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A dog explains why Phoenix's pet store law is such a big win for shelter animals.

In the name of representation, I thought it'd be best if we let an actual dog tackle this topic, transcribed (and loosely translated into human-speak) by me, Evan Porter. Enjoy!

A dog explains why Phoenix's pet store law is such a big win for shelter animals.

Hey! I'm a rescue pup.

I was born a stray, but now I live in a shelter, which means I'm moving up in the world!

Don't feel too bad for me, though. I have lots of things to be excited about. I got a funny celebrity name when I got to the shelter (Esmeralda Gosling!) and — ohmygod does someone have food?


HEY! Where's my byline? Also, do you have food? Photo by Badass Brooklyn Animal Rescue.

But there is some even more awesome news this week that has me and my puppy friends spinning in nonstop circles.

Two years ago, Phoenix told pet stores they were only allowed to sell rescue animals like me.

I was just a puppy back then, not the handsome hound you see today. Pet stores in Phoenix that sell dogs from puppy mills just got a whack on the nose from one of those people who wear black robes and bang those funny wooden hammers that look like something a dog ought to be allowed to chew on.

At the time, some people weren't happy about the new rule and tried to get it thrown out, but this week, that fancy robe-wearing judge-person upheld the decision, which is great news for dogs like me (he also upheld the decision not to let dogs chew on his hammer thingy, which is not great news because it looks sooo chewable).


Whew, I need to lay down for a sec — this is all so exciting! Photo by Badass Brooklyn Animal Rescue.

The judge's decision is important because there are these really bad places called puppy mills, and laws like this one are working to shut them down.

It turns out that most puppies sold in pet stores come from puppy mills; at least, that's what my human friends at the ASPCA say. I might only be a dog, but even I understand basic economics: Without the demand for their product (puppies!), these puppy mills are more likely to go away for good.

Yay!

It's good news for me and my pals, but not everyone is excited.

We don't see a lot of "purebred" puppies here at my shelter, but apparently, they're a big deal to some humans. This new law says pet stores can't sell dogs from breeders, and that's made some people pretty grumpy.

The owners of the Puppies 'N Love pet store in Phoenix got really mad about this back in 2013, and they "sued" the city — whatever that means. The owners said since the law said they couldn't sell dogs from breeders anymore, they would probably go out of business.

The American Kennel Club isn't a fan of this law either because they think it's more important for humans to be able to pick a specific breed of dog than it is to make sure puppy mills are shut down.

"AKC supports freedom of choice for pet purchasers," they said, and, "Those seeking a puppy of a particular breed … may be out of luck."

Well boo-freaking-hoo! It's mutts like me who end up living on the streets while breeders and puppy mills supply purebred puppies straight to pet stores. Why would a pet store want a brand new pup when there are already so many who need good homes?

And besides, I challenge you to find a purebred cuter than me.

I'll wait — I'm really good at "stay"!

Anything that gets us animals off the streets and into loving homes gets four paws up from me.

Let's celebrate — ice cold beer for the humans, ice cold water for dogs! Photo by Badass Brooklyn Animal Rescue.

Maricopa County, where Phoenix sits (good boy, Phoenix!), is second in the nation in pet overpopulation. To give you a taste, my buddies at the Arizona Humane Society say there are about 250,000 free-roaming cats there, and from my time on the streets, I can confirm that I've sniffed at least that many butts.

If saving more animals in need (even cats, yuck) and shutting down cruel puppy mills means professional breeders have to take a hit, that seems like a pretty OK deal to me.

I don't know what a city councillor is, but this one from Phoenix City named Thelda Williams said something I really liked: "[This law] means more protection for puppy lovers and the puppies themselves. We have so many dogs in Arizona that need homes; we don't need to import them."

I'll shake on that.


Photo by Mike Marrah on Unsplash

The "Big 5" is an old term from the colonial era, denoting the five wild animals in Africa that were the most sought-after kills for trophy hunters. Killing those five—lion, leopard, rhinoceros, elephant, and Cape buffalo—meant ultimate success in the big-game hunting world.

Now there's a "New Big 5," but instead of a barbaric goal for trophy hunters, it's a beautiful goal for wildlife photographers.

The initiative was created by British wildlife photographer Graeme Green with the goal of raising awareness about threats to the world's animals including habitat loss, poaching, illegal animal trade, and climate change. In a global call for votes, 50,000 wildlife lovers shared which animals they most wanted to photograph or see in photos. And the winners are:

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Photo by Mike Marrah on Unsplash

The "Big 5" is an old term from the colonial era, denoting the five wild animals in Africa that were the most sought-after kills for trophy hunters. Killing those five—lion, leopard, rhinoceros, elephant, and Cape buffalo—meant ultimate success in the big-game hunting world.

Now there's a "New Big 5," but instead of a barbaric goal for trophy hunters, it's a beautiful goal for wildlife photographers.

The initiative was created by British wildlife photographer Graeme Green with the goal of raising awareness about threats to the world's animals including habitat loss, poaching, illegal animal trade, and climate change. In a global call for votes, 50,000 wildlife lovers shared which animals they most wanted to photograph or see in photos. And the winners are:

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True

Each year, an estimated 1.8 million people in the United States are affected by cancer — most commonly cancers of the breast, lung, prostate, and blood cancers such as leukemia. While not everyone overcomes the disease, thanks to science, more people are surviving — and for longer — than ever before in history.

We asked three people whose lives have been impacted by cancer to share their stories – how their lives were changed by the disease, and how they're using that experience to change the future of cancer treatments with the hope that ultimately, in the fight against cancer, science will win. Here's what they had to say.

Celine Ryan, 55, engineer database programmer and mother of five from Detroit, MI

Photo courtesy of Celine Ryan

In September 2013, Celine Ryan woke up from a colonoscopy to some traumatic news. Her gastroenterologist showed her a picture of the cancerous mass they found during the procedure.

Ryan and her husband, Patrick, had scheduled a colonoscopy after discovering some unusual bleeding, so the suspicion she could have cancer was already there. Neither of them, however, were quite prepared for the results to be positive -- or for the treatment to begin so soon. Just two days after learning the news, Ryan had surgery to remove the tumor, part of her bladder, and 17 cancerous lymph nodes. Chemotherapy and radiation soon followed.

Ryan's treatment was rigorous – but in December 2014, she got the devastating news that the cancer, once confined to her colon, had spread to her lungs. Her prognosis, they said, was likely terminal.

But rather than give up hope, Ryan sought support from online research, fellow cancer patients and survivors, and her medical team. When she brought up immunotherapy to her oncologist, he quickly agreed it was the best course of action. Ryan's cancer, like a majority of colon and pancreatic cancers, had been caused by a defect on the gene KRAS, which can result in a very aggressive cancer that is virtually "undruggable." According to the medical literature, the relatively smooth protein structure of the KRAS gene meant that designing inhibitors to bind to surface grooves and treat the cancer has been historically difficult. Through her support systems, Ryan discovered an experimental immunotherapy trial at the National Institutes of Health (NIH) in Bethesda, MD., and called them immediately to see if she was eligible. After months of trying to determine whether she was a suitable candidate for the experimental treatment, Ryan was finally accepted.

The treatment, known as tumor-infiltrating lymphocyte therapy, or TIL, is a testament to how far modern science has evolved. With this therapy, doctors remove a tumor and harvest special immune cells that are found naturally in the tumor. Doctors then grow the cells in a lab over the next several weeks with a protein that promotes rapid TIL growth – and once the cells number into the billions, they are infused back into the patient's body to fight the cancer. On April 1, 2015, Ryan had her tumor removed at the NIH. Two months later, she went inpatient for four weeks to have the team "wash out" her immune system with chemotherapy and infuse the cells – all 148 billion of them – back into her body.

Six weeks after the infusion, Ryan and Patrick went back for a follow-up appointment – and the news they got was stunning: Not only had no new tumors developed, but the six existing tumors in her lungs had shrunk significantly. Less than a year after her cell infusion, in April 2016, the doctors told Ryan news that would have been impossible just a decade earlier: Thanks to the cell infusion, Ryan was now considered NED – no evaluable disease. Her body was cancer-free.

Ryan is still NED today and continuing annual follow-up appointments at the NIH, experiencing things she never dreamed she'd be able to live to see, such as her children's high school and college graduations. She's also donating her blood and cells to the NIH to help them research other potential cancer treatments. "It was an honor to do so," Ryan said of her experience. "I'm just thrilled, and I hope my experience can help a lot more people."

Patrice Lee, PhD, VP of Pharmacology, Toxicology and Exploratory Development at Pfizer

Photo courtesy of Patrice Lee

Patrice Lee got into scientific research in an unconventional way – through the late ocean explorer Jacques Cousteau.

Lee never met Cousteau but her dreams of working with him one day led her to pursue a career in science. Initially, Lee completed an undergraduate degree in marine biology; eventually, her interests changed and she decided to get a dual doctoral degree in physiology and toxicology at Duke University. She now works at Pfizer's R&D site in Boulder, CO (formerly Array BioPharma), leading a group of scientists who determine the safety and efficacy of new oncology drugs.

"Scientists focused on drug discovery and development in the pharmaceutical industry are deeply committed to inventing new therapies to meet unmet needs," Lee says, describing her field of work. "We're driven to achieve new medicines and vaccines as quickly as possible without sacrificing safety."

Among the drugs Lee has helped develop during her career, including cancer therapies, she says around a dozen are currently in development, while nine have received FDA approval — an incredible accomplishment as many scientists spend their careers without seeing their drug make it to market. Lee's team is particularly interested in therapies for brain metastases — something that Lee says is a largely unmet need in cancer research, and something her team is working on from a variety of angles. "Now that we've had rapid success with mRNA vaccine technology, we hope to explore what the future holds when applying this technology to cancers," Lee says.

But while evaluating potential cancer therapies is a professional passion of Lee's, it's also a mission that's deeply personal. "I'm also a breast cancer survivor," she says. "So I've been on the other side of things and have participated in a clinical trial."

However, seeing how melanoma therapies that she helped develop have affected other real-life cancer patients, she says, has been a highlight of her career. "We had one therapy that was approved for patients with BRAF-mutant metastatic melanoma," Lee recalls. "Our team in Boulder was graced by a visit from a patient that had benefited from these drugs that we developed. It was a very special moment for the entire team."

None of these therapies would be available, Lee says without rigorous science behind it: "Facts come from good science. Facts will drive the development of new drugs, and that's what will help patients."

Chiuying "Cynthia" Kuk (they/them) MS, 34, third-year medical student at Michigan State University College of Human Medicine

Photo courtesy of Cynthia Kuk

Cynthia Kuk was just 10 years old when they had a conversation that would change their life forever.

"My mother, who worked as a translator for the government at the time, had been diagnosed with breast cancer, and after her chemotherapy treatments she would get really sick," Kuk, who uses they/them pronouns, recalls. "When I asked my dad why mom was puking so much, he said it was because of the medicine she was taking that would help her get better."

Kuk's response was immediate: "That's so stupid! Why would a medicine make you feel worse instead of better? When I'm older, I want to create medicine that won't make people sick like that."

Nine years later, Kuk traveled from their native Hong Kong to the United States to do exactly that. Kuk enrolled in a small, liberal arts college for their Bachelor's degree, and then four years later started a PhD program in cancer research. Although Kuk's mother was in remission from her cancer at the time, Kuk's goal was the same as it had been as a 10-year-old watching her suffer through chemotherapy: to design a better cancer treatment, and change the landscape of cancer research forever.

Since then, Kuk's mission has changed slightly.

"My mom's cancer relapsed in 2008, and she ended up passing away about five years after that," Kuk says. "After my mom died, I started having this sense of urgency. Cancer research is such that you work for twenty years, and at the end of it you might have a fancy medication that could help people, but I wanted to help people now." With their mother still at the forefront of their mind, Kuk decided to quit their PhD program and enter medical school.

Now, Kuk plans to pursue a career in emergency medicine – not only because they are drawn to the excitement of the emergency room, but because the ER is a place where the most marginalized people tend to seek care.

"I have a special interest in the LGBTQ+ population, as I identify as queer and nonbinary," says Kuk. "A lot of people in this community and other marginalized communities access care through the ER and also tend to avoid medical care since there is a history of mistreatment and judgement from healthcare workers. How you carry yourself as a doctor, your compassion, that can make a huge difference in someone's care."

In addition to making a difference in the lives of LGBTQ+ patients, Kuk wants to make a difference in the lives of patients with cancer as well, like their mother had.

"We've diagnosed patients in the Emergency Department with cancer before," Kuk says. "I can't make cancer good news but how you deliver bad news and the compassion you show could make a world of difference to that patient and their family."

During their training, Kuk advocates for patients by delivering compassionate and inclusive care, whether they happen to have cancer or not. In addition to emphasizing their patient's pronouns and chosen names, they ask for inclusive social and sexual histories as well as using gender neutral language. In doing this, they hope to make medicine as a whole more accessible for people who have been historically pushed aside.

"I'm just one person, and I can't force everyone to respect you, if you're marginalized," Kuk says. "But I do want to push for a culture where people appreciate others who are different from them."