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The cool new DIY science movement that's changing everything from animals to agriculture.

"We're all here because we want to be the first humans able to fly."

"And we also want to live forever, see through walls, and shoot lasers from our eyeballs," the Ukrainian scientist tells me with a totally straight face. "But that's all science-fiction nonsense for now. So in the meantime, we're just making yogurt with an anti-aging protein, and things like that."


That must be Stamos' secret. GIF from Dannon Oikos/YouTube.

We're standing in the attic of a bicycle repair shop in Somerville, Massachusetts, where a group of local scientists and curious hobbyists have built a do-it-yourself laboratory for homegrown biology experiments.

The space is strewn with secondhand equipment, all scavenged and salvaged from the dumpsters of nearby universities and major pharmaceutical companies. Someone even found a way to use a breast pump to filter out bacteria samples. Yeah.

But as wild as this all may sound, it's hardly the most remarkable thing to come out of the life science revolution that's sweeping across the world.

"I cannot believe my eyes!" — Me, when I saw this stuff. GIF from "Dr. Horrible's Sing-Along Blog."

Recent advancements in biotech have made it easier than ever to manipulate and edit DNA with shocking accuracy.

At the forefront of this biological renaissance is a little thing scientists call CRISPR-Cas9, often shortened to just plain ol' CRISPR. It's a system that we pretty much stole from certain bacteria that uses enzymes and something called guide RNA to target and cut sequences of DNA.

But that's all kinds of confusing for non-science-y types, so think of it like this: DNA is full of information that tells a story, like a book. Previously, if we wanted to change any part of this DNA-book, we had to chop up random sections with our metaphorical scissors, or splash white-out on the pages, trying to scribble in new notes wherever we could. Sure, it got the job done sometimes. But it was also pretty messy and inefficient.

The CRISPR system offers a new kind of "find-and-replace" feature. Now we can take our DNA-book and say, "OK, CRISPR, please find that sentence that specifically says, 'Harry met Hagrid.'" Then we can tell it to cut out that particular sentence and either get rid of it entirely or add our own new, much cooler sentence in its place. (Like "Harry met Hagrid and then they high-fived and it was so epic that they destroyed Voldemort and everyone was awesome.")

Got that?

TL;DR: Everything is awesome with CRISPR. GIF from "The LEGO Movie."

Now imagine that instead of just rewriting their own derivative Harry Potter fanfic, scientists can use this "find-and-replace" feature to turn specific genes "on" or "off," or even add new sequences of base pairs into the genome. This makes it easier than ever to go in and splice, add, or change one little piece of genetic information and see what happens.

"It's like a toolkit, essentially," explained Joanne Kamens, executive director of Addgene. "It's like having just the right screwdriver we never had, and it's allowing scientists to create hundreds of new tools and making everything exponentially faster."

A much-more useful CRISPR explainer video. GIF from Desktop Genetics/YouTube.

This kind of super-accurate gene editing — and genetic synthesis in general — have become more accessible in the past few years.

CRISPR might be the prom queen of the biggest labs, but there are other similar versions of this kind of precision gene-editing technology — like the methods that my Ukrainian friend was using in that attic. And these tools are collectively changing the world as we know it, in attics and labs all over the world.

Let's go down the DNA rabbit hole... GIF from McGovern Institute for Brain Research at MIT/YouTube.

Here are five of the most fascinating inventions and discoveries we've seen in biotech to date:

1. Gene editing could help us limit, or maybe even destroy, diseases like malaria and cancer.

Now that we can slice into DNA with alarming accuracy, we can target exactly where diseases exist in the body and how drugs get delivered to kill those diseases. It's like a microbiological version of "Mission: Impossible" when you're trying to defuse a bomb — gene editing tells you exactly which wire to cut, without the risk of blowing up the building (which in this case is a human body).

Scientists at the University of California San Francisco, for example, have found a way to turn human T cells into hyper-efficient disease-killing machines. Similarly, at Temple University, researchers are using CRISPR to literally cut HIV out of live subjects. Pretty neat, huh?

As for those pesky mosquito-born illnesses plaguing our warming world, CRISPR has already made it easier to identify diseases such as Zika, malaria, and West Nile in patients and hosts alike — and some scientists hope to use gene editing to remove the disease-carrying capability from the mosquito genome entirely, destroying them at the source.

EXACTLY. GIF from "Adventure Time."

2. This same application is revolutionizing how we study mental health, too.

Scientists at MIT have already used gene editing to create lab mice with autism and OCD so they can better understand what causes those conditions and how best to treat them.

If they can create those conditions, they might be able to un-create them, too, by essentially flipping a switch on the problematic genes. (The only trick is figuring out with certainty which specific genes out of the billions in our body are causing the problems, which is easier said than done.)

I know, Krang. It's pretty mind-blowing. GIF from "Teenage Mutant Ninja Turtles."

3. It could also help us bring back the wooly mammoth or any other number of crazy chimera breeds.

Yup: Scientists at Harvard University successfully spliced wooly mammoth DNA into elephant cells. This is just on a cellular level so far, mind you; no one's prepared to go all "Jurassic Park" without looking into all the potential ramifications of such a project.

But, I mean, you knew this was coming, right? As cool and generally comforting as these other remarkable projects have been, we're still talking about genetic engineering, so of course there'd be some kind of super-powered kaiju-animal hybrids in the cards.

In China, scientists have already used CRISPR to breed dogs with twice the muscle mass by simply deleting one gene from their DNA. And in Boston, they've found a way to modify pig organs to make them compatible with human bodies in need of transplant donors.

And if you're wondering about the practical applications and ethical justifications of these kinds of projects, well ... those are totally valid things to be concerned about. But scientists are actively engaged in those discussions, and if it makes you feel any better, we're probably still a long way away from creating fully customizable mature synthetic humans. Probably.


My thoughts exactly, Doc Brown. GIF from "Back to the Future."

4. Gene editing could also help to revamp the entire agriculture industry — without the use of any off-putting genetic additives.

GMOs get a bad wrap. But gene editing is different from, say, adding a bit of flounder DNA into a tomato, which is why the FDA recently approved the first CRISPR-modified mushroom for human consumption.

These specially designed mushrooms have a greater resistance to browning — again, not because of any scary-sounding chemicals or foreign genes, but simply because biologists found a way to isolate and shut off the naturally occurring genes that caused the mushrooms to turn brown after you cut into them.

That's it. Really. Nothing scary about it.

Naturally occurring mushroom-hat parachutes are still in the early developmental stages. GIF from "Super Mario Bros. Super Show."

This method is also working to create disease-resistant plants, which is how a team at Seoul National University is trying to save the banana. Because why bother introducing pesticides or foreign genetic material when you can just poke at the DNA that the plant already has to improve its nutrient content and help it survive under less-than-ideal conditions? It's not quite "natural" in the traditional sense, but it's also not so different from the exchange and selective breeding of crops that's been going on for centuries.

Just, ya know — easier, and cooler-sounding.

So that's what Beaker's been meeping about all these years! GIF from "The Muppet Show."

5. But perhaps most importantly, gene editing is lowering the bar for scientific research and making it accessible to everyone.

Until recently, a lot of genetic and biotech data was protected behind intellectual property laws and institutional restrictions. But now? Anyone can buy an all-in-one CRISPR starter kit online or order a plasmid straight from a place like Addgene for a mere $65 and see what they can do with it ... just like those guys in the Somerville attic.

"It's like designing apps" for smartphones, said DeskGen's A.J. Ajetunmobi. DeskGen is a biotech startup that offers free open-source desktop gene-editing software, allowing anyone to design an experiment from anywhere in the world.

"People can focus on fixing problems instead of learning how to code," he said. "In life sciences, we're still stuck teaching people how to code. It's hard to teach that and still keep minds open."

GIF from "Dexter's Laboratory."

"Diversity of perspective makes everything better. People are so much more innovative when they're not coming at it from a specific overhead," Ajetunmobi added.

The possibilities for progress are endless as long as the opportunities are available to everyone — not just the pharmaceutical companies who can afford to pay millions for special equipment and data.

"The barriers to entry [in biotech] are significant," Ajetunmobi told me with an eyeroll and a laugh, before pointing out that it would be logistically difficult for an individual — say, a 30-year-old writer who is me — to obtain all the necessary plasmids and parts to breed a personal army of altruistic disease-resistant pig-human hybrid super-farmers with laser vision and flight capabilities.

"But now, there's nothing technically stopping anyone from experimenting and exploring."

Maybe you, too, can create your own web-shooters! ... Maybe. GIF from "The Amazing Spider-Man."

Personally, I decided to keep it simple and stick with the DIY bioluminescent yeast starter kit.

I'll leave the cool sci-fi-sounding progress to the pros (or to my new friends trying to find the fountain of youth in yogurt). But it's still nice to know that the opportunity is out there for anyone eager enough to give it a try.

Who knows? Maybe that 14-year-old kid next door will find a way to make pigs fly sooner than we think.

A waiter talking with his hands.

One of the great things about America is that we have a relatively young culture, so many of the foods that we eat were brought over from other countries. That makes America a great place to try out all the different types of food from around the world.

However, we also like to put our own stamp on staples from around the globe that give the American version its own unique flair. Some foods that we claim originated overseas were actually first made right here in the U.S. of A. For example, chimichangas, which can be found in many Mexican restaurants, actually originated in the state of Arizona. Crab Rangoon, a popular “Chinese” dish, was actually invented in San Francisco, and spaghetti and meatballs were never a thing in Italy.


TikTok creator Gabby Donahue posted a video that’s the perfect example of how some ethnic foods get remixed once they become popular in the States. In a video with over 7 million views, her father shows a waiter in Italy a photo of chicken parmesan from Olive Garden so he can order it at the restaurant. The waiter's reaction is an excellent example of someone trying to be polite while he cannot believe what he is seeing.

“My Boston Irish father trying to order a Google image of the Olive Garden chicken parm in Italy,” Donahue wrote in the text overlay.

@gabbydonahuee

@Olive Garden ‘s biggest fan 😭😭😭😭 #italy #cultureshock #chickenparm #olivegarden


When the father showed the picture to the waiter, he seemed a bit confused about the image. “Only in the States,” he said. “It doesn’t exist in Italy.” The father couldn’t believe what he was hearing: “It doesn’t exist in Italy?”

“I don’t know what it is…on the pasta?” the waiter said, trying to make sense of the chicken breast smothered in cheese and sauce. The waiter gave his final verdict while holding his chin: “No. That’s horrible.”

“Horrible? Wow. Look at that. That doesn’t,” the father laughed. “That looks good… but,” the waiter shrugged off the father. “It does look good,” the father continued. “It tastes good. I’ll tell you what, I’m gonna mail you some. I’ll send it to you.”

“Okay? Olive Garden chicken, I’m gonna search,” the waiter said, walking away from the table.


The commenters had a field day analyzing the waiter’s body language. “‘No, that looks good’ while looking completely disgusted was the most Italian reaction ever,” one commenter wrote. “Bro remembered halfway through his disgust that he’s at work,” another added.

It’s not crazy that an American would think that chicken parmesan is an Italian dish; after all, it’s served in most Italian-American restaurants. However, according to Paesana, it was created in America by the Italian diaspora.

“In the Old World, that’s Italy prior to the Italian diaspora—the large-scale emigration of Italians from Italy to America—proteins like chicken were not widely available," according to an article on the site. "As such, the prototypical chicken parmigiana was actually made with breaded, fried slices of eggplant in place of chicken for a dish called melanzane alla Parmigiana."


Even though chicken parmesan didn’t originate in the old country, Pasquale Sciarappa, a popular Italian-born food influencer living in America, has no problem cooking the dish.

"'That’s not Italian!’ I hear this every time I share a dish like Chicken Parmigiana. And you know what? They’re right — it’s not something you’d traditionally find in Italy. But you know what else is true? It’s Italian-American. It was born in immigrant kitchens — from people who left Italy, landed in the U.S., and made do with what they had. They took inspiration from dishes like melanzane alla parmigiana and recreated comfort from memory using what was available,” he wrote.

It’s understandable that an American could go to Italy without knowing that something he’d had in Italian restaurants wasn’t actually from Italy. It’s understandable for an Italian server to balk at a photo of a dish served in an American restaurant that you’d find in a shopping mall.

But we should all agree that one of the wonderful things about American culture is that it's an amalgamation of different cultures stirred around in the same pot, and if that means we get a fresh variation on the burrito, a new way to eat Chinese crab, or a tasty piece of chicken where eggplant used to be, the more the better.

Humor

Massachusetts woman writes her own obituary, leaving her grieving family laughing at her wit

"Well, if you're reading this obituary, I'm dead. WOW, it actually happened..."

Linda Murphy Obituary/McCarthy Funeral Home and Photo credit: Canva

Massachusetts woman's obituary leaves her family laughing

It can be depressing to think about your own mortality, but inevitably, everyone will eventually die. Those diagnosed with a terminal illness have the unfortunate task of thinking about the inevitability much sooner than their peers. Still, those like Linda Murphy aren't letting a diagnosis steal their humor.

Murphy seemed to be the life of the party, always ready to have a good time with friends and family. But over a decade ago, she was diagnosed with breast cancer; after beating that disease, she was diagnosed with Bulbar ALS, which runs in her family.


In her self-written obituary, she shares that her father, who passed away shortly before Murphy, lost his own mother to the same disease. Although devastating, the disease allowed her time to write her own obituary, which left her family and others giggling.

\u200bMassachusetts; Linda Murphy; ALS; obituary; death; dying; funny obituary Glowing tealights in peaceful ambiance.Photo credit: Canva

She starts by pointing out the obvious, "Well, if you are reading this obituary, it looks like I'm dead." That's when the humor kicks in as she jokes about dying from fear of missing out, "WOW, it actually happened ... I died of FOMO due to complications of Bulbar ALS."

Murphy points out that she was just 60 years old and way too young to die, but unfortunately, ALS had other plans. She was loved, as evidenced by her daughter's interview with the local news station. One section of her obituary is all about the yummy food she missed out on due to her no longer being able to swallow.

Linda Murphy; ALS; obituary; death; dying; funny obituary Friends enjoying a delicious meal together.Photo credit: Canva

"As far as eating, it totally stinks to sit at the table while people around you are eating juicy burgers hot off the grill, heaping piles of Chinese food, a healthy portion of pasta Alfredo, or Chipotle — and I just have to smile and act like I'm enjoying my bowl of puréed baby mush!" she wrote.

Even though she expressed how hard it was to live with her disease, Murphy still made sure to throw in some laughs.

While talking about her 42-year marriage to husband David, she teases about the couple becoming a throuple when she had to be put on a respirator. "We both agreed, I was an "A" wife and he was a "B+" husband for a total "A-" which is pretty decent for 42 years together!!!" she wrote. "We became a thruple about 1.5 years ago when, Hosee, (my respirator) moved into our marital bed. From then on, David woke up next to what looked like a fighter pilot with smooshed hair!"

Linda Murphy; ALS; obituary; death; dying; funny obituary Saying goodbye with lilies and love.Photo credit: Canva

Murphy highlights her superpowers before her final plea for kindness. The woman was joyous even after death. Maybe it was her way of easing things for her family members or for herself. Maybe it was simply because that's who she was as a person, and she used her obituary as the final moment to give others a glimpse into her personality. Either way, her reminders about kindness and living life fully are lessons that can extend far beyond her family and friends.

"I lived my life with two super powers," she wrote. "My first, of which everyone was jealous, was that I could drink as much as I wanted and never seemed to get a hangover ... the real wonder is why I didn't die of liver failure. My second super power is that I was always genuinely happy and absolutely loved to be with nice people. Please be kind to everyone: the telemarketer, the grocery clerk, the Dunkin's staff, the tailgater, your family, your friends. Speak nicely and positively. Is there really ever a reason to be negative? I don't think so…"

Harvard researcher Arthur C. Brooks studies what leads to human happiness.

We live in a society that prizes ambition, celebrating goal-setting, and hustle culture as praiseworthy vehicles on the road to success. We also live in a society that associates successfully getting whatever our hearts desire with happiness. The formula we internalize from an early age is that desire + ambition + goal-setting + doing what it takes = a successful, happy life.

But as Harvard University happiness researcher Arthur C. Brooks has found, in his studies as well as his own experience, that happiness doesn't follow that formula. "It took me too long to figure this one out," Brooks told podcast host Tim Ferris, explaining why he uses a "reverse bucket list" to live a happier life.


bucket list, wants, desires, goals, detachment Many people make bucket lists of things they want in life. Giphy

Brooks shared that on his birthday, he would always make a list of his desires, ambitions, and things he wanted to accomplish—a bucket list. But when he was 50, he found his bucket list from when he was 40 and had an epiphany: "I looked at that list from when I was 40, and I'd checked everything off that list. And I was less happy at 50 than I was at 40."

As a social scientist, he recognized that he was doing something wrong and analyzed it.

"This is a neurophysiological problem and a psychological problem all rolled into one handy package," he said. "I was making the mistake of thinking that my satisfaction would come from having more. And the truth of the matter is that lasting and stable satisfaction, which doesn't wear off in a minute, comes when you understand that your satisfaction is your haves divided by your wants…You can increase your satisfaction temporarily and inefficiently by having more, or permanently and securely by wanting less."

Brooks concluded that he needed a "reverse bucket list" that would help him "consciously detach" from his worldly wants and desires by simply writing them down and crossing them off.

"I know that these things are going to occur to me as natural goals," Brooks said, citing human evolutionary psychology. "But I do not want to be owned by them. I want to manage them." He discussed moving those desires from the instinctual limbic system to the conscious pre-frontal cortex by examining each one and saying, "Maybe I get it, maybe I don't," but crossing them off as attachments. "And I'm free…it works," he said.

- YouTube www.youtube.com

"When I write them down, I acknowledge that I have the desire," he explained on X. "When I cross them out, I acknowledge that I will not be attached to this goal."

The idea that attachment itself causes unhappiness is a concept found in many spiritual traditions, but it is most closely associated with Buddhism. Mike Brooks, PhD, explains that humans need healthy attachments, such as an attachment to staying alive and attachments to loved ones, to avoid suffering. But many things to which we are attached are not necessarily healthy, either by degree (over-attachment) or by nature (being attached to things that are impermanent).

"We should strive for flexibility in our attachments because the objects of our attachment are inherently in flux," Brooks writes in Psychology Today. "In this way, we suffer unnecessarily when we don't accept their impermanent nature."

What Arthur C. Brooks suggests that we strive to detach ourselves from our wants and desires because the simplest way to solve the 'haves/wants = happiness' formula is to reduce the denominator. The reverse bucket list, in which you cross off desires before you fulfill them, can help free you from attachment and lead to a happier overall existence.

A 27-year-old woman and a 62-year-old woman.

Ben Keenan, a travel and culture content creator and podcaster, did a great job of saying out loud what many people feel but can’t put into words. When it comes to age, some people feel younger or older regardless of their chronological age. It’s like we get to a certain point where we feel like aging is accelerating, and then, suddenly, context changes, and we feel younger again. Different eras hit differently.

A lot of it has to do with juxtaposing ourselves with our younger or older peers, or whether we are new or experienced in certain phases of life. Like, some people feel like they are an old young person at 39, but suddenly, they hit 40 and feel like a young older person. It’s a beautiful thing knowing that, although you may feel like you’re at an "old age" right now, you may suddenly feel younger on your next birthday.


In a viral Instagram video, Keenan laid out the ages that feel young or old.


Which ages are young and which are old (according to Ben Keenan)

21 to 26, YOUNG

27 to 32, OLD

33 to 36, YOUNG

37 to 39, OLD

40 to 45, YOUNG

46 to 49, OLD

50, YOUNG

51 to 52, OLD

53 to 59, YOUNG

60 to 61, OLD

62 to 65, YOUNG

66 to 68, OLD

69 to 74, YOUNG

75 and up, OLD

The video received nearly unanimous love in the comments, where many people tried to explain why Keenan makes so much emotional sense, though it’s a little shaky on logic.

ahah moment, lightbulb moment, brilliant idea, thought, inspired man A man has a brilliant idea.via Canva/Photos

"People call 30 'old’ because it’s the first collision with real adulthood—the end of carefree youth. Then 31–36 feels young again as you realize nothing truly changed and you’re still growing, just with more confidence. Around 37–39, life’s weight reappears—aging parents, shifting priorities, subtle reminders of time—so it feels “old” again. But by 40, you’ve accepted it all; you stop comparing, start owning who you are, and that acceptance brings back a sense of youth. Rinse and repeat," Ulises wrote.

“Can confirm that when I turned 37, I felt old. I turn 40 this week and feel SO YOUNG. I guess I’ll look forward to following your pattern for the rest of my life,” Heather commented.

“When I turned 60 last year, I decided that I’d gone from a very old young person, to a very young old person - the youngest in my cohort. Cheered me right up,” Jane added.


Does the aging process speed up?

Keenan’s post points out that feeling young or old isn’t necessarily a matter of age, but scientists say there are two significant moments in life when we experience spurts in aging. Researchers at Stanford tracked thousands of different molecules in people aged 25 to 75 and found that people tend to make two big leaps—one around 44 and another around 60.

Keenan’s theory of aging and his followers' rapturous support of the idea should make everyone feel a little better about getting older. If you feel old today, wait a few years, and then you may feel young again. It makes the adage, “Age ain’t nothing but a number,” seem true. According to Keenan, age isn’t really a number, but a phase.