+
Family

This Huntington's disease trial shows how promising gene editing may be.

Huntington's disease is caused by a single mutation in someone's DNA.

A normal protein, huntingtin, becomes warped and toxic. Over time, the toxic protein builds up, killing a person's brain cells and slowly robbing them of cognitive and motor control.

It affects about 30,000 Americans, often shows up later in life, and is fatal. Because it's a genetic disease, it can be passed down through families. It's cruel, unfair, and nobody deserves it.


But what if we could just zap away that one fatal mutation?

That's exactly what a team of scientists from Emory University and the Chinese Academy of Sciences just tried — zapping that mutation right out of the DNA. And it looks like it could work.

Working with sick mice in a lab, the scientists used a gene-editing technique colloquially known as CRISPR. On June 19, 2017, the scientists reported that once injected and inside the brain cells, the CRISPR system could read the mice's DNA, find the huntingtin gene, and snip it apart. This effectively silenced the gene, cutting off the "flow" of the toxic proteins.

When the scientists checked on the mice a few weeks later, the toxic proteins had nearly disappeared from their cells. The scientists reported that the sick mice also regained some, but not all, of their motor control.

This isn't the first trial to use gene editing on Huntington's, but it does represent a new technique.

There's currently no cure for this awful disease, but this kind of research could provide a path to one in the future.

Gene editing is still pretty new; we need to learn more about whether CRISPR is completely safe, for instance, or what the long-term effects of silencing that particular gene would be.

But if we look at the history of humanity, we've conquered many horrible diseases. We've beaten back polio and smallpox and are even tackling childhood cancer. It's not far-fetched to think that, one day, we may be able to add Huntington's to the list.

Finally, someone explains why we all need subtitles

It seems everyone needs subtitles nowadays in order to "hear" the television. This is something that has become more common over the past decade and it's caused people to question if their hearing is going bad or if perhaps actors have gotten lazy with enunciation.

So if you've been wondering if it's just you who needs subtitles in order to watch the latest marathon-worthy show, worry no more. Vox video producer Edward Vega interviewed dialogue editor Austin Olivia Kendrick to get to the bottom of why we can't seem to make out what the actors are saying anymore. It turns out it's technology's fault, and to get to how we got here, Vega and Kendrick took us back in time.

They first explained that way back when movies were first moving from silent film to spoken dialogue, actors had to enunciate and project loudly while speaking directly into a large microphone. If they spoke and moved like actors do today, it would sound almost as if someone were giving a drive-by soliloquy while circling the block. You'd only hear every other sentence or two.

Keep ReadingShow less

Pedro Pascal and Bowen Yang can't keep a straight face as Ego Nwodim tries to cut her steak.

Most episodes of “Saturday Night Live” are scheduled so the funnier bits go first and the riskier, oddball sketches appear towards the end, in case they have to be cut for time. But on the February 4 episode featuring host Pedro Pascal (“The Mandalorian,” “The Last of Us”), the final sketch, “Lisa from Temecula,” was probably the most memorable of the night.

That’s high praise because it was a strong episode, with a funny “Last of Us” parody featuring the Super Mario Brothers and a sketch where Pascal played a protective mother.

Keep ReadingShow less
Pop Culture

One moment in history shot Tracy Chapman to music stardom. Watch it now.

She captivated millions with nothing but her guitar and an iconic voice.

Imagine being in the crowd and hearing "Fast Car" for the first time

While a catchy hook might make a song go viral, very few songs create such a unifying impact that they achieve timeless resonance. Tracy Chapman’s “Fast Car” is one of those songs.

So much courage and raw honesty is packed into the lyrics, only to be elevated by Chapman’s signature androgynous and soulful voice. Imagine being in the crowd and seeing her as a relatively unknown talent and hearing that song for the first time. Would you instantly recognize that you were witnessing a pivotal moment in musical history?

For concert goers at Wembley Stadium in the late 80s, this was the scenario.

Keep ReadingShow less
Pop Culture

The far-right is calling this viral Grammy performance 'Satanic.' Don't fall for it.

Sam Smith and Kim Petras' performance of "Unholy" left some calling it a satanic ritual.

K.G/Youtube

Sam Smith and Kim Petras performing "Unholy" at the Grammy Awards.

Depending on which corners of social media you call home, few happenings from the 2023 Grammy awards were as divisive as Sam Smith and Kim Petras’ performance of the song “Unholy.” Was it a historic moment of inclusion or a historic display of a Satanic ritual broadcast to the world?

On the one hand, the pair made music history. After winning the Grammy Award for Best Pop Duo/Group Performance, Smith became the first non-binary artist to win the category, along with Petra who became the first trans woman to win the category.

However, not everyone was a fan of their live hell-themed performance, featuring Smith clad in red leather and sporting a top hat with devil horns and Petras dancing in a cage surrounded by dominatrixes.

Texas Senator Ted Cruz took to Twitter to call the act “evil,” and his fury was quickly echoed by other conservative influencers who declared it an example of mainstream devil worship.

“Don’t fight the culture wars, they say. Meanwhile demons are teaching your kids to worship Satan. I could throw up.” wrote conservative political commentator Liz Wheeler.

However, it doesn’t take a lot of research to find out what the artist’s original intentions were behind the song.

Keep ReadingShow less
Celebrity

Philadelphia Eagles player is bringing his pregnant wife’s OBGYN to the Super Bowl, just in case

Kylie McDevitt's OBGYN is packing a bag to join the NFL star's wife, just in case baby Kelce decides to see the game too.

Philadelphia Eagles player is bringing his pregnant wife's OBGYN to the Super Bowl

Having a baby is an intimate, vulnerable experience, so people get pretty attached to their healthcare providers. I've met women who have planned an induction to have their baby with their preferred doctor and not whoever would be on call if they went into labor naturally. So it may not be a surprise to birthing people that Kylie McDevitt, Philadelphia Eagles player, Jason Kelce's wife, isn't taking any chances when she travels to Arizona for the Super Bowl.

Kelce made headlines with his brother Travis recently when it was revealed that the Eagles and Kansas City Chiefs would be facing off for the Super Bowl, making the pair the first brothers to compete against each other for a ring. It seems that McDevitt didn't want to miss the history-making moment, even though she'll be two weeks shy of the standard 40 weeks of pregnancy.

Keep ReadingShow less
Photo by alevision.co on Unsplash/ @camerconstewart_uk/Instagram

"Sometimes it pays to learn a language!"

It feels safe to assume that if money were no object, people would always choose to travel business class over economy. After all, who doesn’t want a fast check-in, fancy food and drink choices and more of that sweet, spacious legroom?

However, at anywhere between four to ten times the price of a regular economy ticket, this style of traveling remains a fantasy for many who simply can’t afford it.

Luckily, thanks to one man’s clever travel hack, that fantasy might be more achievable than we realize.

Cameron Stewart, a British photojournalist and camera operator, recently shared how he was able to score business class tickets at a fraction of the price, simply by switching the website language from English to Spanish.
Keep ReadingShow less