Study discovers people don't age steadily, but in dramatic bursts at two specific ages
This explains SO much about your 40s.

If you feel "old" practically overnight, there may be a good reason for that.
Aging is weird. You're trucking along, enjoying your middle-aged life, finally feeling like a real adult, when you look in the mirror one day and gasp. "Where did those wrinkles come from?" "Is that skin on my arm…crepey?!?" "Why am I aching like that?"
Somewhere in your mid-40s, you start noticing obvious signs of aging that seem to arrive overnight. You assume it was a gradual process that you just hadn't noticed, but it sure as heck felt like it happened really fast.
New research indicates that may very well be the case. A study from researchers at Stanford tracked thousands of different molecules in people age 25 to 75 and found that people tend to make two big leaps in aging—one around age 44 and another around age 60. These findings indicate that aging can actually happen in bursts.
“We’re not just changing gradually over time. There are some really dramatic changes,” said senior study author Michael Snyder, Ph.D., a geneticist and director of the Center for Genomics and Personalized Medicine at Stanford University. “It turns out the mid-40s is a time of dramatic change, as is the early 60s. And that’s true no matter what class of molecules you look at.”
The researchers assumed the mid-40s changes would be attributed to menopausal or perimenopausal changes in women influencing the overall numbers, but when they separated the results by sex they saw similar changes in men in their 40s.
"“This suggests that while menopause or perimenopause may contribute to the changes observed in women in their mid-40s, there are likely other, more significant factors influencing these changes in both men and women. Identifying and studying these factors should be a priority for future research,” said study author Xiaotao Shen, PhD, a former Stanford Medicine postdoctoral scholar who now teaches at Nanyang Technological University in Singapore.

The study included 108 participants who submitted blood and other samples every few months for several years. The scientists tracked age-related changes in 135,000 different molecules—nearly 250 billion distinct data points—to see how aging occurs.
The study may shed light on the reasons for jumps in certain diseases and maladies at certain ages. For the 40-somethings, scientists found significant changes in molecules related to alcohol, caffeine, and lipid metabolism, cardiovascular disease, and skin and muscle. For those in their 60s, changes related to carbohydrate and caffeine metabolism, immune regulation, kidney function, cardiovascular disease, and skin and muscle were found.
The study authors did note that lifestyle might play a role in some of these changes. For instance, alcohol metabolism may be influenced by people drinking more heavily in their 40s, which tends to be a period of higher stress for many people. However, the researchers added that these bursts of aging in the mid-40s and early 60s indicate that people may want to pay closer attention to their health around those ages and make lifestyle changes that support greater overall health, such as increasing exercise or limiting alcohol.
The research team plans to study the drivers of these aging bursts to find out why they happen at these ages, but whatever the reasons, it's nice to know that the seemingly sudden onset of age-related woes isn't just in our imaginations.
It's understandable that we worry about aging, as physical signs of aging remind us of our own mortality. We also have all kinds of social messaging that tells us youth is ideal and beautiful and old is bad and ugly, so of course we give aging the side-eye. But none of us can avoid aging altogether, so the more positive and healthy we are in our approach to aging is, the better off we'll be, no matter when and to what degree aging hits us.
This story originally appeared last year.
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A Generation Jones teenager poses in her room.Image via Wikmedia Commons
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An Irish woman went to the doctor for a routine eye exam. She left with bright neon green eyes.
It's not easy seeing green.
Did she get superpowers?
Going to the eye doctor can be a hassle and a pain. It's not just the routine issues and inconveniences that come along when making a doctor appointment, but sometimes the various devices being used to check your eyes' health feel invasive and uncomfortable. But at least at the end of the appointment, most of us don't look like we're turning into The Incredible Hulk. That wasn't the case for one Irish woman.
Photographer Margerita B. Wargola was just going in for a routine eye exam at the hospital but ended up leaving with her eyes a shocking, bright neon green.
At the doctor's office, the nurse practitioner was prepping Wargola for a test with a machine that Wargola had experienced before. Before the test started, Wargola presumed the nurse had dropped some saline into her eyes, as they were feeling dry. After she blinked, everything went yellow.
Wargola and the nurse initially panicked. Neither knew what was going on as Wargola suddenly had yellow vision and radioactive-looking green eyes. After the initial shock, both realized the issue: the nurse forgot to ask Wargola to remove her contact lenses before putting contrast drops in her eyes for the exam. Wargola and the nurse quickly removed the lenses from her eyes and washed them thoroughly with saline. Fortunately, Wargola's eyes were unharmed. Unfortunately, her contacts were permanently stained and she didn't bring a spare pair.
- YouTube youtube.com
Since she has poor vision, Wargola was forced to drive herself home after the eye exam wearing the neon-green contact lenses that make her look like a member of the Green Lantern Corps. She couldn't help but laugh at her predicament and recorded a video explaining it all on social media. Since then, her video has sparked a couple Reddit threads and collected a bunch of comments on Instagram:
“But the REAL question is: do you now have X-Ray vision?”
“You can just say you're a superhero.”
“I would make a few stops on the way home just to freak some people out!”
“I would have lived it up! Grab a coffee, do grocery shopping, walk around a shopping center.”
“This one would pair well with that girl who ate something with turmeric with her invisalign on and walked around Paris smiling at people with seemingly BRIGHT YELLOW TEETH.”
“I would save those for fancy special occasions! WOW!”
“Every time I'd stop I'd turn slowly and stare at the person in the car next to me.”
“Keep them. Tell people what to do. They’ll do your bidding.”
In a follow-up Instagram video, Wargola showed her followers that she was safe at home with normal eyes, showing that the damaged contact lenses were so stained that they turned the saline solution in her contacts case into a bright Gatorade yellow. She wasn't mad at the nurse and, in fact, plans on keeping the lenses to wear on St. Patrick's Day or some other special occasion.
While no harm was done and a good laugh was had, it's still best for doctors, nurses, and patients alike to double-check and ask or tell if contact lenses are being worn before each eye test. If not, there might be more than ultra-green eyes to worry about.