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Family

When I was on antidepressants, I wished I knew why they took so long. Now we might.

For me, the scariest part of taking antidepressants was the purgatory of waiting to see if they worked.

In 2012, I started taking a medicine called bupropion. For about a month, I watched every single thought that came into my head. And it was, if I may be blunt, pretty damn weird.

Am I having a good day because it's one of Seattle's rare sunny winter days? Or is it the drug? If I have a rough day, is it because I've hit a natural, temporary low? Or does this mean I'll have to switch to another medicine (and have to play this game even longer)?


Depression affects about 1 in 5 Americans at some point in their lives, so I know I wasn't alone. But trying to live outside of your own mind — well, it made me feel kind of messed up and very lonely. I felt like I was a stranger, even in my own head.

It was about a month before I could say for sure that the antidepressants were working.

Antidepressants can take a while to work for lots of people, and we're still not entirely sure why.

There are many different types of antidepressants, but the most commonly prescribed kinds, known as SSRIs or SNRIs, can take six to eight weeks to reach their full effect. (Frustratingly, the bad side effects can often happen before the beneficial ones.)

Unfortunately, we don't yet have a complete picture of why that long wait occurs. While we know that antidepressants can work, we're still learning how depression affects the brain and how different antidepressants can change that.

We know, for instance, that some kinds of antidepressants can help boost mood-altering chemicals known as neurotransmitters, but scientists will admit that's not the whole picture.

But new research is helping us find and study new pieces of the puzzle.

Take, for instance, the humble G-protein. It turns out that in depressed people, certain proteins called G-proteins get clumped up in our brain cells. G-proteins are part of big signal-transmitting machines in our cells, and if they clump up, the other parts of the machine can't really get to them. So the signal falters.

A new study suggests that part of what certain antidepressants do is go into the cell and break up these clumps, helping to repair the machinery. It can take a while for the antidepressants to do their job, though, if the G-proteins are really clumped up. This might explain why that purgatory period exists.

The study notes that different antidepressants may have different or even multiple modes of action, so this "anti-clumping" probably isn't the only explanation. But this study does help us learn more about how depression works and might even lead to better therapies or medications one day.

If you're stuck in antidepressant purgatory, there's science behind it, and it's OK to feel frustrated.

It might take a while to find out the best course of treatment for you — maybe antidepressants are the answer, but maybe not. There are other courses of action, such as cognitive behavioral therapy, that work well too. The important thing is to find what works for you.

But if you are trying antidepressants and are stuck in that weird, alienating state, know that it's natural and there's a reason why — and you're not alone.

Nature

Pennsylvania home is the entrance to a cave that’s been closed for 70 years

You can only access the cave from the basement of the home and it’s open for business.

This Pennsylvania home is the entrance to a cave.

Have you ever seen something in a movie or online and thought, "That's totally fake," only to find out it's absolutely a real thing? That's sort of how this house in Pennsylvania comes across. It just seems too fantastical to be real, and yet somehow it actually exists.

The home sits between Greencastle and Mercersburg, Pennsylvania, and houses a pretty unique public secret. There's a cave in the basement. Not a man cave or a basement that makes you feel like you're in a cave, but an actual cave that you can't get to unless you go through the house.

Turns out the cave was discovered in the 1830s on the land of John Coffey, according to Uncovering PA, but the story of how it was found is unclear. People would climb down into the cave to explore occasionally until the land was leased about 100 years later and a small structure was built over the cave opening.

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Architectural Digest/Youtube

This house was made with love.

Celebrity home tours are usually a divisive topic. Some find them fun and inspirational. Others find them tacky or out of touch. But this home tour has seemingly brought unanimous joy to all.

“Stranger Things” actor David Harbour and British singer-songwriter Lily Allen, whose Vegas wedding in 2020 came with an Elvis impersonator, gave a tour of their delightfully quirky Brooklyn townhouse for Architectural Digest, and people were absolutely loving it.

For one thing, the house just looks cool. There’s nothing monotone or minimalist about it. No beige to be seen.

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Finally, someone explains why we all need subtitles

It seems everyone needs subtitles nowadays in order to "hear" the television. This is something that has become more common over the past decade and it's caused people to question if their hearing is going bad or if perhaps actors have gotten lazy with enunciation.

So if you've been wondering if it's just you who needs subtitles in order to watch the latest marathon-worthy show, worry no more. Vox video producer Edward Vega interviewed dialogue editor Austin Olivia Kendrick to get to the bottom of why we can't seem to make out what the actors are saying anymore. It turns out it's technology's fault, and to get to how we got here, Vega and Kendrick took us back in time.

They first explained that way back when movies were first moving from silent film to spoken dialogue, actors had to enunciate and project loudly while speaking directly into a large microphone. If they spoke and moved like actors do today, it would sound almost as if someone were giving a drive-by soliloquy while circling the block. You'd only hear every other sentence or two.

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Health

Oregon utilizes teen volunteers to run their YouthLine teen crisis hotline

“Each volunteer gets more than 60 hours of training, and master’s level supervisors are constantly on standby in the room.”

Oregon utilizes teen volunteers to man YouthLine teen crisis hotline

Editor's Note: If you are having thoughts about taking your own life, or know of anyone who is in need of help, the 988 Suicide & Crisis Lifeline is a United States-based suicide prevention network of over 200+ crisis centers that provides 24/7 service via a toll-free hotline with the number 9-8-8. It is available to anyone in suicidal crisis or emotional distress.

Mental health is a top-of-mind issue for a lot of people. Thanks to social media and people being more open about their struggles, the stigma surrounding seeking mental health treatment appears to be diminishing. But after the social and emotional interruption of teens due the pandemic, the mental health crises among adolescents seem to have jumped to record numbers.

PBS reports that Oregon is "ranked as the worst state for youth mental illness and access to care." But they're attempting to do something about it with a program that trains teenagers to answer crisis calls from other teens. They aren't alone though, as there's a master's level supervisor at the ready to jump in if the call requires a mental health professional.

The calls coming into the Oregon YouthLine can vary drastically, anywhere from relationship problems to family struggles, all the way to thoughts of self-harm and suicide. Teens manning the phones are provided with 60 hours of training and are taught to recognize when the call needs to be taken over by the adult supervisor.

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Family

Mom shares her brutal experience with 'hyperemesis gravidarum' and other moms can relate

Hyperemesis gravidarum is a severe case of morning sickness that can last up until the baby is born and might require medical attention.

@emilyboazman/TikTok

Hyperemesis gravidarum isn't as common as regular morning sickness, but it's much more severe.

Morning sickness is one of the most commonly known and most joked about pregnancy symptoms, second only to peculiar food cravings. While unpleasant, it can often be alleviated to a certain extent with plain foods, plenty of fluids, maybe some ginger—your typical nausea remedies. And usually, it clears up on its own by the 20-week mark. Usually.

But sometimes, it doesn’t. Sometimes moms experience stomach sickness and vomiting, right up until the baby is born, on a much more severe level.

Hyperemesis gravidarum (HG), isn’t as widely talked about as regular morning sickness, but those who go through it are likely to never forget it. Persistent, extreme nausea and vomiting lead to other symptoms like dehydration, fainting, low blood pressure and even jaundice, to name a few.

Emily Boazman, a mom who had HG while pregnant with her third child, showed just how big of an impact it can make in a viral TikTok.

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The cast of TLC's "Sister Wives."

Dating is hard for just about anyone. But it gets harder as people age because the dating pool shrinks and older people are more selective. Plus, changes in dating trends, online etiquette and fashion can complicate things as well.

“Sister Wives” star Christine Brown is back in the dating pool after ending her “spiritual union” with polygamist Kody Brown and she needs a little help to get back in the swing of things. Christine and Kody were together for more than 25 years and she shared him with three other women, Janelle, Meri and Robyn.

Janelle and Meri have recently announced they’ve separated from Kody. Christine publicly admitted that things were over with Kody in November 2021.

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