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The first pill to treat postpartum depression may be ready this year and it could be a game changer

It's in final approvals with the FDA.

postpartum depression, postnatal depression, ppd treatment
via Freepik

A new mother struggling with postpartum depression.

We may be just months away from having the first-ever pill to help treat postpartum depression (PPD). The drug, called Zuranolone, was developed by Sage Therapeutics and Biogen, two companies out of Cambridge, Massachusetts. The FDA has given the drug’s application priority review and the period ends on August 5, 2023.

Currently, there is only one FDA-approved medication for PPD, Zulresso, which is only available through a 60-hour, one-time infusion and can cost up to $35,000 per treatment.

If the medication is approved, it can also be used to treat major depressive disorder (MDD).

What’s unique about the drug is that it is fast-acting. "We feel a tremendous responsibility to patients with MDD and PPD to deliver a potential new treatment option, which is so desperately needed. Most current approved therapies may take weeks or months to work. We are committed to advancing treatments that could help physicians and patients by addressing depression symptoms quickly," Dr. Laura Gault, chief medical officer at Sage Therapeutics Inc., said in a statement.

Zuranolone causes full remission of clinical depression within 45 days in 53% of women versus 30% who received the placebo, according to the study published in the Journal of the American Medical Association Psychiatry.

The new drug could be a godsend to the 500,000 women who suffer from PPD every year. In these women, what starts as a typical case of the “baby blues” can linger and become more intense and lead to an overwhelming loss of energy, irritability, inability to concentrate or make decisions and thoughts of harming themselves or their babies. It also severely inhibits their ability to care for their newborn child.

Symptoms of PPD can begin as early as during pregnancy and as late as a year after giving birth. In rare cases, it can develop into postpartum psychosis, an extreme mood disorder.

PPD is caused by the intense hormonal changes that happen within a woman’s body before and after giving birth. It can also result from numerous anxieties women feel after giving birth, such as the stress of being a “perfect mother,” the effect that pregnancy has on their bodies, being overtired and a lack of free time.

happy mom, happy baby, postpartum depression

A happy, healthy mother and child.

via Pexels.

Zuranolone could also provide faster relief for people dealing with MDD. In 2020, over 14 million Americans were diagnosed with MDD, which creates a persistent feeling of sadness and a loss of interest in things they used to enjoy. It can also affect their ability to have happy, healthy relationships.

In rare situations, MDD can lead to suicidal ideation. Studies show that MDD accounts for up to 89% of all suicides.

If Zuranolone is approved, it will give doctors another vital tool in improving people’s mental health that can relieve debilitating depression in less time. It will also help countless babies that need extra care in their early days from a loving and healthy mother.

If you or someone you know is having thoughts of suicide, call the Suicide and Crisis Lifeline at 988 for free, confidential support.

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Joy

5 small things that made us smile this week

We're giving you the small things that make us smile, every single week

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Hey, have you heard? Life is kind of stressful. Between a news cycle that just won’t quit and the never-ending temptation to doom-scroll, finding small moments of joy throughout the day has become more important than ever.

Case in point: A dog wearing sunglasses.

A news headline that makes you want to high-five a million angels.

A sweet snack that boosts your dopamine, courtesy of our friends at All In.

Or a tweet so perfectly timed it restores your faith in the algorithm (even if only for a second).



These momentary mood boosters are everywhere you look—you just have to be able to find them underneath all the noise. And that’s where we come in.

Consider this weekly web series your cheat sheet to the best of the Internet—not just random memes to make you laugh, but examples of people truly finding something extraordinary in the mundane. We'll be delivering five pieces of media that allow you to stop for a second, take a breath, and feel just a little bit brighter among the daily stress. (Think of us as your chronically online bestie who knows exactly how to make you smile, exactly when you need it the most.)

Ready to laugh? Have your heart melted? Cry happy tears? Let's get into it.

1. Petunia the pig

@knightk64 #petuniathepig#fyp#babypig#alltheprettygirls#animallove ♬ original sound - petuniathepig1

With over nine million views on a single video alone, you know there’s got to be something special about Petunia the Pig. And there is. Behold: the tiniest, most adorable pig we’ve ever laid eyes on. Abandoned by her pig mother, Petunia is a spotted teacup pig who was taken in by TikTok user @knightk64, and we’re all the better for it. She snorts (squeaks) constantly. She tippy-taps across the floor. She takes long naps nestled in her favorite blanket. And she now even has an adopted teacup pig sister named Rosie. Not to be dramatic, but we’d die for this pig.

2. Pop Muzik dances 

@ptpowers Everyone’s #foryoupage the @project21 dance or just us? #dad #baby #dance #fyp #trending ♬ Pop Muzik - M & Robin Scott

Remember when TikTok used to be a dancing app? The dance trends are making a comeback now in the best way—and this new trend is the most fun we’ve seen people having on this app in a while.

The trend started when a mega-talented group of girls from the Project 21 dance studio performed at the NYCDA 2025 dance competition in Las Vegas back in early April. Not only did the girls nab some of the highest awards at the competition, their recorded performance quickly went viral. The song choice? The 1979 classic “Pop Muzik.” The dance? Impossible to look away from. (Here’s a short clip of the girls in all their glory.)

While the original dance is just so fun to watch, what might be even more fun is seeing all the copycat performances and tutorials that have been launched across TikTok ever since. If this doesn’t make you want to get up and dance, nothing will.

3. Seeking out the extra in the ordinary 

There are so many beautiful moments each day that are worth noticing, and the folks at All In are out to help us recognize them. Each week, the All In crew takes to the streets to find the "extra" in the ordinary—small moments of joy that make a typical day just a little bit brighter. Today's moment of joy? Finding community and feeling like you're part of something really special. Can't get much better than that.

4. This tweet series about COVID lockdowns 

Back in 2023, a study in the British Medical Journal made headlines when it claimed that the COVID lockdowns of 2020 only “minimally” affected people’s mental health. As you can probably guess, when news of the study hit Twitter, people were not having it.

Cue one of the funniest and most eye-opening discussions of mental health we’ve possibly ever had as a society. Thousands of people took to the Internet to quote-tweet the article, sharing the most unhinged things they did while stuck in the confines of their house or bedroom, such as: Learning how to play a recorder with one nostril. Watching Glee 26 times in a row. Throwing a birthday party for the dishwasher. The list goes on.

As the fifth year anniversary of COVID lockdowns just passed, these tweets are circulating again. They’re funny, they’re raw, and they shine a spotlight on the effects of isolation on mental health in a way that’s never been done before. Here’s part one of a series, and here are some more. Enjoy!

5. Thirst edits featuring regular people

@coreymbrandon thank you 🥹 @Chili’s Grill & Bar #chilis #CapCut ♬ som original - helo

Here’s where the writer of this article shows her age and admits that, before this trend, she had no idea what a thirst edit was. Allow us to break it down for you: According to ChatGPT, a thirst edit is a video (or series of short videos), usually with specific music or text overlays, created to be seductive and attention grabbing. (Kinda like this, only set to music.)

This new trend takes a normal thirst edit and flips it on its head. Instead of trying to seduce the audience, people are now using thirst traps to romanticize daily life—stuff like eating mozzarella sticks at Chili’s, or hanging out by the pool—or to cheekily boost their own confidence. Set to the song “My Bubble Gum” by Rasheeda, this trend is just normal, everyday people absolutely feeling themselves and celebrating ordinary life. We love to see it.


For even more “extra”-ordinary moments, come find us on social media (@upworthy) or on upworthy.com!

For scrumptious snacks that add an extra boost of joy to your day, be sure to check out All In.

Family

Mom is mortified after her kindergartner tells the teacher what she does for a living

"So, this wasn't on my bingo card."

via Canva/Photos

A mom is embarrassed by her child.

One of the great joys and stresses of parenting is that you never know what will come out of your child’s mouth. When you have kids who are young and inquisitive, they can say really inappropriate things to people without knowing that they were being rude or possibly offensive. TikTok influencer Aurora McCausland (@auroramccausland), known for her DIY cleaning tips, recently told a funny story on the platform about how her son believes she makes a living. The problem was that she heard about it from her child's teacher.

@auroramccausland

so this wasn’t on my bingo card 🥲 #momlife #momtok #sahm #sahmlife #funnyvideo #fypシ

“The other day, I went and picked my five year old up from school and when I get to his classroom his teacher pulls me inside and says, ‘Hey, today he wanted to tell us about what Mommy does for work and said that Mommy makes videos in her bedroom but only when I'm [he’s] not at home,” McCausland recalled.

Given her body language while telling the story, McCausland was clearly mortified after hearing what her child said to his teacher. It makes it look like she may be posting videos to adult sites while her child is at work, which most people wouldn’t want their son’s teacher to know about.

The good news is that another teacher was there to clarify the young boy's comments by adding, “I think she makes TikTok videos.” The uncomfortable situation was a great invitation to chat with her son about what she does for a living. “So I have to have a conversation with my son about how he tells people what I do for work,” she finished her video.

teacher, funny teacher, teacher posing, kindergarten, funny kidsA teacher folding her hands.via Canva/Photos

The funny video went viral, earning over 1.7 million views on TikTok, and inspired many people to share the times when their children had funny ways of explaining their careers.

"My son told everyone that we were homeless (because we don’t own our home, we rent)," KBR wrote.

"I work in ortho.. my daughter told her teacher I steal people's knees bc she heard me talking to my husband about a knee replacement," Aingeal wrote.

"My son told a teacher we were living in our car over the summer. Camping. We went camping," Kera wrote.

"In kinder, my son thought Red Bull was alcohol and told his teacher I liked to have beer on the way to school," Ashley wrote.


"My niece told her teacher her mom and dad work at the wh*re house. They work at the courthouse," Ellis wrote.

"My husband works as a table games dealer at a casino. Kindergartener, 'Daddy's a Dealer!' We now start every school year clearly stating he works at the casino," CMAC

"My son said we lived in a crack house…There’s a tiny chip in the wall from the door knob," KNWerner wrote.

"My dad is a hospice chaplain and officiates a lot of funerals. My son and nephew were asked by their preschool teacher if their papa was retired or had a job. They told her his job was to kill people," Tiffyd wrote.

In the end, McCausland’s story is a fun reminder of how children see things through their own unique lens and, with total innocence, can say some of the funniest things. It’s also a great warning to parents everywhere: if you aren’t clear with your kids about what you do for a living, you may be setting yourself up for a very embarrassing misunderstanding.

This article originally appeared in March

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Pop Culture

Real women trying on 'micro shorts' is the comedy gold we didn't know we needed

Proof we don't need to force ourselves to fit into trends…unless we're needing a good laugh.

Prisma Photo via Canva/Bianca Marie Arreola via Canva

Women are trying Free People's 'micro shorts' with hilarious commentary

With every season, comes a new trendy fashion item that retailers push as the must-have piece. But as we know, no trend is universally flattering.

Case and point, last year, when Free People, a specialty lifestyle brand for bohemian styled fashion, released its "micro shorts," which, as you can probably guess, are teeny tiny. They might check off all the requirements for a pair of shorts...except, they appear to be about the length of underwear.

If you're thinking "there's no way those would look good," you're not wrong! And to prove that point, a couple of women bought some to try on so you don't have to. The videos are not only honest but hilarious.

In one video Nicole Walters, a New York Times best selling author and mom to three girls, decided to order the shorts to see how they looked on someone with, "thigh meat." She wears a size 12 and often jokes about being a curvier on the bottom. When she pulled the shorts out, it looked as if she was going to have to perform a magic trick to get them on. They looked to be the size a small child would wear, but they seemed to have gone on easily even though they looked extremely uncomfortable. She looked uncomfortable. The viewers likely looked uncomfortable.

"Oh wow. They're in there and by in there I mean everywhere. There's a lot of thigh meat happening right now in the, this region," Walters says as she gestures at her upper thighs. "There's some thigh meat, um...uh...I feel like they're definitely in some places that I didn't know I had."

Walter's review of the shorts has people in stitches as she jokes about her Christianity falling out of the shorts.

"It’s the Barbie walk for me lol!!! Thank you for your service," one person says.

"The way you warn us that you’re going to turn around almost made me scream with laughter," someone writes.

"I'm just going to go ahead and dial 911 for help bc looks like you may need the jaws of life to come out them shorts...lol!! Your commentary had me dying laughing..lol," another commenter jokes.

In another Free People "micro shorts" try on video, Nicole Story Dent braved the itty bitty shorts to show her audience the summer trend they can look forward to seeing. The first pair of shorts has multiple flaps that appear to be large pockets which inspires Dent to pretend to fly in them before the discomfort sinks in.

"It's kinda giving waitress...if they ever want to make a Waffle House-Hooters hybrid, we have their uniform, "she said. "We have been asking for more pockets so they delivered. Speaking of delivered, you could deliver a baby without having to take these shorts off."

Dent guessed that the shorts would be more like "jundies" or "janties" than jorts, the shorthand term for jean shorts. Commenters couldn't stop laughing at her description of the shorts while others provided her with words of wisdom.

"Do NOT drop it low in these jundies, that kind of contact with the club floor is NOT hygienic," someone wrote.

"'There is nothing vegan about these. There is absolutely a cat being harmed!' I’m cackling! You really should win something from Free People for this! @freepeople we found your next model," another person joked.

"This is the kind of content the internet was made for, it’s just so good. However my thighs started getting chafed just watching this," added a third.

If you're brave enough to give these micro shorts a try, go ahead and stock up on some baby powder for all the chaffing. However, it's all about long Bermuda shorts this year. And since no one can keep up with fashion's rapid pace anyway, why not just stick with what feels good?

This article originally appeared last year.

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Pop Culture

Born between 1954 and 1965? You might be thrilled to learn you're not a Boomer. You're 'Gen Jones.'

These not-quite-Gen Xers shares some pretty cool and unique traits.

Photo credits: Michelle Obama, Montclair Film, Georges Biard

Michelle Obama, Stephen Colbert and Michelle Yeoh are all Gen Jonesers.

The Silent Generation. Baby boomers. Gen X. Millennials. Gen Z. Gen Alpha. Social science and pop culture commentators have spent decades grouping and analyzing the different generations, assigning various qualities, habits and tendencies to each age group. But some people don’t identify with their generation, or at least these particular categories of them. Those on the cusp between two generations often feel like neither aligns with who they are..

That’s where Generation Jones comes in.

Like the Xennials that straddle Gen X and millennials, Generation Jones are not quite boomers but not quite Gen X. For most of their lives, those born between 1954 and 1965 have been lumped in with the baby boomers, but culturally they’ve never quite fit.

generation jones, boomers, gen x, generational humor, best generationKeanu Reeves is a Gen Joneser. That's how you know it's the best generation. media4.giphy.com

They were too young to be involved in the major civil rights, women’s liberation and Vietnam war movements of the 60s, instead witnessing those social upheavals through children’s eyes. But they were also too old to identify with the Gen X latchkey kid angst.

Jonathan Pontell is the television producer, director, and writer who named Generation Jones and explained what made them unique. “We fill the space between Woodstock and Lollapalooza, between the Paris student riots and the anti-globalisation protests, and between Dylan going electric and Nirvana going unplugged,” he wrote in Politico in 2009.

He also explained why Gen Jonesers make good leaders:

generation jones, boomers, gen x, generational humor, best generation, generational differences, history“What makes us Jonesers also makes us uniquely positioned to bring about a new era in international affairs."

“What makes us Jonesers also makes us uniquely positioned to bring about a new era in international affairs. Our practical idealism was created by witnessing the often unrealistic idealism of the 1960s. And we weren’t engaged in that era’s ideological battles; we were children playing with toys while Boomers argued over issues. Our non-ideological pragmatism allows us to resolve intra-Boomer skirmishes and to bridge that volatile Boomer-GenXer divide. We can lead.”

Many Generation Jonesers have never felt like they had a generational home and are thrilled to learn they actually do have one. Check out how Upworthy readers responded with glee upon discovering they were a part of Gen Jones:

"Thank you! As a definite Gen Jones, I completely relate to this. Too young to be a hippy, therefore was never a yuppy, but too old to be Gen X. Gen Jones works just fine."

generation jones, boomers, gen x, generational humor, best generation, generational differences, historyIt's nice to finally belong. Upworthy Facebook

"I have said for decades that I must be a transitional person into Gen X, because I don’t relate to boomers! I appreciate them, but I am not one of them. I am glad someone finally named my generation!"

"There are definite differences between people born in the 1940s/1950s and those of us born in the early 1960s. Most of us born in the early 1960s do not remember the JFK assassination and we were much too young to participate in Woodstock. The older Boomers were already established in their careers and as homeowners with families in the 1980s when we were in our 20s just starting out and ready to buy our first home. While the older Boomers experienced reasonable mortgage interest rates, the early 1960s Boomers faced mortgage interest rates averaging 14 percent in the 1980s which made it more difficult for us to buy our first home. We definitely need an additional group between Boomers and Gen X, and Generation Jones fits the bill."

"I was born 6 days before 1960…. I’ve felt out of touch with a lot of the boomer life descriptions, and not Gen X enough to fit in there. I’ll take Generation Jones."

generation jones, boomers, gen x, generational humor, best generation, generational differences, historyTen points to Gen Jones.Upworthy Facebook

"1957 here, with older siblings born before 1950. I definitely did not have the same experience growing up that they had. I feel I can identify a little with Boomers and a little with the Gen X experience, so there’s some overlap. (BTW, Gen X needs to stop claiming that they’re the first to have experienced all the things we grew up with. Kids, you didn’t invent drinking out of the garden hose or playing outside until the streetlights came on. Sheesh!) Glad to be a Joneser."

"Of course there is a difference between people raised in the 1950’s and people raised and coming of age in the 1960’s and 1970’s. Society changed a lot in those three decades."

"This is my generation but I never knew we had a name! The description fits perfectly."

Congrats on finding your people, Gen Jones. It's your time to shine.

This article originally appeared last year.

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Pop Culture

Women spots alarming lock on the outside of women's restroom at Texas gas station

“This is a perfect example of see something, say something. Probably helped save girls and women!"

Photo credit: Canva

Everyone should be aware of this.

An alarming video is making rounds on TikTok, showing an external lock fitted to the women's restroom in a Texas gas station. Only on the outside. And only for the women’s restroom.

In the nearly six-minute clip, which has been viewed six million times, a woman named Shelby detailed the unsettling “contraption” she spotted at an Exxon in the city of College Station.

“Maybe I’m crazy but if I am, I would love to know what this contraption is for,” she wrote in her caption. She then demonstrated how the lock could automatically engage once the door closed, leaving a woman trapped inside unless someone from the outside releases it.

@momcallsmeshelby Maybe I’m crazy but if I am, I would love to know what this contraption is for 🙂
♬ original sound - 𝕊𝕙𝕖𝕝𝕓𝕪 🦋

“You have no way of getting out,” she said. Even more disturbing, she also filmed the outside of the men’s room, which obviously did not have such a device.

Shelby recalled that filming her video apparently made the gas station employees “irate,” and kept giving her gestures to indicate they were watching her.

Rightfully, Shelby contacted the police. When they arrived, the workers insisted that the lock was there as protection, to inhibit a “large group of hispanic men” from “destroying” the facility, which supposedly happened in the past.

@momcallsmeshelby Someone ease my mind and tell me I’m crazy & explain the purpose of this thing……
♬ original sound - 𝕊𝕙𝕖𝕝𝕓𝕪 🦋

As you are probably thinking, and as both Shelby and the police agreed, the explanation was incredibly “sketchy” and “didn’t really make sense” since the lock in no way prevented the facility from being destroyed, nor did it keep anyone from entering the restroom.

Considering that Texas is ranked as the second state in the country with the highest rate of human trafficking victims, and that there are many “vulnerable young girls” who live nearby at A&M University, Shelby was right to be alarmed and send out a video as a warning.

She was far from the only one concerned. It wasn’t long before other women began applauding Shelby for taking action.

“This is a perfect example of see something, say something. You went with your guy and probably helped save girls and women! Thank you!"

“A remote controlled lock on the outside of a women’s restroom is absolutely NOT NORMAL! Always always always trust your instincts.”

“As someone who stops in public restrooms all over the country I truly appreciate this post! I will be checking every door I go into now.”

While the police officer Shelby talked to told her that legally there was nothing the department could do (which set off a whole conversation as to whether or not police officers are normally secretly “involved” in this type of activity), she did end up contacting the local Fire Marshal, who did remove the lock.

In a different video (around 55 seconds in) we hear the Marshal telling an employee, “You can call your boss, but no matter how he feels about it, it’s coming down today in front of me, with my tools or yours.”

@nochillheather thank you @𝕊𝕙𝕖𝕝𝕓𝕪 🦋 for bringing this to light. Regardless of what it is, it should never have been on this door. Mighty thankful the police were ON IT & taking it serious 🙏🏻🫡 Anywho stay safe out there everyone but mostly the girlies. 🙂↔️💓✨ #sextraffickingawareness #womensafetytips #womensafety #gasstationstorytime #exxon #fypシ ♬ original sound - Heather 🧚🏼♂️

Of course this is something women should not have to deal with. But in lieu of eradicating every bad guy out there, raising awareness on things like this can at least keep us a little safer.

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Parenting

Parents share 24 unhinged sentences they never imagined saying before having kids

"Please stop licking the shopping cart."

Image via Canva

Parents share funny and unhinged things they've had to say to their kids since becoming parents.

Being a parent brings unexpected surprises everyday. From sudden unexpected talent show appearances to their hilarious locker decor and expert roasting quips, kids are always keeping parents on their toes. And their antics have required a number of unhinged parenting sentences to be uttered. In an online parenting community, member @Plomaster69 posed the question to fellow parents: "What's a sentence you never thought you'd say until you had kids?"

They went on to explain, "'Please stop licking the shopping cart.' I said this to my 4-year-old at Target last week and had to pause for a moment. Like, where do you even begin with that conversation? How did we get to a point where I needed to explain why metal shopping cart handles aren't meant to be tasted?"

It's a conversation that they anticipated many other parents have had to have with their kids. "Before kids, I thought parenting would be about teaching important life lessons and having meaningful conversations. Instead, I spend my days saying things like 'we don't put PlayDoh in our ears' and 'the dog's food is not people food' and 'yes, you still have to wear pants to the grocery store," they shared.

playdoh, playdoh hair, playdoh gif, playdoh fun, playing with playdoh90S Hair GIFGiphy

They ended their post by adding, "The weirdest part is how these completely unhinged sentences just roll off your tongue now. My neighbor heard me tell my kid 'stop trying to marry the vacuum cleaner' and didn't even blink. We've all been there."

Fellow parents had plenty of relatable phrases to share. These are 24 of the most unhinged (and funny) things parents have said to their kids:

"'Don't use your willy to swipe the Kindle screen'." @alancake

"'Stop folding your sister'."@ Cluelessish

"Similar. But, 'Don't lick the toilet!' In a public bathroom." @Musin_Geek

lick toilet, licking toilet, toilet bowl, toilet, lickToliet GIF by Adult SwimGiphy

"'Please stop sniffing each others butts'." @Affectionate_Cow_812

"'Please stop beatboxing when I'm on the phone with a client'." @Mamapalooza

"'Don't drink your bath water'."@ shoshinatl

up nose, stick up nose, put up nose, up your nose, stick in noseGood Burger Dancing GIF by BounceGiphy

"'Don’t put the bottoms of shoes on your face.' 'Don’t lick the cat.' 'Don’t stick that up your nose'." @TopHippo3938

"Hahaha yeah..... things like 'We do not eat stones'. 'Please don't attack the cheese with the scissors', and 'Legos don't belong in the fridge'. 'Please put your plate back on the table and use a fork, you are not a dog.' 'you shouldn't wear your sisters panty on your head when we are going out' are common occurrences and my kids are 7 and 10....Sometimes I run out of words though. My 7yo has developed a habit of climbing up to the very top of doorframes and sticking there like a freaking gecko until someone passes through to pounce... what do I even say. 'You're not a predator, stay on the ground'?" @No_Assistant2804

"We keep a list of ours! Some notable additions: 'Not everything has to be a hat, (child name)'. 'Please don’t play the piano with you face'. 'Try not to sneeze on your pain au chocolat again'. Special mention for one to my husband: 'There’s nothing sexy about piles, Jack.'" @sophie_shadow

"'Did you just GLUE your sister’s foot to that?!' -me, just last night." @winezilla08

glue, glued, school glue, gluing, elmer'selmers glue school GIF by Elmer's ProductsGiphy

"'We do not steal other people’s pets and set up pet shops at the side of the road'. 🙈" @kt1982mt

"'No eating the stairs'. You could swap out stairs for table, garbage can, me. It’s all valid. Poor little guy is going through it but he also refuses to hold anything made for teething and prefers to run wild and free." @imwearingredsocks

"'How many pretzels did you put up your nose?!'" @BabeWithThe_Power


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