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Researchers hacked 5 people's brains so they could see a new and impossible color

The new color 'olo' is neat, but the technique behind it could be groundbreaking.

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Only five people in the world have seen the mysterious color "Olo"

Color is one of the great joys of being alive. The brilliant blue sky, the green grass, the exotic pinks and purples and teals in coral or tropical fish. Soaking it all in is truly a feast for the eyes, and some studies even show that certain colors can trigger specific emotions in people. Orange may evoke feelings of joy, and red may conjure feelings of love, while blue may have a calming effect.

One of the most interesting things about colors, though, is that they are finite. Though the world is full of undiscovered plants, creatures, and even elements, the entire color spectrum is known and documented. Due to the nature of light in our universe and how it reflects off of physical objects, all perceived color must be created by some combination of the primary colors (blue, green, and red — yes, green, not yellow!). There are essentially unlimited combinations, but they all exist on a known spectrum — different hues and shades of pink or emerald or orange.

However, a team of researchers recently decided to push the limits of human perception. They "hacked" participants' retinas to allow them to see an impossible color.


color, green, blue, color wheel, physics, light, wavelengths, scienceThe paint companies are dying to know the secret formula for the new color.Giphy

Scientists from the University of California, Berkeley, developed a new technique called "Oz," which would allow them to activate specific cones in the retina. Cones are light-sensitive cells that respond to different wavelengths of light. When the three types of cones are activated in different ways, our brains perceive colors.

One fascinating bit of background is that the "M" cone, which typically responds strongest to green (Medium wavelength), can not naturally be activated without also activating the Long and Short cones. So even the purest green on the planet would also, to a smaller degree, stimulate the parts of our eyes that are mostly correlated with red and blue.

retinas, eyes, oz, retina scan, retina cones, vision, colorsA close-up of the human eye. Swapnil Potdar/Unsplash

The team wanted to find out what would happen if they could isolate and activate only the M, or green, cone using the new technique.

The result? The five participants reported seeing an absolutely unreal, brilliant shade of green like nothing they had ever experienced. Imagine a bright green laser cranked up to the highest saturation and brilliance possible, the purest and brightest green your brain could possibly comprehend. Participants noted that a bright green laser pointed looked "pale" in comparison to the new color.

The name of the new, impossible color? Olo, or 010 (indicated zero stimulation of the L and S cones and full stimulation of the M cones).

- YouTubewww.youtube.com

It's fair to wonder, if olo is impossible and can never naturally exist without manual stimulation of the retinal cones, what's the point of the experiment?

The introduction of a "new color" is certainly interesting and makes for a good headline, but the real value of this study lies in the future applications of the Oz technique.

The research team hopes that the detailed retinal maps they have developed, along with their ability to stimulate specific rods and cones in the eye in any combination, will enable major breakthroughs in the study and treatment of various visual impairments.

For example, Oz could one day cure color blindness or unlock new treatments for cataracts or glaucoma. It could even play a role down the line in curing certain types of blindness. Isn't it wild how our understanding of how our eyes perceive color tells us so much?

But those days are a long way off, for now. In the meantime, only five people in the world have experienced the brilliance of olo, and the rest of us will just have to imagine it.

Family

How your phone's camera could help detect a rare cancer in kids.

What wasn't available for his son may now save other kids.

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In 2008, 1-year-old Noah Shaw was diagnosed with a rare form of eye cancer called retinoblastoma.

By the time he received the diagnosis, the cancer had progressed and the treatment plan was extremely intense.

Months of chemo and radiation followed, and Noah had to undergo surgery to remove his right eye to keep the cancer from spreading to his brain.


All images from Bryan Shaw, used with permission.

That's a lot to go through in your first year of life.

As worried parents often do, Bryan and Elizabeth Shaw wondered if there were any missing warning signs that would have helped get Noah's diagnosis sooner.

They remembered the photographs that first raised concerns. Instead of the usual red dot of a pupil, they had noticed one of Noah's eyes appeared different from the other.

Being a scientist himself, Bryan wanted to see if he could track down when that difference first appeared. Bryan and Elizabeth turned to Noah's baby pictures to see how early this symptom showed up in photos before he was diagnosed.

Lo and behold, a clear warning sign is exactly what they found.

It's all about a white reflection that appears in the eye in photos with a camera flash.

Blood vessels in the back of the eye will normally reflect red, but if there is a tumor or other issue present, the eye may appear differently.

For Noah, that white glow first began appearing in photos when he was just 12 days old.

The presence of a white glow in a child's eye can help determine whether a baby has leukocoria, an early indicator of an eye problem ranging from a refractive error, where a baby needs glasses, to a rare form of cancer, like in Noah's case.

Noah, now a lively 7-year-old, is doing great. But Bryan never stopped thinking about how he could help other kids detect their eye problems earlier on.

"If I would have had some software in it telling me, 'Hey, go get this checked out,' that would have sped up my son's diagnosis and the tumors would have been just a little bit smaller when we got to them. There might have been fewer," Bryan told NPR.

A chemist at the University of Baylor, Bryan decided to shake up his career path by exploring life as a software designer too.

Bryan launched a free app called CRADLE that screens kids for leukocoria through their photos.

Created with the help of Baylor colleagues and graduate students, the app is available on both iPhone and Android for free under the name CRADLE, which stands for ComputeR Assisted Detector of LEukocoria. Clever.

The app can search your device for all photos that might contain white eye, given that leukocoria can show up inconsistently. It can also be used in real-time, snapping a photo through the app itself.

Even better? The app is working.

If the app finds a photo that could be a leukocoria, it recommends a visit straight to the pediatrician.

"Multiple families have used it to catch cancer in their children at such early stages — way before doctors — that the children received only laser treatment, no chemo, no radiation, no eye removal," Bryan said in an email to Upworthy.

And while retinoblastoma itself is very rare — fewer than 12 out of 1 million children aged 0-4 will develop it — the app goes beyond to help with other eye problems.

Shaw says "white eye" in kids is a symptom of a lot more than cancer. The app has caught Coats' disease, myelinated retinal nerve fiber layer, and a bunch of refractive errors (i.e., kids needing glasses).

Posting and sharing photos is more than just a great way to connect and document life: It can now share valuable information about the health of a child's eyes.

Bryan knows early diagnosis is key and parents see their kids a lot more than doctors do. While it's no substitute for being seen by an actual doctor, there is no question that this app can make a difference.

"From here, the software is going to get better," he told People. "It's going to get more accurate as we collect more and more pictures to train it and make it smarter."

Keep the pictures comin'.