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A mother-and-daughter team have developed what may be the world's first Alzheimer’s vaccine.

A mother-and-daughter team have developed what may be the world's first Alzheimer’s vaccine.

Brain Inflammation from Alzheimer's Disease

Alzheimer's is a terrible disease that robs a person of their personality and memory before eventually leading to death. It's the sixth-largest killer in the U.S. and, currently, there are 5.8 million Americans living with the disease.

It devastates people and families and it's estimated that Alzheimer's and other forms of dementia will cost the U.S. $290 billion dollars this year alone. It's estimated that it will become a trillion-dollar-a-year disease by 2050.


There have been over 200 unsuccessful attempts to find a cure for the disease and the clinical trial termination rate is 98%.
Alzheimer's is caused by plaque deposits that develop in brain tissue that become toxic to brain cells. One of the major hurdles to finding a cure for the disease is that it's impossible to clear out the deposits from the tissue. So scientists have turned their attention to early detection and prevention.

One very encouraging development has come out of the work done by Dr. Chang Yi Wang, PhD. Wang is a prolific bio-inventor, one of her biggest successes is developing a foot-and-mouth vaccine for pigs that has been administered more than three billion times.

Mei Mei Huvia Brainstorm Health / Flickr

In January, United Neuroscience, a biotech company founded by Yi, her daughter Mei Mei Hu, and son-in-law, Louis Reese, announced the first results from a IIa clinical trial on UB-311 an Alzheimer's vaccine.

The vaccine has synthetic versions of amino acid chains that trigger antibodies to attack Alzheimer's protein the blood. Wang's vaccine is a significant improvement over previous attempts because it can attack the Alzheimer's protein without creating any adverse side effects.

"We were able to generate some antibodies in all patients, which is unusual for vaccines,"Yi told Wired. "We're talking about almost a 100 percent response rate. So far, we have seen an improvement in three out of three measurements of cognitive performance for patients with mild Alzheimer's disease."

The researchers also claim it can delay the onset of the disease by five years. While this would be a godsend for people with the disease and their families, according to Elle, it could also save Medicare and Medicaid more than $220 billion.

"You'd want to see larger numbers, but this looks like a beneficial treatment," James Brown, director of the Aston University Research Centre for Healthy Ageing, told Wired. "This looks like a silver bullet that can arrest or improve symptoms and, if it passes the next phase, it could be the best chance we've got."

"A word of caution is that it's a small study," says Drew Holzapfel, acting president of the nonprofit UsAgainstAlzheimer's, said according to Elle. "But the initial data is compelling."

The company is now working on its next clinical trial of the vaccine and while hopes are high, so is the pressure. The company has already invested $100 million developing its vaccine platform. According to Reese, the company's ultimate goal is to create a host of vaccines that will be administered to protect people from chronic illness.

"We have a 50-year vision – to immuno-sculpt people against chronic illness and chronic ageing with vaccines as prolific as vaccines for infectious diseases," he told Elle.

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Making new friends as an adult is challenging. While people crave meaningful IRL connections, it can be hard to know where to find them. But thanks to one Facebook Group, meeting your new best friends is easier than ever.

Founded in 2018, NYC Brunch Squad brings together hundreds of people who come as strangers and leave as friends through its in-person events.

“Witnessing the transformative impact our community has on the lives of our members is truly remarkable. We provide the essential support and connections needed to thrive amid the city's chaos,” shares Liza Rubin, the group’s founder.

Despite its name, the group doesn’t just do brunch. They also have book clubs, seasonal parties, and picnics, among other activities.

NYC Brunch Squad curates up to 10 monthly events tailored to the specific interests of its members. Liza handles all the details, taking into account different budgets and event sizes – all people have to do is show up.

“We have members who met at our events and became friends and went on to embark on international journeys to celebrate birthdays together. We have had members get married with bridesmaids by their sides who were women they first connected with at our events. We’ve had members decide to live together and become roommates,” Liza says.

Members also bond over their passion for giving back to their community. The group has hosted many impact-driven events, including a “Picnic with Purpose” to create self-care packages for homeless shelters and recently participated in the #SquadSpreadsJoy challenge. Each day, the 100 members participating receive random acts of kindness to complete. They can also share their stories on the group page to earn extra points. The member with the most points at the end wins a free seat at the group's Friendsgiving event.

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via UNSW

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@ustheremingtons/TikTok

There's a lot to be gleaned from this.

Participating in paternity leave offers fathers so much more than an opportunity to bond with their new kids. It also allows them to help around the house and take on domestic responsibilities that many new mothers have to face alone…while also tending to a newborn.

All in all, it enables couples to handle the daunting new chapter as a team, making it less stressful on both parties. Or at least equally stressful on both parties. Democracy!

TikTok creator and dad Caleb Remington, from the popular account @ustheremingtons, confesses that for baby number one, he wasn’t able to take a “single day of paternity leave.”

This time around, for baby number two, Remington had the privilege of taking seven weeks off (to be clear—his employer offered four weeks, and he used an additional three weeks of PTO).

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Images via Alan Taylor/Flickr, used with permission.

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Library of Congress

When we think about the era of American slavery, many of us tend to think of it as the far distant past. While slavery doesn't exist as a formal institution today, there are people living who knew formerly enslaved black Americans first-hand. In the wide arc of history, the legal enslavement of people on U.S. soil is a recent occurrence—so recent, in fact, that we have voice recordings of interviews with people who lived it.

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