This doctor saw AIDS firsthand in its darkest hour. Now he's helping make an HIV vaccine.

Dr. Anthony Fauci remembers the first AIDS patient he ever met.

Fauci at a conference in 2015. Photo from Bluerasberry/Wikimedia Commons.

It was 1981. A young man walked into Fauci's office. He was very sick and getting worse. Among his other maladies, an opportunistic infection was attacking his retinas — the man was going blind right in front of Fauci. But there wasn't anything Fauci could do for him.


At the time, doctors didn't even know what AIDS was. It would be a year before the term was even invented.

"It was a very painful and very frustrating because, you know, when you're a physician you're trained as a healer," said Fauci. But he couldn't heal this young man. The patient eventually died of the disease.

"That was the first of several thousand patients I've seen over the last 35 years," Fauci said.

But Fauci didn't give up.

Now, more than 30 years after Fauci met that patient, we may be well on the way to stopping AIDS, thanks to a new vaccine.

Photo from Mujahid Safodien/AFP/Getty Images.

Today, Fauci is the director of the National Institute of Allergy and Infectious Diseases (NIAID). They work to treat and prevent a wide range of diseases, including HIV/AIDS.

Thanks to the work of the NIAID and a whole host of other doctors, scientists, and organizations, our relationship to HIV/AIDS has completely changed since the early '80s. We can track its movements, prevent its spread, and use drugs to de-fang it once it's in the body.

But a vaccine — that holy grail of medicine — has remained elusive. So far, at least.

All that might change, though. A new HIV vaccine trial, known as HVTN 702, has just started, supported in part by Fauci and the NIAID. It's the most hopeful trial yet, based on an attempt from 2009 that lowered HIV infections rates by about 30%.

That first try was exciting, but it wasn't quite good enough to distribute, so Fauci and his team are hoping that this new trial could be the kicker.

For the site of the drug trial, the scientists chose South Africa, a nation that's been hit especially hard by HIV.

A Cape Town pharmacist checks documents on a fridge holding the vaccine. Photo by AP Photo/Schalk van Zuydam.

Fauci and the NIAID aren't the only ones working on this. Dr. Gita Ramjee is the director of South African Medical Research Council’s HIV Prevention Research Unit. She's been working on HIV prevention for years.

Ramjee explained that the location of the trial is significant. Worldwide, HIV/AIDS affects about 37 million people. 7 million of those cases are in South Africa. The country sees about 1,000 new infections every day, and women are especially at risk.

"In Southern Africa, the face of the epidemic is a woman's face," said Ramjee. That's partly due to biological factors, but also social ones. Women don't always have the power to negotiate condom use with their partner, for example, and there may be stigma around getting preventive care.

Ramjee is one of the scientists who has been trying hardest to help these women for years. She joined the vaccine push because she wanted to explore new ways to help people prevent infection and because she's seen the costs of HIV/AIDS far too many times.

"Seeing these women in person, seeing a 16- or 18-year-old already coming to the clinic HIV-positive, it's really, really heartbreaking," said Ramjee.

That's why it's encouraging to see just how big this trial is. South Africa's response recruited over 5,000 volunteers to take part.

One of the trial's 5,400 volunteers at an event in Soshanguve, South Africa. Photo from Mujahid Safodien/AFP/Getty Images.

As part of this latest trial, South Africa enrolled 5,400 sexually active men and women. Half will get the vaccine, half will get a placebo. All will be offered established HIV prevention methods.

The trials will test the efficacy of the vaccine, and they'll also test for any possible side effects. The first patient was enrolled on Oct. 26, 2016. Results are expected in late 2020.

Fauci and Ramjee aren't making any predictions just yet, but both noted how huge an even moderate win could be.

Photo from Mujahid Safodien/AFP/Getty Images.

"Having a vaccine, even if it's 50% efficacious, it's going to add to the toolbox that we have," said Ramjee.

Existing treatment and prevention methods such as condom use or vaginal rings have been able to take the edge off the infection rate, but they haven't been able to completely reverse the disease's trajectory. But immunization is a powerful tool, and added to our repertoire — well, that could be what finally tips the scales. It could be, as both Fauci and Ramjee said, the final nail in HIV's coffin.

Yes, this trial could fail, but even if it doesn't, it's heartening to talk to folks who will keep going until one does. Research is, after all, a learning process.

"Irrespective of what the results are — positive or negative or moderate — we're going to learn a lot," Ramjee said.

That's pretty cool. And on the cusp of this huge trial, it's also worth celebrating just how far we've come since the virus first appeared.

Fauci still sees HIV patients in the very same room where he first met that first patient more than 30 years ago. He said the advancements in HIV/AIDS care he's seen has been nothing short of breathtaking.

HIV/AIDS was once a death sentence. Today, with the right care, people can live long, happy, healthy, essentially normal lives. And we continue to see amazing strides in care, even now.

"It's been a tremendous, extraordinary evolution," he said.

Cats are notoriously weird. Everyone who's had cats knows that they each have their own unique quirks, idiosyncrasies, preferences, habits, and flat-out WTFness.

But even those of us who have experience with bizarre cat behavior are blown away by the antics this "cat dad" is able to get away with.

Kareem and Fifi are the cat parents of Chase, Skye, and Millie—literally the most chill kitties ever. They share their family life on TikTok as @dontstopmeowing, and their videos have been viewed millions of times. When you see them, you'll understand why.

Take Chase's spa days, for example. It may seem unreal at first, but watch what happens when Fifi tries to take away his cucumber slices.

When she puts them back on his eyes? WHAT?! What cat would let you put them on once, much less get mad when you take them off?

This cat. Chase is living his best life.

But apparently, it's not just Chase. Skye and Millie have also joined in "spaw day." How on earth does one couple end up with three hilariously malleable cats?

Oh, and if you think they must have been sedated or something, look at how wide awake they are during bath time. That's right, bath time. Most cats hate water, but apparently, these three couldn't care less. How?

They'll literally do anything. The Don't Stop Meowing channel is filled with videos like this. Cats wearing glasses. Cats wearing hats. Cats driving cars. It's unbelievable yet highly watchable entertainment.

If you're worried that Kareem gets all the love and Fifi constantly gets the shaft, that seems to be a bit for show. Look at Chase and Fifi's conversation about her leaving town for a business trip:

The whole channel is worth checking out. Ever seen a cat being carried in a baby carrier at the grocery store? A cat buckled into a car seat? Three cats sitting through storytime? It's all there. (Just a heads up: A few of the videos have explicit language, so parents might want to do a preview before watching with little ones.) You can follow the couple and their cats on all their social media channels, including Instagram and YouTube if TikTok isn't your thing, here.

If you weren't a cat person before, these videos might change your mind. Fair warning, however: Getting a cat because you want them to do things like this would be a mistake. Cats do what they want to do, and no one can predict what weird traits they will have. Even if you raise them from kittenhood, they're still unpredictable and weird.

And honestly, we wouldn't have them any other way.

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We're redefining what normal means in these uncertain times, and although this is different for all of us, love continues to transform us for the better.

Love is what united Marie-Claire and David Archbold, who met while taking a photography class. "We went into the darkroom to see what developed," they joke—and after a decade of marriage, they know firsthand the deep commitment and connection romantic love requires.

All photos courtesy of Marie-Claire and David Archbold

However, their relationship became even sweeter when they adopted James: a little boy with a huge heart.

In the United States alone, there are roughly 122,000 children awaiting adoption according to the latest report from the U.S Department of Health and Human Services. While the goal is always for a child to be parented by and stay with their biological family, that is not always a possibility. This is where adoption offers hope—not only does it create new families, it gives birth parents an avenue through which to see their child flourish when they are not able to parent. For the right families, it's a beautiful thing.

The Archbolds knew early on that adoption was an option for them. David has three daughters from a previous marriage, but knowing their family was not yet complete, the couple embarked on a two-year journey to find their match. When the adoption agency called and told them about James, they were elated. From the moment they met him, the Archbolds knew he was meant to be part of their family. David locked eyes with the brown-eyed baby and they stared at each other in quiet wonder for such a long time that the whole room fell silent. "He still looks at me like that," said David.

The connection was mutual and instantaneous—love at first sight. The Archbolds knew that James was meant to be a part of their family. However, they faced significant challenges requiring an even deeper level of commitment due to James' medical condition.

James was born with congenital hyperinsulinism, a rare condition that causes his body to overproduce insulin, and within 2 months of his birth, he had to have surgery to remove 90% of his pancreas. There was a steep learning curve for the Archbolds, but they were already in love, and knew they were committed to the ongoing care that'd be required of bringing James into their lives. After lots of research and encouragement from James' medical team, they finally brought their son home.

Today, three-year-old James is thriving, filled with infectious joy that bubbles over and touches every person who comes in contact with him. "Part of love is when people recognize that they need to be with each other," said his adoptive grandfather. And because the Archbolds opted for an open adoption, there are even more people to love and support James as he grows.

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When Donato Di Camillo was a kid, his family couldn't afford film for their Polaroid camera.

So instead, he ran around the house with a film-less camera pretending to be a hotshot photographer on an African safari, mimicking the heroes behind iconic photos he saw in the discarded National Geographic magazines his dad grabbed for him out of the garbage.

Years later, when Di Camillo found himself in prison after collecting a lengthy rap sheet of thefts, he discovered a library full of those same magazines.

While other inmates were working out or getting into trouble, he pored over old issues of National Geographic, Life, and Time.

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There have been many iconic dance routines throughout film history, but how many have the honor being called "the greatest" by Fred Astaire himself?

Fayard and Harold Nicholas, known collectively as the Nicholas Brothers, were arguably the best at what they did during their heyday. Their coordinated tap routines are legendary, not only because they were great dancers, but because of their incredible ability to jump into the air and land in the splits. Repeatedly. From impressive heights.

Their most famous routine comes from the movie "Stormy Weather." As Cab Calloway sings "Jumpin' Jive," the Nicholas Brothers make the entire set their dance floor, hopping and tapping from podium to podium amongst the musicians, dancing up and down stairs and across the top of a piano.

But what makes this scene extra impressive is that they performed it without rehearsing it first and it was filmed in one take—no fancy editing room tricks to bring it all together. This fact was confirmed in a conversation with the brothers in a Chicago Tribune article in 1997, when they were both in their 70s:

"Would you believe that was one of the easiest things we ever did?" Harold told the paper.

"Did you know that we never even rehearsed that number?" added Fayard.

"When it came time to do that part, (choreographer) Nick Castle said: 'Just do it. Don`t rehearse it, just do it.' And so we did it—in one little take. And then he said: 'That's it—we can't do it any better than that.'"

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