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Breakthrough study offers ray of hope to those suffering from anxiety.

Neuroscientists just pinpointed the physical source of anxiety in our brains — and it could lead to a breakthrough treatment.

Using mice. And light rays.

Experiments have located so-called "anxiety cells" located in the hippocampus of mice brains. Using a ray of light, researchers found they could literally turn down the level of anxiety in these cells.


“This is exciting because it represents a direct, rapid pathway in the brain that lets animals respond to anxiety-provoking places without needing to go through higher-order brain regions,” said Mazen Kheirbek, assistant professor of psychiatry at University of California, San Francisco, and a lead investigator on the joint study conducted by UCSF and Columbia University.

Nearly 1 in 5 Americans has experienced an anxiety disorder.

Photo by Alexander Mils/​Unsplash.

According to the National Institute of Mental Health, an estimated 31% of U.S. adults will experience an anxiety disorder in at some point in their lives.

And celebrities are not immune either. Public figures like Kristen Bell, Lady Gaga, and journalist Dan Harris have shared their own difficulties in navigating a mental illness that can seem invisible to everyone else.

The most common treatments typically involve a combination of therapy and medications. Antidepressents, or SSRI drugs, have come under increased scrutiny in recent years, with critics arguing they are often over-prescribed and in less severe cases may even mask symptoms that could be otherwise treated through different approaches.

A ray of hope. Seriously.

Image via Lab of Rene Hen, ColumbiaUniversity Irving Medical Center.

That's what makes this new study so compelling. If there's an alternative approach to treating anxiety that is both more precise and less invasive, it could be a legitimate breakthrough approach to treating anxiety disorders.

Using rays of light, the researchers were able to track the brain activity in freely moving mice, getting real-time feedback about whether the "anxiety neurons" in their brains were activated during stressful situations:

"They found that suppressing the anxiety neuron pathway made animals more comfortable spending time in environments that usually frighten them, while stimulating the same neural connections made mice behave with anxiety even in safely enclosed spaces."

"Now that we’ve found these cells in the hippocampus, it opens up new areas for exploring treatment ideas that we didn’t know existed before," said Jessica Jimenez, lead author of the joint study.

[rebelmouse-image 19345902 dam="1" original_size="1200x800" caption="Photo by Ayo Ogunseinde/Unsplash." expand=1]Photo by Ayo Ogunseinde/Unsplash.

There's still a lot more work to be done.

Even though the study offers a ton of potential, experiments on mice don't always perfectly translate to trials on humans.

Even though he calls the initial results "tremendous progress," NIMH director Joshua Gordon said we're still far from a solution. "You can think of this paper as one brick in a big wall," he told NPR.

Still, there's no denying the promise and potential for the millions of people living with anxiety disorders and the countless others affected by such challenges.

Family

Professional tidier Marie Kondo says she's 'kind of given up' after having three kids

Hearing Kondo say, 'My home is messy,' is sparking joy for moms everywhere.

Marie Kondo playing with her daughters.

Marie Kondo's book, "The Life-Changing Art of Tidying Up," has repeatedly made huge waves around the world since it came out in 2010. From eliminating anything that didn't "spark joy" from your house to folding clothes into tiny rectangles and storing them vertically, the KonMari method of maintaining an organized home hit the mark for millions of people. The success of her book even led to two Netflix series.

It also sparked backlash from parents who insisted that keeping a tidy home with children was not so simple. It's one thing to get rid of an old sweater that no longer brings you joy. It's entirely another to toss an old, empty cereal box that sparks zero joy for you, but that your 2-year-old is inexplicably attached to.

To be fair, Kondo never forced her way into anyone's home and made them organize it her way. But also to be fair, she didn't have kids when she wrote her best-selling book on keeping a tidy home. The reality is that keeping a home organized and tidy with children living in it is a whole other ballgame, as Kondo has discovered now that she has three kids of her own.

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via Pexels

A couple celebrates while packing their home.

One of the topics that we like to highlight on Upworthy is people who are redefining what it means to be in a relationship. Recently, we’ve shared the stories of platonic life partners, moms who work together as part of a “mommune” and a polyamorous family with four equally-committed parents.

A growing number of people are reevaluating traditional relationships and entering lifestyles that work for them instead of trying to fit into preexisting roles. It makes sense because the more lifestyle options that are available, the greater chance we have to be happy.

A recent trend in unconventional relationships is married couples "living apart together," or LATs as they are known among mental health professionals.

Actress Helena Bonham Carter and director Tim Burton, actress Gwyneth Paltrow and producer Brad Falchuk, and photographer Annie Leibovitz and activist Susan Sontag are all high-profile couples who’ve embraced the LAT lifestyle.

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Nature

Pennsylvania home is the entrance to a cave that’s been closed for 70 years

You can only access the cave from the basement of the home and it’s open for business.

This Pennsylvania home is the entrance to a cave.

Have you ever seen something in a movie or online and thought, "That's totally fake," only to find out it's absolutely a real thing? That's sort of how this house in Pennsylvania comes across. It just seems too fantastical to be real, and yet somehow it actually exists.

The home sits between Greencastle and Mercersburg, Pennsylvania, and houses a pretty unique public secret. There's a cave in the basement. Not a man cave or a basement that makes you feel like you're in a cave, but an actual cave that you can't get to unless you go through the house.

Turns out the cave was discovered in the 1830s on the land of John Coffey, according to Uncovering PA, but the story of how it was found is unclear. People would climb down into the cave to explore occasionally until the land was leased about 100 years later and a small structure was built over the cave opening.

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Pop Culture

YouTube star MrBeast sponsors 1,000 people's cataract surgery to help them see again

"I had never heard of MrBeast so I almost hung up. But gratefully did not hang up."

YouTube star sponsors 1,000 people's cataract surgery

Blindness touches people's lives around the world and YouTube star Jimmy Donaldson, more popularly known as MrBeast, is trying to do something about it. Donaldson made it his mission to help 1,000 people regain their eyesight with the help of Dr. Jeff Levenson, an ophthalmologist and surgeon in Jacksonville, Florida.

Levenson has been operating a program called "Gift of Sight" for over 20 years. The program provides free cataract surgery to uninsured people who are legally blind for free, so long as they meet certain criteria. Levenson had never heard of Donaldson, and he almost hung up on him when the YouTube star called to ask about a partnership.

"I had never heard of MrBeast so I almost hung up. But gratefully did not hang up," Levenson told CNN.

After figuring out that Donaldson was indeed a real person who wanted to help others, the duo called around the Jacksonville area to determine the people who needed help the most. They got their list of clients from free clinics and homeless shelters, which covered the United States portion of the surgeries.

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A mom makes sensory sand by putting Cheerios in a blender.

A parenting influencer who goes by the name @ellethevirgo on TikTok has shared a brilliant hack that can turn a simple box of Cheerios into a fun sensory sand experience. The great part is that the sand is edible, so you don’t have to worry if your child puts some in their mouth, which they will inevitably do.

The recipe for Cheerios sensory sand is pretty simple:

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Gaël Monfils makes tennis a must-see.

Tennis isn't always the most entertaining sport to watch, especially if you're not particularly interested in seeing a ball get slapped across a net at 1,000,000 mph approximately 17,000 times. You could probably get whiplash or eye strain if you focused too hard on it. While some people love the sport, others need a little more than grunts and sneaker sounds to capture their attention.

If you're in the group of people who need to be entertained, look no further than Gaël Monfils, a professional French tennis player that has earned the nickname, "The Entertainer." Monfils turned pro in 2004 and has multiple championship matches under his belt, and yet he still takes the time to be...extra while playing.

In a compilation video uploaded to TikTok, we see the 36-year-old tennis player dancing after hitting the ball across the net just out of his opponent's reach. But of course, he also doesn't hit the ball like your average player, either. In one part of the video, Monfils jumps up extremely high and bicycle kicks as he hits the ball with his tongue hanging out of his mouth.

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