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Heroes

Antibiotics just got a sneaky new ally in the fight against superbugs.

In September 2016, the United Nations made a special declaration pledging to fight the rise of antibiotic-resistant bacteria, colloquially known as superbugs.

A lineup of baddies: E. coli in the center, flanked by its goons A. baumannii. Images from James Archer/CDC and David Dorward/NIAID.

About 2 million people catch one of these superbugs each year, and now there are even strains immune to nearly everything we can throw at them. A woman in Nevada recently died of a strain that resisted 26 different antibiotics.


“We’ve lost the ability to use many of our mainstream antibiotics,” said Oregon State University professor Bruce Geller. “Everything’s resistant to them now. That’s left us to try to develop new drugs to stay one step ahead of the bacteria."

But now Geller and a group of scientists have found an interesting twist. Instead of finding a new antibiotic, they found a way to make known medicines work again, thanks to a type of compound called PPMO.

If the fight against antibiotic resistance is a gritty war story, this new approach is like a spy novel.

Fighting against drug-resistant bacteria is an arms race. We make new weapons. They develop new shields against those weapons.

One defense that certain bacteria have is an enzyme known as NDM-1. It's good against a class of antibiotic known as carbapenems. Previously, what we could do to fight NDM-1 is either abandon carbapenems or try to add extra drugs to slow down NDM-1. But Geller's PPMO does something different.

Instead of going after NDM-1 itself, it attacks the messenger RNA that transmits NDM-1's blueprints. It kidnaps the messenger. No messenger means no NDM-1; no NDM-1 means our good-guy antibiotics are back in the fight.

Geller says it'll probably be about three years before human testing of PPMO.

Professor Geller. Image from Oregon State University.

So far, scientists have tested their work both on a petri dish and by giving sick mice the PPMO/antibiotic combo. It worked. They then even tried three different kinds of NDM-1 bacteria; it worked on all of them.

“It’s the same gene in different types of bacteria, so you only have to have one PPMO that’s effective for all of them," said Geller.

That said, creating new drugs is expensive and complicated. It's possible that this won't work for humans. The PPMO should be safe, since humans and other animals don't have NDM-1, but other things like side effects could come up. But even if it doesn't work, this approach opens up whole new avenues for research.

Through innovations like this, we can help push antibiotic resistance back and win the fight.

Family

Professional tidier Marie Kondo says she's 'kind of given up' after having three kids

Hearing Kondo say, 'My home is messy,' is sparking joy for moms everywhere.

Marie Kondo playing with her daughters.

Marie Kondo's book, "The Life-Changing Art of Tidying Up," has repeatedly made huge waves around the world since it came out in 2010. From eliminating anything that didn't "spark joy" from your house to folding clothes into tiny rectangles and storing them vertically, the KonMari method of maintaining an organized home hit the mark for millions of people. The success of her book even led to two Netflix series.

It also sparked backlash from parents who insisted that keeping a tidy home with children was not so simple. It's one thing to get rid of an old sweater that no longer brings you joy. It's entirely another to toss an old, empty cereal box that sparks zero joy for you, but that your 2-year-old is inexplicably attached to.

To be fair, Kondo never forced her way into anyone's home and made them organize it her way. But also to be fair, she didn't have kids when she wrote her best-selling book on keeping a tidy home. The reality is that keeping a home organized and tidy with children living in it is a whole other ballgame, as Kondo has discovered now that she has three kids of her own.

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Pop Culture

13-year-old ventriloquist sings incredible, sassy version of 'You Don't Own Me' on 'AGT'

Ana-Maria Mărgean only started her hobby in 2020 and is already wowing audiences on "America's Got Talent."

America's Got Talent/Youtube

Ana-Maria Mărgean singing "You Don't Own Me" on "America's Got Talent"

It’s not every day a ventriloquist act is so jaw-dropping that it has to be seen to be believed. But when it does happen, it’s usually on “America’s Got Talent.”

Ana-Maria Mărgean was only 11 years old when she first took to the stage on “Romania’s Got Talent” to show off her ventriloquism skills, an act inspired by videos of fellow ventriloquist and “America’s Got Talent” Season 2 champion Terry Fator.

Using puppets built for her by her parents, the young performer tirelessly spent her quarantine time in 2020 learning how to bring them to life, which led to her receiving a Golden Buzzer and eventually winning the entire series in Romania.

Mărgean is now 13 and a competitor on this season of “America’s Got Talent: All-Stars,” hoping to be crowned the winner and perform her own show in Vegas, just like her hero Fator.

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All illustrations are provided by Soosh and used with permission.

I have plenty of space.

This article originally appeared on 04.09.16


It's hard to truly describe the amazing bond between dads and their daughters.

Being a dad is an amazing job no matter the gender of the tiny humans we're raising. But there's something unique about the bond between fathers and daughters.

Most dads know what it's like to struggle with braiding hair, but we also know that bonding time provides immense value to our daughters. In fact, studies have shown that women with actively involved fathers are more confident and more successful in school and business.

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Photo by Tyler Nix on Unsplash

A person of color uses a crosswalk.

This article originally appeared on 11.01.17


You missed a study that illuminates the very real dangers of literally "walking while black."

In addition to rogue police officers targeting people of color on the street, a study from Portland State University found that drivers are less likely to stop for black pedestrians.

The study, a follow-up from one conducted in 2014, administered tests using identically dressed black and white volunteers attempting to cross the same intersection. The 2014 study revealed black male pedestrians waited 32% longer than white male pedestrians for cars to stop. The 2017 research expanded on these tests to include black and white women and marked versus unmarked crosswalks.

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Pop Culture

6 lessons in making life choices based on the wisdom of Warren Buffett

These are the six factors Warren Buffett says he considers when he's making big business decisions.

Warren Buffett speaking at the 2015 Select USA Investment Summit.

True
TD Ameritrade

This article originally appeared on

Warren Buffett isn't just rich. He's known for being ethical, straightforward, and wise. And also generous. Not just with his money but with his ideas.

Buffett straight up spelled out how he makes decisions on how to invest in and acquire businesses in a public letter sent to his shareholders. To be clear: His instincts and insights are what have made him such a rich man. And that's what he's sharing so openly with the world.

These are the six factors Warren Buffett says he considers when he's making big business decisions.

Maybe they could help the rest of us think through some tough decisions in our own lives? Let's see.

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Nature

Pennsylvania home is the entrance to a cave that’s been closed for 70 years

You can only access the cave from the basement of the home and it’s open for business.

This Pennsylvania home is the entrance to a cave.

Have you ever seen something in a movie or online and thought, "That's totally fake," only to find out it's absolutely a real thing? That's sort of how this house in Pennsylvania comes across. It just seems too fantastical to be real, and yet somehow it actually exists.

The home sits between Greencastle and Mercersburg, Pennsylvania, and houses a pretty unique public secret. There's a cave in the basement. Not a man cave or a basement that makes you feel like you're in a cave, but an actual cave that you can't get to unless you go through the house.

Turns out the cave was discovered in the 1830s on the land of John Coffey, according to Uncovering PA, but the story of how it was found is unclear. People would climb down into the cave to explore occasionally until the land was leased about 100 years later and a small structure was built over the cave opening.

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