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The cool new DIY science movement that's changing everything from animals to agriculture.

"We're all here because we want to be the first humans able to fly."

"And we also want to live forever, see through walls, and shoot lasers from our eyeballs," the Ukrainian scientist tells me with a totally straight face. "But that's all science-fiction nonsense for now. So in the meantime, we're just making yogurt with an anti-aging protein, and things like that."


That must be Stamos' secret. GIF from Dannon Oikos/YouTube.

We're standing in the attic of a bicycle repair shop in Somerville, Massachusetts, where a group of local scientists and curious hobbyists have built a do-it-yourself laboratory for homegrown biology experiments.

The space is strewn with secondhand equipment, all scavenged and salvaged from the dumpsters of nearby universities and major pharmaceutical companies. Someone even found a way to use a breast pump to filter out bacteria samples. Yeah.

But as wild as this all may sound, it's hardly the most remarkable thing to come out of the life science revolution that's sweeping across the world.

"I cannot believe my eyes!" — Me, when I saw this stuff. GIF from "Dr. Horrible's Sing-Along Blog."

Recent advancements in biotech have made it easier than ever to manipulate and edit DNA with shocking accuracy.

At the forefront of this biological renaissance is a little thing scientists call CRISPR-Cas9, often shortened to just plain ol' CRISPR. It's a system that we pretty much stole from certain bacteria that uses enzymes and something called guide RNA to target and cut sequences of DNA.

But that's all kinds of confusing for non-science-y types, so think of it like this: DNA is full of information that tells a story, like a book. Previously, if we wanted to change any part of this DNA-book, we had to chop up random sections with our metaphorical scissors, or splash white-out on the pages, trying to scribble in new notes wherever we could. Sure, it got the job done sometimes. But it was also pretty messy and inefficient.

The CRISPR system offers a new kind of "find-and-replace" feature. Now we can take our DNA-book and say, "OK, CRISPR, please find that sentence that specifically says, 'Harry met Hagrid.'" Then we can tell it to cut out that particular sentence and either get rid of it entirely or add our own new, much cooler sentence in its place. (Like "Harry met Hagrid and then they high-fived and it was so epic that they destroyed Voldemort and everyone was awesome.")

Got that?

TL;DR: Everything is awesome with CRISPR. GIF from "The LEGO Movie."

Now imagine that instead of just rewriting their own derivative Harry Potter fanfic, scientists can use this "find-and-replace" feature to turn specific genes "on" or "off," or even add new sequences of base pairs into the genome. This makes it easier than ever to go in and splice, add, or change one little piece of genetic information and see what happens.

"It's like a toolkit, essentially," explained Joanne Kamens, executive director of Addgene. "It's like having just the right screwdriver we never had, and it's allowing scientists to create hundreds of new tools and making everything exponentially faster."

A much-more useful CRISPR explainer video. GIF from Desktop Genetics/YouTube.

This kind of super-accurate gene editing — and genetic synthesis in general — have become more accessible in the past few years.

CRISPR might be the prom queen of the biggest labs, but there are other similar versions of this kind of precision gene-editing technology — like the methods that my Ukrainian friend was using in that attic. And these tools are collectively changing the world as we know it, in attics and labs all over the world.

Let's go down the DNA rabbit hole... GIF from McGovern Institute for Brain Research at MIT/YouTube.

Here are five of the most fascinating inventions and discoveries we've seen in biotech to date:

1. Gene editing could help us limit, or maybe even destroy, diseases like malaria and cancer.

Now that we can slice into DNA with alarming accuracy, we can target exactly where diseases exist in the body and how drugs get delivered to kill those diseases. It's like a microbiological version of "Mission: Impossible" when you're trying to defuse a bomb — gene editing tells you exactly which wire to cut, without the risk of blowing up the building (which in this case is a human body).

Scientists at the University of California San Francisco, for example, have found a way to turn human T cells into hyper-efficient disease-killing machines. Similarly, at Temple University, researchers are using CRISPR to literally cut HIV out of live subjects. Pretty neat, huh?

As for those pesky mosquito-born illnesses plaguing our warming world, CRISPR has already made it easier to identify diseases such as Zika, malaria, and West Nile in patients and hosts alike — and some scientists hope to use gene editing to remove the disease-carrying capability from the mosquito genome entirely, destroying them at the source.

EXACTLY. GIF from "Adventure Time."

2. This same application is revolutionizing how we study mental health, too.

Scientists at MIT have already used gene editing to create lab mice with autism and OCD so they can better understand what causes those conditions and how best to treat them.

If they can create those conditions, they might be able to un-create them, too, by essentially flipping a switch on the problematic genes. (The only trick is figuring out with certainty which specific genes out of the billions in our body are causing the problems, which is easier said than done.)

I know, Krang. It's pretty mind-blowing. GIF from "Teenage Mutant Ninja Turtles."

3. It could also help us bring back the wooly mammoth or any other number of crazy chimera breeds.

Yup: Scientists at Harvard University successfully spliced wooly mammoth DNA into elephant cells. This is just on a cellular level so far, mind you; no one's prepared to go all "Jurassic Park" without looking into all the potential ramifications of such a project.

But, I mean, you knew this was coming, right? As cool and generally comforting as these other remarkable projects have been, we're still talking about genetic engineering, so of course there'd be some kind of super-powered kaiju-animal hybrids in the cards.

In China, scientists have already used CRISPR to breed dogs with twice the muscle mass by simply deleting one gene from their DNA. And in Boston, they've found a way to modify pig organs to make them compatible with human bodies in need of transplant donors.

And if you're wondering about the practical applications and ethical justifications of these kinds of projects, well ... those are totally valid things to be concerned about. But scientists are actively engaged in those discussions, and if it makes you feel any better, we're probably still a long way away from creating fully customizable mature synthetic humans. Probably.


My thoughts exactly, Doc Brown. GIF from "Back to the Future."

4. Gene editing could also help to revamp the entire agriculture industry — without the use of any off-putting genetic additives.

GMOs get a bad wrap. But gene editing is different from, say, adding a bit of flounder DNA into a tomato, which is why the FDA recently approved the first CRISPR-modified mushroom for human consumption.

These specially designed mushrooms have a greater resistance to browning — again, not because of any scary-sounding chemicals or foreign genes, but simply because biologists found a way to isolate and shut off the naturally occurring genes that caused the mushrooms to turn brown after you cut into them.

That's it. Really. Nothing scary about it.

Naturally occurring mushroom-hat parachutes are still in the early developmental stages. GIF from "Super Mario Bros. Super Show."

This method is also working to create disease-resistant plants, which is how a team at Seoul National University is trying to save the banana. Because why bother introducing pesticides or foreign genetic material when you can just poke at the DNA that the plant already has to improve its nutrient content and help it survive under less-than-ideal conditions? It's not quite "natural" in the traditional sense, but it's also not so different from the exchange and selective breeding of crops that's been going on for centuries.

Just, ya know — easier, and cooler-sounding.

So that's what Beaker's been meeping about all these years! GIF from "The Muppet Show."

5. But perhaps most importantly, gene editing is lowering the bar for scientific research and making it accessible to everyone.

Until recently, a lot of genetic and biotech data was protected behind intellectual property laws and institutional restrictions. But now? Anyone can buy an all-in-one CRISPR starter kit online or order a plasmid straight from a place like Addgene for a mere $65 and see what they can do with it ... just like those guys in the Somerville attic.

"It's like designing apps" for smartphones, said DeskGen's A.J. Ajetunmobi. DeskGen is a biotech startup that offers free open-source desktop gene-editing software, allowing anyone to design an experiment from anywhere in the world.

"People can focus on fixing problems instead of learning how to code," he said. "In life sciences, we're still stuck teaching people how to code. It's hard to teach that and still keep minds open."

GIF from "Dexter's Laboratory."

"Diversity of perspective makes everything better. People are so much more innovative when they're not coming at it from a specific overhead," Ajetunmobi added.

The possibilities for progress are endless as long as the opportunities are available to everyone — not just the pharmaceutical companies who can afford to pay millions for special equipment and data.

"The barriers to entry [in biotech] are significant," Ajetunmobi told me with an eyeroll and a laugh, before pointing out that it would be logistically difficult for an individual — say, a 30-year-old writer who is me — to obtain all the necessary plasmids and parts to breed a personal army of altruistic disease-resistant pig-human hybrid super-farmers with laser vision and flight capabilities.

"But now, there's nothing technically stopping anyone from experimenting and exploring."

Maybe you, too, can create your own web-shooters! ... Maybe. GIF from "The Amazing Spider-Man."

Personally, I decided to keep it simple and stick with the DIY bioluminescent yeast starter kit.

I'll leave the cool sci-fi-sounding progress to the pros (or to my new friends trying to find the fountain of youth in yogurt). But it's still nice to know that the opportunity is out there for anyone eager enough to give it a try.

Who knows? Maybe that 14-year-old kid next door will find a way to make pigs fly sooner than we think.

via Pixabay

A sad-looking Labrador Retriever

The sweet-faced, loveable Labrador Retriever is no longer America’s favorite dog breed. The breed best known for having a heart of gold has been replaced by the smaller, more urban-friendly French Bulldog.

According to the American Kennel Club, for the past 31 years, the Labrador Retriever was America’s favorite dog, but it was eclipsed in 2022 by the Frenchie. The rankings are based on nearly 716,500 dogs newly registered in 2022, of which about 1 in 7 were Frenchies. Around 108,000 French Bulldogs were recorded in the U.S. in 2022, surpassing Labrador Retrievers by over 21,000.


The French Bulldog’s popularity has grown exponentially over the past decade. They were the #14 most popular breed in 2012, and since then, registrations have gone up 1,000%, bringing them to the top of the breed popularity rankings.

The AKC says that the American Hairless Terrier, Gordon Setter, Italian Greyhound and Anatolian Shepherd Dog also grew in popularity between 2021 and 2022.

The French Bulldog was famous among America’s upper class around the turn of the 20th century but then fell out of favor. Their resurgence is partly based on several celebrities who have gone public with their Frenchie love. Leonardo DiCaprio, Megan Thee Stallion, Alexandra Ocasio-Cortez, Reese Witherspoon and Lady Gaga all own French Bulldogs.

The breed earned a lot of attention as show dogs last year when a Frenchie named Winston took second place at the Westminster Kennel Club Dog Show and first in the National Dog Show.

The breed made national news in early 2021 when Gaga’s dog walker was shot in the chest while walking two of her Frenchies in a dog heist. He recovered from his injuries, and the dogs were later returned.

They’ve also become popular because of their unique look and personalities.

“They’re comical, friendly, loving little dogs,” French Bull Dog Club of America spokesperson Patty Sosa told the AP. She said they are city-friendly with modest grooming needs and “they offer a lot in a small package.”

They are also popular with people who live in apartments. According to the AKC, Frenchies don’t bark much and do not require a lot of outdoor exercise.

The French Bulldog stands out among other breeds because it looks like a miniature bulldog but has large, expressive bat-like ears that are its trademark feature. However, their popularity isn’t without controversy. “French bulldogs can be a polarizing topic,” veterinarian Dr. Carrie Stefaniak told the AP.

american kennel club, french bulldog, most popular dog

An adorable French Bulldog

via Pixabay

French Bulldogs have been bred to have abnormally large heads, which means that large litters usually need to be delivered by C-section, an expensive procedure that can be dangerous for the mother. They are also prone to multiple health problems, including skin, ear, and eye infections. Their flat face means they often suffer from respiratory problems and heat intolerance.

Frenchies are also more prone to spine deformations and nerve pain as they age.

Here are the AKC’s top ten most popular dog breeds for 2022.

1 French Bulldogs

2 Labrador Retrievers

3 Golden Retrievers

4 German Shepherd Dogs

5 Poodles

6 Bulldogs

7 Rottweilers

8 Beagles

9 Dachshunds

10 German Shorthaired Pointers


This article originally appeared on 03.17.23

Representative Image from Canva

There's no way they didn't understand what she was saying.

Okay, so maybe dogs don’t understand everything we tell them exactly as a human would. But is that gonna stop us from having full blown conversations with them? Of course not. And the times they do seem to comprehend what’s being communicated—pure comedy.

Take this dog mom’s hilarious pre-grooming pep talk with Shih-Tzus Branston, Pickle and Gizmo. She minced no words telling them exactly how this trip was gonna go. And the message seemed to be received.

Branston (the troublemaker, apparently) got a firm warning of what not to do, including telling white lies about his upbringing.

“I don’t need you running in telling the first dog you see that this is what this is what your hair used to look like when you lived in the Bronx running up and down the block, cause I know for a fact, Branston, that you live in a rural village,” she tells him.

Viewers, however, seemed on board with Branston’s Bronx-affiliation, even if it was a little white lie. One person joked, “don’t be mad at the treats that I got, I’m still Branny from the block.”

In the video, Branston is also instructed to not tell everyone that he “identifies as a BUll Mastiff,” which gets the most adorable look of disappointment for wee little Branston.

As for Gizmo and Pickle—mom’s best advice is to pretend like they don’t know Branston.

Perhaps the best part is mom’s British accent, which makes the entire clip feel like something pulled straight outta “Ted Lasso.” That, or the complete shock the Shih-tzu trio has at being informed of their weight class.

Watch:

@branstonandpickle01 Your NOT from the Bronx and you never ran up and down the block!! #dogsoftiktok #peptalktoyourdog #branstonwehavearrived #shihtzusoftiktok #peptalkbranston #funnydogvideos #funnyvideos #nyc #bronx #funny #dogs #dogtok ♬ original sound - Branston,Pickle&Gizmo

Perhaps Branston, Pickle, and Gizmo’s mom isn’t totally off-base by giving them a talking to. According to the website allshihtzu.com, this breed had a “unique intelligence,” which gets best demonstrated by their attuned, empathic connection to their human families. Meaning that while they might not have the same kind of smarts as border collies or other herding dogs, their super power is picking up social cues.

And, again, even if they had no earthly idea what their mom was saying, odds are she’d still be talking to them anyway. Why? Because pets are our babies. And baby talk is fun.jk

Island School Class, circa 1970s.

Parents, do you think your child would be able to survive if they were transported back to the '70s or '80s? Could they live at a time before the digital revolution put a huge chunk of our lives online?

These days, everyone has a phone in their pocket, but before then, if you were in public and needed to call someone, you used a pay phone. Can you remember the last time you stuck 50 cents into one and grabbed the grubby handset?

According to the U.S. Federal Communications Commission, roughly 100,000 pay phones remain in the U.S., down from 2 million in 1999.

Do you think a 10-year-old kid would have any idea how to use a payphone in 2022? Would they be able to use a Thomas Guide map to find out how to get somewhere? If they stepped into a time warp and wound up in 1975, could they throw a Led Zeppelin album on the record player at a party?


Another big difference between now and life in the '70s and '80s has been public attitudes toward smoking cigarettes. In 1965, 42.4% of Americans smoked and now, it’s just 12.5%. This sea change in public opinion about smoking means there are fewer places where smoking is deemed acceptable.

But in the early '80s, you could smoke on a bus, on a plane, in a movie theater, in restaurants, in the classroom and even in hospitals. How would a child of today react if their third grade teacher lit up a heater in the middle of math class?

Dan Wuori, senior director of early learning at the Hunt Institute, tweeted that his high school had a smoking area “for the kids.” He then asked his followers to share “something you experienced as a kid that would blow your children’s minds.”


A lot of folks responded with stories of how ubiquitous smoking was when they were in school. While others explained that life was perilous for a kid, whether it was the school playground equipment or questionable car seats.

Here are a few responses that’ll show today’s kids just how crazy life used to be in the '70s and '80s.

First of all, let’s talk about smoking.

Want to call someone? Need to get picked up from baseball practice? You can’t text mom or dad, you’ll have to grab a quarter and use a pay phone.

People had little regard for their kids’ safety or health.

You could buy a soda in school.

Things were a lot different before the internet.

Remember pen pals?

A lot of people bemoan the fact that the children of today aren’t as tough as they were a few decades back. But that’s probably because the parents of today are better attuned to their kids’ needs so they don't have to cheat death to make it through the day.

But just imagine how easy parenting would be if all you had to do was throw your kids a bag of Doritos and a Coke for lunch and you never worried about strapping them into a car seat?


This article originally appeared on 06.08.22

What is Depression?

In the United States, close to 10% of the population has depression, but sometimes it can take a long time for someone to even understand that they have it.

One difficulty in diagnosis is trying to distinguish between feeling down and experiencing clinical depression. This TED-Ed video from December 2015 can help make the distinction. With simple animation, the video explains how clinical depression lasts longer than two weeks with a range of symptoms that can include changes in appetite, poor concentration, restlessness, sleep disorders (either too much or too little), and suicidal ideation. The video briefly discusses the neuroscience behind the illness, outlines treatments, and offers advice on how you can help a friend or loved one who may have depression.


Unlike the many pharmaceutical ads out there with their cute mascots and vague symptoms, the video uses animation to provide clarity about the mental disorder. It's similar in its poignant simplicity to the HBO short documentary "My Depression," based on Liz Swados' book of the same name.


This article originally appeared on 08.17.19

New baby and a happy dad.


When San Francisco photographer Lisa Robinson was about to have her second child, she was both excited and nervous.

Sure, those are the feelings most moms-to-be experience before giving birth, but Lisa's nerves were tied to something different.

She and her husband already had a 9-year-old son but desperately wanted another baby. They spent years trying to get pregnant again, but after countless failed attempts and two miscarriages, they decided to stop trying.


Of course, that's when Lisa ended up becoming pregnant with her daughter, Anora. Since it was such a miraculous pregnancy, Lisa wanted to do something special to commemorate her daughter's birth.

So she turned to her craft — photography — as a way to both commemorate the special day, and keep herself calm and focused throughout the birthing process.

Normally, Lisa takes portraits and does wedding photography, so she knew the logistics of being her own birth photographer would be a somewhat precarious new adventure — to say the least.

pregnancy, hospital, giving birth, POV

She initially suggested the idea to her husband Alec as a joke.

Photo by Lisa Robinson/Lisa Robinson Photography.

"After some thought," she says, "I figured I would try it out and that it could capture some amazing memories for us and our daughter."

In the end, she says, Alec was supportive and thought it would be great if she could pull it off. Her doctors and nurses were all for Lisa taking pictures, too, especially because it really seemed to help her manage the pain and stress.

In the hospital, she realized it was a lot harder to hold her camera steady than she initially thought it would be.

tocodynamometer, labor, selfies

She had labor shakes but would periodically take pictures between contractions.

Photo by Lisa Robinson/Lisa Robinson Photography.

"Eventually when it was time to push and I was able to take the photos as I was pushing, I focused on my daughter and my husband and not so much the camera," she says.

"I didn't know if I was in focus or capturing everything but it was amazing to do.”

The shots she ended up getting speak for themselves:

nurse, strangers, medical care,

Warm and encouraging smiles from the nurse.

Photo by Lisa Robinson/Lisa Robinson Photography.

experiment, images, capture, document, record

Newborn Anora's first experience with breastfeeding.

Photo by Lisa Robinson/Lisa Robinson Photography.

"Everybody was supportive and kind of surprised that I was able to capture things throughout. I even remember laughing along with them at one point as I was pushing," Lisa recalled.

In the end, Lisa was so glad she went through with her experiment. She got incredible pictures — and it actually did make her labor easier.

Would she recommend every mom-to-be document their birth in this way? Absolutely not. What works for one person may not work at all for another.

However, if you do have a hobby that relaxes you, figuring out how to incorporate it into one of the most stressful moments in your life is a pretty good way to keep yourself calm and focused.

Expecting and love the idea of documenting your own birthing process?

Take some advice from Lisa: "Don't put pressure on yourself to get 'the shot'" she says, "and enjoy the moment as much as you can.”

Lisa's mom took this last one.

grandma, hobby, birthing process

Mom and daughter earned the rest.

Photo via Lisa Robinson/Lisa Robinson Photography.

This article originally appeared on 06.30.16