Want to understand better how human traits are passed on? Just study the fruit fly.
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NC State

Getting fruit flies drunk might sound silly, but it's an important part of Dr. Trudy Mackay's research.

Enter Mackay's lab at NC State University, and you'll find multiple columns stretching from floor to ceiling with alcohol vapor running through them. If you look real close, you'll see the fruit flies in these "inebriometers" partying hard — getting hyperactive, falling all over the place, and then eventually just passing out drunk.

The thing is, that's exactly how a human would react to alcohol. So does this make fruit flies more human? Obviously not. But it does illustrate one of the many traits and characteristics that we have in common with the humble (and occasionally tipsy) fruit fly.


When Mackay read a study in 2000 that said 70-75% of human genes have equivalents in the fruit fly, she knew there was more to be learned about humans.

In fact, the research she gathers from fruit flies can usually translate to humans. And in some cases, what'll make a fruit fly sick will make a human sick as well — meaning we can potentially learn a lot about serious diseases from observing fruit flies.

Dr. Trudy Mackay. All screenshots via NC State/YouTube.

In the case of the alcohol sensitivity, Mackay and her team identified a gene in the flies called "malic enzyme" that was strongly affected by the alcohol. Then when they surveyed humans on their drinking habits, they found that those who consume alcohol had similar results in the same corresponding gene. It's a huge step in understanding how alcohol affects us, but what's key is finding other variants like malic enzyme and observing how they interact with each other.

"This is where we’re going in the future," adds Mackay. "What we would like to know is how the variants combine together to affect risk."

So why test fruit flies in the lab and not, you know, a lab rat?

"They're actually an odd but very good model of human complex traits," Mackay says. "In fact, many of the pathways that we know are involved in cancer, heart disease, other human complex diseases actually have names from flies — where they were first discovered."

Mackay also notes that there are a couple of advantages to using the flies instead of the more common lab mammals. "One is their very short lifespan," she says. Fruit flies don't live all that long, so it's easier to see how the traits they observe are passed from one generation to the next. It also makes it easier to study just that — lifespan.

"The other is that we have community resources that have been built up over many, many decades," adds Mackay. "A whole host of technological advances that we can use to study traits that are relevant to human health."

In fact, one of the most important resources around is one that she created. The Drosophila Genetic Reference Panel (DGRP), a collection of 200 different genetic fruit fly lines, allows other scientists to conduct their own research and compare their trait results with the catalog Mackay has provided. That helped earn Mackay the esteemed Wolf Prize in Agriculture, an award that's known to be an indicator of Nobel Prize winners.

There's still a lot of work left to be done, but that only pushes Mackay even more.

Yes, it's pretty awesome that we have a lot in common with fruit flies. But in the grand scheme of things, it's about so much more than that. "What I think is most important are the general principles of complex trait inheritance that we’ve discovered that I very much think is applied to the same general principles in humans," Mackay notes.

That's why Mackay continues to apply her research to understanding a number of different causes — whether it's glaucoma, aggression, or stress resistance in humans. At the end of the day, it's all about gathering as much information as possible to put the pieces together.

"You can think of it as, the studies we've done up to now is giving us a parts list," Mackay says. "And what we need to do is figure out how those parts go together."

It's a long (and unpredictable) road ahead, but it's one that Mackay would gladly go down anytime. When asked about what inspires her to keep pushing the field forward, Mackay didn't even hesitate.

"The same as any scientist," she says. "Curiosity about the natural world."

Feeling curious yourself? Check out the video below to learn more about Dr. Trudy Mackay's groundbreaking work:

Courtesy of Creative Commons
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After years of service as a military nurse in the naval Marine Corps, Los Angeles, California-resident Rhonda Jackson became one of the 37,000 retired veterans in the U.S. who are currently experiencing homelessness — roughly eight percent of the entire homeless population.

"I was living in a one-bedroom apartment with no heat for two years," Jackson said. "The Department of Veterans Affairs was doing everything they could to help but I was not in a good situation."

One day in 2019, Jackson felt a sudden sense of hope for a better living arrangement when she caught wind of the ongoing construction of Veteran's Village in Carson, California — a 51-unit affordable housing development with one, two and three-bedroom apartments and supportive services to residents through a partnership with U.S.VETS.

Her feelings of hope quickly blossomed into a vision for her future when she learned that Veteran's Village was taking applications for residents to move in later that year after construction was complete.

"I was entered into a lottery and I just said to myself, 'Okay, this is going to work out,'" Jackson said. "The next thing I knew, I had won the lottery — in more ways than one."

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Cats are notoriously weird. Everyone who's had cats knows that they each have their own unique quirks, idiosyncrasies, preferences, habits, and flat-out WTFness.

But even those of us who have experience with bizarre cat behavior are blown away by the antics this "cat dad" is able to get away with.

Kareem and Fifi are the cat parents of Chase, Skye, and Millie—literally the most chill kitties ever. They share their family life on TikTok as @dontstopmeowing, and their videos have been viewed millions of times. When you see them, you'll understand why.

Take Chase's spa days, for example. It may seem unreal at first, but watch what happens when Fifi tries to take away his cucumber slices.

When she puts them back on his eyes? WHAT?! What cat would let you put them on once, much less get mad when you take them off?

This cat. Chase is living his best life.

But apparently, it's not just Chase. Skye and Millie have also joined in "spaw day." How on earth does one couple end up with three hilariously malleable cats?

Oh, and if you think they must have been sedated or something, look at how wide awake they are during bath time. That's right, bath time. Most cats hate water, but apparently, these three couldn't care less. How?

They'll literally do anything. The Don't Stop Meowing channel is filled with videos like this. Cats wearing glasses. Cats wearing hats. Cats driving cars. It's unbelievable yet highly watchable entertainment.

If you're worried that Kareem gets all the love and Fifi constantly gets the shaft, that seems to be a bit for show. Look at Chase and Fifi's conversation about her leaving town for a business trip:

The whole channel is worth checking out. Ever seen a cat being carried in a baby carrier at the grocery store? A cat buckled into a car seat? Three cats sitting through storytime? It's all there. (Just a heads up: A few of the videos have explicit language, so parents might want to do a preview before watching with little ones.) You can follow the couple and their cats on all their social media channels, including Instagram and YouTube if TikTok isn't your thing, here.

If you weren't a cat person before, these videos might change your mind. Fair warning, however: Getting a cat because you want them to do things like this would be a mistake. Cats do what they want to do, and no one can predict what weird traits they will have. Even if you raise them from kittenhood, they're still unpredictable and weird.

And honestly, we wouldn't have them any other way.

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We're redefining what normal means in these uncertain times, and although this is different for all of us, love continues to transform us for the better.

Love is what united Marie-Claire and David Archbold, who met while taking a photography class. "We went into the darkroom to see what developed," they joke—and after a decade of marriage, they know firsthand the deep commitment and connection romantic love requires.

All photos courtesy of Marie-Claire and David Archbold

However, their relationship became even sweeter when they adopted James: a little boy with a huge heart.

In the United States alone, there are roughly 122,000 children awaiting adoption according to the latest report from the U.S Department of Health and Human Services. While the goal is always for a child to be parented by and stay with their biological family, that is not always a possibility. This is where adoption offers hope—not only does it create new families, it gives birth parents an avenue through which to see their child flourish when they are not able to parent. For the right families, it's a beautiful thing.

The Archbolds knew early on that adoption was an option for them. David has three daughters from a previous marriage, but knowing their family was not yet complete, the couple embarked on a two-year journey to find their match. When the adoption agency called and told them about James, they were elated. From the moment they met him, the Archbolds knew he was meant to be part of their family. David locked eyes with the brown-eyed baby and they stared at each other in quiet wonder for such a long time that the whole room fell silent. "He still looks at me like that," said David.

The connection was mutual and instantaneous—love at first sight. The Archbolds knew that James was meant to be a part of their family. However, they faced significant challenges requiring an even deeper level of commitment due to James' medical condition.

James was born with congenital hyperinsulinism, a rare condition that causes his body to overproduce insulin, and within 2 months of his birth, he had to have surgery to remove 90% of his pancreas. There was a steep learning curve for the Archbolds, but they were already in love, and knew they were committed to the ongoing care that'd be required of bringing James into their lives. After lots of research and encouragement from James' medical team, they finally brought their son home.

Today, three-year-old James is thriving, filled with infectious joy that bubbles over and touches every person who comes in contact with him. "Part of love is when people recognize that they need to be with each other," said his adoptive grandfather. And because the Archbolds opted for an open adoption, there are even more people to love and support James as he grows.

This sweet story is brought to you by Sumo Citrus®. This oversized mandarin is celebrated for its incredible taste and distinct looks. Sumo Citrus is super-sweet, enormous, easy-to-peel, seedless, and juicy without the mess. Fans of the fruit are obsessive, stocking up from January to April when Sumo Citrus is in stores. To learn more, visit sumocitrus.com and @sumocitrus.

You know that feeling you get when you walk into a classroom and see someone else's stuff on your desk?

OK, sure, there are no assigned seats, but you've been sitting at the same desk since the first day and everyone knows it.

So why does the guy who sits next to you put his phone, his book, his charger, his lunch, and his laptop in the space that's rightfully yours? It's annoying!

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There have been many iconic dance routines throughout film history, but how many have the honor being called "the greatest" by Fred Astaire himself?

Fayard and Harold Nicholas, known collectively as the Nicholas Brothers, were arguably the best at what they did during their heyday. Their coordinated tap routines are legendary, not only because they were great dancers, but because of their incredible ability to jump into the air and land in the splits. Repeatedly. From impressive heights.

Their most famous routine comes from the movie "Stormy Weather." As Cab Calloway sings "Jumpin' Jive," the Nicholas Brothers make the entire set their dance floor, hopping and tapping from podium to podium amongst the musicians, dancing up and down stairs and across the top of a piano.

But what makes this scene extra impressive is that they performed it without rehearsing it first and it was filmed in one take—no fancy editing room tricks to bring it all together. This fact was confirmed in a conversation with the brothers in a Chicago Tribune article in 1997, when they were both in their 70s:

"Would you believe that was one of the easiest things we ever did?" Harold told the paper.

"Did you know that we never even rehearsed that number?" added Fayard.

"When it came time to do that part, (choreographer) Nick Castle said: 'Just do it. Don`t rehearse it, just do it.' And so we did it—in one little take. And then he said: 'That's it—we can't do it any better than that.'"

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