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Researchers hacked 5 people's brains so they could see a new and impossible color

The new color 'olo' is neat, but the technique behind it could be groundbreaking.

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Only five people in the world have seen the mysterious color "Olo"

Color is one of the great joys of being alive. The brilliant blue sky, the green grass, the exotic pinks and purples and teals in coral or tropical fish. Soaking it all in is truly a feast for the eyes, and some studies even show that certain colors can trigger specific emotions in people. Orange may evoke feelings of joy, and red may conjure feelings of love, while blue may have a calming effect.

One of the most interesting things about colors, though, is that they are finite. Though the world is full of undiscovered plants, creatures, and even elements, the entire color spectrum is known and documented. Due to the nature of light in our universe and how it reflects off of physical objects, all perceived color must be created by some combination of the primary colors (blue, green, and red — yes, green, not yellow!). There are essentially unlimited combinations, but they all exist on a known spectrum — different hues and shades of pink or emerald or orange.

However, a team of researchers recently decided to push the limits of human perception. They "hacked" participants' retinas to allow them to see an impossible color.


color, green, blue, color wheel, physics, light, wavelengths, scienceThe paint companies are dying to know the secret formula for the new color.Giphy

Scientists from the University of California, Berkeley, developed a new technique called "Oz," which would allow them to activate specific cones in the retina. Cones are light-sensitive cells that respond to different wavelengths of light. When the three types of cones are activated in different ways, our brains perceive colors.

One fascinating bit of background is that the "M" cone, which typically responds strongest to green (Medium wavelength), can not naturally be activated without also activating the Long and Short cones. So even the purest green on the planet would also, to a smaller degree, stimulate the parts of our eyes that are mostly correlated with red and blue.

retinas, eyes, oz, retina scan, retina cones, vision, colorsA close-up of the human eye. Swapnil Potdar/Unsplash

The team wanted to find out what would happen if they could isolate and activate only the M, or green, cone using the new technique.

The result? The five participants reported seeing an absolutely unreal, brilliant shade of green like nothing they had ever experienced. Imagine a bright green laser cranked up to the highest saturation and brilliance possible, the purest and brightest green your brain could possibly comprehend. Participants noted that a bright green laser pointed looked "pale" in comparison to the new color.

The name of the new, impossible color? Olo, or 010 (indicated zero stimulation of the L and S cones and full stimulation of the M cones).

- YouTubewww.youtube.com

It's fair to wonder, if olo is impossible and can never naturally exist without manual stimulation of the retinal cones, what's the point of the experiment?

The introduction of a "new color" is certainly interesting and makes for a good headline, but the real value of this study lies in the future applications of the Oz technique.

The research team hopes that the detailed retinal maps they have developed, along with their ability to stimulate specific rods and cones in the eye in any combination, will enable major breakthroughs in the study and treatment of various visual impairments.

For example, Oz could one day cure color blindness or unlock new treatments for cataracts or glaucoma. It could even play a role down the line in curing certain types of blindness. Isn't it wild how our understanding of how our eyes perceive color tells us so much?

But those days are a long way off, for now. In the meantime, only five people in the world have experienced the brilliance of olo, and the rest of us will just have to imagine it.

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7 mindblowing medical breakthroughs that could occur in our lifetime

One day soon, you might be able to grow new teeth. Seriously.

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My family has a history of Parkinson's Disease, so I always see the headlines that promise some major scientific breakthrough in regards to the disease based on small, lab-based experiments or trials run on animals. They give us a glimmer of hope but, far too often, these treatments never see the light of day. The road from promising idea to having a real treatment available for patients is extremely long and arduous. Most potential new medications and therapies don't survive.

But... things do sometimes happen! There are massive medical breakthroughs being achieved all the time. Sometimes it's a new discovery, sometimes it's a successful clinical trial, and sometimes it's the fruit of all that labor finally becoming publicly available to people who need it the most. For example, an RSV vaccine just became available in 2023 for the first time. A powerful non-opioid pain killer was approved in 2024. A new drug came out to treat schizophrenia that was completely different than anything that had come before. Progress is being made every single year.

In our lifetime, say the next five to 20 years, we could see unbelievable advancements in treating certain medical conditions. Here are a few pretty amazing potential developments that are on the horizon.

Scientist working in a laboratory setting. Photo by Adam Bezer on Unsplash

1. Growing new teeth

Unlike sharks, humans are known to grow only two sets of teeth, our baby teeth and permanent adult teeth. If one gets knocked out or lost due to decay or infection, you're out of luck!

But researchers say growth buds exist in our gums for a third set, and scientists in Japan have had success in activating them to grow naturally. It could be a major gamechanger that could one day replace dentures and prosthetics. The team has moved onto human trials and has a target date of having a drug ready by 2030.

2. Cancer vaccines

Medical scientists have made amazing strides in cancer research, especially in the field of vaccines.

Did you know that lung cancer is considered to be the most deadly of the bunch? A lung cancer vaccine could be available very soon. If a cancer vaccine sounds odd, think of it this way: Cancer can be treated by chemotherapy and radiation, but there's always a chance of it coming back. People who have survived cancer could theoretically take the vaccine and massively improve their chances of reoccurrence.

A similar vaccine is showing promising results in clinical trials for pancreatic cancer.

3. Better treatment for Alzheimers

Alzheimer's Disease is one of the most destructive and heartbreaking conditions imaginable. It's also extremely difficult to treat, with most currently available therapies and medications focusing on slowing or temporarily relieving certain symptoms.

One new avenue scientists are exploring is a vaccine that could target a protein called tau, which clumps together and tangles up crucial neurofibers that deliver information in the brain. One such medication aims to activate a patient's immune system and produce "a strong antibody response against both pTau and its harmful aggregated form." The drug was recently fast-tracked by the FDA and has shown promising results in human clinical trials.

Another relatively new development is the availability of monoclonal antibody treatment, which helps slow the progression of the disease. Currently, the treatments are not particularly cost-effective but may become moreso in the near future.


smiling woman in gray cardigan Photo by Tatiana Zanon on Unsplash

4. Breakthrough treatment for Huntington's Disease

Huntington's is a fatal central nervous system disorder that shuts down key brain functions in patients like speech, walking, and cognitive function. Some of the symptoms can be treated but, so far, little can be done to slow or stop the progression of the disease.

However, a new drug known as PTC518 was recently fast-tracked by the FDA due to promising results in clinical trials. It attacks mutant Huntington protein in blood cells and in cerebrospinal fluid and has been shown to improve symptoms of the disease in a 12-month trial run. What's especially exciting is that this drug attacks the disease itself rather than just treating symptoms at the surface level.

5. Targeted viruses that kill antibiotic-resistant bacteria

Bacteria is getting smarter and evolving. Antimicrobial resistance is a grave threat to the global population as well-known antibiotics become less effective against infection and new antibiotics are expensive and difficult to develop.

(If you've ever dealt with a staph infection, you know how scary it is when drugs just... don't work.)

This is where special viruses, called bacteriophages or just phages, come into play. These viruses selectively target and kill bacteria, and were actually first used about 100 years ago. Scientist are coming around to using them again. In select settings, they've proven to be incredibly effective against resistant infections, but will need more testing before they become widely available. However, it's definitely possible that this become a viable alternative to antibiotics in some cases in the next few decades!

6. Synthetic and bioprinted organs


human heart Photo by camilo jimenez on Unsplash

There are simply not enough donor organs going around for all the people who need a healthy liver, heart, or kidney.

Luckily, incredible strides have been made in creating artificial organs that can function like the real thing. A man in Australia just lived for 100 days with a titanium heart while he awaited a transplant! And bioprinting technology – quite literally 3D printing using real tissue and living cells — has the potential to create new working organs from scratch in the near future. Genetically modifying animal organs to function in humans temporarily or maybe even permanently has also come an extremely long way and is a process that will drastically improve in the coming years.

7. A one-pill cure for Hepatitis B

Hepatitis B is a potentially fatal infection of the liver that affects hundreds of millions of people worldwide. There is a safe and effective vaccine available to some people, but it's only preventative and won't treat active infections.

A research team in Israel recently discovered that a low dose of well-known chemotherapy drug, Curaxin-137, completely destroyed a crucial and mysterious protein that the Hepatitis virus depends on. The testing was done in a lab setting, so the next step is clinical trials. The team hopes that one day in the not-so-distant future, patients could take a single dose and completely eradicate the virus in their system. That's about as close to a miracle-cure as you can get!

Not all of these potential breakthroughs will come to fruition, but it's pretty amazing to dig into the advancements and discoveries that are being made every day. This list is just scratching the surface, to say nothing of robotic surgeons that will make major surgeries less invasive, new treatments for baldness, nanotechnologies that can deliver medicine to specific parts of the body, and more. Ultimately, good news is coming relatively soon for people who need it.


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Astronaut shares the profound 'big lie' he realized after seeing the Earth from space

This change in perspective could change humanity.

via Rubén Moreno Montolíu/Flickr

Our home, from space.

Sixty-one years ago, Yuri Gagarin became the first human to make it into space and probably the first to experience what scientists now call the "overview effect." This change occurs when people see the world from far above and notice that it’s a place where “borders are invisible, where racial, religious and economic strife are nowhere to be seen.”

The overview effect makes man’s squabbles with one another seem incredibly petty and presents the planet as it truly is, one interconnected organism.

In a compelling interview with Big Think, astronaut, author and humanitarian Ron Garan explains how if more of us developed this planetary perspective we could fix much of what ails humanity and the planet.

Garan has spent 178 days in space and traveled more than 71 million miles in 2,842 orbits. From high above, he realized that the planet is a lot more fragile than he thought.

“When I looked out the window of the International Space Station, I saw the paparazzi-like flashes of lightning storms, I saw dancing curtains of auroras that seemed so close it was as if we could reach out and touch them. And I saw the unbelievable thinness of our planet's atmosphere. In that moment, I was hit with the sobering realization that that paper-thin layer keeps every living thing on our planet alive,” Garan said in the video.

“I saw an iridescent biosphere teeming with life,” he continues. “I didn't see the economy. But since our human-made systems treat everything, including the very life-support systems of our planet, as the wholly owned subsidiary of the global economy, it's obvious from the vantage point of space that we're living a lie.”

It was at that moment he realized that humanity needs to reevaluate its priorities.

“We need to move from thinking economy, society, planet to planet, society, economy. That's when we're going to continue our evolutionary process,” he added.

Garan says that we are paying a very “high price” as a civilization for our inability to develop a more planetary perspective and that it’s a big reason why we’re failing to solve many of our problems. Even though our economic activity may improve quality of life on one end, it’s also disasterous for the planet that sustains our lives.

It’s like cutting off our nose to spite our face.

Actor William Shatner had a similar experience to Garan's when he traveled into space.

"It was among the strongest feelings of grief I have ever encountered," Shatner wrote. "The contrast between the vicious coldness of space and the warm nurturing of Earth below filled me with overwhelming sadness. Every day, we are confronted with the knowledge of further destruction of Earth at our hands: the extinction of animal species, of flora and fauna … things that took five billion years to evolve, and suddenly we will never see them again because of the interference of mankind."

man in white and black suit standing on white and blue floorPhoto by Yucel Moran on Unsplash

“We're not going to have peace on Earth until we recognize the basic fact of the interrelated structure of all reality,” Garan said.

However dire the situation looks from the surface of Earth, the astronaut has hope that we can collectively evolve in consciousness and wake up and embrace a larger reality. “And when we can evolve beyond a two-dimensional us versus them mindset, and embrace the true multi-dimensional reality of the universe that we live in, that's when we're going to no longer be floating in darkness … and it's a future that we would all want to be a part of. That's our true calling.”


This article originally appeared three years ago.

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For the first time ever, a 13-year-old boy has been cured of a deadly brain cancer

The boy’s tumor disappeared after participating in a new clinical trial.

Lucas Jemeljanova, then aged 5, with his parents and sister a year before he was diagnosed with DIPG. (via Facebook)

Lucas Jemeljanova poses with his family a year before being diagnosed with cancer (Facebook)

Few things strike fear in the heart of parents and doctors more than a cancer called diffuse intrinsic pontine glioma, or DIPG. Primarily found in children, DIPG is a highly aggressive brain tumor that is uniformly fatal, with less than 10 percent of children surviving longer than two years after diagnosis.

But for the first time ever, a 13-year-old boy from Belgium named Lucas Jemeljanova has beaten the odds. Diagnosed with DIPG at age six, Lucas’ doctor Jacques Grill told Lucas’ parents, Cedric and Olesja, that he was unlikely to live very long. Instead of giving up hope, Cedric and Olesja flew Lucas to France to participate in a clinical trial called BIOMEDE, which tested new potential drugs against DIPG.

Lucas was randomly assigned everolimus in the clinical trial, a chemotherapy drug that works by blocking a protein called mTOR. mTOR helps cancer cells divide and grow new blood vessels, while everolimus decreases blood supply to the tumor cells and stops cancer cells from reproducing. Everolimus, a tablet that’s taken once per day, has been approved in the UK and the US to treat cancers in the breast, kidneys, stomach, pancreas, and others—but until the BIOMEDE clinical trial, it had never before been used to treat DIPG.

Lucas Jemeljanova poses with his motherLucas Jemeljanova poses with his mother(lesja Jemeljanova / Facebook)

Though doctors weren’t sure how Lucas would react to the medication, it quickly became clear that the results were good.

“Over a series of MRI scans, I watched as the tumor completely disappeared,” Grill said in an interview. Even more remarkably, the tumor has not returned since. Lucas, who is now thirteen, is considered officially cured of DIPG.

Even after the tumor was gone, Grill, who is the head of the Brain Tumor Program in the Department of Child and Teenage Oncology at Gustave Roussy cancer research hospital in Paris, was reluctant to stop Lucas’ treatments. Until about a year and a half ago, Lucas was still taking everolimus once every day.

“I didn’t know when to stop, or how, because there was no other reference in the world,” Grill said.

While Lucas is the only one in the clinical trial whose tumor has completely disappeared, seven other children have been considered “long responders” to everolimus, meaning their tumors have not progressed for more than three years after starting treatment.

Lucas Jemeljanova poses with his mother to mark cancer awareness monthLucas Jemeljanova with his mother (Facebook)(lesja Jemeljanova / Facebook)

So why did everolimus work so well for Lucas? Doctors think that an extremely rare genetic mutation in Lucas’ tumor “made its cells far more sensitive to the drug,” Grill said, while the drug worked well in other children because of the “biological peculiarities” of their tumors.

While everolimus is by no means a cure, the trial has provided real hope for parents and families of children diagnosed with DIPG. Doctors must now work to better understand why Lucas’ tumor responded so well to the drug and how they can replicate those results in tumor “organoids”—artificially-grown cells that resemble an organ. After that, said Marie-Anne Debily, a researcher in the BIOMEDE trial, “the next step will be to find a drug that works as well on tumor cells.”

In the meantime, however, Lucas’ doctors are thrilled.

“Lucas’ case offers real hope,” said Debily.


Lucas Jemeljanova poses with his familyLucas Jemeljanova with his parents and sister(lesja Jemeljanova / Facebook)

This article originally appeared last year.

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