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The truth behind why Daraprim can cost whatever its CEO wants it to

Five reasons drug companies are getting away with charging a fortune for needed medications.

A greedy, cocksure CEO set off a nation of people tired of mysterious and unchecked drug pricing.

Have you ever suspected that drug manufacturers have been given complete license to charge whatever they want?

You wouldn't be wrong.

Since he got us talking about this, we have to thank Turing Pharmaceuticals CEO Martin Shkreli. He raised the price of the drug Daraprim from $13.50 to $750 per pill.

The justification for the cruel hike?

"It's a more appropriate price."

GIF from CNBC.

What does that even mean? How does a drug manufacturer decide what is an appropriate price?

Well, there are a lot of missed could-be checkpoints in the American health care system that give manufacturers utterly unfettered license to charge whatever they decide.

A quote from The Economist puts into sharp perspective just how ambiguous the process is: "One economist at a closed-door session of pricing experts at [the American Society of Clinical Oncology] dryly remarked that she could find no economic theory to explain how companies price their drugs."

As Jessica Wapner, a researcher and writer on biomedical issues, puts it in her blog: "Drugs cost what the market will bear. It's that simple. Drug prices are set at whatever the market will bear."

Here's why.

Price Gouge License #1: Pharmaceutical companies can advertise directly to Americans, unlike in many other countries.

Image by Pfizer.

In the 1980s, pharmaceutical companies were growing tired of doctors being the gatekeepers between patients and newly available drugs. The first commercial marketed to the general public was in 1986 for Seldane. The profits for Seldane soared beyond anything the marketing team had imagined, and other companies soon followed suit. And in 1997, the FDA further loosened its rules on television ads for prescription medicines, which truly opened the floodgates.

FUN FACT: The only two developed nations that allow this kind of "direct-to-consumer" drug advertising are the United States and New Zealand. It is specifically banned in other countries.

Price Gouge License #2: The pharmaceutical industry has a distinct lack of competition, and in fact is monopolistic by design.

Innovation needs to be rewarded, goes the reasoning. And that point is easy to see. Without some incentive, there are a lot of lifesaving and quality-of-life-changing drugs that would never have been invented.

The good old days. Image via March of Dimes.

But it also stands to reason that innovation can be rewarded at scale and for a finite time, not at ever-increasing margins forever and ever. That's just not sustainable, and it practically begs for some intervening agency to act. As drug companies look for more ways to expand their profits each year — 73% of Americans polled in 2015 already think drug prices are too high — something has to give. Profits can be had, and even attractive ones at that, without carte blanche for the kinds of excesses we're seeing:

"Gleevec, from Novartis, possibly the greatest cancer drug ever invented, cost $24,000 a year when it was introduced in 2001; now it costs $90,000 per year, a quadrupling in price." — "60 Minutes" via Forbes, 2014

FUN FACT: According to a Kaiser Foundation report in 2005, 10 pharmaceutical companies accounted for 60% of U.S. pharmaceutical sales in 2004. It's as if a cluster of multinational corporations have an unwritten understanding that they can just stay in their lanes and get while the getting's good.

Price Gouge License #3: The complicated insurance setup in America gives manufacturers an advantage versus a single-payer situation where prices can be negotiated.

Image via iStock.

Other countries with socialized, single-payer health care systems are able to negotiate prices with drugmakers. Since all the power is collectively concentrated in the one single-paying entity, it forces the drug companies to play nice — or at least act in good faith.

FUN FACT: In 2003, a new act meant to "modernize" Medicare and bring prescription coverage into the mix prohibited Medicare (the largest customer in the American drug industry) from being able to negotiate prices with drug companies.

Price Gouge License #4: There are complex, private pricing strategy sessions that don't get revealed to the public.

We all know what happens when the process of how the sausage gets made never sees the light of day. It can result in some pretty rotten stuff being channeled to consumers.

But Jessica Wapner sheds a little light on what factors come into play in these sessions:

  • How many patients are buying the drug
  • How many are likely to be insured privately or through the government, or are uninsured
  • Length of an average treatment course on the drug
  • How high the stakes are for what the drug treats (desperately needed or only mildly beneficial)
  • How many years the drug will have exclusivity in the market (meaning no generics)
  • Budgeting for patient assistance programs ("If you can't afford your medication, drug company X may be able to help")

That's right. Those drug assistance programs aren't a kindly, out-of-their-own pockets, benevolent gesture. The companies get their money for them — they just tack it on top of what they're already charging.

FUN FACT: There are special forecasting companies that help drug manufacturers evaluate the field and arrive at complex equations regarding prescription prices.

Price Gouge License #5: Many consumers are shielded from the reality of drug prices because of insurance.

That means they keep buying the drug even if their copays go up (making concessions in other parts of their budget as long as they can), which reinforces to the manufacturer that their pricing practices are working. People will just pay it. They will find a way. And though some can't or don't find a way — and sometimes wind up giving up lifesaving drugs out of financial defeat — the sheer numbers don't usually rise to the proportions needed to signal to drug companies that they've made a pricing error.

Because they're still making a profit.

The highest performers in the health technology category in 2015 were Pfizer, Merck, and Johnson & Johnson.

Image via Forbes with permission.

Is there any good news out of all of this?

Yes! Increased attention on drug prices during the last year is culminating in a lot of "we're not gonna take it" talk from politicians and the media. President Obama is attempting to get Medicare negotiation rights for the most expensive drugs.

And I'll say it again: We should thank Martin Shkreli for his severe overreach in pricing Daraprim because it refocused the nation on a huge problem we've all lived with for far too long. I doubt he's very popular with his industry brethren right now — they avoided pitchforks for a long time before he came along. And in response to the public's backlash and, I'm personally betting, pressure from within an industry anxious to avoid intervention, Shkreli did finally say he will reduce the cost.

The pharmaceutical industry is banking on being too difficult to figure out for the average Joe to fight back against. That's why it's important to share this and get people thinking.

The price of drugs, if left unchecked, will eventually debilitate us.

It doesn't have to be this way.

Pop Culture

Parents who grew up in the '70s and '80s remember the experiences that blow their kids' minds

Kids were tougher then for a reason.

via Wikimedia Commons

Island School Class, circa 1970s.

Parents, do you think your child would be able to survive if they were transported back to the '70s or '80s? Could they live at a time before the digital revolution put a huge chunk of our lives online?

These days, everyone has a phone in their pocket, but before then, if you were in public and needed to call someone, you used a pay phone. Can you remember the last time you stuck 50 cents into one and grabbed the grubby handset?

According to the U.S. Federal Communications Commission, roughly 100,000 pay phones remain in the U.S., down from 2 million in 1999.

Do you think a 10-year-old kid would have any idea how to use a payphone in 2022? Would they be able to use a Thomas Guide map to find out how to get somewhere? If they stepped into a time warp and wound up in 1975, could they throw a Led Zeppelin album on the record player at a party?

Another big difference between now and life in the '70s and '80s has been public attitudes toward smoking cigarettes. In 1965, 42.4% of Americans smoked and now, it’s just 12.5%. This sea change in public opinion about smoking means there are fewer places where smoking is deemed acceptable.

But in the early '80s, you could smoke on a bus, on a plane, in a movie theater, in restaurants, in the classroom and even in hospitals. How would a child of today react if their third grade teacher lit up a heater in the middle of math class?

Dan Wuori, senior director of early learning at the Hunt Institute, tweeted that his high school had a smoking area “for the kids.” He then asked his followers to share “something you experienced as a kid that would blow your children’s minds.”


A lot of folks responded with stories of how ubiquitous smoking was when they were in school. While others explained that life was perilous for a kid, whether it was the school playground equipment or questionable car seats.

Here are a few responses that’ll show today’s kids just how crazy life used to be in the '70s and '80s.

First of all, let’s talk about smoking.

Want to call someone? Need to get picked up from baseball practice? You can’t text mom or dad, you’ll have to grab a quarter and use a pay phone.

People had little regard for their kids’ safety or health.

You could buy a soda in school.

Things were a lot different before the internet.

Remember pen pals?

A lot of people bemoan the fact that the children of today aren’t as tough as they were a few decades back. But that’s probably because the parents of today are better attuned to their kids’ needs so they don't have to cheat death to make it through the day.

But just imagine how easy parenting would be if all you had to do was throw your kids a bag of Doritos and a Coke for lunch and you never worried about strapping them into a car seat?


This article originally appeared on 06.08.22

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Pop Culture

Michael B. Jordan runs into his middle-school bully on the red carpet and calls her out

He didn't forget.

via Gage Skidmore/Wikimedia Commons

Michael B. Jordan speaking at the 2017 San Diego Comic Con International, for "Black Panther", at the San Diego Convention Center in San Diego, California.

As long as humans have endeavored to do anything great, there have been those who have tried to take them down. These are the opposite of the creators in life: the bullies, haters and naysayers who only want to bring people down to their level.

But when you have a dream and desire, its easy to tune out the voices of negativity. "It is not the critic who counts; not the man who points out how the strong man stumbles, or where the doer of deeds could have done them better,” Theodore Roosevelt once said. “The credit belongs to the man who is actually in the arena."

Some folks use the naysayers as fuel to push them to work even harder. Basketball legend Michael Jordan was infamous for letting his thirst for revenge drive him to even greater heights on the court.

Another Michael Jordan, "Black Panther" star, Michael B. Jordan, came face to face with someone who doubted that he could reach his dreams, and he wasn’t shy about letting her know that he remembered. What's Upworthy about the encounter is that he did so with class and confidence.

In 2023, Jordan was on the red carpet for the premiere of "Creed III," a film he starred in and directed. He was interviewed by “The Morning Hustle” radio show host Lore’l, who had recently admitted on the “Undressing Room” podcast that she used to make fun of him in school.

“You know what’s so crazy? I went to school with Michael B. Jordan at a point in life,” Lore’l said. “And to be honest with you, we teased him all the damn time because his name was Michael Jordan. Let’s start there, and he was no Michael Jordan.”

“He also would come to school with a headshot,” she added. “We lived in Newark. That’s the hood. We would make fun of him like, ‘What you gonna do with your stupid headshot?’ And now look at him!”

In addition, her co-host, Eva Marcille, referred to Jordan as “corny.”

Jordan had no problem discussing their past on the red carpet. “We go way back, all the way back to Chad Science [Academy] in Newark,” Lore’l told the actor. Oh yeah, I was the corny kid, right?” Jordan responded with a smirk.

“No, you did not hear me say that! I said we used to make fun of the name,” Lore’l said.

“I heard it,” Jordan said. “I heard it. It’s all good. What’s up?” he responded. “But yeah, [you are] obviously killing things out here…you’re not corny anymore,” Lore’l clarified.

After the exchange went viral, Lore’l admitted that she teased Jordan in school, but they were only classmates for one year.

“So the narrative that I bullied him all throughout high school—this was 7th grade. We were like 12 years old, and everyone made fun of each other,” Lore’l said. “That was school, you know. That was one year. And, again, I’ve never bullied him. That just sounds so outrageous to me.”

Jordan later shared some advice on how to deal with bullies.

"Just stay focused, just stay locked in,” he told a reporter from Complex. “You know, just follow your heart, try to block out the noise and distractions as much as possible and run your race. Don't compare yourself to anybody else. Just keep going."

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Joy

Sorry, Labradors. After 31 years, America has a new favorite dog.

The American Kennel Club has crowned a new favorite.

via Pixabay

A sad-looking Labrador Retriever

The sweet-faced, loveable Labrador Retriever is no longer America’s favorite dog breed. The breed best known for having a heart of gold has been replaced by the smaller, more urban-friendly French Bulldog.

According to the American Kennel Club, for the past 31 years, the Labrador Retriever was America’s favorite dog, but it was eclipsed in 2022 by the Frenchie. The rankings are based on nearly 716,500 dogs newly registered in 2022, of which about 1 in 7 were Frenchies. Around 108,000 French Bulldogs were recorded in the U.S. in 2022, surpassing Labrador Retrievers by over 21,000.

The French Bulldog’s popularity has grown exponentially over the past decade. They were the #14 most popular breed in 2012, and since then, registrations have gone up 1,000%, bringing them to the top of the breed popularity rankings.

The AKC says that the American Hairless Terrier, Gordon Setter, Italian Greyhound and Anatolian Shepherd Dog also grew in popularity between 2021 and 2022.

The French Bulldog was famous among America’s upper class around the turn of the 20th century but then fell out of favor. Their resurgence is partly based on several celebrities who have gone public with their Frenchie love. Leonardo DiCaprio, Megan Thee Stallion, Alexandra Ocasio-Cortez, Reese Witherspoon and Lady Gaga all own French Bulldogs.

The breed earned a lot of attention as show dogs last year when a Frenchie named Winston took second place at the Westminster Kennel Club Dog Show and first in the National Dog Show.

The breed made national news in early 2021 when Gaga’s dog walker was shot in the chest while walking two of her Frenchies in a dog heist. He recovered from his injuries, and the dogs were later returned.

They’ve also become popular because of their unique look and personalities.

“They’re comical, friendly, loving little dogs,” French Bull Dog Club of America spokesperson Patty Sosa told the AP. She said they are city-friendly with modest grooming needs and “they offer a lot in a small package.”

They are also popular with people who live in apartments. According to the AKC, Frenchies don’t bark much and do not require a lot of outdoor exercise.

The French Bulldog stands out among other breeds because it looks like a miniature bulldog but has large, expressive bat-like ears that are its trademark feature. However, their popularity isn’t without controversy. “French bulldogs can be a polarizing topic,” veterinarian Dr. Carrie Stefaniak told the AP.

american kennel club, french bulldog, most popular dog

An adorable French Bulldog

via Pixabay

French Bulldogs have been bred to have abnormally large heads, which means that large litters usually need to be delivered by C-section, an expensive procedure that can be dangerous for the mother. They are also prone to multiple health problems, including skin, ear, and eye infections. Their flat face means they often suffer from respiratory problems and heat intolerance.

Frenchies are also more prone to spine deformations and nerve pain as they age.

Here are the AKC’s top ten most popular dog breeds for 2022.

1 French Bulldogs

2 Labrador Retrievers

3 Golden Retrievers

4 German Shepherd Dogs

5 Poodles

6 Bulldogs

7 Rottweilers

8 Beagles

9 Dachshunds

10 German Shorthaired Pointers


This article originally appeared on 03.17.23

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Parenting

Mom creates a stir after refusing to drop her child off at a parent free birthday party

"I loved drop off parties. I didn't want to sit at some kids party."

Photos by Ivan Samkov and Gustavo Fring|Canva

Mom refuses to let kid go to "drop-off" birthday party

There are many Millennial moms that were raised on "Unsolved Mysteries" and "America's Most Wanted" during formative years, which may or may not have influenced the way they parent. It can be hard to think clearly when Robert Stack's voice is echoing in your head every time your child is out of eyesight. The jokes about what is responsible for the average Millennial's parenting style resembling more like a helicopter are endless. But sometimes additional caution is warranted where others may find it unnecessary.

At least that's what many folks on the internet believe after one mom seemingly split parents into two camps with her revelation about children's parties. Liv, who goes by the TikTok handle Liv SAHM, takes to social media to explain that her seven-year-old son was invited to a birthday party but when she went to RSVP, she noticed the invitation said, "drop off only."

The mom explains, "It's at someone's house. I don't know these parents. I don't know that there's actually going to be other adults besides this child's parents."

Liv states that she would not be dropping her young child off alone with strangers. To many parents this seems like a reasonable response. If you don't know the parents or any other adults then how can you ensure your child will be safe. Other parents felt like Liv was completely overreacting with a helicopter parenting style.

"Little kids have been going to peoples birthday parties without clingy parents for decades," one person declares.

"I'm a drop off kinda house. I want the parents to leave that is one less person I have to feed. I don't wanna have to make small talk with other parents," another says.

"That's a big no for me too! And I always try to take my kids to classmates parties because people never show up," someone writes.

"That's so worrisome. I completely agree with you mama bear, same with my son," a commenter says.

"Yeah, that would make me uncomfortable too! It's always a little interesting to me when parents drop off their kids at parties," someone else adds.

@livsahm

No thank you! I don’t feel comfortable with that. #mom #momsoftiktok #momlife #sahm #sahmlife #birthday #birthdayparty #celebration #controversial #parenting #parentingtips #parents #no

There's no right or wrong way to throw a party for a kid because there's no rulebook. Generally parents are accustomed to seeing invitations that say no siblings or the offer of parents staying or leaving. Many commenters pointed out that it seemed odd that the invitation was worded in a way that sounded like parents staying wasn't an option.

Some parents noted that the world has changed since they were children and wouldn't feel safe dropping their kids off either. Others found no issue with it and think fellow parents are overreacting. What do you say, odd or perfectly fine?

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Family

Dad shares what happens when you give your child books instead of a smartphone

The key to fostering healthy habits in children is to be wholly present and reject the “pressures of convenience”

via Armando Hart (used with permission)

Armando Hart and his son, Raya.

One of the most pressing dilemmas for parents these days is how much screen time they should allow their children. Research published by the Mayo Clinic shows that excessive screen time can lead to obesity, disrupted sleep, behavioral issues, poor academic performance, exposure to violence and a significant reduction in playtime.

The American Academy of Pediatrics recommends limiting screen time to 1 to 2 hours daily for children over 2. But American children spend far more time in front of screens than that and the situation is only worsening.

Before the pandemic, kids between the ages of 4 and 12 spent an average of 4.4 hours a day looking at screens, but since 2020, the average child’s daily screen time has increased by 1.75 hours.

A father in Long Beach, California, is getting some love for his TikTok video sharing what happens when you give your kid books instead of an iPhone. Armando Hart posted a video showing his 10-year-old son, Raya, reading a book in the back of a car and it’s been seen over 8 million times.

"Give them books instead of phones when they are little and this is the result," the caption reads. "Thank me later."

We’re so blessed with our son Raya. I think he’s read more books than I have.

@lifeinmotion08

We’re so blessed with our son Raya. I think he’s read more books than I have. #Books #Read #Fyp

Hart and his wife started reading to their son every night before bedtime, hoping to instill a love for books. "It was all about leading by example and creating a nurturing environment where reading was celebrated," Hart told Newsweek. These days, Raya is an avid reader who enjoys just about anything.

“My son likes novels, fiction, nonfiction, and realistic fiction,” Hart told Upworthy. “He also likes informative content, such as reading the almanac and other informative magazines. He loves to build, cook from recipes, and make art.”

For Hart, reading is all about creating a sense of balance in his son’s life.

“It's not about being against technology but about fostering a balanced approach that prioritizes meaningful experiences and hands-on learning,” he told Upworthy. “By instilling a love for reading, creativity, and exploration early on, we're equipping Raya with the skills and mindset he needs to thrive in an ever-changing world.”

Hart believes that the screen time discussion isn’t just about technology but a trend that goes deeper. “It speaks to a broader societal problem: our youth's lack of self-esteem, confidence and fundamental values. While screen time may exacerbate these issues, it is not the sole cause,” he told Upworthy.

“In contrast, physical activity, such as exercise, promotes joy and well-being. Spending hours scrolling on a phone can detract from genuine moments of happiness and fulfillment,” he continued. “Therefore, we must address the deeper underlying issues affecting our youth's mental and emotional health rather than solely attributing them to screen time.”

Hart believes the key to fostering healthy habits in children is to be wholly present and reject the “pressures of convenience” that encourage parental complacency.

“We prioritize quality time together, whether exploring nature, sharing meals with the best available foods, or engaging in meaningful conversations. In today's rapidly advancing technological world, staying grounded in our humanity and embodying integrity in everything we do is crucial,” he continued. “This means staying connected to our authentic selves and teaching our son the importance of honesty, kindness, and respect.”

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