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We asked three people how cancer changed their lives. Here are their stories – and how cancer is changing because of them.

We asked three people how cancer changed their lives. Here are their stories – and how cancer is changing because of them.
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Each year, an estimated 1.8 million people in the United States are affected by cancer — most commonly cancers of the breast, lung, prostate, and blood cancers such as leukemia. While not everyone overcomes the disease, thanks to science, more people are surviving — and for longer — than ever before in history.

We asked three people whose lives have been impacted by cancer to share their stories – how their lives were changed by the disease, and how they're using that experience to change the future of cancer treatments with the hope that ultimately, in the fight against cancer, science will win. Here's what they had to say.

Celine Ryan, 55, engineer database programmer and mother of five from Detroit, MI

Photo courtesy of Celine Ryan

In September 2013, Celine Ryan woke up from a colonoscopy to some traumatic news. Her gastroenterologist showed her a picture of the cancerous mass they found during the procedure.

Ryan and her husband, Patrick, had scheduled a colonoscopy after discovering some unusual bleeding, so the suspicion she could have cancer was already there. Neither of them, however, were quite prepared for the results to be positive -- or for the treatment to begin so soon. Just two days after learning the news, Ryan had surgery to remove the tumor, part of her bladder, and 17 cancerous lymph nodes. Chemotherapy and radiation soon followed.

Ryan's treatment was rigorous – but in December 2014, she got the devastating news that the cancer, once confined to her colon, had spread to her lungs. Her prognosis, they said, was likely terminal.

But rather than give up hope, Ryan sought support from online research, fellow cancer patients and survivors, and her medical team. When she brought up immunotherapy to her oncologist, he quickly agreed it was the best course of action. Ryan's cancer, like a majority of colon and pancreatic cancers, had been caused by a defect on the gene KRAS, which can result in a very aggressive cancer that is virtually "undruggable." According to the medical literature, the relatively smooth protein structure of the KRAS gene meant that designing inhibitors to bind to surface grooves and treat the cancer has been historically difficult. Through her support systems, Ryan discovered an experimental immunotherapy trial at the National Institutes of Health (NIH) in Bethesda, MD., and called them immediately to see if she was eligible. After months of trying to determine whether she was a suitable candidate for the experimental treatment, Ryan was finally accepted.

The treatment, known as tumor-infiltrating lymphocyte therapy, or TIL, is a testament to how far modern science has evolved. With this therapy, doctors remove a tumor and harvest special immune cells that are found naturally in the tumor. Doctors then grow the cells in a lab over the next several weeks with a protein that promotes rapid TIL growth – and once the cells number into the billions, they are infused back into the patient's body to fight the cancer. On April 1, 2015, Ryan had her tumor removed at the NIH. Two months later, she went inpatient for four weeks to have the team "wash out" her immune system with chemotherapy and infuse the cells – all 148 billion of them – back into her body.

Six weeks after the infusion, Ryan and Patrick went back for a follow-up appointment – and the news they got was stunning: Not only had no new tumors developed, but the six existing tumors in her lungs had shrunk significantly. Less than a year after her cell infusion, in April 2016, the doctors told Ryan news that would have been impossible just a decade earlier: Thanks to the cell infusion, Ryan was now considered NED – no evaluable disease. Her body was cancer-free.

Ryan is still NED today and continuing annual follow-up appointments at the NIH, experiencing things she never dreamed she'd be able to live to see, such as her children's high school and college graduations. She's also donating her blood and cells to the NIH to help them research other potential cancer treatments. "It was an honor to do so," Ryan said of her experience. "I'm just thrilled, and I hope my experience can help a lot more people."

Patrice Lee, PhD, VP of Pharmacology, Toxicology and Exploratory Development at Pfizer

Photo courtesy of Patrice Lee

Patrice Lee got into scientific research in an unconventional way – through the late ocean explorer Jacques Cousteau.

Lee never met Cousteau but her dreams of working with him one day led her to pursue a career in science. Initially, Lee completed an undergraduate degree in marine biology; eventually, her interests changed and she decided to get a dual doctoral degree in physiology and toxicology at Duke University. She now works at Pfizer's R&D site in Boulder, CO (formerly Array BioPharma), leading a group of scientists who determine the safety and efficacy of new oncology drugs.

"Scientists focused on drug discovery and development in the pharmaceutical industry are deeply committed to inventing new therapies to meet unmet needs," Lee says, describing her field of work. "We're driven to achieve new medicines and vaccines as quickly as possible without sacrificing safety."

Among the drugs Lee has helped develop during her career, including cancer therapies, she says around a dozen are currently in development, while nine have received FDA approval — an incredible accomplishment as many scientists spend their careers without seeing their drug make it to market. Lee's team is particularly interested in therapies for brain metastases — something that Lee says is a largely unmet need in cancer research, and something her team is working on from a variety of angles. "Now that we've had rapid success with mRNA vaccine technology, we hope to explore what the future holds when applying this technology to cancers," Lee says.

But while evaluating potential cancer therapies is a professional passion of Lee's, it's also a mission that's deeply personal. "I'm also a breast cancer survivor," she says. "So I've been on the other side of things and have participated in a clinical trial."

However, seeing how melanoma therapies that she helped develop have affected other real-life cancer patients, she says, has been a highlight of her career. "We had one therapy that was approved for patients with BRAF-mutant metastatic melanoma," Lee recalls. "Our team in Boulder was graced by a visit from a patient that had benefited from these drugs that we developed. It was a very special moment for the entire team."

None of these therapies would be available, Lee says without rigorous science behind it: "Facts come from good science. Facts will drive the development of new drugs, and that's what will help patients."

Chiuying "Cynthia" Kuk (they/them) MS, 34, third-year medical student at Michigan State University College of Human Medicine

Photo courtesy of Cynthia Kuk

Cynthia Kuk was just 10 years old when they had a conversation that would change their life forever.

"My mother, who worked as a translator for the government at the time, had been diagnosed with breast cancer, and after her chemotherapy treatments she would get really sick," Kuk, who uses they/them pronouns, recalls. "When I asked my dad why mom was puking so much, he said it was because of the medicine she was taking that would help her get better."

Kuk's response was immediate: "That's so stupid! Why would a medicine make you feel worse instead of better? When I'm older, I want to create medicine that won't make people sick like that."

Nine years later, Kuk traveled from their native Hong Kong to the United States to do exactly that. Kuk enrolled in a small, liberal arts college for their Bachelor's degree, and then four years later started a PhD program in cancer research. Although Kuk's mother was in remission from her cancer at the time, Kuk's goal was the same as it had been as a 10-year-old watching her suffer through chemotherapy: to design a better cancer treatment, and change the landscape of cancer research forever.

Since then, Kuk's mission has changed slightly.

"My mom's cancer relapsed in 2008, and she ended up passing away about five years after that," Kuk says. "After my mom died, I started having this sense of urgency. Cancer research is such that you work for twenty years, and at the end of it you might have a fancy medication that could help people, but I wanted to help people now." With their mother still at the forefront of their mind, Kuk decided to quit their PhD program and enter medical school.

Now, Kuk plans to pursue a career in emergency medicine – not only because they are drawn to the excitement of the emergency room, but because the ER is a place where the most marginalized people tend to seek care.

"I have a special interest in the LGBTQ+ population, as I identify as queer and nonbinary," says Kuk. "A lot of people in this community and other marginalized communities access care through the ER and also tend to avoid medical care since there is a history of mistreatment and judgement from healthcare workers. How you carry yourself as a doctor, your compassion, that can make a huge difference in someone's care."

In addition to making a difference in the lives of LGBTQ+ patients, Kuk wants to make a difference in the lives of patients with cancer as well, like their mother had.

"We've diagnosed patients in the Emergency Department with cancer before," Kuk says. "I can't make cancer good news but how you deliver bad news and the compassion you show could make a world of difference to that patient and their family."

During their training, Kuk advocates for patients by delivering compassionate and inclusive care, whether they happen to have cancer or not. In addition to emphasizing their patient's pronouns and chosen names, they ask for inclusive social and sexual histories as well as using gender neutral language. In doing this, they hope to make medicine as a whole more accessible for people who have been historically pushed aside.

"I'm just one person, and I can't force everyone to respect you, if you're marginalized," Kuk says. "But I do want to push for a culture where people appreciate others who are different from them."

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Joy

A stray dog saves her dying puppy’s life by bringing her to the veterinarian in Istanbul

A dog's motherly instinct and trust in humans saved a puppy's life

@beylikduzu_alfa_veteriner

A stray dog brought her lifeless puppy to the doorstep of a local veterinarian clinic, saving its life.

In the Beylikdüzü district in Istanbul, security camera footage showed a stray dog holding a puppy in its mouth and bringing it to the doorstep of a local veterinary clinic. The veterinarian that answered the door found the puppy lifeless and took it in while the pup’s mother followed.

The puppy received emergency treatment, as it was dying from a slow heartbeat due to the cold outside. Throughout the treatment, the mother dog stayed at her puppy’s side. Thanks to quick action and care, the puppy survived and is being cared for at the clinic alongside its mother. This puppy turned out to be related to another puppy that was brought in by other animal lovers beforehand, with the belief that it was the sole survivor of its litter.

"We thought all of them had died. It turns out there was one sibling that survived,” said veterinarian and clinic owner, Baturalp Oğhan in an interview. “When our technician noticed the situation, he brought it inside. We realized the puppy's heart was beating. We placed it in intensive care. It is currently continuing treatment with its sibling."


A veterinarian treating a puppy on a table in a clinic as a mother dog watches nearbyThe puppy's mother stayed with her child as the veterinarian administered treatment.@beylikduzu_alfa_veteriner


While it is unfortunate that the rest of the litter had passed, this mother dog’s actions not only saved one of her pups but had reunited her with another one.

According to World Population Review, there is a pet dog in 30% of all households globally. There are 90 million pet dogs housed in the United States alone. Bear in mind, that is counting the dogs that are housed and cared for by humans. Just imagine how many dogs are still out there like that mother dog, along with the number of dogs that sadly didn’t make it like that lucky puppy.

Two puppies eating out of a bowlThe puppy is recovering nicely alongside its sibling.@beylikduzu_alfa_veteriner


While it is remarkable that this mother dog, out of memory, instinct, desperation, or a combination of those traits took her puppy to the clinic, the onus cannot be on dogs themselves to receive the help and care they need. Fortunately, there are several animal shelters and clinics that can help care for these animals, but they still need to find ways to get there. Not all of them have smart dog mothers that can get them to a helpful human vet.

Puppy sleeping against a mother dogThe puppy lives thanks to its mother's quick action and trust in local veterinarians.@beylikduzu_alfa_veteriner

If you wish to help out a stray animal, such as a dog or cat, there are some steps you can take to be prepared if the situation presents itself. The Humane Society has a bunch of quality tips, such as keeping your car with supplies like fresh water, bowls, pet food, heavy blankets,and such to keep the animal comfortable while waiting for animal control to arrive at the scene or if you choose to transport them yourself to a nearby shelter. Before you stock up, you should research to see if there are any state or local laws regarding housing lost or stray animals to make sure you’re following the legal methods.

We share a lot of space with “man’s best friend” and the least we can do is be a best friend back to them, especially when they’re in need.

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Health

Difference in how 'managers' and 'makers' view time explains why some hate meetings so much

Paul Graham's explanation is spot on.

Reese Jones/Facebook

The way makers use time makes meetings far more disruptive than they are for managers.

Most people don't look at their work calendar on any given day and say, "Yay! I have a meeting!" Most of us just understand and accept that meetings are a part of work life in most industries.

Some people, however, are far more negatively impacted by scheduled meetings than others. For people involved in creating or producing, meetings are actively disruptive to work in a way that isn't often the case for managers.

A viral post with an explanation from Paul Graham breaks down why.

Graham is a computer scientist, entrepreneur, venture capitalist, and author. In 2009, he described on his website the differences between the way managers and makers utilize work time and how meetings affect their workflow. It's a brilliant observation that rings true for people in various fields, and understanding this difference can help bridge the gap that often exists between those who work in creation or production and those who manage them.

Graham's explanation was shared by Reese Jones on Facebook with a graphic that shows the difference in how time is seen between managers (people who manage others—the bosses) and makers (writers, artists, programmers—the creators). The manager's time during the day is split into small blocks, whereas the maker's is split into two large chunks.

"One reason programmers dislike meetings so much is that they're on a different type of schedule from other people," Graham wrote. "Meetings cost them more."


Graham explained that managers and makers work on two different types of schedules. The manager's schedule looks more like an appointment book, with the day broken into one-hour intervals.

"You can block off several hours for a single task if you need to, but by default, you change what you're doing every hour," he explained. "When you use time that way, it's merely a practical problem to meet with someone. Find an open slot in your schedule, book them, and you're done."

Generally, the folks in power are on this kind of schedule. But those who make things don't think in hours. Writers, artists, programmers, and others who create for a living work in half-day units at least.

"You can't write or program well in units of an hour," wrote Graham. "That's barely enough time to get started."

Then he got to the heart of the problem with managers making meetings for makers:

"When you're operating on the maker's schedule, meetings are a disaster. A single meeting can blow a whole afternoon, by breaking it into two pieces each too small to do anything hard in. Plus you have to remember to go to the meeting. That's no problem for someone on the manager's schedule. There's always something coming on the next hour; the only question is what. But when someone on the maker's schedule has a meeting, they have to think about it.

"For someone on the maker's schedule, having a meeting is like throwing an exception. It doesn't merely cause you to switch from one task to another; it changes the mode in which you work."

Bingo. As a "maker" myself, I can attest to this description being spot on for me personally. If I have to attend a meeting, it's best for it to be right at the beginning or end of those two blocks of time. Tossing one into the middle of the morning or middle of the afternoon is far more disruptive than someone who isn't a maker might understand.

Many people in the comments complained about meetings being a waste of time, but I don't think that's the case all or even most of the time. I see the value in many kinds of meetings and as someone who largely works alone, I actually do sometimes look at the calendar and say "Yay! A meeting!" The issue isn't so much meetings themselves as their timing.

Graham explained that a meeting can sometimes blow half a day for a maker—not that the meeting itself takes half a day—purely due to the interruption of the workflow.

"Each type of schedule works fine by itself," he wrote. "Problems arise when they meet. Since most powerful people operate on the manager's schedule, they're in a position to make everyone resonate at their frequency if they want to. But the smarter ones restrain themselves, if they know that some of the people working for them need long chunks of time to work in."

Graham's post can be read in its entirety here. It's worth perusing whether you're a manager or a maker. The more we understand the different ways different people operate, the more we can learn to respect and honor one another's needs, which ultimately makes us all more successful.


This article originally appeared three years ago.

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Pets

Family brings home the wrong dog from daycare until their cats saved the day

A quick trip to the vet confirmed the cats' and family's suspicions.

Fox 9 Minneapolis-St. Paul|YouTube

Family accidentally brings wrong dog home but their cats knew

It's not a secret that nearly all golden retrievers are identical. Honestly, magic has to be involved for owners to know which one belongs to them when more than one golden retriever is around. Seriously, how do they all seem have the same face? It's like someone fell asleep on the copy machine when they were being created.

Outside of collars, harnesses and bandanas, immediately identifying the dog that belongs to you has to be a secret skill because at first glance, their personalities are also super similar. That's why it's not surprising when one family dropped off their sweet golden pooch at daycare and to be groomed, they didn't notice the daycare sent out the wrong dog.

See, not even their human parents can tell them apart because when the swapped dog got home, nothing seemed odd to the owners at first. She was freshly groomed so any small differences were quickly brushed off. But this accidental doppelgänger wasn't fooling her feline siblings.

Once the dog was in their house, they noticed that their cats started behaving strangely towards their canine sibling. The cats started attacking the dog, likely trying to get it to tell them what they did with their real dog sister. Cat slaps and a house full of strange people didn't dampen the imposter's spirit though, in fact, that's what helped reveal the switcharoo.

This dog kept handing out face kisses and had no interest in seeing her favorite neighbor. After putting all of those things together, the owners decided to hightail it to the vet's office to scan the dog's microchip. Alas, they indeed had the wrong dog.

"We just never even thought that that would happen, and of course we thought we would know right? Like we're her parents, we would know something was wrong, we would know right off the bat that it wasn't Emmy," Kebby Kelley told Fox 9 Minneapolis-St. Paul.

Seems both golden retrievers got to go on a really strange adventure that deserves a lifetime of delicious dog treats for the confusion.

See both sweet pups below:

This article originally appeared two years ago.

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Education & Information

Professor's hilariously exasperated message to students illustrates how teachers are so done

"I will then promptly print 100 copies of the assignment out, put them in a pile, light that pile on fire, and dance around the rubble as it burns. I will then put my hand on the smoldering embers so that I may feel again. Feel what, you might ask? Anything. Literally anything."

Photo by Vanessa Garcia from Pexels

A professor's message to students has gone viral.

If you know any teachers, you probably know how utterly exhausted they all are, from preschools all the way up through college. Pandemic schooling has been rough, to say the least, and teachers have borne the brunt of the impact it's had on students.

Most teachers I've known have bent over backwards to help students succeed during this time, taking kids' mental and emotional health into consideration and extending the flexibility and grace we all could use. But teachers have their own mental and emotional needs, too, and at some point, something's gotta give.

A college student posted screenshots of a professor's message on X (formerly Twitter) with the comment "someone PLEASE check on my professor." It's simply incredible.

The message reads:

"There is no class tomorrow. I've got some things to take care of regarding this and my other class, and my full time job. I have received countless emails about zeroes on assignments either through errors I've made, you've made, or simply people not realizing or knowing they were supposed to turn it in and then realizing in panic they received a zero on it for (surprise), not turning it in. It seems that giving you a free assignment so long as you turn SOMETHING in created far more chaos than good will. Apologies. That's on me. And you. But also me. But also you."

Then it went on…

The professor gave a bulleted list of instructions for what clearly sounds like a very simple, easy assignment designed to give students an opportunity to boost their grades:

  • Submit it. I've extended the deadline until tomorrow before Midnight.
  • If you do NOT turn it in before then. I'm sorry. It's a zero. No excuses at this point and frankly, I regret ever trying to make this assignment easier because it's created more problems at this point.
  • I will look at these, do not do something stupid like type 'b' or 'i did it'. I will become enraged and bitch about you for exactly 15 seconds to anyone within my proximity who will listen. I will not hold back.
  • After I receive these, I will give you full credit (pending the above prerequisites). I will then promptly print 100 copies of the assignment out, put them in a pile, light that pile on fire, and dance around the rubble as it burns. I will then put my hand on the smoldering embers so that I may feel again. Feel what, you might ask? Anything. Literally anything.
  • I will then sleep like a baby, having put this nightmare behind me.

Absolutely classic.

The professor saw the tweet his students shared after it went viral and chimed in with a response.

And he added an update on how things were going on the assignment front.

Other teachers responded to his woes, commiserating over students being handed a chance to improve their scores and simply … not doing it.

It's been a challenge during the pandemic to figure out how much to expect of any of us, hasn't it? Some leeway is definitely warranted, but are we enabling bad habits when we give too much? There are no right answers to that question. We're all winging it, trying to navigate uncharted waters and having to constantly readjust as things change.

It's exhausting. We're all exhausted. But teachers are at a level of "done" that few of us can fathom. Healthcare workers can fathom it. Anyone working with the public during the pandemic might get close. But until you've actually taught, you don't know. Teaching is hard under normal circumstances. Pandemic teaching is a whole other ballgame.

We feel you, teachers. Hang in there, and enjoy this bit that will undoubtedly feel familiar:

This article originally appeared four years ago.

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Pop Culture

George Harrison's elaborate prank on Phil Collins may be the funniest joke in rock history

George Harrison wasn't just a great musician, he was hilarious.

via Philippe Roos / Flickr and Wikimedia Commons

Phil Collins and George Harrison

Beatle George Harrison was pigeon-holed as the "Quiet Beatle," but the youngest member of the Fab Four had an acerbic, dry sense of humor that was as sharp as the rest of his bandmates.

He gave great performances in the musical comedy classics, "A Hard Days Night" and "Help!" while holding his own during The Beatles' notoriously anarchic press conferences. After he left the band in 1970, in addition to his musical career, he would produce the 1979 Monty Python classic, The Life of Brian.

Harrison clearly didn't lose his sense of humor for the rest of his life. Shortly before his death in 2001, he played an elaborate prank on Phil Collins that shows how the "Here Comes the Sun" singer would go the extra mile for a laugh.

gif of George Harrison making facesThe Beatles Love GIF - Find & Share on GIPHYGiphy

In 1970, Harrison was recording his first solo record (and arguably the best by a Beatle), All things Must Pass. The session for the song, "The Art of Dying," featured former Beatle Ringo Starr on drums, keyboard legend Billy Preston on keys, the famed Eric Clapton on guitar, and was produced by the notorious Phil Spector.

Harrison wanted a conga player for the session, so Ringo's chauffeur reached out to Phil Collins' manager. At the time, Collins was a relative unknown who was about to join Genesis, a band that would bring him worldwide stardom.

The 18-year-old Collins was starstruck playing on a session with two former Beatles, so he played extra hard in rehearsals, resulting in blood blisters on both hands.

gif of Phil CollinsPhil Collins 80S GIF - Find & Share on GIPHYGiphy

"Anyway, after about two hours of this, Phil Spector says, 'Okay congas, you play this time.' And I'd had my mic off, so everybody laughed, but my hands were shot," Collins told Express.

"And just after that they all disappeared—someone said they were watching TV or something—and I was told I could go." After that, Collins was relieved of his duties and told to go home. A few months later, Collins bought the massive triple album in the record shop and was devastated to learn he'd been edited out of the song.

"There must be some mistake! Collins thought. "But it's a different version of the song, and I'm not on it."

Some thirty years later, Collins bought the home of Formula One driver Jackie Stewart, a close friend of Harrison. Stewart mentioned to Collins that Harrison was remixing "All Things Must Pass" for a rerelease.

"And he said, 'You were on it, weren't you?' And I said, 'Well I was there,"' Collins recalled.

gif of George Harrison album coverGeorge Harrison Animated Album Cover GIF by uDiscoverMusic - Find & Share on GIPHYGiphy

Two days later, a tape was delivered from Harrison to Collins with a note that read: "Could this be you?" Collins continued: "I rush off and listen to it, and straight away I recognize it." It was a recording of "The Art of Dying."

"Suddenly the congas come in— too loud and just awful," said Collins. Then at the end of the take, Harrison can be heard saying, "Hey, Phil, can we try another without the conga player?" Collins was devastated, to say the least.

A while later, Stewart calls Collins and puts Harrison on the line. "'Did you get the tape?' Harrison asked. "I now realize I was fired by a Beatle," Collins sighed. The two changed the subject, but a few minutes later, Harrison couldn't stop laughing.

"Don't worry, it was a piss-take. I got Ray Cooper to play really badly and we dubbed it on," Harrison admitted. "Thought you'd like it!" So, Harrison had an entire recording session with a conga player who he asked to play poorly, just to pull one over on Collins.

gif of George Harrison smilingThe Beatles Smile GIF - Find & Share on GIPHYGiphy

If you're in the mood for another of rock's greatest pranks. The story of "The Ring" told by Beastie Boys' Adam "Ad-Rock" Horovitz shared in Beastie Boys Story is another great example of someone going to incredible lengths just for a laugh.

The story revolves around the late Beasties' rapper Adam "MCA" Yach, his bandmate Horovitz, and a very creepy ring given to him by a fan backstage at a concert. Check it out below:

Ahh, rock stars.


This article originally appeared four years ago.

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