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Health

A female scientist’s discovery may lead to the first 'on-demand' male birth control pill

“Men need an option so that the burden of contraception is not on females anymore,” says Dr. Melanie Balbach.

birth control, makle contraception, male pill
via Free Images

Close up of a man taking a pill.

Even though men have condoms and vasectomies, throughout history, the burden of contraception has ultimately been felt by women because they bear the ultimate responsibility if they become pregnant. To maintain their reproductive freedom, women must take hormone-altering pills, wear patches or insert hormone-filled rings into their vaginas.

They also deal with copper IUDs, shots and spermicide-soaked sponges.

Women also have to manage the cost and hassle of doctors' visits to get their contraception and are at the mercy of the state if they have an unwanted pregnancy. Isn’t it time more men stepped up and took responsibility for contraception?

The good news is that new medical development may provide hope for the countless women who are tired of the pills, IUDs and headaches that come with female contraceptives. The cool thing is that a woman is behind its discovery.

A new pill developed by Weill Cornell Medicine could become the first “on-demand” male oral contraceptive. The drug has been found to stop sperm “in their tracks” and prevents pregnancies in preclinical models.

The pill is fast-acting and can have a man ready for sex 30 to 60 minutes before intercourse. That’s about as long as it takes for Viagra to work its magic.

"Our inhibitor works within 30 minutes to an hour," Dr. Melanie Balbach, a postdoctoral associate in their lab, said in a statement. "Every other experimental hormonal or nonhormonal male contraceptive takes weeks to bring sperm count down or render them unable to fertilize eggs."

The inhibitor was discovered by Dr. Balbach accidentally while working on a treatment for an eye condition. Dr. Balbach found that when mice took a drug that inactivates soluble adenylyl cyclase (sAC), they produced sperm that could not propel themselves through the vaginal tract.

Research shows that men who cannot produce sAC due to genetic mutations are infertile.

After the drug takes hold, the sperm are rendered useless for about 24 hours and then return to normal. So, the drug is not only fast acting but rapidly reversible.

“What I like about the proposed contraceptive in this study is the on-demand option,” says Ulrike Schimpf at the KTH Royal Institute of Technology in Sweden. “It would act rapidly, temporarily, and is efficient at the first dose.”

The discovery could be a sea change in how males approach contraception. But some are rightfully afraid that men may lie about taking the pill in the heat of the moment.

After all these years that women have had to bear the burden of responsibility, there’s something poignant about the first potential male contraceptive pill being discovered by a woman.

“We need more [birth control] options, and men need an option so that the burden of contraception is not on females anymore,” Balbach told New Scientist. “We’re very optimistic that once men take the inhibitor, it will have the same effect.”

Dr. Balbach and Dr. Jochen Buck, a professor of pharmacology at Weill Cornell Medicine, are currently working to develop a new version of the drug that lasts longer before testing it on humans. They hope to go to clinical trials by 2025.

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women's health
Science

The longest — and probably largest — proof of our current climate catastrophe ever caught on camera.

It was the largest such event ever filmed.

Exposure Labs

All GIFs and images via Exposure Labs.


Photographer James Balog and his crew were hanging out near a glacier when their camera captured something extraordinary.

They were in Greenland, gathering footage from the time-lapse they'd positioned all around the Arctic Circle for the last several years.

They were also there to shoot scenes for a documentary. And while they were hoping to capture some cool moments on camera, no one expected a huge chunk of a glacier to snap clean off and slide into the ocean right in front of their eyes.


science, calving, glaciers

A glacier falls into the sea.

assets.rebelmouse.io

ocean swells, sea level, erosion, going green

Massive swells created by large chunks of glacier falling away.

assets.rebelmouse.io

It was the largest such event ever filmed.

For nearly an hour and 15 minutes, Balog and his crew stood by and watched as a piece of ice the size of lower Manhattan — but with ice-equivalent buildings that were two to three times taller than that — simply melted away.

geological catastrophe, earth, glacier melt

A representation demonstrating the massive size of ice that broke off into the sea.

assets.rebelmouse.io

As far as anyone knows, this was an unprecedented geological catastrophe and they caught the entire thing on tape. It won't be the last time something like this happens either.

But once upon a time, Balog was openly skeptical about that "global warming" thing.

Balog had a reputation since the early 1980s as a conservationist and environmental photographer. And for nearly 20 years, he'd scoffed at the climate change heralds shouting, "The sky is falling! The sky is falling!"

"I didn't think that humans were capable of changing the basic physics and chemistry of this entire, huge planet. It didn't seem probable, it didn't seem possible," he explained in the 2012 documentary film "Chasing Ice."

There was too much margin of error in the computer simulations, too many other pressing problems to address about our beautiful planet. As far as he was concerned, these melodramatic doomsayers were distracting from the real issues.

That was then.

Greenland, Antarctica, glacier calving

The glacier ice continues to erode away.

assets.rebelmouse.io

In fact, it wasn't until 2005 that Balog became a believer.

He was sent on a photo expedition of the Arctic by National Geographic, and that first northern trip was more than enough to see the damage for himself.

"It was about actual tangible physical evidence that was preserved in the ice cores of Greenland and Antarctica," he said in a 2012 interview with ThinkProgress. "That was really the smoking gun showing how far outside normal, natural variation the world has become. And that's when I started to really get the message that this was something consequential and serious and needed to be dealt with."

Some of that evidence may have been the fact that more Arctic landmass has melted away in the last 20 years than the previous 10,000 years.

Watch the video of the event of the glacier calving below:

This article originally appeared on 11.04.15

From Your Site Articles
Pop Culture

People are arguing whether this is a picture of Tom Hanks or Bill Murray

Can you tell?

via Reasons My Son is Crying/Facebook

Tom Hanks and Bill Murray


What do you think?


via Reasons My Son is Crying/Facebook

SCROLL DOWN FOR THE ANSWER

Given the narrow beauty standards in Hollywood, there are a lot of actors and actresses that look look amazingly similar.

Heath Ledger and Joseph Gordon-Levitt look a lot alike…


As do Katy Perry and Zooey Deschanel…

But has anyone ever said, "You know which 60-something actors look identical? Tom Hanks and Bill Murray." Because they don't look alike. Although, funnily enough, Bill Murray did famously turn down the leads in Hanks' hits "Forrest Gump" and "Philadelphia," but I'm guessing nobody has ever screamed, "Loved you in 'Ghostbusters'" at Hanks as he walked down the street.

But for some reason, call it fate, call it luck, call it karma, the man making the "waaah" face in the orange raincoat above could easily be either man.

Here's what people are saying on Facebook:

via Reasons My Son is Crying/Facebook

The truth (should you choose to accept it):

The photo above is of Bill Murray and Laura DiMichele-Ross holding her crying son, Alexander, at the Alfred Dunhill Links golf competition at St. Andrews in October 2012. DiMichele-Ross posted the photo to a popular Facebook blog "Reasons My Son Is Crying" in May 2013. The photo resurfaced in October 2016 on the Today Show website, reigniting the controversy all over again.

Regardless of what the Internet is saying, DiMichele-Ross backs her original claim that it's Murray. "It's totally Bill," she reiterated in a comment on her post. "I can vouch cause I'm the one in the photo with the massive grin thinking 'Oh my god this is going to be an awesome photo!'"


This article originally appeared on 10.26.16

From Your Site Articles
comedy
Pop Culture

The Bee Gees a capella version of 'How Deep is Your Love' might be even better than the original

Only family can harmonize this well.

via Edu Seijas/YouTube

The Bee Gees singing "How Deep is Your Love" in 1998.

In 1998, the Bee Gees, brothers Barry, Robin and Maurice Gibb, stopped by ITV’s “Des O'Connor Tonight” with acoustic guitars in hand to promote their recent release, “One Night Only,” an album and live concert DVD featuring many of the band’s biggest hits.

The highlight of the performance was when Barry got ready to strum his guitar for a performance of “How Deep is Your Love,” the 1977 megahit from the “Saturday Night Fever Soundtrack,” but instead chose to sing the song a capella.

Barry starts the song solo in his beautiful falsetto, but then, when his brothers join him, they create a wonderful harmony that only brothers can make. The show’s host, Des O’Conner, a notable singer himself, even joins in for a few bars.

- YouTubeyoutu.be

Earlier in the performance, the brothers played their version of “Islands in the Stream,” a song made famous by Dolly Parton and Kenny Rodgers in 1983 that was written by the Bee Gees. In 1998, the song was enjoying a resurgence as its melody was used in the song “Ghetto Superstar” by Pras of The Fugees.

Robin Gibb later admitted that the song was initially written for Marvin Gaye to sing, but he was tragically murdered in 1984 by his father. The band also had Diana Ross in mind while composing the tune.

During the appearance, the band also sang “Guilty,” a song that the Bee Gees wrote for Barbara Streisand and Barry produced in 1980.

You can watch the entire performance in the video below.

- YouTubewww.youtube.com

From Your Site Articles
the bee gees
Mental Health

The danger of high-functioning depression as told by a college student

Overachievers can struggle with mental health issues, too.


I first saw a psychiatrist for my anxiety and depression as a junior in high school.

During her evaluation, she asked about my coursework. I told her that I had a 4.0 GPA and had filled my schedule with pre-AP and AP classes. A puzzled look crossed her face. She asked about my involvement in extracurricular activities. As I rattled off the long list of groups and organizations I was a part of, her frown creased further.

Finally, she set down her pen and looked at me, saying something along the lines of "You seem to be pretty high-functioning, but your anxiety and depression seem pretty severe. Actually, it's teens like you who scare me a lot."


Now I was confused. What was scary about my condition? From the outside, I was functioning like a perfectly "normal" teenager. In fact, I was somewhat of an overachiever.

I was working through my mental illnesses and I was succeeding, so what was the problem?

I left that appointment with a prescription for Lexapro and a question that I would continue to think about for years. The answer didn't hit me all at once.

Instead, it came to me every time I heard a suicide story on the news saying, "By all accounts, they were living the perfect life."

It came to me as I crumbled under pressure over and over again, doing the bare minimum I could to still meet my definition of success.

It came to me as I began to share my story and my illness with others, and I was met with reactions of "I had no idea" and "I never would have known." It's easy to put depression into a box of symptoms.

lighted candles on man's hand lying on the floorPhoto by Fernando @cferdophotography on Unsplash

Even though we're often told that mental illness comes in all shapes and sizes, I think we're still stuck with certain "stock images" of mental health in our heads.

When we see depression and anxiety in adolescents, we see teens struggling to get by in their day-to-day lives. We see grades dropping, and we see involvement replaced by isolation. But it doesn't always look like this.

And when we limit our idea of mental illness, at-risk people slip through the cracks.

We don't see the student with the 4.0 GPA or the student who's active in choir and theater or a member of the National Honor Society or the ambitious teen who takes on leadership roles in a religious youth group.

person holding white printer paperPhoto by Sydney Sims on Unsplash

No matter how many times we are reminded that mental illness doesn't discriminate, we revert back to a narrow idea of how it should manifest, and that is dangerous.

Recognizing this danger is what helped me find the answer to my question.

Watching person after person — myself included — slip under the radar of the "depression detector" made me realize where that fear comes from. My psychiatrist knew the list of symptoms, and she knew I didn't necessarily fit them. She understood it was the reason that, though my struggles with mental illness began at age 12, I didn't come to see her until I was 16.

If we keep allowing our perception of what mental illness looks like to dictate how we go about recognizing and treating it, we will continue to overlook people who don't fit the mold.

We cannot keep forgetting that there are people out there who, though they may not be able to check off every symptom on the list, are heavily and negatively affected by their mental illness. If we forget, we allow their struggle to continue unnoticed, and that is pretty scary.


This article was written by Amanda Leventhal and originally appeared on 06.03.16













From Your Site Articles
Joy

A struggling cook asked Gordon Ramsay a personal question, and he responded in an unexpected way.

This was totally surprising.

Image (Cropped) from Dave Pullig/Wikimedia Commons/Attribution 2.0 Generic.

Gordon Ramsay at play... work.


Gordon Ramsay is not exactly known for being nice.

Or patient.

Or nurturing.

On his competition show "Hell's Kitchen," he belittles cooks who can't keep up. If people come to him with their problems, he berates them. If someone is struggling to get something right in the kitchen, he curses them out.


His whole TV persona is based on being the world's worst boss.

Ramsay went on Reddit and allowed users to ask him any question they wanted.

So when a fellow cook asked him a sincere, deeply personal question about what to do when you've hit a roadblock in your career, you could probably guess what was coming.

economics, inspiration, mentorship

How do you deal with it Ramsay?

Indeed, I thought the guy was making a terrible mistake pouring his heart out to a chef as notoriously tough as Ramsay:

"My hopes and dreams are nowhere to be found as I scale and portion salmon after salmon, shelling pods after pods of broad beans.
...
Sometimes I look out the tiny window and I can see people walking around the streets, enjoying the sunlight, while I'm here, questioning my dedication to this art as I rotate stock in the cool room, getting frost bitten, but the fear of the chef stops me from stepping outside to warm up.
...
The closest thing to feeling any kind of joy I get is those rare moments when I walk through the dining room near the end of service to get some coffee for everyone, and there will be a few diners left, idly sampling those little petite fours that we've painstakingly ensured are all perfectly round, identical, and just plain delicious. Then, one of them will stop the conversation they're having with their company, look up from their food and say, 'Thank you, chef. This is delicious,' and making the previous 14-hours of sweat and tears kind of worthwhile.

My question is, how did you deal with it? How the fuck did you deal with all the bullshit, Gordon?”

But the way Ramsay responded? Totally amazing. And completely unexpected.

uplifting, chef, labor laws

That’s an amazing question.

assets.rebelmouse.io

Turns out, real-life Gordon Ramsay? He actually can be a really kind, big-hearted dude.

He's sympathetic to the guy. Not just because he's a good person. But because he's been there.

Working in restaurants is a tough, tough business. As of 2012, the average salary for cooks was less than $23,000/year. And those who are just starting out often have to work unglamorous, tedious jobs that no one else wants to do. Ramsay didn't have fancy culinary school training. He rose up through the ranks putting in long hours for low pay in kitchens all over the world. That's why he gets it.

Which brings up another point.

Diet Dieting GIF by Bobbi DeCarlo - Find & Share on GIPHY

diners, food, job security, restaurants

(Does this salad dressing have black pepper in it?? No tip for you!)

Diet Dieting GIF by Bobbi DeCarlo - from GIPHY.

When we go out to eat, we, as a culture, tend to behave ... how should I put this?

Let's go with "not like perfect angels."

Of course, no one likes getting the wrong order. Or waiting a really long time for a meal. Or eating something that doesn't taste the way you expect it to.

But it's important to remember that the people behind the food, like Ramsay's anonymous letter-writer, might be working 14-hour days. Or might be a recent immigrant who speaks limited English, trying to support a family thousands of miles away. And possibly making very little money. And sure, they screw up sometimes. But we all screw up at our jobs sometimes.

Because they, like the rest of us, are human beings.

Which is why saying...

"Thank you, chef. This is delicious."

Could mean everything to someone.


This article originally appeared on 04.22.15

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