More

1 year later, the Ice Bucket Challenge funds this breakthrough in ALS research.

Money raised by the viral campaign is making a big difference.

1 year later, the Ice Bucket Challenge funds this breakthrough in ALS research.

Remember the Ice Bucket Challenge?

Of course you do. It was that viral video campaign that took off last summer where you'd log into Facebook and see a steady stream of your friends dumping water on themselves in the name of awareness and research for the ALS Association.


For science! Brrrrrr. Photo by Clive Mason/Getty Images.

Some brushed the movement off as an example of "slacktivism," but it actually helped raise more than $100 million. When you compare it to the $2.8 million raised by the organization during the same period a year earlier, it's clear that the Ice Bucket challenge paid off.

ALS, also known as amyotrophic laterals sclerosis or Lou Gehrig's Disease, affects an estimated 30,000 living people at any given time.

It's a disorder that affects nerve and muscle function. Just 20% of those with the disease will live more than five years following diagnosis. It's brutal.

But there's good news — due, in part, to the money raised by the Ice Bucket Challenge.

While that man doesn't seem to be having such a great time, I really need to find out what kind of seemingly IBC-proof makeup the woman on the left is using. Photo by Scott Barbour/Getty Images.

During a reddit "Ask Me Anything" session, ALS researcher Jonathan Ling unveiled a major breakthrough in his work.

Ling wanted to do an "Ask Me Anything" to debunk some of the negative things being said by skeptics about the success of the Ice Bucket Challenge.

"I mainly wanted to do this ["Ask Me Anything"] because I remember reading a lot of stories about people complaining that the ice bucket challenge was a waste and that scientists weren't using the money to do research, etc. I assure you that this is absolutely false," Ling writes.

"All of your donations have been amazingly helpful and we have been working tirelessly to find a cure. With the amount of money that the ice bucket challenge raised, I feel that there's a lot of hope and optimism now for real, meaningful therapies."

So what's the big breakthrough? Well, it has to do with protein — or rather, one specific protein.

Ling's research focuses on TDP-43, a protein in cells that's he's been able to link to ALS.

Ling breaks down the purpose of TDP-43 with an analogy involving a library that's easy for us non-scientist types to understand:

"DNA is located in the nucleus of a cell. You can think of a nucleus as a library except that instead of having books neatly lined up on shelves, the books in a nucleus have all of their pages ripped out and thrown around randomly.

To sort through this mess, the cell has great librarians that go around collecting all these pages, collating them and neatly binding them together as books. These librarians then ship these 'books' out of the nucleus so that other workers in the cell can do their jobs. Think of these books as instruction manuals.

TDP-43 is a very special type of librarian. TDP-43's job is to ensure that nucleus librarians don't accidentally make a mistake and put a random nonsense page (usually filled with gibberish) into the books that they ship out. If one of these nonsense pages makes it into an 'instruction manual,' the workers in the cell get really confused and mess things up. For terminology, we call these nonsense pages 'cryptic exons.'"



His team found that in 97% of ALS cases, TDP-43 wasn't doing its job. And now that they know this, they've been able to begin work on new therapies to do TDP-43's job for it. If successful, he believes this can slow down the progression of the disease.

How cool is that?

Baseball Hall-of-Famer Lou Gehrig became the face of ALS after he tearfully retired from baseball upon diagnosis. Photo by Hulton Archive/Getty Images.

But what about the other 3%? Well, we don't have all the answers just yet.

One redditor asked that question, and essentially, it boils down to the fact that ALS is still pretty unpredictable. While TDP-43 may play a large part in the disease's progression, it's not the whole picture. For those individuals for whom ALS runs in the family, that seems to be linked to a gene called SOD1, and not TDP-43.

That's why research needs to continue.

"When you look at ALS from a genetics perspective, about 10% of the cases are called 'familial', [that is], lots of people in the family have ALS and it seems to be passed down. The other 90% of ALS appears to occur completely by unfortunate chance and we call that 'sporadic.'

As researchers, we look to the genetics for clues to study the disease. One of the first family-linked genes discovered was a gene called SOD1 that is found in about 30% of familial cases. But it's starting to seem like SOD1 is an outlier because TDP-43 doesn't seem to be messed up. Instead, SOD1 seems to clump together due to the mutation. We get the 3% because 30% of 10% familial is 3%." — Ling

But yeah, this is pretty neat, exciting stuff!

Ling hopes to have therapies based on his research making their way to clinical trials within the next two-three years.

And from there, who knows? Maybe this is the breakthrough that sets up the next big step in finding a cure for this absolutely ruthless disorder. 76 years after it first entered the public consciousness with Lou Gehrig's emotional farewell speech, a cure feels closer than ever before.

Last year, we shared a video by Anthony Carbajal, a man who had been recently diagnosed with ALS.

ALS runs in Carbajal's family. His grandmother, his mother, and he have all been diagnosed with the disorder. His Ice Bucket Challenge video was powerful because it put a face to the research and the desperation for a cure.


GIF via Anthony Carbajal.

The research made possible by the Ice Bucket Challenge gives hope to people like Anthony. It's just so important.

Saying that 30,000 people live with ALS doesn't mean a whole lot until you see the pain it causes those living with it and watching their loved ones do battle. When you watch Anthony's video, his tears welling up in his eyes, it's clear just how much the world needed something like the Ice Bucket Challenge to fund the research we need to put an end to ALS once and for all.

Courtesy of Farwiza Farhan
True

Growing up in Indonesia, Farwiza Farhan always loved the ocean. It's why she decided to study marine biology. But the more she learned, the more she realized that it wasn't enough to work in the ocean. She needed to protect it.

"I see the ocean ecosystem collapsing due to overfishing and climate change," she says. "I felt powerless and didn't know what to do [so] I decided to pursue my master's in environmental management."

This choice led her to work in environmental protection, and it was fate that brought her back home to the Leuser Ecosystem in Sumatra, Indonesia — one of the last places on earth where species such as tigers, orangutans, elephants and Sumatran rhinoceros still live in the wild today. It's also home to over 300 species of birds, eight of which are endemic to the region.

"When I first flew over the Leuser Ecosystem, I saw an intact landscape, a contiguous block of lush, diverse vegetation stretched through hills and valleys. The Leuser is truly a majestic landscape — one of a kind."

She fell in love. "I had my first orangutan encounter in the Leuser Ecosystem," she remembers. "As the baby orangutan swung from the branches, seemingly playing and having fun, the mother was observing us. I was moved by the experience."

Courtesy of Farwiza Farhan

"Over the years," she continues, "the encounters with wildlife, with people, and with the ecosystem itself compounded. My curiosity and interest towards nature have turned into a deep desire to protect this biodiversity."

So, she began working for a government agency tasked to protect it. After the agency dismantled for political reasons in the country, Farhan decided to create the HAkA Foundation.

"The goals [of HAkA] are to protect, conserve and restore the Leuser Ecosystem while at the same time catalyzing and enabling just economic prosperity for the region," she says.

"Wild areas and wild places are rare these days," she continues. "We think gold and diamonds are rare and therefore valuable assets, but wild places and forests, like the Leuser Ecosystems, are the kind of natural assets that essentially provide us with life-sustaining services."

"The rivers that flow through the forest of the Leuser Ecosystem are not too dissimilar to the blood that flows through our veins. It might sound extreme, but tell me — can anyone live without water?"

Courtesy of Farwiza Farhan

So far, HAkA has done a lot of work to protect the region. The organization played a key role in strengthening laws that bring the palm oil companies that burn forests to justice. In fact, their involvement led to an unprecedented, first-of-its-kind court decision that fined one company close to $26 million.

In addition, HAkA helped thwart destructive infrastructure plans that would have damaged critical habitat for the Sumatran elephants and rhinos. They're working to prevent mining destruction by helping communities develop alternative livelihoods that don't damage the forests. They've also trained hundreds of police and government rangers to monitor deforestation, helping to establish the first women ranger teams in the region.

"We have supported multiple villages to create local regulation on river and land protection, effectively empowering communities to regain ownership over their environment."

She is one of Tory Burch's Empowered Women this year. The donation she receives as a nominee is being awarded to the Ecosystem Impact Foundation. The small local foundation is working to protect some of the last remaining habitats of the critically endangered leatherback turtle that lives on the west coast of Sumatra.

"The funds will help the organization keep their ranger employed so they can continue protecting the islands, endangered birds and sea turtle habitats," she says.

To learn more about Tory Burch and Upworthy's Empowered Women program visit https://www.toryburch.com/empoweredwomen. Do you know an inspiring woman like Farwiza? Nominate her today!

Jennifer Lawrence

After being a Hollywood staple, Jennifer Lawrence vanished from the public eye following the release of "X-Men Dark Phoenix" in 2019.

Sure, the pandemic had something to do with that … in addition to the usual way our society treats Hollywood "it" girls, once it grows accustomed to the flavor. But in a recent interview with Vanity Fair, Lawrence opens up about some other reasons she chose to step away for a time.

Lawrence went from being a highly sought-after Oscar-winning actress to starring in less-than-successful films like "Passengers," "Mother!" and "Red Sparrow." The films were not only poorly received among critics, but commercially as well.

"I was not pumping out the quality that I should have," she told VF. "I just think everybody had gotten sick of me. I'd gotten sick of me. It had just gotten to a point where I couldn't do anything right. If I walked a red carpet, it was, 'Why didn't she run?'"

So then, why do it? As any workaholic would know, it's about so much more than money.

Keep Reading Show less
Courtesy of Ms. Lopez
True

Marcella Lopez didn't always want to be a teacher — but once she became one, she found her passion. That's why she's stayed in the profession for 23 years, spending the past 16 at her current school in Los Angeles, where she mostly teaches children of color.

"I wanted purpose, to give back, to live a life of public service, to light the spark in others to think critically and to be kind human beings," she says. "More importantly, I wanted my students to see themselves when they saw me, to believe they could do it too."

Ms. Lopez didn't encounter a teacher of color until college. "That moment was life-changing for me," she recalls. "It was the first time I felt comfortable in my own skin as a student. Always remembering how I felt in that college class many years ago has kept me grounded year after year."

It's also guided her teaching. Ms. Lopez says she always selects authors and characters that represent her students and celebrate other ethnicities so students can relate to what they read while also learning about other cultures.

"I want them to see themselves in the books they read, respect those that may not look like them and realize they may have lots in common with [other cultures] they read about," she says.

She also wants her students to have a different experience in school than she did.

When Ms. Lopez was in first grade, she "was speaking in Spanish to a new student, showing her where the restroom was when a staff member overheard our conversation and directed me to not speak in Spanish," she recalls. "In 'this school,' we only speak English," she remembers them saying. "From that day forward, I was made to feel less-than and embarrassed to speak the language of my family, my ancestors; the language I learned to speak first."

Part of her job, she says, is to find new ways to promote acceptance and inclusion in her classroom.

"The worldwide movement around social justice following the death of George Floyd amplified my duty as a teacher to learn how to discuss racial equity in a way that made sense to my little learners," she says. "It ignited me to help them see themselves in a positive light, to make our classroom family feel more inclusive, and make our classroom a safe place to have authentic conversations."

One way she did that was by raising money through DonorsChoose to purchase books and other materials for her classroom that feature diverse perspectives.

Courtesy of Ms. Lopez

The Allstate Foundation recently partnered with DonorsChoose to create a Racial Justice and Representation category to encourage teachers like Ms. Lopez to create projects that address racial equity in the classroom. To launch the category, The Allstate Foundation matched all donations to these projects for a total of $1.5 million. Together, they hope to drive awareness and funding to projects that bring diversity, inclusion, and identity-affirming learning materials into classrooms across the country. You can see current projects seeking funding here.

When Ms. Lopez wanted to incorporate inclusive coloring books into her lesson plans, The Allstate Foundation fully funded her project so she was able to purchase them.

"I'm a lifelong learner, striving to be my best version of myself and always working to inspire my little learners to do the same," she says. Each week, Ms. Lopez and the students would focus on a page in the book and discuss its message. And she plans to do the same again this school year.

"DonorsChoose has been a gamechanger for my students. Without the support of all the donors that come together on this platform, we wouldn't have a sliver of what I've been able to provide for my students, especially during the pandemic," she says.

"My passion is to continue striving to be excellent, and to continue to find ways to use literature as an anchor, depicting images that reflect my students," she says.

To help teachers like Ms. Lopez drive this important mission forward, donate on DonorsChoose.

Courtesy of Ms. Lopez

This story was originally published on The Mighty and originally appeared here on 07.21.17


Most people imagine depression equals “really sad," and unless you've experienced depression yourself, you might not know it goes so much deeper than that. Depression expresses itself in many different ways, some more obvious than others. While some people have a hard time getting out of bed, others might get to work just fine — it's different for everyone.

Keep Reading Show less

Tired of avocados turning brown? Try this simple trick.

Ah, the delicious, creamy avocado. We love it, despite its fleeting ripeness and frustrating tendency to turn brown when you try to store it. From salads to guacamole to much-memed millennial avocado toast, the weird berry (that's right—it's a berry) with the signature green flesh is one of the more versatile fruits, but also one of the more fickle. Once an avocado is ready, you better cut it open within hours because it's not going to last.

Once it's cut, an avocado starts to oxidize, turning that green flesh a sickly brown color. It's not harmful to eat, but it's not particularly appetizing. The key to keeping the browning from happening is to keep the flesh from being exposed to oxygen.

Some people rub an unused avocado half with oil to keep oxidation at bay. Others swear by squeezing some lemon juice over it. Some say placing plastic wrap tightly over it with the pit still in it will keep it green.

But a YouTube video from Avocados from Mexico demonstrates a quick, easy, eco-friendly way to store half an avocado that doesn't require anything but a container and some water.

Keep Reading Show less