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10 reasons to love the new Mrs. Universe, Ashley Burnham

"People think pageant girls are just tall, beautiful, and have nothing to say. I have a lot to say."

10 reasons to love the new Mrs. Universe, Ashley Burnham

Ashley Burnham, a native of the great country of Canada, recently won the Mrs. Universe Pageant.

Mrs. Universe is a beauty pageant for married women. But now it's more than that. It's a beauty pageant for beautiful women who aren't afraid to speak their minds and make me want to do a cartwheel of joy.

Tomorrow night a new @mrsuniverse2015 will be crowned. I worked so hard to get to this day in hopes of becoming the next Mrs Universe. Whatever the outcome may be I know I've done my best and I will continue to do the charitable work I love to do. Stay tuned... πŸ˜Šβ€οΈπŸ‡¨πŸ‡¦πŸ‘‘
A photo posted by Ashley Burnham (Callingbull) (@ash_burnham) on

OK, so she's got the beauty part down. Wait for the rest ...


She is also the first aboriginal winner of Mrs. Universe.

Know this: Beauty queens, for all the stigma around pageants and all that, work hard. It ain't easy. Even after all that, Ashley Burnham β€” also known as Ashley Callingbull β€” is a cut above. Why?

Well, I've got 10 reasons she is SO much more than the average beauty queen.

1. She's a part of the Enoch Cree Nation of Alberta, Canada.


Powwow selfie
A photo posted by Ashley Burnham (Callingbull) (@ash_burnham) on

First Nation realness.

2. She's getting political, and she doesn't care if you don't like it.

As she told CBC news, "There's just so many problems with it for First Nations people. We're always put on the back burner. With the bills that have been passed, we are being treated like terrorists if we're fighting for our land and our water. It's our right to, and now we're being treated like terrorists if we do anything about it. ... It's ridiculous."

On her first day as Mrs. Universe, she basically urged all First Nations people to vote out the current Canadian prime minister.

BOOM!

3. She reps her heritage.


Excited to dance this weekend πŸ™‹πŸΎ A photo posted by Ashley Burnham (Callingbull) (@ash_burnham) on


4. She responded to critics on a Facebook post that got over 12,000 reposts and counting.

After tweeting about political issues affecting the First Nations and encouraging people to vote (shocking, I know), some folks on the Internet were calling her "too political."

Well ... she had something to say to them.

Look out is right!

5. She also said this: "We need to all come together and protest what we deserve as human beings. We can't be silenced by our governments."


Me either, RuPaul. Me either.

Feeling glamorous and ready for @mrsuniverse2015 πŸ‘‘
A photo posted by Ashley Burnham (Callingbull) (@ash_burnham) on

What's she thinking? Something awesome, I bet.

6. She won the pageant. That ain't easy, folks!


Hometown paper πŸ’• A photo posted by Ashley Burnham (Callingbull) (@ash_burnham) on

And she celebrated by sharing a gram from her hometown paper. <3

7. She's a big supporter of No More Stolen Sisters, an organization that is trying to raise awareness about the BIG problem with violence against indigenous women.

She also started Who Is She, a campaign a campaign that fights the disproportional violence against indigenous women.

According to a report that the Royal Canadian Mounted Police shared with The Guardian, indigenous women are 3 to 4 times more likely to be murdered than other women. Additionally, "while aboriginal women represent just 4.3% of Canada's female population, they represent 16% of female homicide victims and 11% of missing persons cases involving women."

This chart from a report done by the Canadian government on the topic of murdered and missing indigenous women backs it up.


And as the new Mrs. Universe, Ashley is *so* not here for that.

I'm going to keep speaking up for our stolen sisters ❀️ #mmiw #whoisshe
A video posted by Ashley Burnham (Callingbull) (@ash_burnham) on


8. As a vocal survivor of childhood abuse, she's serious about breaking the stigma and silence.

And she's vocal about finding healthy ways to heal.

GIFS via " Canada AM."

9. She's sorry she's not sorry. ;)


Sorry NOT sorry πŸ™ŒπŸΎ
A photo posted by Ashley Burnham (Callingbull) (@ash_burnham) on

Ooooooh, snap!

10. Basically she's fierce af.


Official Mrs Universe Canada swimsuit shot. I'm all settled into Minsk, Belarus and my roommate is Mrs Belarus! 5 days till @mrsuniverse2015 finals! β€οΈπŸ‡¨πŸ‡¦β€οΈ
A photo posted by Ashley Burnham (Callingbull) (@ash_burnham) on

And she also does a fab Throwback Thursday #tbt moment.

Me and @xxvii.vii.mmii have been cruising together since we were babies. She's my passenger in life. ❀️
A photo posted by Ashley Burnham (Callingbull) (@ash_burnham) on


Calling all beauty queens: Get on her level.

Yes. She's got a pretty face, and beauty standards can be oppressive, but amen to what she's using it to say.

Her fierce beliefs, strong character and fearlessness in the face of people who would silence her make her a TRUE beauty to me. Reign on, my queen!

"I'm not your typical beauty queen. I have a voice for change and I'm going to use it!" β€” Ashley Burnham, Mrs. Universe 2015
via The Late Show with Stephen Colbert

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Stewart believes the virus probably came from the Wuhan Institute of Virology, instead of the once near universally accepted belief that it emerged from wet markets in the area.

"Science has, in many ways, helped ease the suffering of this pandemic … which was more than likely caused by science," he said to nervous laughter.

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via The Late Show with Stephen Colbert

Former "Daily Show" host Jon Stewart made Stephen Colbert and his audience uncomfortable on the "Late Show" Monday night when he went on a rant about the origins of the COVID-19 pandemic.

Stewart believes the virus probably came from the Wuhan Institute of Virology, instead of the once near universally accepted belief that it emerged from wet markets in the area.

"Science has, in many ways, helped ease the suffering of this pandemic … which was more than likely caused by science," he said to nervous laughter.

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True

Each year, an estimated 1.8 million people in the United States are affected by cancer β€” most commonly cancers of the breast, lung, prostate, and blood cancers such as leukemia. While not everyone overcomes the disease, thanks to science, more people are surviving β€” and for longer β€” than ever before in history.

We asked three people whose lives have been impacted by cancer to share their stories – how their lives were changed by the disease, and how they're using that experience to change the future of cancer treatments with the hope that ultimately, in the fight against cancer, science will win. Here's what they had to say.

Celine Ryan, 55, engineer database programmer and mother of five from Detroit, MI

Photo courtesy of Celine Ryan

In September 2013, Celine Ryan woke up from a colonoscopy to some traumatic news. Her gastroenterologist showed her a picture of the cancerous mass they found during the procedure.

Ryan and her husband, Patrick, had scheduled a colonoscopy after discovering some unusual bleeding, so the suspicion she could have cancer was already there. Neither of them, however, were quite prepared for the results to be positive -- or for the treatment to begin so soon. Just two days after learning the news, Ryan had surgery to remove the tumor, part of her bladder, and 17 cancerous lymph nodes. Chemotherapy and radiation soon followed.

Ryan's treatment was rigorous – but in December 2014, she got the devastating news that the cancer, once confined to her colon, had spread to her lungs. Her prognosis, they said, was likely terminal.

But rather than give up hope, Ryan sought support from online research, fellow cancer patients and survivors, and her medical team. When she brought up immunotherapy to her oncologist, he quickly agreed it was the best course of action. Ryan's cancer, like a majority of colon and pancreatic cancers, had been caused by a defect on the gene KRAS, which can result in a very aggressive cancer that is virtually "undruggable." According to the medical literature, the relatively smooth protein structure of the KRAS gene meant that designing inhibitors to bind to surface grooves and treat the cancer has been historically difficult. Through her support systems, Ryan discovered an experimental immunotherapy trial at the National Institutes of Health (NIH) in Bethesda, MD., and called them immediately to see if she was eligible. After months of trying to determine whether she was a suitable candidate for the experimental treatment, Ryan was finally accepted.

The treatment, known as tumor-infiltrating lymphocyte therapy, or TIL, is a testament to how far modern science has evolved. With this therapy, doctors remove a tumor and harvest special immune cells that are found naturally in the tumor. Doctors then grow the cells in a lab over the next several weeks with a protein that promotes rapid TIL growth – and once the cells number into the billions, they are infused back into the patient's body to fight the cancer. On April 1, 2015, Ryan had her tumor removed at the NIH. Two months later, she went inpatient for four weeks to have the team "wash out" her immune system with chemotherapy and infuse the cells – all 148 billion of them – back into her body.

Six weeks after the infusion, Ryan and Patrick went back for a follow-up appointment – and the news they got was stunning: Not only had no new tumors developed, but the six existing tumors in her lungs had shrunk significantly. Less than a year after her cell infusion, in April 2016, the doctors told Ryan news that would have been impossible just a decade earlier: Thanks to the cell infusion, Ryan was now considered NED – no evaluable disease. Her body was cancer-free.

Ryan is still NED today and continuing annual follow-up appointments at the NIH, experiencing things she never dreamed she'd be able to live to see, such as her children's high school and college graduations. She's also donating her blood and cells to the NIH to help them research other potential cancer treatments. "It was an honor to do so," Ryan said of her experience. "I'm just thrilled, and I hope my experience can help a lot more people."

Patrice Lee, PhD, VP of Pharmacology, Toxicology and Exploratory Development at Pfizer

Photo courtesy of Patrice Lee

Patrice Lee got into scientific research in an unconventional way – through the late ocean explorer Jacques Cousteau.

Lee never met Cousteau but her dreams of working with him one day led her to pursue a career in science. Initially, Lee completed an undergraduate degree in marine biology; eventually, her interests changed and she decided to get a dual doctoral degree in physiology and toxicology at Duke University. She now works at Pfizer's R&D site in Boulder, CO (formerly Array BioPharma), leading a group of scientists who determine the safety and efficacy of new oncology drugs.

"Scientists focused on drug discovery and development in the pharmaceutical industry are deeply committed to inventing new therapies to meet unmet needs," Lee says, describing her field of work. "We're driven to achieve new medicines and vaccines as quickly as possible without sacrificing safety."

Among the drugs Lee has helped develop during her career, including cancer therapies, she says around a dozen are currently in development, while nine have received FDA approval β€” an incredible accomplishment as many scientists spend their careers without seeing their drug make it to market. Lee's team is particularly interested in therapies for brain metastases β€” something that Lee says is a largely unmet need in cancer research, and something her team is working on from a variety of angles. "Now that we've had rapid success with mRNA vaccine technology, we hope to explore what the future holds when applying this technology to cancers," Lee says.

But while evaluating potential cancer therapies is a professional passion of Lee's, it's also a mission that's deeply personal. "I'm also a breast cancer survivor," she says. "So I've been on the other side of things and have participated in a clinical trial."

However, seeing how melanoma therapies that she helped develop have affected other real-life cancer patients, she says, has been a highlight of her career. "We had one therapy that was approved for patients with BRAF-mutant metastatic melanoma," Lee recalls. "Our team in Boulder was graced by a visit from a patient that had benefited from these drugs that we developed. It was a very special moment for the entire team."

None of these therapies would be available, Lee says without rigorous science behind it: "Facts come from good science. Facts will drive the development of new drugs, and that's what will help patients."

Chiuying "Cynthia" Kuk (they/them) MS, 34, third-year medical student at Michigan State University College of Human Medicine

Photo courtesy of Cynthia Kuk

Cynthia Kuk was just 10 years old when they had a conversation that would change their life forever.

"My mother, who worked as a translator for the government at the time, had been diagnosed with breast cancer, and after her chemotherapy treatments she would get really sick," Kuk, who uses they/them pronouns, recalls. "When I asked my dad why mom was puking so much, he said it was because of the medicine she was taking that would help her get better."

Kuk's response was immediate: "That's so stupid! Why would a medicine make you feel worse instead of better? When I'm older, I want to create medicine that won't make people sick like that."

Nine years later, Kuk traveled from their native Hong Kong to the United States to do exactly that. Kuk enrolled in a small, liberal arts college for their Bachelor's degree, and then four years later started a PhD program in cancer research. Although Kuk's mother was in remission from her cancer at the time, Kuk's goal was the same as it had been as a 10-year-old watching her suffer through chemotherapy: to design a better cancer treatment, and change the landscape of cancer research forever.

Since then, Kuk's mission has changed slightly.

"My mom's cancer relapsed in 2008, and she ended up passing away about five years after that," Kuk says. "After my mom died, I started having this sense of urgency. Cancer research is such that you work for twenty years, and at the end of it you might have a fancy medication that could help people, but I wanted to help people now." With their mother still at the forefront of their mind, Kuk decided to quit their PhD program and enter medical school.

Now, Kuk plans to pursue a career in emergency medicine – not only because they are drawn to the excitement of the emergency room, but because the ER is a place where the most marginalized people tend to seek care.

"I have a special interest in the LGBTQ+ population, as I identify as queer and nonbinary," says Kuk. "A lot of people in this community and other marginalized communities access care through the ER and also tend to avoid medical care since there is a history of mistreatment and judgement from healthcare workers. How you carry yourself as a doctor, your compassion, that can make a huge difference in someone's care."

In addition to making a difference in the lives of LGBTQ+ patients, Kuk wants to make a difference in the lives of patients with cancer as well, like their mother had.

"We've diagnosed patients in the Emergency Department with cancer before," Kuk says. "I can't make cancer good news but how you deliver bad news and the compassion you show could make a world of difference to that patient and their family."

During their training, Kuk advocates for patients by delivering compassionate and inclusive care, whether they happen to have cancer or not. In addition to emphasizing their patient's pronouns and chosen names, they ask for inclusive social and sexual histories as well as using gender neutral language. In doing this, they hope to make medicine as a whole more accessible for people who have been historically pushed aside.

"I'm just one person, and I can't force everyone to respect you, if you're marginalized," Kuk says. "But I do want to push for a culture where people appreciate others who are different from them."