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Meet the man behind a new HIV vaccine that could help end the virus for good.

Dr. Robert Gallo has spent decades aiming to end AIDS.

If there ever were a pioneer in the war on AIDS, Dr. Robert Gallo would certainly fit the bill.

 

Photo by Win McNamee/Getty Images.

He was among the leading researchers who discovered HIV actually causes AIDS back in 1984.

 

Photo by Jim Watson/AFP/Getty Images.

That may seem like common knowledge today. But back in the 1980s — when the AIDS crisis was ravaging communities across the U.S. and very little was known about the virus — it was nothing short of groundbreaking.

He then spearheaded a blood test that can detect the virus in humans.

 

Photo by Win McNamee/Getty Images.

The blood test has had big ramifications in curbing HIV infections, as health care workers became equipped to rapidly diagnose infected patients.

And on Oct. 8, 2015, Gallo was at it again, announcing yet another big step in the fight against HIV: His potentially game-changing vaccine is going to human trial.

 

Photo by Jim Watson/AFP/Getty Images.

Sure, there are other HIV-fighting vaccines in human trial (about 30, in fact). But Gallo's vaccine, which has taken his team at the University of Maryland's Institute of Human Virology nearly two decades to produce, stands out ... in a good way.

There are many strains of HIV that can affect the immune system. And that makes creating a universal vaccine that stops all of them a bit tricky. If proven successful, however, Gallo's vaccine would protect patients' immune systems from the variations of the virus classified under "HIV-1," which constitutes the vast majority of infections worldwide.

"Our HIV/AIDS vaccine candidate is designed to bind to the virus at the moment of infection, when many different strains of HIV found around the world can be neutralized. We believe this mechanism is a major prerequisite for an effective HIV preventive vaccine." — Dr. Gallo

Enrollment in the trial opened this month, and the institute is looking for 60 people to participate in its year-long phase 1, according to The Baltimore Sun.

It's a promising step forward in the fight against a virus that's had a massive impact on global health.

There are about 35 million people living with HIV/AIDS around the world, according to the World Health Organization. About 1.5 million people died from the virus in 2013 alone. Sub-Saharan Africa — where nearly 71% of people living with HIV globally reside — has been affected far more than other regions of the world.

 

An HIV-positive mother holds her baby in Malawi. Photo by Marco Longari/AFP/Getty Images.

Although new medicines have helped HIV patients live longer, healthier lives, there is still no cure for the virus. And even for those fortunate enough to be living in regions with access to such medicines, drugs can be expensive (although that doesn't stop some greedy pharmaceutical company CEOs from inflating prices even further ... yeah, I'm talking about you, Martin Shkreli).

Gallo's vaccine could be huge. But even if it turns out to be, there are plenty of hurdles before patients can benefit.

Gallo's announcement is exciting! But let's not put the cart before the horse. Before the vaccine gets clearance from the FDA and becomes a welcomed reality for patients, it has to successfully pass a range of human trials. And that will take several years to complete.

 

Photo by Jim Watson/AFP/Getty Images.

But Gallo is confident the long road ahead will bring promising results.

"Can I promise absolute success? No," Gallo said of the vaccine's potential, according to The Baltimore Sun. "Do I hope it leads to a series of advances in the fields? Yes. And I think it will lead to some advances."

Joy

Dad shares the hilarious conversations he has with 5-year-old daughter and folks are cracking up

"Why do people congratulate you when Mom is making the baby?

via James Breakwell/X

All parents have had similar convos with thier kiddos.

Raising kids is tough, but there's a lot of laughs along the way. Especially when actual conversations start, as kids begin trying to make sense out of the world around them, ask questions, and test mommy and daddy's resolve.

Back in 2018, comedy writer and children's book author James Breakwell, with four daughters who were all under the age of eight at the time, shared their hilarious conversations on X. From these tweets, it looks like comedy runs in the family. Here's a sampling of some Breakwell's funniest kid-inspired tweets.

 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 


 

While Breakwell's 7-year-old wasn't as heavily featured, when she was quoted, the sarcasm was palpable. Which makes sense, considering that kiddos begin understanding this mechanism around that age.

 


 


 


 


 


 


 


 


 


 


 


 


 

Kids really do say the darnedest things, and we love them for it. It one of the many, many ways then bring so much joy to the world. It almost makes up for the headaches and sleepless nights, doesn't it.

This article originally appeared seven years ago.

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'The Tiffany Problem' explains why people think historically accurate things are wrong

Anachronisms aren't always what they seem.

Ali Shaker/VOA, Tylwyth Eldar/Wikimedia Commons

The name Tiffany goes way back to Tiphaine Raguenel, who lived in Mont Saint Michel in the 1300s.

Depending on what generation you belong to, when you hear the name Tiffany, you might think of the famous jewelry store, the teen singer from the 80s or the much-less-in-the-spotlight daughter of President Trump. Most likely, you don't think of a woman who lived in the Middle Ages.

In fact, if you were listening to an audiobook set in medieval times and the narrator introduced a character named Tiffany, you'd probably get yanked right out of the story as your brain would say, "Wait, why is there a Tiffany in this story? Isn't that a much more modern name?"

 tiffany, 1980s, the name tiffany Tiffany was a popular name—and singer—in the 80s.  Giphy  

It's actually not, which is exactly why The Tiffany Problem is called The Tiffany Problem.

The Tiffany Problem refers to the fact that people in modern times will sometimes see something as anachronistic when it's not. It's something writers, filmmakers and other storytellers have to be aware of, as it can feel like there's a historical problem even if there isn't an actual historical problem.

Abraham Piper explains the dilemma and how it was coined:

 

As Piper shares, fantasy author Jo Walton coined the term "The Tiffany Problem" and explained it:

"Your readers are modern people and know what they know, which is fine except when what they know isn’t actually right. For instance, the name Tiffany sounds extremely modern to us. It feels jarring when we read it as a character name in a historical setting, where we’d be quite happy with names like Anna and Jane. But our instinct is wrong, because Tiffany is a form of Theophania, and it was fairly common in medieval England and France. It went out of fashion later, and it’s because we don’t have seventeenth to nineteenth century examples that it feels modern. But you still can’t use it in a fantasy novel set in the exact time and place when the name would have been historically accurate, because it will jerk the reader out of their reading trance. They know it’s wrong and you can’t tell them that what they know is wrong."

 you know I'm right, schitt's creek People often don't realize that what they think they know is wrong.  Giphy GIF by Schitt's Creek 

Piper had also shared that "ha ha," which seems like a casual, modern colloquialism, is actually very old, with the first known use coming from a monk 1,000 years ago. He also mentions "OMG," which was used by a World War I admiral in a letter to Winston Churchill in 1917. And "hubby" as a slang term for husband? That goes way back to the 1680s. Who knew?

It's a bit ironic that writers who strive to ensure their historical fiction works are historically accurate can find themselves stymied by people being just flat-out wrong about what's accurate and what's not. Humans are interesting creatures, aren't we?

For more info about the name Tiffany than you ever thought you wanted to know but will be delighted to learn, CGP Grey created a whole video about the name that has 4.7 million views. Tiffany exploded the 1980s, but CGP Grey goes all the way back to the year 300 to uncover the origins of the name. It's genuinely entertaining. Watch:

  - YouTube  youtu.be  

 

If you're still here and want to take an even deeper dive into the history of Tiffany, this other video from CGP Grey is an incredible rabbit hole that will make you appreciate the work historians do and marvel at how much digging Grey actually did to provide the original Tiffany history video. We're talking trips to the deep dark corners of The British Library, the largest library in the world, and hours and hours of paging through books just to find the original source of this one poem that includes the name "Tiffany." It's a journey, but a fascinating one.

Enjoy "Someone Dead Ruined My Life… Again":

  - YouTube  youtu.be  

 

This article originally appeared two years ago.

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'Wicked' author says one line in 'The Wizard of Oz' inspired Elphaba and Glinda's backstory

Gregory Maguire says he "fell down to the ground" laughing when the idea hit him.

Public domain

The two witches in "The Wizard of Oz" clearly had a history together.

Have you ever watched a movie or read a book or listened to a piece of music and wondered, "How did they come up with that idea?" The creative process is so enigmatic even artists themselves don't always know where their ideas come from, so It's a treat when we get to hear the genesis of a brilliant idea straight from the horse's mouth. If you've watched "Wicked" and wondered where the idea for the friendship between Elphaba (the Wicked Witch) and Glinda (the Good Witch) came from, the author of the book has shared the precise moment it came to him.

The hit movie "Wicked" is based on the 20-year-old hit stage musical, which is based on the novel "Wicked: The Life and Times of the Wicked Witch of the West" written by Gregory Maguire. While the musical is a simplified version of the 1995 book, the basic storyline—the origin story of the two witches from "The Wizard of Oz"—lies at the heart of both. In an interview with BBC, Maguire explained how Elphaba and Glinda's friendship popped into his head.

 

Maguire was visiting Beatrix Potter's farm in Cumbria, England, and thinking about "The Wizard of Oz," which he had loved as a child and thought could be an interesting basis for a story about evil.

"I thought 'alright, what do we know about 'The Wizard of Oz' from our memories,'" he said. "We have the house falling on the witch. What do we know about that witch? All we know about that witch is that she has feet. So I began to think about Glinda and the Wicked Witch of the West…

 glinda, elphaba, wicked,  In "Wicked," the two Oz witches met as students at Shiz University.  Giphy GIF by Wicked 

"There is one scene in the 1939 film where Billie Burke [Glinda the Good Witch] comes down looking all pink and fluffy, and Margaret Hamilton [the Wicked Witch of the West] is all crawed and crabbed and she says something like, 'I might have known you'd be behind this, Glinda!' This was my memory, and I thought, now why is she using Glinda's first name? They have known each other. Maybe they've known each other for a long time. Maybe they went to college together. And I fell down onto the ground in the Lake District laughing at the thought that they had gone to college together."

In "Wicked," Glinda and the Wicked Witch, Elphaba, meet as students at Shiz University, a school of wizardry. They get placed as roommates, loathe each other at first, but eventually become best friends. The story grows a lot more complicated from there (and the novel goes darker than the stage play), but it's the character development of the two witches and their relationship with one another that force us to examine our ideas about good and evil.

  - YouTube  youtu.be  

 

Maguire also shared with the Denver Center for Performing Arts what had inspired him to use the "Wizard of Oz" characters in the first place.

"I was living in London in the early 1990’s during the start of the Gulf War. I was interested to see how my own blood temperature chilled at reading a headline in the usually cautious British newspaper, the Times of London: 'Sadaam Hussein: The New Hitler?' I caught myself ready to have a fully formed political opinion about the Gulf War and the necessity of action against Sadaam Hussein on the basis of how that headline made me feel. The use of the word Hitler – what a word! What it evokes! When a few months later several young schoolboys kidnapped and killed a toddler, the British press paid much attention to the nature of the crime. I became interested in the nature of evil, and whether one really could be born bad. I considered briefly writing a novel about Hitler but discarded the notion due to my general discomfort with the reality of those times. But when I realized that nobody had ever written about the second most evil character in our collective American subconscious, the Wicked Witch of the West, I thought I had experienced a small moment of inspiration. Everybody in America knows who the Wicked Witch of the West is, but nobody really knows anything about her. There is more to her than meets the eye."

 wizard of oz, wicked witch of the west The Wicked Witch of the West has a story of her own.  Giphy  

Authors and artists—and their ideas—help hold a mirror up to humanity for us to see and reflect on who we are, and "Wicked" is one of those stories that makes us take a hard look at what we're seeing in that mirror. Thanks, Gregory Maguire, for launching us on a collective journey that not only entertains but has the potential to change how we see one another.

This story originally appeared last year.

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Best friends, 88 and 92, experience Disneyland for the first time and their joy is contagious

Watch them hopping out of their wheelchairs to dance in New Orleans Square.

Photo courtesy of Disney

June and Ann felt the Disney magic on their first trip to Disneyland.

Good friends can come along at all ages and stages of our lives. While some friendships start early and blossom slowly, others arrive later—sometimes much later—and quickly burst into full bloom.

Ann was nearly 90 years old when she met her bestie, June, and their friendship blossomed instantly. Ann's son, Alonzo, started dating June's daughter, Lauria, three years ago, and the two moms have been inseparable since then. Now 88 and 92, June and Ann do pretty much everything together. "They've known each other almost as long as [Alonzo and I] have been together," says Lauria, "and they've been causing trouble ever since."

 disneyland, disney park, disneyland resort, first trip to disneyland June, Lauria, Alonzo, and Ann enjoying The Happiest Place on Earth.Photo courtesy of Disney

Only good trouble, of course. June tells Upworthy that she and Ann are often told they look alike and they've grown to be more like sisters than just friends. "Our closeness in age allows us to do things together that the younger people wouldn't understand," she says, "like laughing at things we feel are funny or going to dinner, shopping, watching game shows and taking walks together."

And, apparently, hopping out of their wheelchairs to dance to the music in Disneyland's New Orleans Square. June and Ann recently took their first trip to Disneyland and the Disney magic didn't disappoint.

Watch how joyfully these two kicked up their heels with their kids:

 

  June and Ann loved dancing in New Orleans Square.Video courtesy of Disney 

 

"[Experiencing the Disneyland resort] was a wonderful, fun, and exciting experience," Ann tells Upworthy. "It exceeded my expectations and made my first visit to Disneyland a magical experience that I will never forget. I plan on returning for another visit if God is willing."

June says the kindness, patience, and laughter of the cast members stood out to her during their visit. "All the people were so kind to us and I will never forget how warm and happy and inviting they made me feel," she says.

  Disney Perfect Loops GIF  Giphy  

Both of them said their favorite parts were dancing in New Orleans Square and taking a boat ride to see the animals. "We still laugh about all those animals," says June.

Disneyland is celebrating its 70th anniversary in 2025, which means the children who first visited the park the year it opened are now well into retirement. But as we can see from June and Ann's joy, you're never too old to enjoy a little sprinkle of Tinkerbell's magic.

June and Ann's experience with employees—known as cast members—isn't unique. Part of what has made Disneyland such a special place for seven decades is the dedication of the people who work there. Cast members strive to ensure that every guest, no matter their age or how many times they've been to Disneyland, experiences the Disney magic and truly feels they've arrived at The Happiest Place on Earth.

In honor of its 70th year, Disneyland shared a video highlighting a handful of long-time cast members who have been welcoming guests for decades, including Disney's longest-serving cast member, Henry Ameen—affectionately known as Hank—who first started working at the park in 1958.

@disneyparks

At Disneyland, happiness is generational 🏰✨ Since 1955, more than 300,000 cast members have followed in Walt's footsteps to welcome guests to The Happiest Place on Earth, and we can’t wait for everyone to Celebrate Happy during our 70th anniversary.

Disneyland has earned the loyalty of cast members and guests alike since 1955 by honoring the imaginative child that lives in all of us. June and Ann are a delightful reminder that sharing joy with your favorite people is a big part of what makes Disneyland "The Happiest Place on Earth." Whether you're 9 or 92, friendship combined with a sprinkle of that mysterious Disney magic is the perfect recipe for unforgettable memories.

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Science

Experts say America's fast-fashion obsession can be fixed with this 20-outfit wardrobe

Brace yourselves. They suggest only two outfits for festive occasions.

Canva

A woman dives into her messy closet.

How much is too much? This is a question so many of us ask ourselves, especially when we're attempting to de-clutter and scale down. For many, there's no place more baffling than our closets and t-shirt drawers. Letting go can be extremely difficult, but even more challenging? Not constantly adding to our ever-growing piles, especially as fast fashion often makes clothes so inexpensive.

According to sustainability studies researched in the last few years, Americans are buying way too many clothes. (It's not just Americans, of course.)

  Decluttering a closet.   www.youtube.com, Home Reimagined 

In the Hot or Cool Institute fashion report, they find, "Recent trends in fashion consumption are clear: we are consuming more fashion and at a faster rate than ever before, while paying increasingly less for it and weaving a dirty tapestry of social and environmental impacts."

In Vogue's article, "How Many Clothes Do I Need, Exactly?" Emily Chan and Christina Pérez point out (citing the same study) that if we were to keep in accordance with the Paris Agreement, we only need to buy five items of clothing a year. They write, "Since the average American currently buys 53 new items a year, that means that the vast majority of us would need to cut back on the number of clothes we purchase for our yearly wardrobes by at least 90%."

 declutter, closet, clothes, sustainability  A rack of clothing hanging in a closet.   Photo by Ani Rain on Unsplash  

But perhaps this is a bit of old news. The question becomes - what can we DO about it? Chan and Perez state, "With this in mind, the researchers found that a 'sufficient' wardrobe consists of 74 garments and 20 outfits total for those who live in a two-season climate, and 85 garments in total for those who live in a four-season climate."

They cite examples from the study. "They’ve suggested that this modern capsule wardrobe could consist of an average of six outfits for work, three outfits for home wear, three outfits for sports, and two outfits for festive occasions, plus four outdoor jackets and pants or skirts."

Some might cringe just thinking about having only two outfits for festive occasions. How realistic is this for the average person? Luckily Reddit has a few other ideas and it was surprising to find that many of them kept in accordance with climate sustainability.

In the subreddit group r/declutter, someone asks, "How many clothes SHOULD I have?" In part, they write, "I feel like setting # amounts on categories of clothes might help me with these obstacles, so like saying I can only keep 10 short sleeve shirts, 5 pants, or so on.... but I'm not sure what realistic numbers are? Has anyone decluttered in this way before or have any advice that could help me?"

 declutter, messy, closet, sustainability  Hands open up a messy closet.   Giphy Tidy Up GIF 

One person says it should be decided based on your laundry cycle and their proposal is even fewer outfits. They suggest, "Let's assume 7 day laundry cycle, so 10 days worth of clothes. Pull everything out of your closet, pull together the best 10 outfits that are seasonally appropriate for the next 3 to 6 months - essentially what will take you to the next big season change. You can reuse pieces, if they go with multiple items, eg of your 10 outfits, 4 might involve one pair of jeans. Underwear and anything that needs washing after one wear you will need 10 of."

Another Redditor suggests using the hanger method to determine what to keep and what to donate. "Yesterday, I started the turn-around hanger method to see what I actually wear over the course of a year. TBH: I know what I don't wear, but I want to see it for myself. If you keep washing and wearing the same stuff (and the other stuff never gets worn), then that's the focus."

And quite a few swear by The Container Concept, discussed by Dana K. White in her book Decluttering at the Speed of Life.

  - YouTube  www.youtube.com  

The commenter explains regarding this concept: "Your wardrobe, your dresser - that is the space you have for clothes. So first take everything out and then portion your space up. For example, this is the drawer for socks, this is the section of rail for shirts, and so on. Then for each type of clothing, start putting things back in, based on what you wear most, what you like most, what you need most. Do one round of your top items, then do another round, then another until your drawer/shelf/rail is full. That's it! There's no more space, so the rest has to go."

Most agree - less is more. It's better for your peace of mind. And more importantly, the planet will thank you.

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