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If you feel "old" practically overnight, there may be a good reason for that.

Aging is weird. You're trucking along, enjoying your middle-aged life, finally feeling like a real adult, when you look in the mirror one day and gasp.

"Where did those wrinkles come from?"

"Is that skin on my arm…crepey?!?"

"Why am I aching like that?"

Somewhere in your mid-40s, you start noticing obvious signs of aging that seem to arrive overnight. You assume it was a gradual process that you just hadn't noticed, but it sure as heck felt like it happened really fast.


New research indicates that may very well be the case. A study from researchers at Stanford tracked thousands of different molecules in people age 25 to 75 and found that people tend to make two big leaps in aging—one around age 44 and another around age 60. These findings indicate that aging can actually happen in bursts.

“We’re not just changing gradually over time. There are some really dramatic changes,” said senior study author Michael Snyder, Ph.D, geneticist and director of the Center for Genomics and Personalized Medicine at Stanford University. “It turns out the mid-40s is a time of dramatic change, as is the early 60s. And that’s true no matter what class of molecules you look at.”

The researchers assumed the mid-40s changes would be attributed to menopausal or perimenopausal changes in women influencing the overall numbers, but when they separated the results by sex they saw similar changes in men in their 40s.

"“This suggests that while menopause or perimenopause may contribute to the changes observed in women in their mid-40s, there are likely other, more significant factors influencing these changes in both men and women. Identifying and studying these factors should be a priority for future research,” said study author Xiaotao Shen, PhD, a former Stanford Medicine postdoctoral scholar who now teaches at Nanyang Technological University Singapore.

older couple smiling togetherAging happens in bursts, scientists find.Photo by Tristan Le/Pexels

The study included 108 participants who submitted blood and other samples every few months for several years. The scientists tracked age-related changes in 135,000 different molecules—nearly 250 billion distinct data points—to see how aging occurs.

The study may shed light on the reasons for jumps in certain diseases and maladies at certain ages. For the 40-somethings, scientists found significant changes in molecules related to alcohol, caffeine and lipid metabolism; cardiovascular disease; and skin and muscle. For those in their 60s, changes related to carbohydrate and caffeine metabolism, immune regulation, kidney function, cardiovascular disease, and skin and muscle were found.

The study authors did note that lifestyle might play a role in some of these changes. For instance, alcohol metabolism may be influenced by people drinking more heavily in their 40s, which tends to be a period of higher stress for many people. However, the researchers added that these bursts of aging in the mid-40s and early 60s indicate that people may want to pay closer attention to their health around those ages and make lifestyle changes that support greater overall health, such as increasing exercise or limiting alcohol.

The research team plans to study the drivers of these aging bursts to find out why they happen at these ages, but whatever the reasons, it's nice to know that the seemingly sudden onset of age-related woes isn't just in our imaginations.

It's understandable that worry about aging, as physical signs of aging remind us of our own mortality. We also have all kinds of social messaging that tells us youth is ideal and beautiful and old is bad and ugly, so of course we give aging the side-eye. But none of us can avoid aging altogether, so the more positive and healthy we are in our approach to aging is, the better off we'll be, no matter when and to what degree aging hits us.

Photo by Syed Ali on Unsplash

Mosquitoes are attracted to certain viral smells in both humans and mice.

As much as I love summer, there is one thing I could do without: bugs. More specifically, mosquitoes. Those pesky little buggers can wreak havoc on a beautiful summer day. Who hasn't spent time outside in summer and then come in all itchy and covered in bites? There are multiple reasons why some people are more susceptible to mosquito bites than others, but there's a new one that likely isn't on people's radars. Mosquitoes could be attracted to the odor certain viruses create in the body.

There is evidence that mosquitoes are attracted to the odor given off by mice infected by the parasite that causes malaria. Now, a team is looking at how the scent of mosquito-borne viruses such as dengue and Zika would attract mosquitoes to people rather than mice.


For those who may be unfamiliar with the two viruses, the most important thing to know about them both is how dangerous they are to humans. Some effects of dengue include vomiting, aches and pains, and in severe cases, internal bleeding, according to the CDC. Zika virus is best known for being dangerous for pregnant women, as it can cause certain kinds of birth defects in fetuses, per the CDC.

Because both viruses rely on mosquitoes for transmission, it begs the question: Do people infected with either viruses give off extra tasty odors? That's what the team was looking to discover.

"I mean, the infection just increase[s] the chance to be located by a mosquito," Penghua Wang, an immunologist with University of Connecticut Health, told NPR.

Wang and the rest of his team set out to find out if it's true that infected people become mosquito chow, and undertook a study, which was recently published in the journal Cell. In the study, they blew two different types of air: one infected with either of the two viruses and one without, over two different groups of mice. As to be expected, the mosquitoes buzzed around those infected mice like they were a buffet dinner.

"These two viruses can alter a person's body odor to be more attractive to mosquitoes," Wang said. What happens is that the smell alters the skin's microbiome to make it more appetizing to the blood-sucking little critters. Wang explained to NPR that he was "excited" by this new development as it could lead to a lot of understanding of virus transmission by mosquitoes.

While this is an incredibly positive prospect, it's important to keep in mind that experimenting on mice isn't really the same as experimenting on people. And just because this is going well with mice doesn't mean it will go well with people. But, during the study, the team discovered that people infected with dengue had similar attention from the mosquitoes.

The other promising thing? Since they've discovered the attraction, they were also able to find a possible treatment plan. They discovered that when they gave the sick mice a vitamin A supplement, the mosquitoes lost interest. Knowing this information can help researchers explore how Zika and dengue spread. According to Wang, in some of the areas where dengue and Zika are most common, many people are vitamin A deficient.

Whatever they discover, I'm very curious to see if this information will offer insight on not only how diseases get spread, but also what makes people (like me) more susceptible to getting bitten in the first place.




Health

Optimistic women are more likely to live past 90, study finds

They also found living longer transcends race and ethnicity.

Photo by Robin Noguier on Unsplash

Who knew optimism was the key to a longer life?

There's something to be said for having a positive outlook on life. Optimism may not only make you happier, it can also help you live longer. Yes, you're reading that correctly: Being optimistic can actually add years to your life. A study done by researchers from the Harvard T.H. Chan School of Public Health and published in the Journal of the American Geriatrics Society found a correlation between lifespan and optimism in women. The authors discovered that optimistic women had a longer lifespan, many living past the age of 90.

In a previous version of this study, data showed the correlation between living past the age of 85 and higher levels of optimism. But that study looked at a mostly white people. This later study expanded the pool of participants to include more people from diverse backgrounds.



In this version of the study, the research team looked at data from 159, 255 participants from the Women’s Health Initiative. The group included women between the ages of 50 and 79 (specifically postmenopausal women). The women had to fall into that age bracket between 1993 and 1998, then they were followed for 26 years.

“Although optimism itself may be affected by social structural factors, such as race and ethnicity, our research suggests that the benefits of optimism may hold across diverse groups,” Hayami Koga, a Ph.D. student in the Graduate School of Arts and Sciences Population Health Sciences program in partnership with Harvard Chan School, and lead author of the study said in a press release.

According to the press release, the study "found no interaction between optimism and any categories of race and ethnicity, and these trends held true after taking into account demographics, chronic conditions, and depression."

“A lot of previous work has focused on deficits or risk factors that increase the risks for diseases and premature death. Our findings suggest that there’s value to focusing on positive psychological factors, like optimism, as possible new ways of promoting longevity and healthy aging across diverse groups," Koga said.

Think about it. There's a lot to be said about positive thinking—it's not always easy to do, and yes, toxic positivity is a very real thing. But reframing your way of thinking to allow for more positivity clearly isn't a bad thing. Will it allow you to transcend things like structural racism, discrimination and other legitimate life barriers? Absolutely not. It will, however, give you a stronger foundation to pull from when those things start to make you weary.

I don't know if there's a way to teach people to be optimistic without it feeling hokey. However, if you tell someone, "Hey, this could put years on your life clock," they might be more interested. Koga believes that the findings of this study can allow people to look at how they approach their health.

As the study reveals, a lot of the factors that contribute to longevity that we traditionally think of, such as diet, exercise and other lifestyle changes, don't seem to hold as much weight compared to an optimistic outlook. According to the study's findings, lifestyle choices "accounted for less than a quarter of the optimism-lifespan association," and more than half of the women in the group (53%) achieved "exceptional longevity." It defines exceptional longevity as living 90 years or longer. When compared to the least optimistic participants, the optimistic women had a 5.4% longer lifespan. According to the CDC, as of 2020, the average life expectancy for women is 80.5 years. So those who have a more optimistic outlook might live 10 years longer than the current average lifespan. That definitely gives you something to think about!

“We tend to focus on the negative risk factors that affect our health,” Koga said. “It is also important to think about the positive resources such as optimism that may be beneficial to our health, especially if we see that these benefits are seen across racial and ethnic groups.”

A 2009 study found that dogs have the intelligence of a two-and-a-half-year-old child. They can also understand up to 250 words and gestures. And they've had a long time to get it right. We started domesticating dogs 10,000 to 15,000 years ago, and that domestication runs deep. It turns out, even dogs who have never heard a human yell "roll over" might still understand basic commands. A new study found that stray dogs can understand human gestures, such as pointing, which suggests that dogs innately understand people.

Dr. Anindita Bhadra of the Indian Institute of Science Education and Research Kolkata and her colleagues studied 160 stray dogs across several cities in India. Two covered bowls were placed in front of each dog. One bowl contained raw chicken, and the other bowl was both empty and food-scented.


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Another experimenter then pointed at one of the bowls for varying amounts of time. The humans stood away from the bowls in order to allow the dog to "judge what the humans intention is and then make a decision," Bhadra told National Geographic.

Half of the dogs refused to come close to the researchers, and many seemed anxious. According to Bhadra, it's likely these dogs had prior bad experiences with people.

Of the dogs that did participate in the study, 80% of dogs went to the bowl that was being pointed at regardless of the length of time the pointing occurred. They hadn't ben trained to understand pointing, they just went. Researchers believe this indicates that dogs can understand complex human gestures. You have to give it to the dogs. Some animals would just sit there and smell the pointing finger.

"We thought it was quite amazing that the dogs could follow a gesture as abstract as momentary pointing. This means that they closely observe the human, whom they are meeting for the first time, and they use their understanding of humans to make a decision. This shows their intelligence and adaptability," Badhra told National Geographic.

RELATED: Dog owners are more likely to kiss their dogs than their significant others

However, the dogs weren't above developing trust issues. If the dog discovered that the human was pointing to the empty bowl, the dog was less likely to follow the human's cues again.

Badhra says the study can help children and adults have "a more peaceful co-existence" with stray dogs by helping humans learn how to interact with the animals. There are approximately 300 million stray dogs in the world, many of which carry diseases such as rabies. Knowing how to deal with a stray dog can help prevent such attacks from occurring.

Now if only researchers could figure out if dogs innately know how to eat pasta from the same bowl as another dog, Lady and the Tramp-style…