+
upworthy
Science

The surprising reason medicine tends to work better for men than women.

Yet another reason why we need more equality.

research, animal testing, gender, health
Canva

Even the medical field has bias.

Men.

We have it pretty good. Especially when it comes to our health.

Not only do we get to write the health care legislation, but increasingly, we're getting all the good medical treatment.

We can thank lab animals for this — and the researchers who study them.


For a long time, researchers believed that male animals were better for trials of new medicine.

It was widely assumed that hormone cycles in females would screw up the results.

As a result, currently, over 75% of all lab animals are male.

animal research, studies, gender bias, disease

Lab mouse in a surgically gloved hand.

Image by Rama/Wikimedia Commons/CeCILL.

The problem is, when you test primarily on male animals, you're making medicine that's more likely to be effective for, well, men.

According to a report in New Scientist, researcher Natasha Karp and a team from the U.K.'s Wellcome Trust Sanger Institute studied tens of thousands of mice of both sexes. They found that when you switch off genes in male mice, the mice express different traits then when you switch off the same genes in female mice.

If genes express themselves differently depending on the sex of the animal, the researchers found, so do some genetic diseases.

drugs, health, politics, community

Gene therapy: rad as hell.

Photo by National Cancer Institute on Unsplash

The team concluded that "drugs optimized for male animals may be less effective in females, or even cause harm." Of the 10 drugs that were pulled from the market between 1997 and 2001, they explained, eight were riskier for women.

Male animal-bias also means drugs that work better for women might not even make it into testing to begin with.

As with the debate over what constitutes an "essential" health care benefit (according to some hi-larious U.S. senators, mammograms shouldn't), when it comes to "who constitutes a full human," it appears men are the considered default setting, while women are an afterthought.

equal rights, equal representation, experiments, medical advancements

A bearded man looking off into the distance all manly.

Photo by Jakob Owens on Unsplash

It's a pretty sweet gig for us men.

The thing is, women are half of us. We like them.

As fully formed human beings with lives, free will, hopes, dreams, and so on, it'd be nice if medicine worked better on them when they got diseases.

There's been some progress toward making medical experiments more equitable, at least where human subjects are concerned.

Clinical trials (on humans) used to involve pretty much no women. Now most are 30-40% female, though that still means women are underrepresented.

Thanks to efforts of researchers like Karp and her team, we now know we need to extend that progress to the animal kingdom as well.

"Unless there’s a really good reason not to, we should be using both sexes in biomedical research," Karp told New Scientist.

Male animals, she argued, have traits just as particular as female hormone cycles that make them similarly varied from an ideal "norm."

Ultimately, more comprehensive research benefits us all — men and women.

Better studies lead to more effective medicine, which leads to less sickness and sadness all around.

That's the hope anyway.

The animals of both genders who turn out to help us out with this project deserve a hearty "thank you."

If we start with equal treatment, we might finally get some equal treatment.

This article originally appeared on 06.29.17

True

Making new friends as an adult is challenging. While people crave meaningful IRL connections, it can be hard to know where to find them. But thanks to one Facebook Group, meeting your new best friends is easier than ever.

Founded in 2018, NYC Brunch Squad brings together hundreds of people who come as strangers and leave as friends through its in-person events.

“Witnessing the transformative impact our community has on the lives of our members is truly remarkable. We provide the essential support and connections needed to thrive amid the city's chaos,” shares Liza Rubin, the group’s founder.

Despite its name, the group doesn’t just do brunch. They also have book clubs, seasonal parties, and picnics, among other activities.

NYC Brunch Squad curates up to 10 monthly events tailored to the specific interests of its members. Liza handles all the details, taking into account different budgets and event sizes – all people have to do is show up.

“We have members who met at our events and became friends and went on to embark on international journeys to celebrate birthdays together. We have had members get married with bridesmaids by their sides who were women they first connected with at our events. We’ve had members decide to live together and become roommates,” Liza says.

Members also bond over their passion for giving back to their community. The group has hosted many impact-driven events, including a “Picnic with Purpose” to create self-care packages for homeless shelters and recently participated in the #SquadSpreadsJoy challenge. Each day, the 100 members participating receive random acts of kindness to complete. They can also share their stories on the group page to earn extra points. The member with the most points at the end wins a free seat at the group's Friendsgiving event.

Keep ReadingShow less
Joy

Terrified, emaciated dog comes to life as volunteer sits with him for human connection

He tries making himself so small in the kennel until he realizes he's safe.

Terrified dog transforms after human sits with him.

There's something about dogs that makes people just want to cuddle them. They have some of the sweetest faces with big curious eyes that make them almost look cartoonish at times. But not all dogs get humans that want to snuggle up with them on cold nights; some dogs are neglected or abandoned. That's where animal shelters come in, and they work diligently to take care of any medical needs and find these animals loving homes.

Volunteers are essential to animal shelters running effectively to fill in the gaps employees may not have time for. Rocky Kanaka has been volunteering to sit with dogs to provide comfort. Recently he uploaded a video of an extremely emaciated Vizsla mix that was doing his best to make himself as small as possible in the corner of the kennel.

Kanaka immediately wanted to help him adjust so he would feel comfortable enough to eat and eventually get adopted. The dog appeared scared of his new location and had actually rubbed his nose raw from anxiety, but everything changed when Kanaka came along.

Keep ReadingShow less
Health

Woman's felony charge for 'abuse of a corpse' sheds light on the realities of miscarriage

Let's start with the unspoken and uncomfortable fact that miscarriages at home usually happen in a toilet.

Woman's felony charge after miscarriage highlights need for education.

Content Warning: This story discusses pregnancy loss details that may be uncomfortable for some readers.

Losing a pregnancy is not something anyone can prepare for. There's no course you can take to tell you what to expect, how you'll feel or what to do after the miscarriage occurs. It's not something that's widely talked about, even in conversations about miscarriage.

About 1 in 4 pregnancies end in miscarriage in the first trimester and 1 in 5 in the second, according to the March of Dimes. Many women who reveal they've lost a pregnancy talk about how difficult it was emotionally, but they rarely talk about the lack of information from medical professionals or the details of the process of miscarrying. It makes sense because it's hard enough to discuss pregnancy loss, and to go into detail may be much worse on their mental health.

There also may be a level of shame attached to the process, partly because the topic of miscarriage is still taboo but also because many at-home miscarriages happen in the toilet. It's an uncomfortable truth that haunts people who have experienced the process. But the truth of the matter is, hospitals don't usually admit you for a miscarriage; they send you home with little to no instructions on what to do after it happens. So to people who have experienced the pain of a miscarriage at home, it makes sense that a woman in Ohio, currently on trial for "abuse of a corpse" would have no idea what to do after miscarrying.

Keep ReadingShow less
Joy

Family posts a very chill note to neighbors explaining why their dog is on the roof

“We appreciate your concern but please do not knock on our door.."

via Reddit

Meet Huckleberry the dog.

If you were taking a stroll through a quiet neighborhood and happened to catch a glance of this majestic sight, you might bat an eye. You might do a double take. If you were (somewhat understandably) concerned about this surprising roof-dog's welfare, you might even approach the homeowners to tell them, "Uh, I'm not sure if you know...but there's a...dog...on your ROOF."

Well, the family inside is aware that there's often a dog on their roof. It's their pet Golden, Huckleberry, and he just sorta likes it up there.

Keep ReadingShow less
Education

Woman's wild story of surviving 14,500 ft skydive fall because of fire ants is a must read

It's usually a bad thing to land in a mound of fire ants at 80 mph. But not if you're Joan Murray.

Canva

Picture of a fire ant. Eek.

You have a 50% chance of surviving a fall of 48 feet, roughly equaling a 4-story building. The mortality rate rushes all the way up to 90% when you fall 84 feet, the distance of a 7-story building.

So if you’re falling from a whopping 14,500 feet, just over two-and-a-half miles, you can safely bet that you’re most definitely not getting out alive.

But one woman did. And that’s not even the wildest part of her story.
Keep ReadingShow less

This company lets children transform ordinary backpacks into creative masterpieces

Dommei’s innovative designs are empowering children to unleash their artistic potential.

Imagine a world where a simple backpack becomes a canvas for imagination and a tool for learning. That's the world Dommei has created.

Born out of a desire to blend creativity with everyday utility, Dommei is not just another company; it's a hub of innovation. In a time when screens often dominate our children's attention, Dommei brings back the joy of tangible, hands-on creativity.

@dommei_inc Play in different! Dommei DIY Backpack combine the functionality of display board, toys, and tools.
♬ 原聲 - Dommei Inc

Each backpack from Dommei is more than a bag; it's a gateway to worlds of space, oceans, dinosaurs, and more. It's where art meets education, and ordinary backpacks transform into extraordinary masterpieces, empowering children to unleash their artistic potential and explore new horizons.

1. The Concept Behind Dommei

During the 2020 pandemic, when the world seemed to pause, Dommei hit the play button on creativity and innovation. The company's journey began with a question: How can we turn everyday objects into something extraordinary? Inspired by the grandeur and innovation symbolized by the Crystal Palace of the first World Expo, Dommei decided to reinvent something as simple as a backpack into a canvas of imagination and learning.

At its core, Dommei stands on three pillars: create, have fun, and share. It's not just about making a product; it's about creating an experience that blends joy with education. The brand encourages children and adults alike to explore their creativity, turning personal expression into an interactive adventure. By marrying practicality with play, Dommei backpacks are more than just storage; they're tools for storytelling, learning, and sharing experiences. Each backpack is a celebration of personal expression, underlining the brand's commitment to making education not only accessible but also enjoyable.

2. The Space Domepak Kit

Blast off into a universe of learning and creativity with the Space Domepak Kit! This isn't just a backpack; it's a launchpad for young astronauts' imaginations. Loaded with a space-themed display board, stellar toys, and tools for connecting, the Space Domepak turns the mystery of the cosmos into an interactive adventure. It’s perfect for those little dreamers who gaze up at the stars and wonder.

By bringing the wonders of the universe to their fingertips, this kit encourages curiosity, learning, and creativity, making the vastness of space feel a little closer and a lot more personal. It’s not just carrying a backpack but a galaxy of possibilities.

3. The Ocean Domepak Kit

Dive into the deep blue with the Ocean Domepak Kit, where every zip opens up a world of underwater exploration. This kit is more than a backpack; it's an oceanic expedition for young explorers! It is packed with marine-themed toys, a vibrant display board, and tools inviting interaction

It's a treasure trove for budding marine biologists. Kids discover and learn about mysterious marine species, fostering a love for our oceans and their creatures. It's a hands-on experience that brings the ocean's wonders to the surface, igniting a wave of curiosity and care for the aquatic world.

4. The Dinosaur Domepak Kit

Step back in time with the Dinosaur Domepak Kit, a prehistoric playground for the little paleontologist in your life. This isn't just any backpack; it's a time machine to when dinosaurs roamed the Earth. Loaded with dinosaur-themed toys, a prehistoric display board, and tools for hands-on learning, it brings the ancient world of dinosaurs into the present.

This kit makes learning about these magnificent creatures fun and accessible, sparking a fascination with natural history. It's more than a journey into the past; it’s an exploration of a world that once was, igniting a lifelong passion for discovery and science.

5. The Combo Domepak Kit

Meet the chameleon of backpacks: the Combo Domepak Kit. This ingenious creation adapts to whatever your child’s heart desires, be it the cosmos, the deep sea, or the age of dinosaurs.

Each kit comes with a variety of themes, making it a jack-of-all-trades in the world of creative learning. It's not just versatile; it's a playground for the imagination. Whether your little one is an aspiring astronaut today or a marine biologist tomorrow, this backpack evolves with their changing passions. It's a celebration of their growing interests, offering a canvas that's as dynamic and creative as their young minds.

6. The Plus Domepak Kit

For the little artist with a big imagination, the Plus Domepak Kit is a masterpiece waiting to happen. This isn’t just a backpack; it's an artist's studio on the go. With its comprehensive set, including a DIY painting kit, it turns every outing into an opportunity for artistic expression.

The Plus Domepak isn't just about carrying supplies; it's about carrying ideas and dreams. Whether it's painting a prehistoric landscape or a starry galaxy, this kit combines art, education, and endless fun. It’s perfect for nurturing creativity, blending the joy of making art with the thrill of learning something new every day.

Learn More

Dommei's backpacks are more than just bags; they're windows to worlds of creativity and learning. Each one is a unique adventure, inviting kids to explore, create, and grow.

So, why settle for ordinary when your child can carry a masterpiece? Click here to dive into Dommei's world and see where creativity takes you.

Family

People kept telling me to watch 'Bluey.' I still was not prepared.

Some adults say it's healing their inner child, but there's something in the popular Australian kids' show for everyone.

"Bluey" is popular with all ages, despite being aimed at kids.

I have a confession to make. I'm 48 years old, my youngest child is in high school and I can't stop watching "Bluey."

For the uninitiated, "Bluey" is a kids' cartoon from Australia aimed at 5 to 7-year-olds. It's been nearly a decade since my household has seen that demographic, so when people kept telling me I should watch "Bluey," my reaction was basically, "Yeah, I've already done my kiddie show time, thankyouverymuch."

Then my almost-15-year-old started watching it just to see what the fuss was about. And as I started tuning in, I saw why people love it so much. I figured it was going to be a wholesome show with some good lessons for kids, and it is.

But it's also laugh-out-loud hilarious.

Keep ReadingShow less