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1 year later, the Ice Bucket Challenge funds this breakthrough in ALS research.

Money raised by the viral campaign is making a big difference.

Remember the Ice Bucket Challenge?

Of course you do. It was that viral video campaign that took off last summer where you'd log into Facebook and see a steady stream of your friends dumping water on themselves in the name of awareness and research for the ALS Association.


For science! Brrrrrr. Photo by Clive Mason/Getty Images.

Some brushed the movement off as an example of "slacktivism," but it actually helped raise more than $100 million. When you compare it to the $2.8 million raised by the organization during the same period a year earlier, it's clear that the Ice Bucket challenge paid off.

ALS, also known as amyotrophic laterals sclerosis or Lou Gehrig's Disease, affects an estimated 30,000 living people at any given time.

It's a disorder that affects nerve and muscle function. Just 20% of those with the disease will live more than five years following diagnosis. It's brutal.

But there's good news — due, in part, to the money raised by the Ice Bucket Challenge.

While that man doesn't seem to be having such a great time, I really need to find out what kind of seemingly IBC-proof makeup the woman on the left is using. Photo by Scott Barbour/Getty Images.

During a reddit "Ask Me Anything" session, ALS researcher Jonathan Ling unveiled a major breakthrough in his work.

Ling wanted to do an "Ask Me Anything" to debunk some of the negative things being said by skeptics about the success of the Ice Bucket Challenge.

"I mainly wanted to do this ["Ask Me Anything"] because I remember reading a lot of stories about people complaining that the ice bucket challenge was a waste and that scientists weren't using the money to do research, etc. I assure you that this is absolutely false," Ling writes.

"All of your donations have been amazingly helpful and we have been working tirelessly to find a cure. With the amount of money that the ice bucket challenge raised, I feel that there's a lot of hope and optimism now for real, meaningful therapies."

So what's the big breakthrough? Well, it has to do with protein — or rather, one specific protein.

Ling's research focuses on TDP-43, a protein in cells that's he's been able to link to ALS.

Ling breaks down the purpose of TDP-43 with an analogy involving a library that's easy for us non-scientist types to understand:

"DNA is located in the nucleus of a cell. You can think of a nucleus as a library except that instead of having books neatly lined up on shelves, the books in a nucleus have all of their pages ripped out and thrown around randomly.

To sort through this mess, the cell has great librarians that go around collecting all these pages, collating them and neatly binding them together as books. These librarians then ship these 'books' out of the nucleus so that other workers in the cell can do their jobs. Think of these books as instruction manuals.

TDP-43 is a very special type of librarian. TDP-43's job is to ensure that nucleus librarians don't accidentally make a mistake and put a random nonsense page (usually filled with gibberish) into the books that they ship out. If one of these nonsense pages makes it into an 'instruction manual,' the workers in the cell get really confused and mess things up. For terminology, we call these nonsense pages 'cryptic exons.'"



His team found that in 97% of ALS cases, TDP-43 wasn't doing its job. And now that they know this, they've been able to begin work on new therapies to do TDP-43's job for it. If successful, he believes this can slow down the progression of the disease.

How cool is that?

Baseball Hall-of-Famer Lou Gehrig became the face of ALS after he tearfully retired from baseball upon diagnosis. Photo by Hulton Archive/Getty Images.

But what about the other 3%? Well, we don't have all the answers just yet.

One redditor asked that question, and essentially, it boils down to the fact that ALS is still pretty unpredictable. While TDP-43 may play a large part in the disease's progression, it's not the whole picture. For those individuals for whom ALS runs in the family, that seems to be linked to a gene called SOD1, and not TDP-43.

That's why research needs to continue.

"When you look at ALS from a genetics perspective, about 10% of the cases are called 'familial', [that is], lots of people in the family have ALS and it seems to be passed down. The other 90% of ALS appears to occur completely by unfortunate chance and we call that 'sporadic.'

As researchers, we look to the genetics for clues to study the disease. One of the first family-linked genes discovered was a gene called SOD1 that is found in about 30% of familial cases. But it's starting to seem like SOD1 is an outlier because TDP-43 doesn't seem to be messed up. Instead, SOD1 seems to clump together due to the mutation. We get the 3% because 30% of 10% familial is 3%." — Ling

But yeah, this is pretty neat, exciting stuff!

Ling hopes to have therapies based on his research making their way to clinical trials within the next two-three years.

And from there, who knows? Maybe this is the breakthrough that sets up the next big step in finding a cure for this absolutely ruthless disorder. 76 years after it first entered the public consciousness with Lou Gehrig's emotional farewell speech, a cure feels closer than ever before.

Last year, we shared a video by Anthony Carbajal, a man who had been recently diagnosed with ALS.

ALS runs in Carbajal's family. His grandmother, his mother, and he have all been diagnosed with the disorder. His Ice Bucket Challenge video was powerful because it put a face to the research and the desperation for a cure.


GIF via Anthony Carbajal.

The research made possible by the Ice Bucket Challenge gives hope to people like Anthony. It's just so important.

Saying that 30,000 people live with ALS doesn't mean a whole lot until you see the pain it causes those living with it and watching their loved ones do battle. When you watch Anthony's video, his tears welling up in his eyes, it's clear just how much the world needed something like the Ice Bucket Challenge to fund the research we need to put an end to ALS once and for all.

Leah Menzies/TikTok

Leah Menzies had no idea her deceased mother was her boyfriend's kindergarten teacher.

When you start dating the love of your life, you want to share it with the people closest to you. Sadly, 18-year-old Leah Menzies couldn't do that. Her mother died when she was 7, so she would never have the chance to meet the young woman's boyfriend, Thomas McLeodd. But by a twist of fate, it turns out Thomas had already met Leah's mom when he was just 3 years old. Leah's mom was Thomas' kindergarten teacher.

The couple, who have been dating for seven months, made this realization during a visit to McCleodd's house. When Menzies went to meet his family for the first time, his mom (in true mom fashion) insisted on showing her a picture of him making a goofy face. When they brought out the picture, McLeodd recognized the face of his teacher as that of his girlfriend's mother.

Menzies posted about the realization moment on TikTok. "Me thinking my mum (who died when I was 7) will never meet my future boyfriend," she wrote on the video. The video shows her and McLeodd together, then flashes to the kindergarten class picture.

“He opens this album and then suddenly, he’s like, ‘Oh my God. Oh my God — over and over again,” Menzies told TODAY. “I couldn’t figure out why he was being so dramatic.”

Obviously, Menzies is taking great comfort in knowing that even though her mother is no longer here, they can still maintain a connection. I know how important it was for me to have my mom accept my partner, and there would definitely be something missing if she wasn't here to share in my joy. It's also really incredible to know that Menzies' mother had a hand in making McLeodd the person he is today, even if it was only a small part.

@speccylee

Found out through this photo in his photo album. A moment straight out of a movie 🥲

♬ iris - 🫶

“It’s incredible that that she knew him," Menzies said. "What gets me is that she was standing with my future boyfriend and she had no idea.”

Since he was only 3, McLeodd has no actual memory of Menzies' mother. But his own mother remembers her as “kind and really gentle.”

The TikTok has understandably gone viral and the comments are so sweet and positive.

"No the chills I got omggg."

"This is the cutest thing I have watched."

"It’s as if she remembered some significance about him and sent him to you. Love fate 😍✨"

In the caption of the video, she said that discovering the connection between her boyfriend and her mom was "straight out of a movie." And if you're into romantic comedies, you're definitely nodding along right now.

Menzies and McLeodd made a follow-up TikTok to address everyone's positive response to their initial video and it's just as sweet. The young couple sits together and addresses some of the questions they noticed pop up. People were confused that they kept saying McLeodd was in kindergarten but only 3 years old when he was in Menzies' mother's class. The couple is Australian and Menzies explained that it's the equivalent of American preschool.

They also clarified that although they went to high school together and kind of knew of the other's existence, they didn't really get to know each other until they started dating seven months ago. So no, they truly had no idea that her mother was his teacher. Menzies revealed that she "didn't actually know that my mum taught at kindergarten."

"I just knew she was a teacher," she explained.

She made him act out his reaction to seeing the photo, saying he was "speechless," and when she looked at the photo she started crying. McLeodd recognized her mother because of the pictures Menzies keeps in her room. Cue the "awws," because this is so cute, I'm kvelling.

Photo by Heather Mount on Unsplash

Actions speak far louder than words.

It never fails. After a tragic mass shooting, social media is filled with posts offering thoughts and prayers. Politicians give long-winded speeches on the chamber floor or at press conferences asking Americans to do the thing they’ve been repeatedly trained to do after tragedy: offer heartfelt thoughts and prayers. When no real solution or plan of action is put forth to stop these senseless incidents from occurring so frequently in a country that considers itself a world leader, one has to wonder when we will be honest with ourselves about that very intangible automatic phrase.

Comedian Anthony Jeselnik brilliantly summed up what "thoughts and prayers" truly mean. In a 1.5-minute clip, Jeselnik talks about victims' priorities being that of survival and not wondering if they’re trending at that moment. The crowd laughs as he mimics the actions of well-meaning social media users offering thoughts and prayers after another mass shooting. He goes on to explain how the act of performatively offering thoughts and prayers to victims and their families really pulls the focus onto the author of the social media post and away from the event. In the short clip he expertly expresses how being performative on social media doesn’t typically equate to action that will help victims or enact long-term change.

Of course, this isn’t to say that thoughts and prayers aren’t welcomed or shouldn’t be shared. According to Rabbi Jack Moline "prayer without action is just noise." In a world where mass shootings are so common that a video clip from 2015 is still relevant, it's clear that more than thoughts and prayers are needed. It's important to examine what you’re doing outside of offering thoughts and prayers on social media. In another several years, hopefully this video clip won’t be as relevant, but at this rate it’s hard to see it any differently.

Moricz was banned from speaking up about LGBTQ topics. He found a brilliant workaround.

Senior class president Zander Moricz was given a fair warning: If he used his graduation speech to criticize the “Don’t Say Gay” law, then his microphone would be shut off immediately.

Moricz had been receiving a lot of attention for his LGBTQ activism prior to the ceremony. Moricz, an openly gay student at Pine View School for the Gifted in Florida, also organized student walkouts in protest and is the youngest public plaintiff in the state suing over the law formally known as the Parental Rights in Education law, which prohibits the discussion of sexual orientation or gender identity in grades K-3.

Though well beyond third grade, Moricz nevertheless was also banned from speaking up about the law, gender or sexuality. The 18-year-old tweeted, “I am the first openly-gay Class President in my school’s history–this censorship seems to show that they want me to be the last.”

However, during his speech, Moricz still delivered a powerful message about identity. Even if he did have to use a clever metaphor to do it.

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