When you twist an Oreo, why does the ‘cream’ always stick to one side? MIT has the answer.

One of the world’s greatest mysteries has finally been solved.

oreo cookie, oreo twist, how to eat oreo
Photo credit: via Mike Mozart/Flickr Delicious Oreo cookies.

There are a lot of snack foods people eat ritualistically. When I get a Twix bar I like to eat the caramel or peanut butter topping first and then the cookie wafer second. The cookie part is so delicious that I have to savor it by itself.

Some folks have a ritual with Reese’s peanut butter cups where they eat the top layer of chocolate and then swipe out the peanut butter center with their tongue.

When it comes to Oreo cookies, few people eat the cookie all at once. Many prefer to deconstruct the cookie by twisting the black wafer sides and then licking out the creme off of each side. Part of the fun is attempting to twist the cookie and have an even amount of creme on each side of the wafer—a feat that is nearly impossible.

(Note: The white center of an Oreo cookie is made with what Nabisco refers to as “creme,” not cream because it isn’t made with any dairy.)


People have been perplexed for decades over why almost all of the creme always ends up sticking to one side of the separated cookie. The phenomenon is so mysterious that the brilliant minds at Massachusetts Institute of Technology (MIT) took up the monumental task of pursuing the answer.

“When I was little, I tried twisting wafers to split the cream evenly between the wafers so there’s some on both halves — which in my opinion tastes much better than having one wafer with a lot of creme and one with almost none. This was hard to do when I was trying it by hand,” Crystal Owens, lead author of a study published Tuesday in the journal American Institute of Physics and a researcher in mechanical engineering at MIT, said according to CBS Boston.

“There’s the fascinating problem of trying to get the creme to distribute evenly between the two wafers, which turns out to be really hard,” says Max Fan, an undergraduate in MIT’s Department of Mechanical Engineering.

To figure out why the creme always sticks to one side, researchers developed the Oreometer, a device that rotates and splits the cookie with an identical amount of torque on each wafer. Researchers found that the amount of torque needed to split a cookie was equivalent to the pressure needed to twist a doorknob.

The team subjected the cookies to standard rheology tests and found that the creme center almost always stuck to just one side of the cookie. The only time they could get the creme to be distributed evenly is when the box of cookies was older.

The researchers realized that the dominant wafer is determined when the cookie is manufactured.

“Videos of the manufacturing process show that they put the first wafer down, then dispense a ball of cream onto that wafer before putting the second wafer on top,” Owens said. “Apparently that little time delay may make the cream stick better to the first wafer.”

Mystery solved.

The good news is that if you‘ve been trying for years to master the perfect twist that results in evenly distributed creme and failed, you’re not the problem, it’s the cookie. The odds were stacked against you and you didn’t know it.

  • Upworthy exclusive: Neil deGrasse Tyson on the best way to make first contact with aliens
    Photo credit: NASA Goddard Space Flight Center/Flickr & Danie Franco/UnsplashNeil deGrasse Tyson, left, and an illustration of a flying saucer.
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    Upworthy exclusive: Neil deGrasse Tyson on the best way to make first contact with aliens

    Tyson shares why he finally wrote a book about aliens and how we should greet them if—or when!—they land on Earth.

    Neil deGrasse Tyson—astrophysicist, director of the Hayden Planetarium, and host of the StarTalk podcast—is one of America’s most popular science communicators. He has worked tirelessly for more than four decades to improve scientific literacy and instill a greater sense of awe about the cosmos.

    In his new book, Take Me to Your Leader, Tyson loosens his space tie a bit and has fun examining the possibility of aliens visiting Earth from scientific, historical, and pop-culture perspectives.

    Upworthy spoke with Tyson about why he chose this moment to discuss aliens, how we should greet them if—or when!—they land, and how he hopes to broaden people’s perspectives through the alien narrative.

    Take Me to Your Leader cover. Photo credit: Simon & Schuster

    Why now is the perfect time to talk about aliens

    The September 9, 2025, congressional hearing, “Restoring Public Trust Through UAP Transparency and Whistleblower Protection,” was a watershed moment for UFO/UAP disclosure, shifting the conversation from science fiction and conspiracy theories to a national security issue. 

    “The real transition for me was the high-ranking officials who came forth in Congress,” Tyson said. “Much of which landed in that two-hour, hour-and-fifty-minute documentary, Day of Disclosure. So it elevated once it hit that level. It was no longer the sleepy farmer in the back 40 reporting on a glowing object over his farm. It was no longer the drunken revelers coming out of the bar at 2 a.m. reporting on the glowing thing in the sky. Upon reaching that, I said, ‘All right, I can’t sit back any further. I have to write this book.’”

    flying saucer, aliens, UFOs, abduction, alien abduction
    An illustration of a flying saucer. Photo credit: Danie Franco/Unsplash

    The turning point in the public discussion about aliens inspired Tyson to examine extraterrestrials from a practical, science-based perspective.

    “It’s an attempt to anchor the conversation, to celebrate the imaginations that have created aliens in our pop culture, and to pose a set of questions for those who may have had a one-on-one encounter with aliens,” he said.

    Who should represent humanity if aliens arrived on Earth?

    What if aliens were to visit Earth, as his book’s title suggests, and demand, “Take me to your leader”? The Earth doesn’t have a singular leader to turn to, so who would Tyson anoint to make first contact with the alien delegation? His choice: former president Barack Obama.

    Bill Nye, then-President Barack Obama, and Neil deGrasse Tyson. Photo credit: WhiteHouse/Wikimedia Commons

    Tyson says that Obama would be a great representative of Earth after a recent conversation the 44th president had with Stephen Colbert, in which he said he “would be a good emissary for the planet. I feel I have a diverse background, some experience in statecraft and diplomacy. I’m friendly. I actually think I can do a pretty good job.”

    “He thinks he would be a good emissary for Earth, and that would be true,” Tyson shared. “First, he’s a nice guy, plus he’s smart, and he’s also scientifically literate. I think he sees his value there because a politician who’s also a diplomat would value that role if you’re meeting someone from another land, another place, another time.”

    However, Tyson wouldn’t send Obama alone to greet the aliens. He said Obama would need a team of experts to greet the delegation, including a cryptographer, an astrophysicist, an engineer, and a mathematician, “because math is the language of the universe.”

    Who would be the astrophysicist? Tyson, of course. “I’d be the astrophysicist just for good measure,” he joked. That’s no surprise, considering one of the first lines in his book is: “Ever since childhood I’ve wanted to be abducted by aliens.”

    Tyson adds that it would be dangerous for humanity if we sent conspiracy theorists to meet our new friends.

    “There are people who don’t think we went to the moon, people who think Earth is flat. And I say without hesitation to leave them behind on your first encounter with the alien,” he warned. “You’ve got to leave the best impression on them as you possibly can. So, you want humans to have a fighting chance to be respected by our new friends.”

    Tyson challenges Hollywood’s conceptions of alien life

    In Take Me to Your Leader, Tyson deconstructs the notion that if aliens were to visit Earth, they would be humanoid creatures, such as the bar patrons on Mos Eisley in Star Wars or the big-eyed “gray” aliens popularized by Whitley Strieber’s Communion series.

    I’d like to think of it as a force for Hollywood to up its game. That’s what [author] Andy Weir did with Project Hail Mary. His alien was crab-oid, not humanoid, and it was made of a material that resembled rocks, and they were really good engineers,” Tyson said. “So, Andy Weir tried to break that mold. And I would be happier if I saw more of that.”

    The alien question holds up a mirror to humanity

    Ultimately, Take Me to Your Leader is a lighthearted look at how aliens appear in American culture through movies and TV, conspiracy theories, sci-fi speculation, quasi-encounters, and our collective imaginations. Some may be disappointed that it doesn’t provide hard evidence of alien existence. But its real accomplishment is helping humans better understand themselves through imagining otherworldly beings.

    “It is the summation of my life’s thinking and observing. Humans, what we believe, what we count as evidence, what convinces us. The universe is quite susceptible to people’s personal theories about things,” Tyson said. “A lot of the cultural references, it’s not because I am some deep anthropologist, although in a small way, we all are. My father was a sociologist, so I have some baptism in thinking about people and what makes us tick. So the referencing to aliens and our relationship with them and their relationship with us was pumped by these very factors.” 

    This interview was edited for clarity and time.

  • Man builds the ‘world’s smallest tiny house’ and somehow makes it work in 19 square feet
    Photo credit: Levi Kelly Tours/YouTubeLevi Kelly's tiny house.

    Levi Kelly wanted to go small. Very small. As someone who loves building and touring tiny homes, along with unique Airbnbs and cabins, he wanted to create something truly special. Though the idea of a tiny home isn’t new and certainly began picking up steam in the early 2000s, Kelly wanted to raise— or, in this case, lower—the bar and make a statement about just how efficient he could get.

    In an Instagram clip originally posted just over a year ago, but now making the rounds on social media again, Kelly shows viewers this extraordinary tiny home. Reminiscent of a tree house, its dark brown exterior and cheery windows look genuinely inviting. The most shocking part? It’s only 19.46 square feet.

    19.46 square feet

    The quick tour begins with an exterior view of the home, which is hitched to a two-wheeled trailer. Kelly explains, “I built the world’s smallest tiny house by square footage. It’s 19.46 square feet. Totally off-grid. You can see the solar panels up there. And it’s on a trailer. Take it anywhere you want to go.”

    He then pulls open the door and says, “Walking inside, let’s see how I fit everything in here.” The door opens to an extremely narrow hallway. On one side is a small sitting area with wooden drawers underneath. Straight ahead is a sink beneath a rather large window, at least relative to the size of the space.

    Kelly’s tour continues: “There is a seating area here to the left. Underneath, we have your AC and heating units, and it comes out of this little vent right there. And then on the other side is a battery bank for the solar panel. And that’s how everything in here gets plugged in.”

    Running water, too

    Blink and you’re in the kitchen, where a tiny fridge sits atop the counter. “Up here is your kitchen. We have a mini fridge up here for some drinks.” He removes a light brown cover from a square opening, almost like a jigsaw puzzle piece, revealing that the countertop also doubles as a sink. “Here’s your sink. Open this up and it unfolds.” He turns on the water. “Check that out. Running water. So we’ll shut that back up for more countertop space.”

    He opens a cabinet beneath this area. “Underneath, we have our water tanks, and you can have a little electric grill to take out and put there if you need to.” He then points to another tiny space on the counter.

    Can’t be taller than 5’10”

    Some, at this point, might wonder where someone would sleep in this house. “You’re wondering about the bed situation. Well, it’s up here.” He then points upward, where a platform is hooked to the ceiling. That is indeed the bed. He explains, “It folds down and can fit somebody that’s 5’10” or shorter.”

    As for the bathroom? Kelly has that covered. Once again, he takes the camera outside and shows a small shower head attached to the corner of the house. “You’re probably wondering about the bathroom situation. The outdoor shower is right here. Set this up and turn on the water and you’ve got yourself a little shower.”

    And what about the toilet? Off to the side, there’s an even smaller “storage area.” He explains, “You can take the lid off. The storage is stored in there, which is now right behind me.” The camera then cuts to a fresh white toilet sitting on the lawn. “You can go use the bathroom in nature anywhere you want. And it does flush.”

    Only a month and $5,000

    In a more detailed tour of the tiny home posted on YouTube, Kelly shares additional details:

    “This took over a month and $5,000. It’s a truly functioning tiny house. It has power, running water, kitchen, separate seating, separate bed, shower, flushing toilet, AC, and heating—everything a modern house has, just in the size of 19.46 square feet (1.8 square meters). The nicest tiny house of this relative size I have ever seen.”

    He also shares more details about the materials used, including the padauk wood on the window sills and the walnut kitchen countertops. He even demonstrates what it’s like to have three people sitting in the bench area at the same time. “Here’s a clip of me, Weston (his son), and my wife.”

    We also get a full look at how the “bed” works, which Kelly admits was his one slight miscalculation. There isn’t much space to climb up to the bed, but he demonstrates how to do it by stepping onto the countertop and hoisting himself into the small cubby.

    One YouTube commenter joked that if the bed doesn’t work, “you can sleep on the roof like Snoopy.”

    Another commenter was a big fan, even imagining what it could look like during the holidays: “Imagine adding tiny picture frames or minuscule paintings to the walls, and Christmas decorations outside in winter. The absolute coziest house ever conceived.”

    A few commenters were concerned about the complete lack of storage, joking that someone might have to keep their belongings in their car. But if you like the idea of the tiny house and don’t necessarily want to break any records, Kelly has other tiny homes with a bit more room. One can even be packed up and “unfolded in a single day.”

  • Airline pilot reveals the crucial reason why there’s a tiny hole in every airplane window
    Photo credit: CanvaA woman looking out of a plane window.
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    Airline pilot reveals the crucial reason why there’s a tiny hole in every airplane window

    You’ll see them on every plane no matter where you sit or which airline you’re flying.

    Have you ever been crammed into the window seat in a plane and, while gazing down at the terra firma beneath you, noticed that there was a tiny hole in the window? According to Petter Hörnfeldt, aka Mentour Pilot, a Swedish commercial airline captain, those holes could one day save your life.

    In a TikTok video, Hörnfeldt explains that there are three layers to the windows on a commercial airliner. The outside window is the strongest because it was designed “to handle any impacts as well as the pressure difference between the thin high altitude air outside of the plane and a pressurized air inside,” Hörnfeldt says.

    Then there is the middle layer, with a tiny hole, designed to protect the outer layer. The final layer is the one you can touch or press your nose up against to see what you’re flying over.

    Why do airplane windows have tiny holes?

    “So why the hole then? Well, because there is air between those layers. Differences in pressure and temperature would otherwise start causing forces to build up between the layers, trying to bend them inwards or outwards, which is something that we obviously do not want, since especially the inner two layers are not designed to take those kind of forces. So that little hole is put there to allow air to flow through slowly and relieve that potential pressure difference. Hence the name breather hole,” Hörnfeldt says.

    pane window, window hole, looking out window, aviation, commercial airliner
    The tiny hole in an airplane window. Credit: Canva

    “Now, the inner window layer, the one that’s closest to you, doesn’t really need a hole because it’s fitted in a way that allows air to flow around it. But that breather hole also serves a different job, which is to make it more difficult for moisture to become trapped between the layers and start fogging up your window, stopping you from admiring the view outside,” Hörnfeldt continues.

    In his most popular video, Hörnfeldt admitted that commercial airline pilots know when you’ve flushed the toilet on a plane.

    Do pilots know when you flush the toilet on a plane?

    According to Hörnfeldt, pilots don’t know that you’ve flushed a toilet based on an alert, security camera footage, or a sudden power surge. They know that the toilet has been flushed because of a slight change in cabin pressurization. Airplane toilets use a special vacuum flushing mechanism to suck the contents out. The vacuum system is calibrated to the cabin air pressure. “But that flushing actually does show up on our instruments as a sudden cabin climb on our cabin vertical speed indicator,” Hörnfeldt says. “So we can see it. And it kind of makes sense, if you think about it.”

    Next time you see the tiny hole in an airplane window as you gaze upon your hometown at 35,000 feet, you know that it’s not a manfcatingring mistake. It’s here to keep you safe in a cabin with a pressurized system that also knows if you used the bathroom. Aren’t airplanes just incredible?

  • Astronaut explains the profound existential pain he felt after returning from moon orbit
    https://www.flickr.com/photos/nasahqphoto/55203734853/in/dateposted/Astronaut Reid Wiseman, the Earth, and the moon.
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    Astronaut explains the profound existential pain he felt after returning from moon orbit

    “I don’t think humanity has evolved to the point of being able to comprehend what we are looking at right now.”

    After going into space for the first time, astronauts experience a profound shift in perspective known as the overview effect. When they look down on Earth, they no longer see borders, politics, or religion. Instead, they see a beautiful blue marble floating in space where everything on its surface is magically connected. After seeing the Earth from afar, many of humankind’s squabbles and battles seem petty and inconsequential. This incredible shift in perspective can be exhilarating, but also isolating.

    The four astronauts who were aboard the recent Artemis II mission, NASA‘s first trip around the moon since Apollo 17 in 1972, shared their experiences of the overview effect upon returning home on April 10. Astronaut Reid Wiseman struggled to find words to express his incredible, unique experience.

    Seeing Earth from space was life-changing for astronaut Reid Wiseman

    “I’m not really a religious person, but there was no other avenue for me to explain anything or experience anything,” Wiseman said. “So I asked for the chaplain on the Navy ship to just come visit us for a minute. When that man walked in, I’d never met him before in my life, but I saw the cross on his collar, and I just broke down in tears.”

    Wiseman added that it is “very hard to fully grasp what we just went through.”

    “When the sun eclipsed behind the moon, I turned to [astronaut Victor Glover] and said ‘I don’t think humanity has evolved to the point of being able to comprehend what we are looking at right now,’” Wiseman said.

    Astronaut Jeremy Hansen also said that he had trouble “trying to find words” to describe his time in space accurately. “But what kept grabbing my attention, when the lighting was right, and we were looking out the window, is that I kept seeing this depth to the galaxy,” he said. “That was mind–blowing for me. The sense I had of fragility and feeling infinitesimally small.”

    Reid Wiseman
    Astronaut Reid Wiseman. Credit: NASA HQ/Flickr

    A thin blue line separates life on Earth from the darkness of space

    Another profound realization astronauts have is that Earth’s atmosphere appears remarkably thin from space. “You see the thin blue line of the atmosphere, and then when you’re on the dark side of the Earth, you actually see this very thin green line that shows you where the atmosphere is,” Mission Specialist Christina Koch said, according to NASA. “What you realize is every single person that you know is sustained and inside of that green line, and everything else outside of it is completely inhospitable.”

    atmosphere, eath, space photos, earth form above, aurora
    The aurora australis glowing over the Indian Ocean. Credit NASA Johnson/Flickr

    Ultimately, when someone experiences a major shift in perspective, the important thing is how they incorporate it into their lives. “You come back to sea level, and then you have a choice,” Glover told NASA. “Are you going to try to live your life a little differently? Are you going to really choose to be a member of this community of Earth?”

  • In 1958, NASA recruited 11 Deaf men to test how zero gravity affects humans
    Photo credit: NASAThe Gallaudet Eleven volunteer for space research.
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    In 1958, NASA recruited 11 Deaf men to test how zero gravity affects humans

    Their work helped build the incredible space missions that followed.

    We are constantly being reminded of Isaac Newton’s famous quote, “If I have seen further, it is by standing on the shoulders of giants.” Eleven such giants were recruited as volunteers from Gallaudet University (then Gallaudet College) in Washington, D.C. in 1958. Their task was to help researchers understand the effects of weightlessness on Deaf people who didn’t experience motion sickness.

    Deemed the Gallaudet Eleven, they helped pave the way for hundreds of space flights, including the most recent Artemis II. Ranging in age from 25 to 48 years, the eleven men included Harold Domich, Robert Greenmun, Barron Gulak, Raymond Harper, Jerald Jordan, Harry Larson, David Myers, Donald Peterson, Raymond Piper, Alvin Steele, and John Zakutney. Each and every one of them selflessly gave their time and their bodies to what would become monstrous breakthroughs in astrophysics.

    Houston had a problem

    Actor and Deaf activist, Nyle DiMarco, recently took to social media to share the historical tidbit, lest people forget. In an Instagram reel, he wrote,

    “Everyone’s talking about Artemis II. The first humans to travel to the moon in 50 years. Historic mission. But nobody’s talking about the Deaf men who made it possible.

    In the late 1950s, NASA had a problem. They needed to understand what weightlessness does to the human body. But every test subject kept getting violently motion sick.

    So they came to Gallaudet.

    Eleven Deaf men. Most of them had lost their hearing to spinal meningitis as children, which also damaged their vestibular system. Their inner ears couldn’t be overwhelmed. They were immune to motion sickness.

    NASA put them in centrifuges. Zero-gravity flights. A rotating room for twelve straight days. One experiment on a ferry in choppy Nova Scotia waters. The researchers got so seasick they had to cancel it. The Gallaudet Eleven? They were playing cards.

    Their bodies gave NASA the data it needed to send humans into space.

    No Gallaudet Eleven — no Mercury. No Mercury — no Apollo. No Apollo — no Artemis II.

    Sixty years later, four astronauts just flew 252,000 miles from Earth and came home safely. They stood on the shoulders of eleven Deaf men most people have never heard of. Now you know! #nasa #gallaudet11 #artemisii @nasa”

    The post has already received nearly 400,000 likes and over 6,000 comments. One Instagrammer writes, “Diversity in all its forms is what makes us great. And all of us working together is what helps us advance as a civilization! Thank you for sharing this and bringing visibility to this piece of history, and thank you Gallaudet 11 for your contribution.”

    The tests

    The official NASA website shared some of the tests in which the brave volunteers took part. “One test saw four subjects spend 12 straight days inside a 20-foot slow rotation room, which remained in a constant motion of ten revolutions per minute.”

    Then, of course, there were the zero-g flights. “In another scenario, subjects participated in a series of zero-g flights in the notorious ‘Vomit Comet’ aircraft to understand connections between body orientation and gravitational cues.”

    They even took the volunteers to Nova Scotia to test big waves. “Another experiment, conducted in a ferry off the coast of Nova Scotia, tested the subjects’ reactions to the choppy seas. While the test subjects played cards and enjoyed one another’s company, the researchers themselves were so overcome with seasickness that the experiment had to be canceled. The Gallaudet test subjects reported no adverse physical effects and, in fact, enjoyed the experience.”

    “We were young and adventurous”

    The test subjects themselves shared their experiences. Barron Gulak reminisced, “In retrospect, yes, it was scary…but at the same time we were young and adventurous.”

    On DiMarco’s identical Facebook post, Harry Larson’s child, “Moose” Larson, shared a photo and wrote, “They were recently recognized with a cool plaque at Gallaudet! My dad is one of them and, funny enough, never really talked about it.” A commenter responded, “I’ve worked with your dad a lot on this project during the museum exhibition several years ago. He’s been so wonderful, always willing to come to events. I’m so glad he’s sharing his story now.”

  • A 13-year-old boy has become the first person to be cured of this deadly brain cancer
    Photo credit: Lesja Jemeljanova via FacebookLucas Jemeljanova poses with his family a year before being diagnosed with cancer

    It’s a parent’s worst nightmare: Taking your child to the doctor and receiving a life-changing diagnosis. It only adds to the heartbreak when they find out there may be no effective treatment at all, and that all they can do is hope for the best.

    Few diagnoses strike fear in the heart of parents and doctors more than a cancer called diffuse intrinsic pontine glioma, or DIPG. Primarily found in children, DIPG is a highly aggressive brain tumor that is uniformly fatal, with less than 10 percent of children surviving longer than two years after diagnosis. The tumors grow fast and on extremely vital areas like the spine and brain stem, making them exceptionally hard to remove. Though young patients have been treated with radiation, chemotherapy, and surgeries, no one had ever been cured of the fatal cancer.

    But for the first time ever, a 13-year-old boy from Belgium named Lucas Jemeljanova has beaten the odds.

    DIPG, cancer, childhood cancer, clinical trial, pediatric medicine
    Various brain scans. Photo credit:

    Diagnosed with DIPG at age six, Lucas’ doctor Jacques Grill told Lucas’ parents, Cedric and Olesja, that he was unlikely to live very long. Instead of giving up hope, Cedric and Olesja flew Lucas to France to participate in a clinical trial called BIOMEDE, which tested new potential drugs against DIPG.

    Lucas was randomly assigned a medication called everolimus in the clinical trial, a chemotherapy drug that works by blocking a protein called mTOR. mTOR helps cancer cells divide and grow new blood vessels, while everolimus decreases blood supply to the tumor cells and stops cancer cells from reproducing. Everolimus, a tablet that’s taken once per day, has been approved in the UK and the US to treat cancers in the breast, kidneys, stomach, pancreas, and others—but until the BIOMEDE clinical trial, it had never before been used to treat DIPG.

    DIPG, cancer, childhood cancer, clinical trial, pediatric medicine
    Lucas Jemeljanova poses with his mother. Photo credit: Lesja Jemeljanova via Facebook

    Though doctors weren’t sure how Lucas would react to the medication, it quickly became clear that the results were good.

    “Over a series of MRI scans, I watched as the tumor completely disappeared,” Grill said in an interview. Even more remarkably, the tumor has not returned since. Lucas, who is now thirteen, is considered officially cured of DIPG.

    Even after the tumor was gone, Grill, who is the head of the Brain Tumor Program in the Department of Child and Teenage Oncology at Gustave Roussy cancer research hospital in Paris, was reluctant to stop Lucas’ treatments. Until about a year and a half ago, Lucas was still taking everolimus once every day.

    “I didn’t know when to stop, or how, because there was no other reference in the world,” Grill said.

    While Lucas is the only one in the clinical trial whose tumor has completely disappeared, seven other children have been considered “long responders” to everolimus, meaning their tumors have not progressed for more than three years after starting treatment.

    DIPG, cancer, childhood cancer, clinical trial, pediatric medicine
    Lucas with his mother. Photo credit: Lesja Jemeljanova via Facebook

    So why did everolimus work so well for Lucas? Doctors think that an extremely rare genetic mutation in Lucas’ tumor “made its cells far more sensitive to the drug,” Grill said, while the drug worked well in other children because of the “biological peculiarities” of their tumors.

    While everolimus is by no means a cure, the trial has provided real hope for parents and families of children diagnosed with DIPG. Doctors must now work to better understand why Lucas’ tumor responded so well to the drug and how they can replicate those results in tumor “organoids”—artificially-grown cells that resemble an organ. After that, said Marie-Anne Debily, a researcher in the BIOMEDE trial, “the next step will be to find a drug that works as well on tumor cells.”

    A more recent clinical trial tested a new immunotherapy treatment on young DIPG patients and showed promising results. Many of the patients’ tumors shrank and several participants saw functional improvements in their symptoms and day-to-day lives. But only one of the 11 patients has seen success that rivals Lucas’ — a young man identified only as Drew, who has been thriving tumor-free for over four years after receiving treatment.

    Once considered a definitive death sentence, there is real hope for the first time. But there’s much more research and work to be done. Until then, however, Lucas’ doctors are thrilled.

    “Lucas’ case offers real hope,” said Debily.

    DIPG, cancer, childhood cancer, clinical trial, pediatric medicine
    Lucas with his parents and sister. Photo credit: Lesja Jemeljanova via Facebook

    This article originally appeared two years ago. It has been updated.

  • A man who wanted to ‘see music’ paired a piano with bioluminescent algae. It’s magical to watch.
    Photo credit: HTX Studio/YouTubeBioluminescent algae respond when the piano keys are played.

    Music is meant to be heard and not seen, right? Sure, we can watch musicians play instruments, and we can see music notation on paper. But that’s not the same as seeing music itself.

    A young man named He Tongxue from HTX Studio, a team of DIY innovators from Hangzhou, China, wanted to be able to “see music.” He had just started learning piano and felt like the visible dimension was missing. There are plenty of computer programs that create digital visual effects with music, of course. But the goal was to make music visible in real life.

    It took the studio three years, four prototypes, and endless tests to come up with just the right combination of elements. They wanted something that would rise from the piano and light up when the keys were pressed.

    “Our first thought was smoke,” he said. They figured they could line up smoke machines that would be triggered by the piano keys and use lasers to light up the smoke as it rises.

    The studio built a prototype, and at first, it looked pretty cool. But after playing the piano for a few minutes, the cool factor wore off. He later described it as “a disaster.”

    “The smoke drifts everywhere,” he said. “You can’t tell which light matches which note. It feels like a genie is coming out. And after a while, it feels like someone is barbecuing inside the piano.”

    They wanted the smoke to rise in chunks, like solid musical notes, instead of spreading out. That led them to the idea of vortex rings. Essentially, they could make smoke rings that would give the visible “notes” more structure.

    music, smoke, innovation, tech
    A vortex ring of smoke floats through the air. Photo credit: Canva

    A second prototype was made to test out this idea. And it did look really cool…at first. The vortex rings worked, but there was too much extraneous smoke that eventually built up and made it hard to see the rings. The contraptions that made the rings were also too large to make separate ones for all 88 keys of the piano, and making them smaller rendered them unusable.

    Back to the drawing board again.

    Since a vortex ring is essentially rotating fluid, they shifted to different fluids: water and paint. They created yet another piano prototype that would shoot paint vortex rings into water. Yet again, cool at first, but soon the water simply clouded up as the paint rings dissipated. They tried using oil paints, which wouldn’t dissolve in water, but that also disappointed. Oil paint didn’t form rings, but rather broke apart into small spheres in the water.

    Bubbles, water, tech, visual
    When smoke didn’t work, the studio turned to water. Photo credit: Canva

    However, the spheres gave them the idea of simply using droplets. They created a piano that would push up a droplet of colored glycerin into the water tank with each note played. Lights would illuminate them.

    The idea was solid, but the execution left something to be desired. The beauty of the lit-up droplets didn’t extend throughout the tank. The droplets drifted, and attempts to rein them in with glass tubes ruined the magical effect.

    “By this point, the project had dragged on for two years,” he said. “We had tried everything we could think of. I honestly didn’t know what I was to do. We’ve abandoned projects before. But never one that consumed this much time, energy, and effort from almost everyone in the studio.”

    Then disaster struck. One night, the glass tank shattered under the water pressure, destroying the entire system.

    Watch the full story here:

    “If the universe was telling me to stop, this felt like the sign,” he said. But in the midst of significant setbacks and creeping self-doubt, the idea of turning to nature arose. What if they used bioluminescent algae, which light up all on their own?

    “Around the world, you can see this blue glow in coastal waters,” he said. “It’s caused by a reaction between luciferin and luciferase when the algae are stimulated. We didn’t spray algae into water. We filled the entire tank with them, then disturbed them with bubbles so they would glow all the way to the surface.”

    He and his studio mates did it. No AI. No digital effects. Real-life, 3D visible music with an assist from nature. They named it the Blue Tears Piano.

    Here’s German pianist Oskar Roman Jezior playing “Golden Hour” on it:

    You can follow HTX Studio on YouTube for more incredible innovations.

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