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1 year later, the Ice Bucket Challenge funds this breakthrough in ALS research.

Money raised by the viral campaign is making a big difference.

Remember the Ice Bucket Challenge?

Of course you do. It was that viral video campaign that took off last summer where you'd log into Facebook and see a steady stream of your friends dumping water on themselves in the name of awareness and research for the ALS Association.

For science! Brrrrrr. Photo by Clive Mason/Getty Images.

Some brushed the movement off as an example of "slacktivism," but it actually helped raise more than $100 million. When you compare it to the $2.8 million raised by the organization during the same period a year earlier, it's clear that the Ice Bucket challenge paid off.

ALS, also known as amyotrophic laterals sclerosis or Lou Gehrig's Disease, affects an estimated 30,000 living people at any given time.

It's a disorder that affects nerve and muscle function. Just 20% of those with the disease will live more than five years following diagnosis. It's brutal.

But there's good news — due, in part, to the money raised by the Ice Bucket Challenge.

While that man doesn't seem to be having such a great time, I really need to find out what kind of seemingly IBC-proof makeup the woman on the left is using. Photo by Scott Barbour/Getty Images.

During a reddit "Ask Me Anything" session, ALS researcher Jonathan Ling unveiled a major breakthrough in his work.

Ling wanted to do an "Ask Me Anything" to debunk some of the negative things being said by skeptics about the success of the Ice Bucket Challenge.

"I mainly wanted to do this ["Ask Me Anything"] because I remember reading a lot of stories about people complaining that the ice bucket challenge was a waste and that scientists weren't using the money to do research, etc. I assure you that this is absolutely false," Ling writes.

"All of your donations have been amazingly helpful and we have been working tirelessly to find a cure. With the amount of money that the ice bucket challenge raised, I feel that there's a lot of hope and optimism now for real, meaningful therapies."

So what's the big breakthrough? Well, it has to do with protein — or rather, one specific protein.

Ling's research focuses on TDP-43, a protein in cells that's he's been able to link to ALS.

Ling breaks down the purpose of TDP-43 with an analogy involving a library that's easy for us non-scientist types to understand:

"DNA is located in the nucleus of a cell. You can think of a nucleus as a library except that instead of having books neatly lined up on shelves, the books in a nucleus have all of their pages ripped out and thrown around randomly.

To sort through this mess, the cell has great librarians that go around collecting all these pages, collating them and neatly binding them together as books. These librarians then ship these 'books' out of the nucleus so that other workers in the cell can do their jobs. Think of these books as instruction manuals.

TDP-43 is a very special type of librarian. TDP-43's job is to ensure that nucleus librarians don't accidentally make a mistake and put a random nonsense page (usually filled with gibberish) into the books that they ship out.If one of these nonsense pages makes it into an 'instruction manual,' the workers in the cell get really confused and mess things up. For terminology, we call these nonsense pages 'cryptic exons.'"



His team found that in 97% of ALS cases, TDP-43 wasn't doing its job. And now that they know this, they've been able to begin work on new therapies to do TDP-43's job for it. If successful, he believes this can slow down the progression of the disease.

How cool is that?

Baseball Hall-of-Famer Lou Gehrig became the face of ALS after he tearfully retired from baseball upon diagnosis. Photo by Hulton Archive/Getty Images.

But what about the other 3%? Well, we don't have all the answers just yet.

One redditor asked that question, and essentially, it boils down to the fact that ALS is still pretty unpredictable. While TDP-43 may play a large part in the disease's progression, it's not the whole picture. For those individuals for whom ALS runs in the family, that seems to be linked to a gene called SOD1, and not TDP-43.

That's why research needs to continue.

"When you look at ALS from a genetics perspective, about 10% of the cases are called 'familial', [that is], lots of people in the family have ALS and it seems to be passed down. The other 90% of ALS appears to occur completely by unfortunate chance and we call that 'sporadic.'

As researchers, we look to the genetics for clues to study the disease. One of the first family-linked genes discovered was a gene called SOD1 that is found in about 30% of familial cases. But it's starting to seem like SOD1 is an outlier because TDP-43 doesn't seem to be messed up. Instead, SOD1 seems to clump together due to the mutation. We get the 3% because 30% of 10% familial is 3%." — Ling

But yeah, this is pretty neat, exciting stuff!

Ling hopes to have therapies based on his research making their way to clinical trials within the next two-three years.

And from there, who knows? Maybe this is the breakthrough that sets up the next big step in finding a cure for this absolutely ruthless disorder. 76 years after it first entered the public consciousness with Lou Gehrig's emotional farewell speech, a cure feels closer than ever before.

Last year, we shared a video by Anthony Carbajal, a man who had been recently diagnosed with ALS.

ALS runs in Carbajal's family. His grandmother, his mother, and he have all been diagnosed with the disorder. His Ice Bucket Challenge video was powerful because it put a face to the research and the desperation for a cure.


GIF via Anthony Carbajal.

The research made possible by the Ice Bucket Challenge gives hope to people like Anthony. It's just so important.

Saying that 30,000 people live with ALS doesn't mean a whole lot until you see the pain it causes those living with it and watching their loved ones do battle. When you watch Anthony's video, his tears welling up in his eyes, it's clear just how much the world needed something like the Ice Bucket Challenge to fund the research we need to put an end to ALS once and for all.

Pop Culture

Parents who grew up in the '70s and '80s remember the experiences that blow their kids' minds

Kids were tougher then for a reason.

via Wikimedia Commons

Island School Class, circa 1970s.

Parents, do you think your child would be able to survive if they were transported back to the '70s or '80s? Could they live at a time before the digital revolution put a huge chunk of our lives online?

These days, everyone has a phone in their pocket, but before then, if you were in public and needed to call someone, you used a pay phone. Can you remember the last time you stuck 50 cents into one and grabbed the grubby handset?

According to the U.S. Federal Communications Commission, roughly 100,000 pay phones remain in the U.S., down from 2 million in 1999.

Do you think a 10-year-old kid would have any idea how to use a payphone in 2022? Would they be able to use a Thomas Guide map to find out how to get somewhere? If they stepped into a time warp and wound up in 1975, could they throw a Led Zeppelin album on the record player at a party?

Another big difference between now and life in the '70s and '80s has been public attitudes toward smoking cigarettes. In 1965, 42.4% of Americans smoked and now, it’s just 12.5%. This sea change in public opinion about smoking means there are fewer places where smoking is deemed acceptable.

But in the early '80s, you could smoke on a bus, on a plane, in a movie theater, in restaurants, in the classroom and even in hospitals. How would a child of today react if their third grade teacher lit up a heater in the middle of math class?

Dan Wuori, senior director of early learning at the Hunt Institute, tweeted that his high school had a smoking area “for the kids.” He then asked his followers to share “something you experienced as a kid that would blow your children’s minds.”


A lot of folks responded with stories of how ubiquitous smoking was when they were in school. While others explained that life was perilous for a kid, whether it was the school playground equipment or questionable car seats.

Here are a few responses that’ll show today’s kids just how crazy life used to be in the '70s and '80s.

First of all, let’s talk about smoking.

Want to call someone? Need to get picked up from baseball practice? You can’t text mom or dad, you’ll have to grab a quarter and use a pay phone.

People had little regard for their kids’ safety or health.

You could buy a soda in school.

Things were a lot different before the internet.

Remember pen pals?

A lot of people bemoan the fact that the children of today aren’t as tough as they were a few decades back. But that’s probably because the parents of today are better attuned to their kids’ needs so they don't have to cheat death to make it through the day.

But just imagine how easy parenting would be if all you had to do was throw your kids a bag of Doritos and a Coke for lunch and you never worried about strapping them into a car seat?


This article originally appeared on 06.08.22

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Pop Culture

Michael B. Jordan runs into his middle-school bully on the red carpet and calls her out

He didn't forget.

via Gage Skidmore/Wikimedia Commons

Michael B. Jordan speaking at the 2017 San Diego Comic Con International, for "Black Panther", at the San Diego Convention Center in San Diego, California.

As long as humans have endeavored to do anything great, there have been those who have tried to take them down. These are the opposite of the creators in life: the bullies, haters and naysayers who only want to bring people down to their level.

But when you have a dream and desire, its easy to tune out the voices of negativity. "It is not the critic who counts; not the man who points out how the strong man stumbles, or where the doer of deeds could have done them better,” Theodore Roosevelt once said. “The credit belongs to the man who is actually in the arena."

Some folks use the naysayers as fuel to push them to work even harder. Basketball legend Michael Jordan was infamous for letting his thirst for revenge drive him to even greater heights on the court.

Another Michael Jordan, "Black Panther" star, Michael B. Jordan, came face to face with someone who doubted that he could reach his dreams, and he wasn’t shy about letting her know that he remembered. What's Upworthy about the encounter is that he did so with class and confidence.

In 2023, Jordan was on the red carpet for the premiere of "Creed III," a film he starred in and directed. He was interviewed by “The Morning Hustle” radio show host Lore’l, who had recently admitted on the “Undressing Room” podcast that she used to make fun of him in school.

“You know what’s so crazy? I went to school with Michael B. Jordan at a point in life,” Lore’l said. “And to be honest with you, we teased him all the damn time because his name was Michael Jordan. Let’s start there, and he was no Michael Jordan.”

“He also would come to school with a headshot,” she added. “We lived in Newark. That’s the hood. We would make fun of him like, ‘What you gonna do with your stupid headshot?’ And now look at him!”

In addition, her co-host, Eva Marcille, referred to Jordan as “corny.”

Jordan had no problem discussing their past on the red carpet. “We go way back, all the way back to Chad Science [Academy] in Newark,” Lore’l told the actor. Oh yeah, I was the corny kid, right?” Jordan responded with a smirk.

“No, you did not hear me say that! I said we used to make fun of the name,” Lore’l said.

“I heard it,” Jordan said. “I heard it. It’s all good. What’s up?” he responded. “But yeah, [you are] obviously killing things out here…you’re not corny anymore,” Lore’l clarified.

After the exchange went viral, Lore’l admitted that she teased Jordan in school, but they were only classmates for one year.

“So the narrative that I bullied him all throughout high school—this was 7th grade. We were like 12 years old, and everyone made fun of each other,” Lore’l said. “That was school, you know. That was one year. And, again, I’ve never bullied him. That just sounds so outrageous to me.”

Jordan later shared some advice on how to deal with bullies.

"Just stay focused, just stay locked in,” he told a reporter from Complex. “You know, just follow your heart, try to block out the noise and distractions as much as possible and run your race. Don't compare yourself to anybody else. Just keep going."

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Sorry, Labradors. After 31 years, America has a new favorite dog.

The American Kennel Club has crowned a new favorite.

via Pixabay

A sad-looking Labrador Retriever

The sweet-faced, loveable Labrador Retriever is no longer America’s favorite dog breed. The breed best known for having a heart of gold has been replaced by the smaller, more urban-friendly French Bulldog.

According to the American Kennel Club, for the past 31 years, the Labrador Retriever was America’s favorite dog, but it was eclipsed in 2022 by the Frenchie. The rankings are based on nearly 716,500 dogs newly registered in 2022, of which about 1 in 7 were Frenchies. Around 108,000 French Bulldogs were recorded in the U.S. in 2022, surpassing Labrador Retrievers by over 21,000.

The French Bulldog’s popularity has grown exponentially over the past decade. They were the #14 most popular breed in 2012, and since then, registrations have gone up 1,000%, bringing them to the top of the breed popularity rankings.

The AKC says that the American Hairless Terrier, Gordon Setter, Italian Greyhound and Anatolian Shepherd Dog also grew in popularity between 2021 and 2022.

The French Bulldog was famous among America’s upper class around the turn of the 20th century but then fell out of favor. Their resurgence is partly based on several celebrities who have gone public with their Frenchie love. Leonardo DiCaprio, Megan Thee Stallion, Alexandra Ocasio-Cortez, Reese Witherspoon and Lady Gaga all own French Bulldogs.

The breed earned a lot of attention as show dogs last year when a Frenchie named Winston took second place at the Westminster Kennel Club Dog Show and first in the National Dog Show.

The breed made national news in early 2021 when Gaga’s dog walker was shot in the chest while walking two of her Frenchies in a dog heist. He recovered from his injuries, and the dogs were later returned.

They’ve also become popular because of their unique look and personalities.

“They’re comical, friendly, loving little dogs,” French Bull Dog Club of America spokesperson Patty Sosa told the AP. She said they are city-friendly with modest grooming needs and “they offer a lot in a small package.”

They are also popular with people who live in apartments. According to the AKC, Frenchies don’t bark much and do not require a lot of outdoor exercise.

The French Bulldog stands out among other breeds because it looks like a miniature bulldog but has large, expressive bat-like ears that are its trademark feature. However, their popularity isn’t without controversy. “French bulldogs can be a polarizing topic,” veterinarian Dr. Carrie Stefaniak told the AP.

american kennel club, french bulldog, most popular dog

An adorable French Bulldog

via Pixabay

French Bulldogs have been bred to have abnormally large heads, which means that large litters usually need to be delivered by C-section, an expensive procedure that can be dangerous for the mother. They are also prone to multiple health problems, including skin, ear, and eye infections. Their flat face means they often suffer from respiratory problems and heat intolerance.

Frenchies are also more prone to spine deformations and nerve pain as they age.

Here are the AKC’s top ten most popular dog breeds for 2022.

1 French Bulldogs

2 Labrador Retrievers

3 Golden Retrievers

4 German Shepherd Dogs

5 Poodles

6 Bulldogs

7 Rottweilers

8 Beagles

9 Dachshunds

10 German Shorthaired Pointers


This article originally appeared on 03.17.23

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Parenting

Mom creates a stir after refusing to drop her child off at a parent free birthday party

"I loved drop off parties. I didn't want to sit at some kids party."

Photos by Ivan Samkov and Gustavo Fring|Canva

Mom refuses to let kid go to "drop-off" birthday party

There are many Millennial moms that were raised on "Unsolved Mysteries" and "America's Most Wanted" during formative years, which may or may not have influenced the way they parent. It can be hard to think clearly when Robert Stack's voice is echoing in your head every time your child is out of eyesight. The jokes about what is responsible for the average Millennial's parenting style resembling more like a helicopter are endless. But sometimes additional caution is warranted where others may find it unnecessary.

At least that's what many folks on the internet believe after one mom seemingly split parents into two camps with her revelation about children's parties. Liv, who goes by the TikTok handle Liv SAHM, takes to social media to explain that her seven-year-old son was invited to a birthday party but when she went to RSVP, she noticed the invitation said, "drop off only."

The mom explains, "It's at someone's house. I don't know these parents. I don't know that there's actually going to be other adults besides this child's parents."

Liv states that she would not be dropping her young child off alone with strangers. To many parents this seems like a reasonable response. If you don't know the parents or any other adults then how can you ensure your child will be safe. Other parents felt like Liv was completely overreacting with a helicopter parenting style.

"Little kids have been going to peoples birthday parties without clingy parents for decades," one person declares.

"I'm a drop off kinda house. I want the parents to leave that is one less person I have to feed. I don't wanna have to make small talk with other parents," another says.

"That's a big no for me too! And I always try to take my kids to classmates parties because people never show up," someone writes.

"That's so worrisome. I completely agree with you mama bear, same with my son," a commenter says.

"Yeah, that would make me uncomfortable too! It's always a little interesting to me when parents drop off their kids at parties," someone else adds.

@livsahm

No thank you! I don’t feel comfortable with that. #mom #momsoftiktok #momlife #sahm #sahmlife #birthday #birthdayparty #celebration #controversial #parenting #parentingtips #parents #no

There's no right or wrong way to throw a party for a kid because there's no rulebook. Generally parents are accustomed to seeing invitations that say no siblings or the offer of parents staying or leaving. Many commenters pointed out that it seemed odd that the invitation was worded in a way that sounded like parents staying wasn't an option.

Some parents noted that the world has changed since they were children and wouldn't feel safe dropping their kids off either. Others found no issue with it and think fellow parents are overreacting. What do you say, odd or perfectly fine?

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Family

Dad shares what happens when you give your child books instead of a smartphone

The key to fostering healthy habits in children is to be wholly present and reject the “pressures of convenience”

via Armando Hart (used with permission)

Armando Hart and his son, Raya.

One of the most pressing dilemmas for parents these days is how much screen time they should allow their children. Research published by the Mayo Clinic shows that excessive screen time can lead to obesity, disrupted sleep, behavioral issues, poor academic performance, exposure to violence and a significant reduction in playtime.

The American Academy of Pediatrics recommends limiting screen time to 1 to 2 hours daily for children over 2. But American children spend far more time in front of screens than that and the situation is only worsening.

Before the pandemic, kids between the ages of 4 and 12 spent an average of 4.4 hours a day looking at screens, but since 2020, the average child’s daily screen time has increased by 1.75 hours.

A father in Long Beach, California, is getting some love for his TikTok video sharing what happens when you give your kid books instead of an iPhone. Armando Hart posted a video showing his 10-year-old son, Raya, reading a book in the back of a car and it’s been seen over 8 million times.

"Give them books instead of phones when they are little and this is the result," the caption reads. "Thank me later."

We’re so blessed with our son Raya. I think he’s read more books than I have.

@lifeinmotion08

We’re so blessed with our son Raya. I think he’s read more books than I have. #Books #Read #Fyp

Hart and his wife started reading to their son every night before bedtime, hoping to instill a love for books. "It was all about leading by example and creating a nurturing environment where reading was celebrated," Hart told Newsweek. These days, Raya is an avid reader who enjoys just about anything.

“My son likes novels, fiction, nonfiction, and realistic fiction,” Hart told Upworthy. “He also likes informative content, such as reading the almanac and other informative magazines. He loves to build, cook from recipes, and make art.”

For Hart, reading is all about creating a sense of balance in his son’s life.

“It's not about being against technology but about fostering a balanced approach that prioritizes meaningful experiences and hands-on learning,” he told Upworthy. “By instilling a love for reading, creativity, and exploration early on, we're equipping Raya with the skills and mindset he needs to thrive in an ever-changing world.”

Hart believes that the screen time discussion isn’t just about technology but a trend that goes deeper. “It speaks to a broader societal problem: our youth's lack of self-esteem, confidence and fundamental values. While screen time may exacerbate these issues, it is not the sole cause,” he told Upworthy.

“In contrast, physical activity, such as exercise, promotes joy and well-being. Spending hours scrolling on a phone can detract from genuine moments of happiness and fulfillment,” he continued. “Therefore, we must address the deeper underlying issues affecting our youth's mental and emotional health rather than solely attributing them to screen time.”

Hart believes the key to fostering healthy habits in children is to be wholly present and reject the “pressures of convenience” that encourage parental complacency.

“We prioritize quality time together, whether exploring nature, sharing meals with the best available foods, or engaging in meaningful conversations. In today's rapidly advancing technological world, staying grounded in our humanity and embodying integrity in everything we do is crucial,” he continued. “This means staying connected to our authentic selves and teaching our son the importance of honesty, kindness, and respect.”

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