A mother-and-daughter team have developed what may be the world's first Alzheimer’s vaccine.

Brain Inflammation from Alzheimer's Disease

Alzheimer's is a terrible disease that robs a person of their personality and memory before eventually leading to death. It's the sixth-largest killer in the U.S. and, currently, there are 5.8 million Americans living with the disease.

It devastates people and families and it's estimated that Alzheimer's and other forms of dementia will cost the U.S. $290 billion dollars this year alone. It's estimated that it will become a trillion-dollar-a-year disease by 2050.


There have been over 200 unsuccessful attempts to find a cure for the disease and the clinical trial termination rate is 98%.
Alzheimer's is caused by plaque deposits that develop in brain tissue that become toxic to brain cells. One of the major hurdles to finding a cure for the disease is that it's impossible to clear out the deposits from the tissue. So scientists have turned their attention to early detection and prevention.

One very encouraging development has come out of the work done by Dr. Chang Yi Wang, PhD. Wang is a prolific bio-inventor, one of her biggest successes is developing a foot-and-mouth vaccine for pigs that has been administered more than three billion times.

Mei Mei Huvia Brainstorm Health / Flickr

In January, United Neuroscience, a biotech company founded by Yi, her daughter Mei Mei Hu, and son-in-law, Louis Reese, announced the first results from a IIa clinical trial on UB-311 an Alzheimer's vaccine.

The vaccine has synthetic versions of amino acid chains that trigger antibodies to attack Alzheimer's protein the blood. Wang's vaccine is a significant improvement over previous attempts because it can attack the Alzheimer's protein without creating any adverse side effects.

"We were able to generate some antibodies in all patients, which is unusual for vaccines,"Yi told Wired. "We're talking about almost a 100 percent response rate. So far, we have seen an improvement in three out of three measurements of cognitive performance for patients with mild Alzheimer's disease."

The researchers also claim it can delay the onset of the disease by five years. While this would be a godsend for people with the disease and their families, according to Elle, it could also save Medicare and Medicaid more than $220 billion.

"You'd want to see larger numbers, but this looks like a beneficial treatment," James Brown, director of the Aston University Research Centre for Healthy Ageing, told Wired. "This looks like a silver bullet that can arrest or improve symptoms and, if it passes the next phase, it could be the best chance we've got."

"A word of caution is that it's a small study," says Drew Holzapfel, acting president of the nonprofit UsAgainstAlzheimer's, said according to Elle. "But the initial data is compelling."

The company is now working on its next clinical trial of the vaccine and while hopes are high, so is the pressure. The company has already invested $100 million developing its vaccine platform. According to Reese, the company's ultimate goal is to create a host of vaccines that will be administered to protect people from chronic illness.

"We have a 50-year vision – to immuno-sculpt people against chronic illness and chronic ageing with vaccines as prolific as vaccines for infectious diseases," he told Elle.

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On an old episode of "The Oprah Winfrey Show" in July 1992, Oprah put her audience through a social experiment that puts racism in a new light. Despite being nearly two decades old, it's as relevant today as ever.

She split the audience members into two groups based on their eye color. Those with brown eyes were given preferential treatment by getting to cut the line and given refreshments while they waited to be seated. Those with blue eyes were made to put on a green collar and wait in a crowd for two hours.

Staff were instructed to be extra polite to brown-eyed people and to discriminate against blue-eyed people. Her guest for that day's show was diversity expert Jane Elliott, who helped set up the experiment and played along, explaining that brown-eyed people were smarter than blue-eyed people.

Watch the video to see how this experiment plays out.

Oprah's Social Experiment on Her Audience www.youtube.com

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Cadbury has removed the words from its Dairy Milk chocolate bars in the U.K. to draw attention to a serious issue, senior loneliness.

On September 4, Cadbury released the limited-edition candy bars in supermarkets and for every one sold, the candy giant will donate 30p (37 cents) to Age UK, an organization dedicated to improving the quality of life for the elderly.

Cadbury was prompted to help the organization after it was revealed that 225,000 elderly people in the UK often go an entire week without speaking to another person.

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Well Being

Young people today are facing what seems to be greater exposure to complex issues like mental health, bullying, and youth violence. As a result, teachers are required to be well-versed in far more than school curriculum to ensure students are prepared to face the world inside and outside of the classroom. Acting as more than teachers, but also mentors, counselors, and cheerleaders, they must be equipped with practical and relevant resources to help their students navigate some of the more complicated social issues – though access to such tools isn't always guaranteed.

Take Dr. Jackie Sanderlin, for example, who's worked in the education system for over 25 years, and as a teacher for seven. Entering the profession, she didn't anticipate how much influence a student's home life could affect her classroom, including "students who lived in foster homes" and "lacked parental support."

Dr. Jackie Sanderlin, who's worked in the education system for over 25 years.

Valerie Anglemyer, a middle school teacher with more than 13 years of experience, says it can be difficult to create engaging course work that's applicable to the challenges students face. "I think that sometimes, teachers don't know where to begin. Teachers are always looking for ways to make learning in their classrooms more relevant."

So what resources do teachers turn to in an increasingly fractured world? "Joining a professional learning network that supports and challenges thinking is one of the most impactful things that a teacher can do to support their own learning," Anglemyer says.

Valerie Anglemyer, a middle school teacher with more than 13 years of experience.

A new program for teachers that offers this network along with other resources is the WE Teachers Program, an initiative developed by Walgreens in partnership with ME to WE and Mental Health America. WE Teachers provides tools and resources, at no cost to teachers, looking for guidance around the social issues related to poverty, youth violence, mental health, bullying, and diversity and inclusion. Through online modules and trainings as well as a digital community, these resources help them address the critical issues their students face.

Jessica Mauritzen, a high school Spanish teacher, credits a network of support for providing her with new opportunities to enrich the learning experience for her students. "This past year was a year of awakening for me and through support… I realized that I was able to teach in a way that built up our community, our school, and our students, and supported them to become young leaders," she says.

With the new WE Teachers program, teachers can learn to identify the tough issues affecting their students, secure the tools needed to address them in a supportive manner, and help students become more socially-conscious, compassionate, and engaged citizens.

It's a potentially life-saving experience for students, and in turn, "a great gift for teachers," says Dr. Sanderlin.

"I wish I had the WE Teachers program when I was a teacher because it provides the online training and resources teachers need to begin to grapple with these critical social issues that plague our students every day," she adds.

In addition to the WE Teachers curriculum, the program features a WE Teachers Award to honor educators who go above and beyond in their classrooms. At least 500 teachers will be recognized and each will receive a $500 Walgreens gift card, which is the average amount teachers spend out-of-pocket on supplies annually. Teachers can be nominated or apply themselves. To learn more about the awards and how to nominate an amazing teacher, or sign up for access to the teacher resources available through WE Teachers, visit walgreens.com/metowe.

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One of the major differences between women and men is that women are often judged based on their looks rather than their character or abilities.

"Men as well as women tend to establish the worth of individual women primarily by the way their body looks, research shows. We do not do this when we evaluate men," Naomi Ellemers Ph.D. wrote in Psychology Today.

Dr. Ellers believes that this tendency to judge a woman solely on her looks causes them to be seen as an object rather than a person.

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Culture