduation:

@focuswithdan When your little cuzzy graduates and her school honours her with a haka #maori #māori #haka #focuswithdan #fyp #graduation @its_keshamarley ♬ Te Kura Kaupapa Māori o Ngāti Ruanui - 𝕱𝖔𝖈𝖚𝖘𝖂𝖎𝖙𝖍𝕯𝖆𝖓

Heke even has some fun with the trolls and racists in the comments who try to tell him his culture is dead (what?).

@focuswithdan Credit to you all my AMAZING FOLLOWERS! #focuswithdan #maori #māori #followers #fyp #trolls ♬ original sound - sounds for slomo_bro!

Unfortunately, it's not just ignorant commenters who spew racist bile. A radio interview clip that aired recently called Maori people "genetically predisposed to crime, alcohol, and underperformance," among other terrible things. (The host, a former mayor of Auckland, has been let go for going along with and contributing to the caller's racist narrative.)

@focuswithdan #newzealand radio in 2021 delivering racist commentaries 🤦🏽‍♂️ #māori #maori #focuswithdan #racism DC: @call.me.lettie2.0 ♬ original sound - luna the unicow

That clip highlights why what Heke is sharing is so important. The whole world is enriched when Indigenous people like the Maori have their voices heard and their culture celebrated. The more we learn from each other and our diverse ways of life, the more enjoyable life on Earth will be and the better we'll get at collaborating to confront the challenges we all share.


This article originally appeared on 01.28.21

From Your Site Articles
indigenous people
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