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In September 2016, the United Nations made a special declaration pledging to fight the rise of antibiotic-resistant bacteria, colloquially known as superbugs.

A lineup of baddies: E. coli in the center, flanked by its goons A. baumannii. Images from James Archer/CDC and David Dorward/NIAID.

About 2 million people catch one of these superbugs each year, and now there are even strains immune to nearly everything we can throw at them. A woman in Nevada recently died of a strain that resisted 26 different antibiotics.


“We’ve lost the ability to use many of our mainstream antibiotics,” said Oregon State University professor Bruce Geller. “Everything’s resistant to them now. That’s left us to try to develop new drugs to stay one step ahead of the bacteria."

But now Geller and a group of scientists have found an interesting twist. Instead of finding a new antibiotic, they found a way to make known medicines work again, thanks to a type of compound called PPMO.

If the fight against antibiotic resistance is a gritty war story, this new approach is like a spy novel.

Fighting against drug-resistant bacteria is an arms race. We make new weapons. They develop new shields against those weapons.

One defense that certain bacteria have is an enzyme known as NDM-1. It's good against a class of antibiotic known as carbapenems. Previously, what we could do to fight NDM-1 is either abandon carbapenems or try to add extra drugs to slow down NDM-1. But Geller's PPMO does something different.

Instead of going after NDM-1 itself, it attacks the messenger RNA that transmits NDM-1's blueprints. It kidnaps the messenger. No messenger means no NDM-1; no NDM-1 means our good-guy antibiotics are back in the fight.

Geller says it'll probably be about three years before human testing of PPMO.

Professor Geller. Image from Oregon State University.

So far, scientists have tested their work both on a petri dish and by giving sick mice the PPMO/antibiotic combo. It worked. They then even tried three different kinds of NDM-1 bacteria; it worked on all of them.

“It’s the same gene in different types of bacteria, so you only have to have one PPMO that’s effective for all of them," said Geller.

That said, creating new drugs is expensive and complicated. It's possible that this won't work for humans. The PPMO should be safe, since humans and other animals don't have NDM-1, but other things like side effects could come up. But even if it doesn't work, this approach opens up whole new avenues for research.

Through innovations like this, we can help push antibiotic resistance back and win the fight.

Photo courtesy of Girls at Work

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Girls are bombarded with messages from a very young age telling them that they can’t, that is too big, this is too heavy, those are too much.

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via Pixabay

The show must go on… and more power to her.

There are few things that feel more awful than being stranded at the altar by your spouse-to-be. That’s why people are cheering on Kayley Stead, 27, from the U.K. for turning a day of extreme disappointment into a party for her friends, family and most importantly, herself.

According to a report in The Metro, on Thursday, September 15, Stead woke up in an Airbnb with her bridemaids, having no idea that her fiance, Kallum Norton, 24, had run off early that morning. The word got to Stead’s bridesmaids at around 7 a.m. the day of the wedding.

“[A groomsman] called one of the maids of honor to explain that the groom had ‘gone.’ We were told he had left the caravan they were staying at in Oxwich Bay (the venue) at 12:30 a.m. to visit his family, who were staying in another caravan nearby and hadn’t returned. When they woke in the morning, he was not there and his car had gone,” Jordie Cullen wrote on a GoFundMe page.

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All images provided by Bombas

We can all be part of the giving movement

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We all know that small acts of kindness can turn into something big, but does that apply to something as small as a pair of socks?

Yes, it turns out. More than you might think.

A fresh pair of socks is a simple comfort easily taken for granted for most, but for individuals experiencing homelessness—they are a rare commodity. Currently, more than 500,000 people in the U.S. are experiencing homelessness on any given night. Being unstably housed—whether that’s couch surfing, living on the streets, or somewhere in between—often means rarely taking your shoes off, walking for most if not all of the day, and having little access to laundry facilities. And since shelters are not able to provide pre-worn socks due to hygienic reasons, that very basic need is still not met, even if some help is provided. That’s why socks are the #1 most requested clothing item in shelters.

homelessness, bombasSocks are a simple comfort not everyone has access to

When the founders of Bombas, Dave Heath and Randy Goldberg, discovered this problem, they decided to be part of the solution. Using a One Purchased = One Donated business model, Bombas helps provide not only durable, high-quality socks, but also t-shirts and underwear (the top three most requested clothing items in shelters) to those in need nationwide. These meticulously designed donation products include added features intended to offer comfort, quality, and dignity to those experiencing homelessness.

Over the years, Bombas' mission has grown into an enormous movement, with more than 75 million items donated to date and a focus on providing support and visibility to the organizations and people that empower these donations. These are the incredible individuals who are doing the hard work to support those experiencing —or at risk of—homelessness in their communities every day.

Folks like Shirley Raines, creator of Beauty 2 The Streetz. Every Saturday, Raines and her team help those experiencing homelessness on Skid Row in Los Angeles “feel human” with free makeovers, haircuts, food, gift bags and (thanks to Bombas) fresh socks. 500 pairs, every week.

beauty 2 the streetz, skid row laRaines is out there helping people feel their beautiful best

Or Director of Step Forward David Pinson in Cincinnati, Ohio, who offers Bombas donations to those trying to recover from addiction. Launched in 2009, the Step Forward program encourages participation in community walking/running events in order to build confidence and discipline—two major keys to successful rehabilitation. For each marathon, runners are outfitted with special shirts, shoes—and yes, socks—to help make their goals more achievable.

step forward, helping homelessness, homeless non profitsRunning helps instill a sense of confidence and discipline—two key components of successful recovery

Help even reaches the Front Street Clinic of Juneau, Alaska, where Casey Ploof, APRN, and David Norris, RN give out free healthcare to those experiencing homelessness. Because it rains nearly 200 days a year there, it can be very common for people to get trench foot—a very serious condition that, when left untreated, can require amputation. Casey and Dave can help treat trench foot, but without fresh, clean socks, the condition returns. Luckily, their supply is abundant thanks to Bombas. As Casey shared, “people will walk across town and then walk from the valley just to come here to get more socks.”

step forward clinic, step forward alaska, homelessness alaskaWelcome to wild, beautiful and wet Alaska!

The Bombas Impact Report provides details on Bombas’s mission and is full of similar inspiring stories that show how the biggest acts of kindness can come from even the smallest packages. Since its inception in 2013, the company has built a network of over 3,500 Giving Partners in all 50 states, including shelters, nonprofits and community organizations dedicated to supporting our neighbors who are experiencing- or at risk- of homelessness.

Their success has proven that, yes, a simple pair of socks can be a helping hand, an important conversation starter and a link to humanity.

You can also be a part of the solution. Learn more and find the complete Bombas Impact Report by clicking here.

via UNSW

This article originally appeared on 07.10.21


Dr. Daniel Mansfield and his team at the University of New South Wales in Australia have just made an incredible discovery. While studying a 3,700-year-old tablet from the ancient civilization of Babylon, they found evidence that the Babylonians were doing something astounding: trigonometry!

Most historians have credited the Greeks with creating the study of triangles' sides and angles, but this tablet presents indisputable evidence that the Babylonians were using the technique 1,500 years before the Greeks ever were.


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via Lewis Speaks Sr. / Facebook

This article originally appeared on 02.25.21


Middle school has to be the most insecure time in a person's life. Kids in their early teens are incredibly cruel and will make fun of each other for not having the right shoes, listening to the right music, or having the right hairstyle.

As if the social pressure wasn't enough, a child that age has to deal with the intensely awkward psychological and biological changes of puberty at the same time.

Jason Smith, the principal of Stonybrook Intermediate and Middle School in Warren Township, Indiana, had a young student sent to his office recently, and his ability to understand his feelings made all the difference.

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