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Health

A female scientist’s discovery may lead to the first 'on-demand' male birth control pill

“Men need an option so that the burden of contraception is not on females anymore,” says Dr. Melanie Balbach.

Close up of a man taking a pill.

Even though men have condoms and vasectomies, throughout history, the burden of contraception has ultimately been felt by women because they bear the ultimate responsibility if they become pregnant. To maintain their reproductive freedom, women must take hormone-altering pills, wear patches or insert hormone-filled rings into their vaginas.

They also deal with copper IUDs, shots and spermicide-soaked sponges.

Women also have to manage the cost and hassle of doctors' visits to get their contraception and are at the mercy of the state if they have an unwanted pregnancy. Isn’t it time more men stepped up and took responsibility for contraception?

The good news is that new medical development may provide hope for the countless women who are tired of the pills, IUDs and headaches that come with female contraceptives. The cool thing is that a woman is behind its discovery.


A new pill developed by Weill Cornell Medicine could become the first “on-demand” male oral contraceptive. The drug has been found to stop sperm “in their tracks” and prevents pregnancies in preclinical models.

The pill is fast-acting and can have a man ready for sex 30 to 60 minutes before intercourse. That’s about as long as it takes for Viagra to work its magic.

"Our inhibitor works within 30 minutes to an hour," Dr. Melanie Balbach, a postdoctoral associate in their lab, said in a statement. "Every other experimental hormonal or nonhormonal male contraceptive takes weeks to bring sperm count down or render them unable to fertilize eggs."

The inhibitor was discovered by Dr. Balbach accidentally while working on a treatment for an eye condition. Dr. Balbach found that when mice took a drug that inactivates soluble adenylyl cyclase (sAC), they produced sperm that could not propel themselves through the vaginal tract.

Research shows that men who cannot produce sAC due to genetic mutations are infertile.

After the drug takes hold, the sperm are rendered useless for about 24 hours and then return to normal. So, the drug is not only fast acting but rapidly reversible.

“What I like about the proposed contraceptive in this study is the on-demand option,” says Ulrike Schimpf at the KTH Royal Institute of Technology in Sweden. “It would act rapidly, temporarily, and is efficient at the first dose.”

The discovery could be a sea change in how males approach contraception. But some are rightfully afraid that men may lie about taking the pill in the heat of the moment.

After all these years that women have had to bear the burden of responsibility, there’s something poignant about the first potential male contraceptive pill being discovered by a woman.

“We need more [birth control] options, and men need an option so that the burden of contraception is not on females anymore,” Balbach told New Scientist. “We’re very optimistic that once men take the inhibitor, it will have the same effect.”

Dr. Balbach and Dr. Jochen Buck, a professor of pharmacology at Weill Cornell Medicine, are currently working to develop a new version of the drug that lasts longer before testing it on humans. They hope to go to clinical trials by 2025.

Trump won. Now what?

Photo by Chip Somodevilla/Getty Images.

President-elect Trump ran a campaign of exclusion and fear. So until he shows us otherwise, it's smart to hope for the best but expect the worst when it comes to his governing style.


But there is some ... good news. There are 70 full days between noon Eastern time today, Nov. 10, 2016, and noon on Inauguration Day on Jan. 20, 2017.

If Trump intends to act on any or all of the promises he made in the past 18 months, there are a few things you and your family might want to do now to prepare for a Trump presidency.

Here they are:

1. If you're working or living in this country on a visa, work permit, or outdated passport, know the status of your documents.

Photo by Rhona Wise/AFP/Getty Images.

Trump campaigned on building a wall between the U.S. and Mexico and didn't rule out mass deportations. As news of his election spread, uncertainty and fear took over.

"They are crying in despair," immigrant advocate Gaby Pacheco wrote in a Facebook post. "To those who voted for Trump, know that you have put a target on our backs."

Before Trump makes any sweeping changes to immigration policy, make sure you and your family secure or renew your work permits or visas as needed.

Also, if you're transgender, take this time to secure or renew your passport in your correct gender. That may be very difficult to do under the new administration.

2. Talk to your health care provider about birth control options that will outlast a Trump presidency.

Image via iStock.

Under the Obama administration, Congress worked tirelessly to defund Planned Parenthood and push abstinence-only sex education. With Obama in the Oval Office, their plans stopped cold. He even delivered on free birth control. But that may change.

Abortion providers and reproductive justice organizations remained optimistic in the wake of the news. “He’s not the first Republican president who has wanted to overturn Roe," National Abortion Federation President Vicki Saporta told BuzzFeed News. "Ronald Regan and the two Bushes did, and none of them were successful.”

Even so, if Trump rolls back Obamacare or cuts funding to Planned Parenthood and other community health organizations, many women and families could be left without affordable contraception options. If you're currently taking birth control, talk to your health care provider about options for reversible, long-term birth control like implants or intra-uterine devices. Depending on your plan, or lack thereof, these options may be available for free or a reduced cost.

3. Get loud and serious about climate change.

Photo by Alex Wong/Getty Images.

We're about to have a president who thinks global warming is a hoax.

Just one day after the election, stock in the world's largest manufacturer of wind turbines plummeted. The future of green jobs, much-needed regulation, and tough policy looks bleak.

But we can do a lot in 70 days and after that.  It's time to get loud. We need to stand by our experts, our academics, our Leonardo DiCaprios and make this the issue of our day. Because it is. In the interim, make small changes around your home and re-think the way you eat, shop, and travel. Small changes can add up, and in the wake of sweeping change, it's all we've got.

4. Support organizations making all of these things possible with your time, energy, or dollars.

Image via iStock.

Helping new residents and undocumented families, protecting reproductive rights, and funding green innovations isn't often easy or cheap. There are people and organizations working hard to do all of these things and much, much more. But these organizations can't persist without support.

Step up to the plate and volunteer. If you have the capacity to do so, contribute money or in-kind donations. Tweet, talk-up, and share the brilliant work these organizations do so those in need can find these valuable resources.

5. Embrace kindness.

Support people who don't feel at home in Trump's America.

Photo by Kena Betancur/Getty Images.

This one isn't just for the next 70 days; it's forever.

Trump succeeded because he used hate and fear to divide and activate the electorate. He was openly hostile to Latinos, Muslims, blacks, the LGBTQ community, and people with disabilities. And while that worked for his campaign, that's no way to run a country. All of us dedicated to goodness, truth, and kindness need to stand together and stand up to white supremacy, misogyny, and discrimination.

Let's stand together, no matter what. Embrace kindness. Listen to and uplift underrepresented voices. Don't look to Canada; look right here. Let's make the country we want. Bigotry will not win the day.

We have — at most — 70 days before Obama hands the White House over to Trump.

But we have a lifetime to work toward a common goal: creating a nation and government that works for all of us.

It starts today.

There once was a study about male birth control that made everyone freak out.

You know the study I'm talking about, right? The one where a handful of dudes took male birth control, and they got all sad and bloaty, and then most of them quit the whole thing altogether.The one that recently spawned dozens of articles making fun of those dudes' fragile masculinity.

In the study, which ran from 2008 to 2011, 266 monogamously committed guys in 10 different countries tried out a sperm-suppressing injection that looked to be 98% effective. In the end, 7.5% of the guys who took the male birth control dropped out for maybe experiencing side effects similar to women who take birth control. The study was also really tragic because it might have permanently sterilized a guy, and some of the subjects attempted or died from self-harm.


Photo via iStock.

As a dude who would happily take birth control, I have some thoughts about this study and our response to it. Because there's a lot more going on here than it sounds like, and we need to talk about, well, all of it.

First, just to get this out of the way, this study was total crap.

Dr. Jen Gunter, an OB-GYN and, yes, a woman, runs through the study in detail on her blog, and suffice to say: The parameters behind it were a bust. It just wasn’t worth continuing.

The sample size was a mess: There were 320 guys at the start of the study, but that number dropped to 266 before the depression-bloaty-acne issues (plus 1,500 other side effects) came up. By the time it ended in 2011, the study was down to 111 subjects.

"Trust me, I'm a doctor." SMDH. Photo by Manoocher Deghati/AFP/Getty Images.

They also didn't control for consistency across the different testing locations. They hadn't screened participants for mental health or in any way that would allow them to measure their emotionality. So when they realized, for example, that most of the adverse side effects were coming out of Indonesia, they had no idea if that was cultural, dietary, or tied to the meds.

On top of that, the Food and Drug Administration requires 20,000 menstrual cycles' worth of safety data for women. But since men don't cycle, no one has determined how long men's birth control would need to be tested to be deemed safe.

Coupled with the difficulty of establishing placebo controls for contraceptives (giving someone a sugar pill and telling them it's fine to have unprotected sex is generally frowned upon), the potential rewards of this particular study were really, really unreliable.

Well, guess we're back to the ol' go-to! Photo by William B. Plowman/Getty Images.

The anger behind the findings of this study is totally valid, though, because of the shoddy history behind women’s birth control.

It turns out, birth control studies have almost always been deplorable and rooted in a very deep history of gendered medicine and racist abuse.

The short version of the story: Puerto Rican women and asylum inmates were forced to participate in early trials for female birth control pills in 1955. In fact, in Puerto Rico, where contraception and abortion were legal and available but forced sterilization was also occurring, the researchers specifically sought out the "ovulating intelligent" in medical school, where the trials became a required part of their curriculum. If they dropped out or refused to participate, they'd be expelled from school.

Photo by H. William Tetlow/Fox Photos/Getty Images.

Later, when the drug was tested under slightly more humane circumstances, there were still some big problems: The researchers enticed women with the "no pregnancy" part while conveniently leaving out the details about the potential side effects of the pills. If the recent male trial that got everyone up in arms was bad by modern standards (which it was), then these adverse effects were monstrous: 17% of participants had serious complaints, three people may or may not have died as a result, and one of the researchers even straight up admitted that there were "too many side reactions to be generally acceptable."

But they stuck with it anyway, using a dosage that was 10 times higher than necessary for contraception, and got the thing approved.

Photo by Evening Standard/Getty Images.

The progress and development of the pill over the last 50 years was only possible because women fought to make it better once it was out in the world, despite its nightmarish origin story.

So yes, you are absolutely right to be outraged when it comes to this study: Women have carried the brunt of birth control side effects for way too long. While this one recent male study was crap, so were many that came before it that were much worse for women.

Apparently scientists did briefly consider making a birth control pill for men just before the Puerto Rican trials, by the way, but they figured dudes couldn't handle the mild shrinkage and that women were better suited to silently suffer through the side effects because of their higher pain tolerance.

That's just further proof that women have been putting up with this kind of shit for long enough, and we shouldn't have waited so long to start developing a male birth control pill. (Of course, if we had started earlier, who knows how many more blatant human rights violations would have occurred? Grr.)

Photo by Brendan Smialowski/AFP/Getty Images.

The good news is that a majority of men are totally on board with using a pill to keep our swimmers on the sidelines.

We don't even mind the side effects! Really! In fact, 75% of the participants in this particular study and their respective partners said they were down to keep doing it.

In another study of 9,000 men in nine different countries, 57% were open to popping a (theoretical) pill. For comparison, about 17.5% of women ages 15-44 in the U.S. use oral contraceptives. So the odds there aren't bad. Lots of us guys are down with this — I promise.

Photo by Evening Standard/Getty Images.

There are lots of other people working on alternative forms of male birth control, too.

Gandarusa is an Indonesian herb that produces an enzyme that basically prevents individual sperm from making it all the way to egg. It apparently originated as a stress reliever with temporary infertility as a possible side effect.

The "clean sheets pill" does exactly what it sounds like: It stops you from actually spillin' yer stuff but still keeps the sensation of an orgasm otherwise intact.

There's also Vasalgel, which is not a pill, per se, but a gel injection into the vas deferens to keep the sperm out of your semen. A similar process involves injecting gold nanorods into your testicles, which, um, probably makes for an interesting pickup line, at the very least. Ahem.

BE A HERO LIKE THIS GUY. Photo via iStock.

Sex, contraception, and pregnancy are all shared responsibilities. They are consensual.

So, dudes, let’s get moving. You want to help push an actual male birth control pill through? Talk to your doctor. Sign up for a study. Talk about it, yell it from the rooftops, maybe try screaming it in bed if that's your thing. (Hey, you never know until you try.)

A lot of guys already know this, but if you don't, here it is: We all need to do a better job for working toward more equitable solutions, and not just for birth control. So let's make that clear to the women in our lives, and let’s move along from this crap study and design some better ones. It’s time to get shit done.

Family

This comic explains why America needs Planned Parenthood.

Planned Parenthood offers a variety of resources for reproductive and sexual health.