+
upworthy
Heroes

Game-changing genetic editing just let one teenager 'dodge' sickle cell disease.

Chalk up another big potential win for science – it just helped one kid avoid some of the devastating effects of sickle cell disease.

Sickle cell disease is a chronic, genetic blood disorder that affects about 100,000 Americans. It can affect anyone, although it disproportionately occurs in African-Americans. It’s manageable with medicine and proper care, but can still be dangerous and extremely painful. It's a lifelong condition.

Or, maybe not. Because that last part — about it being a lifelong condition – might be changing.


A French teenager may have just dodged most of the effects of the disorder thanks to gene editing.

A worker preparing cells for gene editing research. Ben Birchall/PA via AP.

That's according to a March 2, 2017, report in The New England Journal of Medicine.

Sickle cell is caused by a single genetic typo in the gene that produces hemoglobin — an important blood protein. That typo can cause normally disc-shaped red blood cells to warp into sickle-shaped crescents.

On the right are normal-shaped red blood cells. On the left is one deformed into the classic sickle shape. Image from Sickle Cell Foundation of Georgia.

These can get trapped in small blood vessels, causing painful, sometimes dangerous blood clots.

The researchers behind the study used gene editing to install a typo-free copy of the gene into the DNA of some of the boy's cells.

A modified virus shepherded a copy of the normal hemoglobin gene into the boy's bone marrow stem cells (which produce red blood cells).

Now, more than two years later, about half of the boy’s red blood cells are carrying that normal protein.

"It’s not a cure, but it doesn’t matter," explained Philippe Leboulch, who helped invent the therapy, because the results were enough for the patient to avoid most of the effects of sickle cell.

Other gene therapy studies for sickle cell are also underway in Los Angeles and California.

The treatment is still preliminary work, but if it holds out in the long run, it could be a huge win for a lot of people.

In Indianapolis, a newborn's blood is taken to test for inherited diseases such as sickle cell. Photo from AP Photo/Michael Conroy.

"It could be a game changer," Oxford geneticist Deborah Gill told New Scientist. "The fact the team has a patient with real clinical benefit, and biological markers to prove it, is a very big deal."

In the past, researchers have had success fighting sickle cell with stem cell transplants, but finding a compatible donor can be difficult for many patients. Gene therapy, however, only needs one person — the patient.

Of course, there's still a ways to go before this could be widely available. But if it works out, this technique could help over 100,000 Americans live without the chronic pain of sickle cell. Which is the very definition of "a very big deal."

Community

How to end hunger, according to the people who face it daily

Here’s what people facing food insecurity want you to know about solving the hunger problem in America

True

Even though America is the world’s wealthiest nation, about 1 in 6 of our neighbors turned to food banks and community programs in order to feed themselves and their families last year. Think about it: More than 9 million children faced hunger in 2021 (1 in 8 children).

In order to solve a problem, we must first understand it. Feeding America, the nation’s largest domestic hunger-relief organization, released its second annual Elevating Voices: Insights Report and turned to the experts—people experiencing hunger—to find out how this issue can be solved once and for all.

Here are the four most important things people facing hunger want you to know.

Keep ReadingShow less
Pets

Family brings home the wrong dog from daycare until their cats saved the day

A quick trip to the vet confirmed the cats' and family's suspicions.

Family accidentally brings wrong dog home but their cats knew

It's not a secret that nearly all golden retrievers are identical. Honestly, magic has to be involved for owners to know which one belongs to them when more than one golden retriever is around. Seriously, how do they all seem have the same face? It's like someone fell asleep on the copy machine when they were being created.

Outside of collars, harnesses and bandanas, immediately identifying the dog that belongs to you has to be a secret skill because at first glance, their personalities are also super similar. That's why it's not surprising when one family dropped off their sweet golden pooch at daycare and to be groomed, they didn't notice the daycare sent out the wrong dog.

See, not even their human parents can tell them apart because when the swapped dog got home, nothing seemed odd to the owners at first. She was freshly groomed so any small differences were quickly brushed off. But this accidental doppelgänger wasn't fooling her feline siblings.

Keep ReadingShow less
Family

15 best colostrum supplements

Invigorate your journey to optimal health with these wellness-enhancing colostrum supplements.

Editor's Note: Upworthy earns a percentage of revenue from items purchased on this list.


Embarking on a journey toward enhanced well-being is a rewarding endeavor, and when it comes to unlocking nature's potential, colostrum supplements stand as remarkable allies. Did you know that the global colostrum market is projected to experience a growth of over 3.5% in the coming years, a testament to the increasing recognition of its incredible benefits? Moreover, scientific interest in colostrum's immune-boosting properties has led to a surge in research publications, with a remarkable 37% rise observed in the last five years alone. As we delve into the realm of wellness-enhancing supplements, this article unveils an illuminating guide to the 15 best colostrum supplements, offering a chance to embrace vitality and invigorate the journey to optimal health.

15 best colostrum supplements

  1. Elm & Rye Colostrum Supplements
  2. Swanson Ultra High Immunoglobulin Colostrum Supplement
  3. California Gold Nutrition, Colostrum
  4. ARMRA Colostrum Immune Revival Unflavored
  5. Mt. Capra Goat Milk Colostrum
  6. PipingRock Ultra Colostrum Quick Release Capsules
  7. NOW Foods, Colostrum Powder
  8. Nature’s Sunshine Colostrum Capsules
  9. Ancestral Supplements Grass Fed Beef Colostrum Supplement
  10. WONDERCOW Colostrum Powder Supplement
  11. Symbiotics Colostrum Chewables
  12. Brain Basics Ultra-Pure Colostrum
  13. Surthrival: Colostrum Powder Capsules
  14. Double Wood Supplements Colostrum Supplement Capsules
  15. Pure Velvet Colostrum Powder
Keep ReadingShow less
Sandra Maria/Youtube, Official Lives & Music Videos/Youtube

You can't not sing this song.

The music of Queen has a profound visceral effect on everyone. Few pieces of art can cause complete strangers to put aside their differences and come together in song, but by golly, “Bohemian Rhapsody” is one of them. It would be cheesy if it weren’t so absolutely beautiful.

This pertains even to non-English-speaking countries, it appears. Recently, thousands of Harry Styles concertgoers in Warsaw, Poland, began cheering as those iconic beginning piano notes penetrated the air.
Keep ReadingShow less
Photo by Long Truong on Unsplash
woman in white sleeveless dress kissing man in blue dress shirt


"It may be the most important thing we do in life; learn how to love and be loved."

At least, that's according to Harvard psychologist and researcher Rick Weissbourd.

He's been collecting data on the sex and love habits of young people for years through surveys, interviews, and even informal conversation — with teens and the important people in their lives.

Through it all, one thing has been abundantly clear:

"We spend enormous amount of attention helping parents prepare their kids for work and school," Weissbourd says. "We do almost nothing to prepare them for the tender, tough, subtle, generous, focused work of developing mature healthy relationships. I'm troubled by that."

Keep ReadingShow less

Mom shares PSA on about being a sports mom while also working

Being a mom can be challenging enough, but when you add in working full time and kids activities, it feels like you need a few clones to help you out. Recently we signed our youngest up for soccer, he's 5-years-old and happens to be ten years younger than his closest sibling, so I've done the sports stuff.

At one point I was working full-time while my daughter took tap, ballet and jazz while also on a soccer team and my two older boys played soccer, baseball and football. We rarely saw the inside of our home unless it was to sleep, I'm not even sure I knew how my stove worked during those years. Now here we are starting all over again.

So when Mo, a mom running the TikTok page Rex & Mo posted a video ranting about how impossible it feels to add organized activities for kids into the mix, parents everywhere related, myself included.

Keep ReadingShow less
@mychal3ts/TikTok

This is "the power of the library"

Editor's Note: This story discusses suicide. If you are having thoughts about taking your own life, or know of anyone who is in need of help, the 988 Suicide & Crisis Lifeline is a United States-based suicide prevention network of over 200+ crisis centers that provides 24/7 service via a toll-free hotline with the number 9-8-8. It is available to anyone in suicidal crisis or emotional distress.


Libraries aren’t just a place to score free books. For many, they provide safe refuge.

This secondary offering has lately been overshadowed by political controversy, as there has been a laser focus from conservatives on the types of literature libraries provide, especially titles that pertain to LGBTQ and racial topics.

But one librarian’s retelling of a life saving encounter reminds us of how essential these community spaces really are—and it has nothing to do with books at all.

Keep ReadingShow less