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Woman uses her super sense of smell to help scientists detect Parkinson's in minutes

Joy Milne first smelled the disease on her husband 10 years before his diagnosis.

Photo by Fulvio Ciccolo on Unsplash

There is currently no definitive test to detect Parkinson's.

We don’t always choose our gifts. Joy Milne’s superpower, one she inherited from her mother’s side of the family, was having a highly acute sense of smell.

Milne might have never used her olfactory talent as a force for good, had it not been for her late husband, Les Milne.

According to NPR, Les and Joy met in their teens and it was love at first sniff. "He had a lovely male musk smell. He really did," she told NPR.

After many years of a happy marriage, Joy noticed her husband, then in his 30s, had developed an “overpowering sort of nasty yeast smell.” The running joke-slash-complaint was that Les “wasn’t washing enough.”

Eventually Les’ scent wouldn’t be the only thing to change. Joy told NPR that her once funny, thoughtful husband completely transformed, becoming “moody,” irritable and even aggressive. He wouldn’t receive a proper Parkinson’s diagnosis until the age of 45.

Joy didn’t suspect that she could somehow detect the disease until going with Les to a Parkinson’s support group and noticing that the same distinctive smell seemed to fill the room. After sharing the discovery with her husband, she knew she had to take action.

Joy began working with researchers at University of Edinburgh and through a series of experiments confirmed that she could sniff out Parkinson’s with flawless accuracy. Now scientists have created a breakthrough method of detection based on Joy’s special ability.

This new test works in mere minutes.

Twitter

Under the belief that Parkinson’s affects a person’s odor due to a chemical change in sebum, or skin oil, doctors simply run a cotton ball along the back of the neck, then identify specific molecules linked to the neurological condition. The BBC reported that the skin-swab test is 95% accurate under laboratory conditions.

Though this medical advancement is still in its early stages, the discovery is promising. There is currently no definitive test to get a Parkinson’s diagnosis and, as Joy explained to Sky News, it is often not identified until patients have “over 50% of neuronal damage.”

Joy Milne, who can 'smell Parkinson's Disease' has helped scientists from The University of Manchester develop a test to diagnose the disease within minutes. 👃 pic.twitter.com/j68oSQnM2o
— The University of Manchester (@OfficialUoM) September 8, 2022

Les died in 2015 at 65. An earlier diagnosis might have provided the opportunity to improve his lifestyle, which could possibly have offset symptoms. “It has been found that exercise and change of diet can make a phenomenal difference,” Joy told The Guardian.

She also recalled to BBC News that it would have meant having an explanation for the mood swings, not to mention traveling, spending more time with family … making the most out of what time was left. That perhaps is the biggest saving grace an early diagnosis could offer.

Les’ final wish before he passed was for Joy to continue using her gift, assuring that "it will make a difference." Joy is keeping that promise and currently extending her “super smeller” power to help smell other diseases like cancer and tuberculosis (TB).

While she notes that her superpower does make outings like shopping a “curse sometimes,” she also sees it as a “benefit” allowing her to help others.

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breakthroughs

Heroes

What if cement could help save the planet? Thanks to this discovery, it might.

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Earlier this year, a Swiss startup began removing CO2 from the atmosphere using a large vacuum-like machine.

Their ultimate goal is to start reversing the damaging effects of climate change by reducing CO2 — a major component of atmospheric pollution — on a global scale.

While the machine's development is a huge step forward, one little problem remains — where does all that collected CO2 go?

Gaurav Sant, a professor of civil and environmental engineering at UCLA, has one solution: turn it into cement.

(And we're not just talking about any old cement.)

Gaurav Sant. Photo via UCLA.

Sant has figured out how to make a stronger, more lightweight, more structurally sound cement out of — wait for it — CO2.

Believe it or not, the regular construction of cement is responsible for 9% of the world's CO2 emissions. And it is widely accepted that CO2 emissions play a huge role in global warming and, by effect, climate change.

Sant, along with his team at UCLA, decided to try to turn two negatives into a positive. They found a way to integrate CO2 into the production of cement, thereby keeping it out of the atmosphere and upcycling it into something useful and even profitable.

It all started from tiny cement cylinders created by Sant's 3D printer.

Sant with his 3D printer. Photo via UCLA.

Well, that and a pretty important discovery of how CO2 can help accelerate the cement-making process.

In simplest terms, Sant's team discovered that the CO2 in flue gas streams from coal and natural gas power plants accelerates the mineral-making processes that can be used to create cementing agents. They decided to use CO2 to produce a new type of concrete that they've named CO₂NCRETE^TM.

Curious how they did that? Here's the breakdown.

When a mineral called portlandite absorbs CO2, it turns into limestone, which is a cementing agent. While this process normally takes years to happen naturally, Sant's team figured out how to make it happen quickly — 450 pounds of CO2 into several tons of CO₂NCRETE^TM quickly — and efficiently using their 3D printer.

Unlike traditional cement-making on a construction site, 3D technologies allow them to create basic construction pieces out of their new CO2-based concrete that fit together perfectly.

This means they can make cement pieces that are stronger, more lightweight, and more structurally sound.

Sant with a fellow researcher creating cones of CO₂NCRETE^TM. Photo via UCLA.

"As a child that played with Legos, I have long recognized that the idea of constructing buildings and infrastructure like a large Lego set is (a) fast, (b) intuitive, and, (c) offers improved quality control since 'factory made' pieces are simply assembled on site," Sant explains in an email.

What sort of impact could this have on reducing global CO2 emissions? Turns out, a pretty big one.

[rebelmouse-image 19475646 dam="1" original_size="600x338" caption="Traditional concrete being poured. Photo by Circe Denyer/PublicDomainPictures.net." expand=1]Traditional concrete being poured. Photo by Circe Denyer/PublicDomainPictures.net.

According to Sant and his team, if CO₂NCRETE^TMwere to be mass-produced globally, it could reduce CO2 emissions from traditionally made cement by 50%. And since those emissions currently make up 9% of all CO2 emissions on the planet, that's no small amount.

What's more, since there's been little change made in the construction industry over the last two centuries, it's primed for an efficiency makeover.

"CO₂NCRETE^TM has the potential to serve as an example of how CO2 emissions — even those associated with dilute CO2 streams — can be repurposed to create value and minimize environmental impact," writes Sant.

[rebelmouse-image 19475647 dam="1" original_size="1280x854" caption="Photo by Robert Jones/Pixabay." expand=1]Photo by Robert Jones/Pixabay.

And it's not like this goal is a faraway dream. They've made incredible progress on this new cement and are starting to shop it around.

They've figured out how to streamline the cement-making process so it takes much less time and energy than it did initially. They've also done an analysis of the construction market and see huge potential for such a sustainable product.

"This is especially significant as jurisdictions, globally, including states and nations, seek to limit CO2 emissions and impose CO2 penalties on industrial processes," writes Sant.

And in terms of progress with CO2 capture, Sant's work could offer an economically viable alternative to storing the CO2 underground, which can get pretty expensive.

If the world recognizes the economic value of upcycled cement along with the environmental impact, this discovery could revolutionize the future of construction.

[rebelmouse-image 19475648 dam="1" original_size="1280x720" caption="Photo by Pexels/Pixabay." expand=1]Photo by Pexels/Pixabay.

Engineering solutions like this can offer a way to mitigate climate change and be profitable at the same time. Now it's just about keeping an open mind and seeing the enormous potential in a small, concrete cylinder.

As for Sant and his associates, they're just thrilled to be on the precipice of real, necessary change.

"As humans, we all want to make positive impact," says Sant. "To be a part of the solution is a very empowering accomplishment that we wish to socialize."

How 2 cousins saved their family's oyster company with underwater farming.

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When Ryan and Travis Croxton decided to bring back their grandfather's oyster company, it coincided with Chesapeake Bay’s lowest oyster harvest ever.

All images via Upworthy.

Their town's once-flourishing industry was collapsing. In fact, things got so bad, their native oyster was almost put on the endangered species list. It was a pretty big dilemma (and inconvenient timing), to say the least. But it only spurred the Croxton cousins' Rappahannock Oyster Company even more to find a solution.

They scoured the internet to see what other countries were doing, how they were producing their seafood. What they found was a more advanced, efficient technique that could help save not just their own business, but Chesapeake Bay's entire oyster industry.

Watch how this amazing journey unfolded right here:

This community of dedicated fishermen is making sure the Chesapeake Bay oyster doesn't end up on the endangered species list.
Posted by Upworthy Video on Friday, March 17, 2017

Rather than just gathering what oysters were left, the Croxtons turned to aquaculture, which is basically the farming and harvesting of anything that lives underwater.

Outside of aquaculture, gathering fish and oysters is just about that — gathering. Get, get, get. Fish, fish, fish. You collect as big a bounty as you can and you sell it for top dollar. The problem with that model is it becomes all about how much you can get, leaving little regard for resources.

In contrast, aquaculture is all about those resources. It focuses oncreating a sustainable ecosystem where underwater plants and animals can thrive more naturally.

And when it comes down to it, oyster aquaculture can be a boon to both the environment and the economy.

For one thing, oysters are a natural cleaner and they act as an amazing filter for pollutants, such as nitrogen. "During its duration in the water, it's filtering 50 to 60 gallons of water a day," explained Ryan Croxton.

Promoting a habitat and life cycle that allows these oysters to blossom benefits Mother Nature (and our tummies) even more. "The oysters we grow actually increase the population of the wild oysters," added Travis Croxton. "You see underwater vegetation coming back, which provides sanctuary for marine animals."

When it comes to aquaculture and fish, however, the method does have potential downsides. Installing cages to farm the fish is necessary, and building them can damage a coast's natural ecosystem. On top of that, waste can accumulate in these structures and contaminate an area's water supply.

Aquaculture also has the potential to create countless new jobs. In the U.S. alone, aquaculture production hit just over a billion dollars back in 2012. But when you compare it to the $120 billion worldwide industry that it was valued at that same year, you can see there are still many opportunities for growth.

And it's already happening.

When the the Croxtons first started out, only a few businesses were doing aquaculture in their community. Now? Several hundred. "I've increased my workforce by about 30%," said Richard Harding, owner of Purcell’s Seafood Company. "We're a small business in a small community, so every job counts."

The best part? Aquaculture has the potential to improve food access for people all around the world.

A 2015 report by WorldFish shows how fish consumption is rising in developing nations — and future demand worldwide is only expected to increase in the coming decades. This means that aquaculture is going to play a pivotal role in making sure that everyone gets fed.

In fact, by 2030, it's already estimated that two-thirds of the global fish supply will be produced via aquaculture.

So yes, demand, populations, challenges — they're all rising. But, you know what? So is the know-how of the people addressing this issue. "Aquaculture is one of the rare things in this world that is a win-win for everything," added Travis Croxton.

The next time you grab an oyster platter, think about how that little gooey organism is helping change the world. Then, of course, think about how dang delicious it is.

Family

Women were dying from childbirth at hospitals. This 19th-century doctor figured out why.

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Today, we know that washing our hands is one of the most important steps we can take to avoid getting sick and spreading germs.

But how we came to know that is pretty fascinating.

Image via iStock.

Handwashing is actually a relatively new practice — even for doctors.

In fact, one of the first doctors to realize how important handwashing could be — Ignaz Semmelweis — didn’t discover this fact until 1847. And even after he did realize it, the battle to convince the rest of the medical community wasn’t easy.

The 19th century has been described by some historians as “a golden age of the physician and scientist” because for the first time, doctors were expected to have scientific training.

They were also expected to use symptom-based diagnoses to solve medical ailments. And to do this, of course, medicine relied on understanding what was happening inside the human body to get at the root of disease.

So, autopsies became all the rage.

Not only did they form a critical part of a doctor’s training, but the doctors who regularly performed them were the most respected in the medical community. An unfortunate byproduct of this, though, was the erroneous belief that the dirtier the doctor, the better the doctor.

In fact, there are accounts of doctors going directly from their last autopsy to deliver a baby or treat a patient without changing their clothes.

Enter Hungarian doctor Ignaz Semmelweis.

A portrait of Ignaz Phillip Semmelweis. Image via Jeño Doby/Wikimedia Commons.

In 1846, Semmelweis had just started his new job at the maternity clinic at Vienna General Hospital.

At that time, women were dying at staggering rates in hospitals shortly after giving birth from “childbed fever,” a disease also called puerperal fever. It was a cruel infection, causing raging fevers, painful abscesses, an infection in the uterus and birth canal, sepsis, and then finally, death — all within about three days of the baby’s delivery. And it was the single most common cause of maternal death at the time.

Being a man of science, Semmelweis wanted to understand why so many women were dying in his clinic. So he studied two maternity wards in the hospital — one staffed by doctors and medical students, the other by midwives — and recorded the number of deaths in each ward.

Vienna General Hospital, where Semmelweis worked. Image via Josef & Peter Schafer/Wikimedia Commons.

His results showed that women died at a rate nearly five times higher in the ward staffed by doctors and medical students.

But it wasn’t until one of his colleagues, a pathologist, got sick and died after pricking his finger in an autopsy of someone who had died from childbed fever that Semmelweis realized that anyone, not just mothers, could get sick from puerperal fever, and the reason the midwives' ward had fewer deaths was because they didn't do autopsies.

He theorized that there must be some “cadaverous particles” or “morbid poison” that doctors were getting on their hands during autopsies. And the doctors in the ward were then transferring these particles inside the women when they delivered the baby, which then made the women sick.

Today, these “cadaverous particles” are known as bacteria, such as streptococcus pyogenes.

A photomicrograph of streptococcus pyogenes bacteria, which causes puerperal fever. Image via the Centers for Disease Control and Prevention/Wikimedia Commons.

Semmelweis immediately ordered the medical staff to start cleaning their hands and instruments before delivering babies.

They were told to use a chlorine lime solution, not soap, until they could no longer smell the bodies they had dissected.

And it worked — chlorine is actually a great disinfectant. The rate of puerperal fever fell drastically in the doctor’s ward.

The first edition of Semmelweis' published findings. Image via István Benedek/Wikimedia Commons.

Unfortunately, the Semmelweis' colleagues did not embrace his findings — they were outraged at the suggestion that they were the cause of their patients' deaths. Semmelweis was fired from the hospital and eventually committed to an asylum. He died at the asylum two weeks later. (Several historians believe that he died, after being beaten at the asylum, from sepsis — an infection in the bloodstream caused by germs.)

It would take about 20 years before his ideas would start to be accepted by the medical community. And even then, it was "germ theory" — and the work of Louis Pasteur in the late-1860s — that really convinced anyone of the importance of hygiene and handwashing.

Over a 150 years later, though, Semmelweis is finally getting the recognition he deserves because the simple act of handwashing is one of the most important tools we have in public health.

And its benefits extend well beyond the hospital. Washing your hands reduces the chances of getting diarrheal illnesses by 31%, according to the Centers for Disease Control and Prevention (CDC). It also reduces the occurrence of respiratory illnesses — including colds — by 16 to 21%.

That’s why in the 1980s, the first nationally endorsed hand hygiene guidelines were released by the CDC, after a series of outbreaks of food-borne and health care-associated infections. And over the next few decades, a number of other guidelines have followed to stress the importance to the general public.

Image via iStock.

Today, the battle to promote this public health tool is still not over.

Diarrhea and respiratory infections remain leading causes of death in the developing world — claiming about 3.5 million children every year — because people either don't know how important handwashing is or don't have access to a reliable, clean water source. There are also still over 1.4 million cases of health care-associated infections around the world. But through education initiatives, NGOs all over the world are hoping to bring about change with this one simple habit.

Proper hand hygiene is still one of the best ways to fight these infections and diseases — and we have Dr. Semmelweis to thank.

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Heroes

This DIY toy is fun and simple — and could help tackle malaria and other diseases.

If you're, say, researching a new drug or vaccine, this lab might be perfect.

Image via iStock.

But not everyone is lucky enough to have access to such resources. If you're not in a big city, for example, or if you're one of the world's many remote health care workers, in which case you might be going someplace where you can bring only what fits in your Jeep.

Which means that lab is just not coming along.

One of the tools we'd really like to make "back-of-Jeep" friendly is the centrifuge.

Centrifuges are one of the most common scientific tools and work by spinning samples at ridiculously high speeds. In medicine they're used to prep blood samples for analysis. Unfortunately, typical centrifuges are bulky, heavy, expensive, and electronic, which led designers to search for alternative solutions.

Designers often look for inspiration in everyday objects. Some have tried salad spinners as a centrifuge replacement. Others tried egg beaters. Both of those were too slow and awkward, but now researchers at Stanford might have found something awesome.

This simple toy is known as a whirligig.

Image from Nature/YouTube.

You may have played with one before, and if you haven't, they're dead simple to make. Researchers spotted it and were curious: Could this thing work as a centrifuge? It certainly spun, but how fast? The researchers decided to build their own prototype and test it out.

Using a high-speed camera and some seriously impressive physics calculations, they found that a whirligig could get up to a blisteringly fast 125,000 revolutions per minute. That's not just fast, that's centrifuge fast.

Since the first test, researchers have come up with a new whirligigdesign that could hold small amounts of blood or other scientific samples. They're calling it the "paperfuge" and are working with health care workers in Madagascar to learn how to improve and distribute it.

Image from Nature/YouTube.

Initial results seem good. They can get blood samples to separate in just 90 seconds. After 15 minutes, results were fine enough to even identify malaria parasites. This means the paperfuge might be able to bring a ton of new tests — from basic health checkups to serious diagnostics — to the millions of people who live outside the range of typical labs.

A lot of science is, unfortunately, out of reach for normal people. Clever design like this could remove some of the barriers.

Image from Nature/YouTube.

Creating more accessible equipment could help democratize science, says Dr. Manu Prakash, one of the researchers who worked on the paperfuge. There are a ton of smart, knowledgable people out there, but living in a place where you can easily get and use thousand-dollar centrifuges is a privilege many do not get.New tools like the paperfuge could change that.

Science is one of the best ways we have to learn about and change our world. Imagine what we can do once everyone has access to it.

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Heroes

He thought he'd never be able to see again. Thanks to his tongue, he can.

Andy woke up with no sight and a tube down his throat.

On Sept. 28, 2011, an unknown person assaulted Andy. The attack knocked him unconscious, and when he woke up, he couldn't see anymore. The assault had damaged his optic nerve.

"I thought to myself, 'Hah. Whatever. You'll just open me up, reattach the wires and lights come back on again,'" recalls Andy. But that wasn't going to happen. "[The doctor] put his hand on my shoulder and said, 'I'm sorry, Andy.'"

Over time, Andy adjusted to losing his sight. But it wasn't easy.

More than 7 million American adults are blind or have a visual disability and it doesn't necessarily have to be a sad thing. But for Andy, losing his sight was difficult.

"The hardest thing for me being completely blind is not seeing my family every day," says Andy. "For me to learn to accept, 'You're never going to see again, Andy. You're never going to see your wife, your children, your dog.' Taken away in the blink of an eye. It's not fair."

But then the doctor said he might know something that could help.

There's a weird device out there called the BrainPort. It lets people see with their tongues. Yeah — their tongues. The device has three parts: a small camera, an iPhone-sized computer, and a weird half-spatula/half-lollipop-looking thing.

Using it is pretty simple: The camera and computer capture an image, then send it as a pattern of buzzes to the lollipop, which the person puts in their mouth (the buzzes apparently feel kind of like Pop Rocks candy.)

A buzzing lollipop sounds pretty weird, but it does seem to work.

Our brains are actually pretty good at figuring out how to use new information (it also helps that our tongues are incredibly sensitive, as anyone who's accidentally bitten theirs can tell you). It took a little while for Andy to get used to the buzzing sensation, but not that long.

"I felt this buzzing on my tongue, and I felt the impression. And then I saw my hand. For the first time in five years, I saw my hand," Andy explains. "Something that small is huge."

If certain studies are correct, Andy's brain could have processed the signals in his vision centers, as if the information was coming from his eyes themselves.

Seeing his hand must have been big. But not as big as seeing his family again.

"The first person was [my son] little Andy. He shook his hand back and forth and he said, 'Dad, you can see me?'" says Andy. You could see the emotion in his face. "He said, 'Hey, pop.'"

"It had been five years since I've seen my kids," Andy says. "It's incredible."

Watch Andy's story below:

Heroes

A 13-year-old girl invented a bandage to help wounds heal faster.

Parents and judges told her it was impossible, but she didn't listen.

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Anushka Naiknaware may only be 13 years old, but she just invented a bandage that could help patients with chronic wounds heal faster.

The eighth-grader from Portland, Oregon, created a bandage that senses moisture in a wound dressing. "A lot of people don't immediately relate moisture to wounds," she explained, "but the truth is that moisture is one of the key determining factors in how fast a chronic wound heals."

Naiknaware in front of a previous science fair presentation. All images via Rekha Naiknaware, used with permission.

Why does moisture matter? Well, many open wounds need to be kept moist to promote healing; but if a wound is too wet, that can be a sign of infection. Simply put: Keeping the wound in a healthy moisture range helps it heal faster.

Naiknaware's bandage allows a doctor to monitor the status of the wound (without having to unwrap the dressing) and address issues accordingly. The bandage is intended to be used on patients with chronic wounds, which are common in elderly patients and folks with diabetes and usually take three months or longer to heal.

Ravleen Kaur from the Beaverton Valley Times reported that the bandage may even have implications for the military, "helping injured soldiers in a rapid and cost-effective manner."

Naiknaware's creation won the Lego Education Builder Award at the 2016 Google Science Fair. Heads up: That's a pretty big deal.

It's a prize that comes with $15,000, a trip to Denmark, and a one-year mentorship with Lego to help get the project into production.

Naiknaware after winning her award at the Google Science Fair.

The project all started when Naiknaware was 3 or 4 years old and her parents would take her to a local science museum. She loved all the exhibits there (particularly chemistry) and over the years her interest in science blossomed.

"There's a natural progression from one field to another," she said. "After you learn math and chemistry, you can do biology, physics, computer science, anything. It just keeps building and there’s no real end to it."

Naiknaware's love of the science museum fueled an interest in nanoparticles (which she began researching in fourth grade). Eventually, this research became the foundation of her submission to the Google Science Fair.

A budding scientist.

"I actually created an ink out of nanoparticles and filled that into a normal inkjet cartridge," Naiknaware explained. "This allowed me to print out a conductive circuit." After hooking that circuit up to a small battery and passing a current through it, she could measure the resistance and get a reading of the moisture content.

The success of Naiknaware's invention is huge. But throughout her process, she was no stranger to failure.

She had particular difficulty perfecting the ink circuit. "How many times did my ink fail? 40 times? 50 times? Quite a few." She also mentioned a few jammed up printers in the garage.

Naiknaware's wound dressing presentation.

On top of that, Naiknaware encountered her fair share of discouragement from adults. "When I started doing things with nanoparticles," she recalled, "a lot of people — parents, judges — told me, 'What you're doing is impossible. It's not going to work.'"

But she knew that her theory worked on paper. She had confidence in her own idea and a few encouraging mentors on her side — including her sixth grade science teacher, Ms. Svenson.

After her experience with the bandage, Naiknaware's advice to other passionate kids interested in science is simple: "Just because people say your idea won't work, doesn't mean you can't prove them wrong."