She's 71 and has literally never felt pain. Her strange condition could help revolutionize pain management.

Jo Cameron has been pain-free all her life — something many might dub a superpower of sorts.

While other women struggle with the pain that comes along with childbirth, when Cameron gave birth to her two children, she felt only “a tickle.” Later on in life, she didn’t realize she needed to have her hip replaced until she physically couldn’t walk. She also couldn’t tell she had been burned until others smelled burning flesh, and failed to notice cuts until someone else pointed out blood. Spicy foods — such as Scotch bonnet chili peppers — didn’t set her mouth on fire and instead left her with a “pleasant glow.”

Her body also heals more quickly than most, with her injuries rarely resulting in scars.


Image by Hans/Pixabay.

While all this sounds pretty incredible, Cameron didn’t think much of it until around five years ago, after she underwent surgery on her hand. She told her doctor, Dr. Devjit Srivastava, that she wouldn’t need any pain medication during recovery. Obviously, this was an unusual patient request, but after delving into her medical history, he quickly realized she was a special case.

So he sent her to see a team of doctors and researchers focused on how genetics can be used to understand the biology of pain and touch at the University College London’s Molecular Nociception Group. Eventually they wrote a paper, which was published on Thursday in The British Journal of Anaesthesia, on the curious case of Cameron, whose pain-free existence seemed unexplainable.

Though these specialists had worked with several individuals who process pain differently, Cameron’s genetic profile was unique for an individual who couldn’t feel pain.

Eventually they discovered her uniqueness could be explained by the fact that she is missing the front of a gene they have dubbed FAAH-OUT — a gene all us have — but they claim she is the only individual they know about who has this specific genetic mutation.

Image by Public Domain/Pixabay.

“We’ve never come across a patient like this,” John Wood, the head of the Molecular Nociception Group at University College London, revealed to the New York Times.

According to researchers, this mutated gene does more than prevents Cameron from feeling pain. She also can’t feel fear or anxiety, which doctors think have something to do with the gene mutation making her more forgetful.

"It's called the happy gene or forgetful gene. I have been annoying people by being happy and forgetful all my life - I've got an excuse now," she told the BBC.

Jo Cameron believes she inherited the mutation from her late father, who she remembers suffered from little pain as well.

“I can’t remember him needing any painkillers,” she told the New York Times. “I think that’s why I didn’t find it odd.” Since he is no longer living, there is no way to know if he was a carrier. While her daughter and mother do not have the mutation, according to her doctors, her son “has the same microdeletion in FAAH-OUT, but does not have the other mutation that confers reduced FAAH function.” So he’s insensitive to some pain, but not all.

Could Cameron’s extraordinary gene help others manage their pain and anxiety better? Doctors are hopeful, but the road ahead is long.

Researchers hope that further studies will help them design gene therapy, pain intervention methods or anxiety medications, though expect it will take many years and a lot of money before a product will emerge.

“I’m reasonably confident that the lessons we are learning from the genes involved in pain will lead to the development of an entirely new class of pain medications,” Dr. Stephen G. Waxman, a Yale neurologist who was not involved with the paper but has studied the subject matter, told the New York Times.

Image by Steve Buissinne/Pixabay

Considering that painkillers on the market today — especially opioids like oxycodone (OxyContin®), hydrocodone (Vicodin®), codeine and morphine — are incredibly addictive and responsible for tens of thousands of drug overdoses every year, finding a responsible pain cure could save so many lives. And if there are more people like Cameron out there, the likelihood of this mutation resulting in a novel pain treatment system is even higher.

There are lots of unknowns, but scientists have come a long way in their research with genetics in recent years. It will be exciting to see the impact an unusual case like Cameron’s has on medicine in the years to come.

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Shopping sustainably is increasingly important given the severity of the climate crisis, but sometimes it's hard to know where to turn. Thankfully, Amazon is making it a little easier to browse thousands of products that have one or more of 19 sustainability certifications that help preserve the natural world.

The online retailer recently announced Climate Pledge Friendly, a program to make it easier for customers to discover and shop for more sustainable products. To determine the sustainability of a product, the program partnered with third-party certifications, including governmental agencies, nonprofits, and independent labs.

With a selection of items spanning grocery, household, fashion, beauty, and personal electronics, you'll be able to shop more sustainably not just for the holiday season, but throughout the year for your essentials, as well.

You can browse all of the Climate Pledge Friendly products here, labeled with an icon and which certification(s) they meet. To get you on your way to shopping more sustainably, we've rounded up eight of our favorite Climate Pledge Friendly-products that will make great gifts all year long.

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Jack Wolfskin Women's North York Coat

Give the gift of warmth and style with this coat, available in a variety of colors. Sustainability is built into all Jack Wolfskin products and each item comes with a code that lets you trace back to its origins and understand how it was made.

Bluesign: Bluesign products are responsibly manufactured by using safer chemicals and fewer resources, including less energy, in production.


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Amazon All-new Echo Dot (4th Gen)

For the tech-obsessed. This Alexa smart speaker, which comes in a sleek, compact design, lets you voice control your entertainment and your smart home as well as connect with others.

Reducing CO2: Products with this certification reduce their carbon footprint year after year. Certified by the Carbon Trust.


Amazon

Burt's Bees Family Jammies Matching Holiday Organic Cotton Pajamas

Get into the holiday spirit with these fun matching PJs for the whole family. Perfect for pictures that even Fido can get in on.

Global Organic Textile Standard: This certifies each step of the organic textile supply chain against strict ecological and social standards. Each product with this certification contains 95%-100% organic content.

Amazon

Naturistick 5-Pack Lip Balm Gift Set

With 100% natural ingredients that are gentle on ultra-sensitive lips, this gift is a great gift for the whole family.

Compact by Design (Certified by Amazon): Products with this certification are packaged without excess air and water, which reduces the carbon footprint of shipping and packaging.


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Arus Women's GOTS Certified Organic Cotton Hooded Full Length Turkish Bathrobe

For those who love to lounge around, this full-length organic cotton bathrobe is the way to go. Available in five different colors, it has comfortable cuffed sleeves, a hood, pockets, and adjustable belt.

Global Organic Textile Standard: This certifies each step of the organic textile supply chain against strict ecological and social standards. Each product with this certification contains 95%-100% organic content.

Amazon

L'Occitane Extra-Gentle Vegetable Based Soap

This luxe soap, made with moisturizing shea butter and scented with verbena, is perfect for the self-care obsessed.

Compact by Design (Certified by Amazon): Products with this certification are packaged without excess air and water, which reduces the carbon footprint of shipping and packaging.

Amazon

Goodthreads Men's Sweater-Knit Fleece Long-Sleeve Bomber

For the fashionable men in your life, this fashion-forward knit bomber is an excellent choice. The sweater material keeps it cozy and warm, while the bomber jacket-cut, zip front, and rib-trim neck make it look elevated.

Recycled Claim Standard 100: Products with this certification use materials made from at least 95% recycled content.

Amazon

All-new Fire TV Stick with Alexa Voice Remote

Make it even easier to access your favorite movies and shows this holiday season. The new Fire TV Stick lets you use your voice to search across apps. Plus it controls the power and volume on your TV, so you'll never need to leave the couch! Except for snacks.

Reducing CO2: Products with this certification reduce their carbon footprint year after year. Certified by the Carbon Trust.

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If the past year has taught us nothing else, it's that sending love out into the world through selfless acts of kindness can have a positive ripple effect on people and communities. People all over the United States seemed to have gotten the message — 71% of those surveyed by the World Giving Index helped a stranger in need in 2020. A nonprofit survey found 90% helped others by running errands, calling, texting and sending care packages. Many people needed a boost last year in one way or another and obliging good neighbors heeded the call over and over again — and continue to make a positive impact through their actions in this new year.

Upworthy and P&G Good Everyday wanted to help keep kindness going strong, so they partnered up to create the Lead with Love Fund. The fund awards do-gooders in communities around the country with grants to help them continue on with their unique missions. Hundreds of nominations came pouring in and five winners were selected based on three criteria: the impact of action, uniqueness, and "Upworthy-ness" of their story.

Here's a look at the five winners:

Edith Ornelas, co-creator of Mariposas Collective in Memphis, Tenn.

Edith Ornelas has a deep-rooted connection to the asylum-seeking immigrant families she brings food and supplies to families in Memphis, Tenn. She was born in Jalisco, Mexico, and immigrated to the United States when she was 7 years old with her parents and sister. Edith grew up in Chicago, then moved to Memphis in 2016, where she quickly realized how few community programs existed for immigrants. Two years later, she helped create Mariposas Collective, which initially aimed to help families who had just been released from detention centers and were seeking asylum. The collective started out small but has since grown to approximately 400 volunteers.