In September 2016, the United Nations made a special declaration pledging to fight the rise of antibiotic-resistant bacteria, colloquially known as superbugs.

A lineup of baddies: E. coli in the center, flanked by its goons A. baumannii. Images from James Archer/CDC and David Dorward/NIAID.

About 2 million people catch one of these superbugs each year, and now there are even strains immune to nearly everything we can throw at them. A woman in Nevada recently died of a strain that resisted 26 different antibiotics.


“We’ve lost the ability to use many of our mainstream antibiotics,” said Oregon State University professor Bruce Geller. “Everything’s resistant to them now. That’s left us to try to develop new drugs to stay one step ahead of the bacteria."

But now Geller and a group of scientists have found an interesting twist. Instead of finding a new antibiotic, they found a way to make known medicines work again, thanks to a type of compound called PPMO.

If the fight against antibiotic resistance is a gritty war story, this new approach is like a spy novel.

Fighting against drug-resistant bacteria is an arms race. We make new weapons. They develop new shields against those weapons.

One defense that certain bacteria have is an enzyme known as NDM-1. It's good against a class of antibiotic known as carbapenems. Previously, what we could do to fight NDM-1 is either abandon carbapenems or try to add extra drugs to slow down NDM-1. But Geller's PPMO does something different.

Instead of going after NDM-1 itself, it attacks the messenger RNA that transmits NDM-1's blueprints. It kidnaps the messenger. No messenger means no NDM-1; no NDM-1 means our good-guy antibiotics are back in the fight.

Geller says it'll probably be about three years before human testing of PPMO.

Professor Geller. Image from Oregon State University.

So far, scientists have tested their work both on a petri dish and by giving sick mice the PPMO/antibiotic combo. It worked. They then even tried three different kinds of NDM-1 bacteria; it worked on all of them.

“It’s the same gene in different types of bacteria, so you only have to have one PPMO that’s effective for all of them," said Geller.

That said, creating new drugs is expensive and complicated. It's possible that this won't work for humans. The PPMO should be safe, since humans and other animals don't have NDM-1, but other things like side effects could come up. But even if it doesn't work, this approach opens up whole new avenues for research.

Through innovations like this, we can help push antibiotic resistance back and win the fight.

Leah Menzies/TikTok

Leah Menzies had no idea her deceased mother was her boyfriend's kindergarten teacher.

When you start dating the love of your life, you want to share it with the people closest to you. Sadly, 18-year-old Leah Menzies couldn't do that. Her mother died when she was 7, so she would never have the chance to meet the young woman's boyfriend, Thomas McLeodd. But by a twist of fate, it turns out Thomas had already met Leah's mom when he was just 3 years old. Leah's mom was Thomas' kindergarten teacher.

The couple, who have been dating for seven months, made this realization during a visit to McCleodd's house. When Menzies went to meet his family for the first time, his mom (in true mom fashion) insisted on showing her a picture of him making a goofy face. When they brought out the picture, McLeodd recognized the face of his teacher as that of his girlfriend's mother.

Menzies posted about the realization moment on TikTok. "Me thinking my mum (who died when I was 7) will never meet my future boyfriend," she wrote on the video. The video shows her and McLeodd together, then flashes to the kindergarten class picture.

“He opens this album and then suddenly, he’s like, ‘Oh my God. Oh my God — over and over again,” Menzies told TODAY. “I couldn’t figure out why he was being so dramatic.”

Obviously, Menzies is taking great comfort in knowing that even though her mother is no longer here, they can still maintain a connection. I know how important it was for me to have my mom accept my partner, and there would definitely be something missing if she wasn't here to share in my joy. It's also really incredible to know that Menzies' mother had a hand in making McLeodd the person he is today, even if it was only a small part.

@speccylee

Found out through this photo in his photo album. A moment straight out of a movie 🥲

♬ iris - 🫶

“It’s incredible that that she knew him," Menzies said. "What gets me is that she was standing with my future boyfriend and she had no idea.”

Since he was only 3, McLeodd has no actual memory of Menzies' mother. But his own mother remembers her as “kind and really gentle.”

The TikTok has understandably gone viral and the comments are so sweet and positive.

"No the chills I got omggg."

"This is the cutest thing I have watched."

"It’s as if she remembered some significance about him and sent him to you. Love fate 😍✨"

In the caption of the video, she said that discovering the connection between her boyfriend and her mom was "straight out of a movie." And if you're into romantic comedies, you're definitely nodding along right now.

Menzies and McLeodd made a follow-up TikTok to address everyone's positive response to their initial video and it's just as sweet. The young couple sits together and addresses some of the questions they noticed pop up. People were confused that they kept saying McLeodd was in kindergarten but only 3 years old when he was in Menzies' mother's class. The couple is Australian and Menzies explained that it's the equivalent of American preschool.

They also clarified that although they went to high school together and kind of knew of the other's existence, they didn't really get to know each other until they started dating seven months ago. So no, they truly had no idea that her mother was his teacher. Menzies revealed that she "didn't actually know that my mum taught at kindergarten."

"I just knew she was a teacher," she explained.

She made him act out his reaction to seeing the photo, saying he was "speechless," and when she looked at the photo she started crying. McLeodd recognized her mother because of the pictures Menzies keeps in her room. Cue the "awws," because this is so cute, I'm kvelling.

A simple solution for all ages, really.

School should feel like a safe space. But after the tragic news of yet another mass shooting, many children are scared to death. As a parent or a teacher, it can be an arduous task helping young minds to unpack such unthinkable monstrosities. Especially when, in all honesty, the adults are also terrified.

Katelyn Campbell, a clinical psychologist in South Carolina, worked with elementary school children in the aftermath of the Sandy Hook shooting. She recently shared a simple idea that helped then, in hopes that it might help now.

The psychologist tweeted, “We had our kids draw pictures of scenery that made them feel calm—we then hung them up around the school—to make the ‘other kids who were scared’ have something calm to look at.”



“Kids, like adults, want to feel helpful when they feel helpless,” she continued, saying that drawing gave them something useful to do.

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It can be hard to find hope in hard times, but we have examples of humanity all around us.

I almost didn't create this post this week.

As the U.S. reels from yet another horrendous school massacre, barely on the heels of the Buffalo grocery store shooting and the Laguna Woods church shooting reminding us that gun violence follows us everywhere in this country, I find myself in a familiar state of anger and grief and frustration. One time would be too much. Every time, it's too much. And yet it keeps happening over and over and over again.

I've written article after article about gun violence. I've engaged in every debate under the sun. I've joined advocacy groups, written to lawmakers, donated to organizations trying to stop the carnage, and here we are again. Round and round we go.

It's hard not to lose hope. It would be easy to let the fuming rage consume every bit of joy and calm and light that we so desperately want and need. But we have to find a balance.

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