The problem with men explaining things. Plus, the best of the web this week.

The best of the Web this week includes an explanation of "mansplaining," an amazing art project in China, 61 things you didn't know about hoboes, five tricks Facebook uses when dealing with your privacy, and more. Enjoy!


Arts and Culture

The Problem With Men Explaining Things / Rebecca Solnit / Mother Jones

This piece floored me. You should read it, especially if you're a man. Or a woman.





Obituary: Neil Armstrong / The Economist

An amazing man and story: "The original landing area turned out to be full of large boulders. ... By the time he found his spot, there was only 25 seconds of fuel left in the thanks."




61 Things I Learned At The National Hobo Convention / Matt Stopera / BuzzFeed

A wonderful story, animated by curiosity and genuine interest. Lots of gems, including: "6. When a hobo dies, they are said to have 'caught the Westbound.'"




Green Pedestrian Crossing In China Creates Leaves From Footprints / Christopher Jobson / Colossal

Art and advocacy meet in this clever and beautiful campaign.




Politics and World Affairs

I'm Right, You're Wrong And Other Political Truths / Ramesh Ponnuru / Bloomberg

Finally, something people from both parties can all agree on!




Fear Of A Black President / Ta-Nehisi Coates / The Atlantic

A searching and sobering consideration of race relations in America, and of the poignant mixture of disappointment and pride Coates finds in Obama and his administration.




What I Learned At Bain Capital / Mitt Romney / The Wall Street Journal

Romney makes the case for how his business experience has equipped him to turn around the economy.




So, Mitt, What Do You Really Believe? / The Economist

Ouch: "A businessman without a credible plan to fix a problem stops being a credible businessman. So does a businessman who tells you one thing at breakfast and the opposite at supper." (via Maurice)




The Reality Of Trying To Shrink Government / Lawrence Summers / The Washington Post

Important perspective: "For structural reasons, even preserving the amount of government functions that predated the financial crisis will require substantial increases in the share of U.S. economy devoted to the public sector."




Business and Economics

The Cheapest Generation / Derek Thompson and Jordan Weissman / The Atlantic

Car and home ownership are down significantly among millennials, with many interesting explanations and implications. One insight: "young people prize 'access over ownership.'"




The Acqui-Hire Scourge: Whatever Happened To Failure In The Valley? / Sarah Lacy / PandoDaily

Interesting and well-argued piece. "Everyone loves to say that Silicon Valley's great strength is an acceptance of failure." But widespread acquisitions may be undermining this.




The Case For Spending A Little More Sometimes / Carl Richards / The New York Times

Simple advice: Avoid the temptation of cheap and disposable, and invest in things that are worth owning for the long haul.





Tootsie's Secret Empire / Ben Kesling / The Wall Street Journal

A fun story on the candy company's secretive, and aging, CEO. Plus, this great lede: "How many licks does it take to get to the center of Tootsie Roll Industries? No one really knows."




Smart Service Design Needs A New Language For Anonymity / Jan Chipcase / Co.Design

Some interesting nuggets on the value, and dangers, of personal recognition in customer service. (via @dbkahn)




Science and Technology

Digital Scarcity / Tuhin Kumar

Soon enough, digital "... will replace physical as the primary dimension in which we spend our time. ... We need to find a better way to tell others what is worth their time."





5 Design Tricks Facebook Uses To Affect Your Privacy Decisions / Avi Charkham / TechCrunch

Side-by-side comparisons show a concerted effort to make it less clear what permissions you're granting.




Apple V. Samsung Verdict Is In: $1 Billion Loss For Samsung / Joe Mullin / Ars Technica

Interesting context: "Apple's ultimate target is Google," whose Android operating system so enraged Steve Jobs that he promised "thermonuclear war."




The Worldfalls / Oliver Morton / Heliophage

A short, vivid mental image that will change the way you think about energy, from the author of a book on photosynthesis called "Eating the Sun."




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This article originally appeared on August 27, 2015

Oh, society! We have such a complicated relationship with relationships.

It starts early, with the movies we are plopped in front of as toddlers.

Keep Reading Show less

This article originally appeared on August 27, 2015

Oh, society! We have such a complicated relationship with relationships.

It starts early, with the movies we are plopped in front of as toddlers.

Keep Reading Show less
True

Each year, an estimated 1.8 million people in the United States are affected by cancer — most commonly cancers of the breast, lung, prostate, and blood cancers such as leukemia. While not everyone overcomes the disease, thanks to science, more people are surviving — and for longer — than ever before in history.

We asked three people whose lives have been impacted by cancer to share their stories – how their lives were changed by the disease, and how they're using that experience to change the future of cancer treatments with the hope that ultimately, in the fight against cancer, science will win. Here's what they had to say.

Celine Ryan, 55, engineer database programmer and mother of five from Detroit, MI

Photo courtesy of Celine Ryan

In September 2013, Celine Ryan woke up from a colonoscopy to some traumatic news. Her gastroenterologist showed her a picture of the cancerous mass they found during the procedure.

Ryan and her husband, Patrick, had scheduled a colonoscopy after discovering some unusual bleeding, so the suspicion she could have cancer was already there. Neither of them, however, were quite prepared for the results to be positive -- or for the treatment to begin so soon. Just two days after learning the news, Ryan had surgery to remove the tumor, part of her bladder, and 17 cancerous lymph nodes. Chemotherapy and radiation soon followed.

Ryan's treatment was rigorous – but in December 2014, she got the devastating news that the cancer, once confined to her colon, had spread to her lungs. Her prognosis, they said, was likely terminal.

But rather than give up hope, Ryan sought support from online research, fellow cancer patients and survivors, and her medical team. When she brought up immunotherapy to her oncologist, he quickly agreed it was the best course of action. Ryan's cancer, like a majority of colon and pancreatic cancers, had been caused by a defect on the gene KRAS, which can result in a very aggressive cancer that is virtually "undruggable." According to the medical literature, the relatively smooth protein structure of the KRAS gene meant that designing inhibitors to bind to surface grooves and treat the cancer has been historically difficult. Through her support systems, Ryan discovered an experimental immunotherapy trial at the National Institutes of Health (NIH) in Bethesda, MD., and called them immediately to see if she was eligible. After months of trying to determine whether she was a suitable candidate for the experimental treatment, Ryan was finally accepted.

The treatment, known as tumor-infiltrating lymphocyte therapy, or TIL, is a testament to how far modern science has evolved. With this therapy, doctors remove a tumor and harvest special immune cells that are found naturally in the tumor. Doctors then grow the cells in a lab over the next several weeks with a protein that promotes rapid TIL growth – and once the cells number into the billions, they are infused back into the patient's body to fight the cancer. On April 1, 2015, Ryan had her tumor removed at the NIH. Two months later, she went inpatient for four weeks to have the team "wash out" her immune system with chemotherapy and infuse the cells – all 148 billion of them – back into her body.

Six weeks after the infusion, Ryan and Patrick went back for a follow-up appointment – and the news they got was stunning: Not only had no new tumors developed, but the six existing tumors in her lungs had shrunk significantly. Less than a year after her cell infusion, in April 2016, the doctors told Ryan news that would have been impossible just a decade earlier: Thanks to the cell infusion, Ryan was now considered NED – no evaluable disease. Her body was cancer-free.

Ryan is still NED today and continuing annual follow-up appointments at the NIH, experiencing things she never dreamed she'd be able to live to see, such as her children's high school and college graduations. She's also donating her blood and cells to the NIH to help them research other potential cancer treatments. "It was an honor to do so," Ryan said of her experience. "I'm just thrilled, and I hope my experience can help a lot more people."

Patrice Lee, PhD, VP of Pharmacology, Toxicology and Exploratory Development at Pfizer

Photo courtesy of Patrice Lee

Patrice Lee got into scientific research in an unconventional way – through the late ocean explorer Jacques Cousteau.

Lee never met Cousteau but her dreams of working with him one day led her to pursue a career in science. Initially, Lee completed an undergraduate degree in marine biology; eventually, her interests changed and she decided to get a dual doctoral degree in physiology and toxicology at Duke University. She now works at Pfizer's R&D site in Boulder, CO (formerly Array BioPharma), leading a group of scientists who determine the safety and efficacy of new oncology drugs.

"Scientists focused on drug discovery and development in the pharmaceutical industry are deeply committed to inventing new therapies to meet unmet needs," Lee says, describing her field of work. "We're driven to achieve new medicines and vaccines as quickly as possible without sacrificing safety."

Among the drugs Lee has helped develop during her career, including cancer therapies, she says around a dozen are currently in development, while nine have received FDA approval — an incredible accomplishment as many scientists spend their careers without seeing their drug make it to market. Lee's team is particularly interested in therapies for brain metastases — something that Lee says is a largely unmet need in cancer research, and something her team is working on from a variety of angles. "Now that we've had rapid success with mRNA vaccine technology, we hope to explore what the future holds when applying this technology to cancers," Lee says.

But while evaluating potential cancer therapies is a professional passion of Lee's, it's also a mission that's deeply personal. "I'm also a breast cancer survivor," she says. "So I've been on the other side of things and have participated in a clinical trial."

However, seeing how melanoma therapies that she helped develop have affected other real-life cancer patients, she says, has been a highlight of her career. "We had one therapy that was approved for patients with BRAF-mutant metastatic melanoma," Lee recalls. "Our team in Boulder was graced by a visit from a patient that had benefited from these drugs that we developed. It was a very special moment for the entire team."

None of these therapies would be available, Lee says without rigorous science behind it: "Facts come from good science. Facts will drive the development of new drugs, and that's what will help patients."

Chiuying "Cynthia" Kuk (they/them) MS, 34, third-year medical student at Michigan State University College of Human Medicine

Photo courtesy of Cynthia Kuk

Cynthia Kuk was just 10 years old when they had a conversation that would change their life forever.

"My mother, who worked as a translator for the government at the time, had been diagnosed with breast cancer, and after her chemotherapy treatments she would get really sick," Kuk, who uses they/them pronouns, recalls. "When I asked my dad why mom was puking so much, he said it was because of the medicine she was taking that would help her get better."

Kuk's response was immediate: "That's so stupid! Why would a medicine make you feel worse instead of better? When I'm older, I want to create medicine that won't make people sick like that."

Nine years later, Kuk traveled from their native Hong Kong to the United States to do exactly that. Kuk enrolled in a small, liberal arts college for their Bachelor's degree, and then four years later started a PhD program in cancer research. Although Kuk's mother was in remission from her cancer at the time, Kuk's goal was the same as it had been as a 10-year-old watching her suffer through chemotherapy: to design a better cancer treatment, and change the landscape of cancer research forever.

Since then, Kuk's mission has changed slightly.

"My mom's cancer relapsed in 2008, and she ended up passing away about five years after that," Kuk says. "After my mom died, I started having this sense of urgency. Cancer research is such that you work for twenty years, and at the end of it you might have a fancy medication that could help people, but I wanted to help people now." With their mother still at the forefront of their mind, Kuk decided to quit their PhD program and enter medical school.

Now, Kuk plans to pursue a career in emergency medicine – not only because they are drawn to the excitement of the emergency room, but because the ER is a place where the most marginalized people tend to seek care.

"I have a special interest in the LGBTQ+ population, as I identify as queer and nonbinary," says Kuk. "A lot of people in this community and other marginalized communities access care through the ER and also tend to avoid medical care since there is a history of mistreatment and judgement from healthcare workers. How you carry yourself as a doctor, your compassion, that can make a huge difference in someone's care."

In addition to making a difference in the lives of LGBTQ+ patients, Kuk wants to make a difference in the lives of patients with cancer as well, like their mother had.

"We've diagnosed patients in the Emergency Department with cancer before," Kuk says. "I can't make cancer good news but how you deliver bad news and the compassion you show could make a world of difference to that patient and their family."

During their training, Kuk advocates for patients by delivering compassionate and inclusive care, whether they happen to have cancer or not. In addition to emphasizing their patient's pronouns and chosen names, they ask for inclusive social and sexual histories as well as using gender neutral language. In doing this, they hope to make medicine as a whole more accessible for people who have been historically pushed aside.

"I'm just one person, and I can't force everyone to respect you, if you're marginalized," Kuk says. "But I do want to push for a culture where people appreciate others who are different from them."