A woman slowly aging from her 20s to her 50s.
It’s often assumed that aging is a consistent process where we grow to a certain point and then our bodies begin to wear down at a predictable pace until the inevitable end. However, according to a new study out of China, the average human body has an accelerated leap during the aging process before returning to its normal rate.
According to the researchers at the Chinese Academy of Sciences, aging begins to accelerate at the age of 50. Or, when women are going through menopause and men are starting to love Kirkland jeans. "Based on aging-associated protein changes, we developed tissue-specific proteomic age clocks and characterized organ-level aging trajectories. Temporal analysis revealed an aging inflection around age 50, with blood vessels being a tissue that ages early and is markedly susceptible to aging," the team led by scientists from the Chinese Academy of Sciences wrote in the journal Cell.
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Why does aging accelerate at 50?
To put it in layman’s terms: By looking at how specific body proteins change as we age, researchers made special tools to measure how old organs vary in biological age. They found that around age 50, the aging process accelerates, and blood vessels start aging earlier than other organs.
To learn more about the aging princess, the researchers collected tissue samples from 76 organ donors between the ages of 14 and 68 who had died of traumatic brain injury. The samples were taken from seven of the body’s systems: cardiovascular (heart and aorta), digestive (liver, pancreas, and intestine), immune (spleen and lymph node), endocrine (adrenal gland and white adipose), respiratory (lung), integumentary (skin), and musculoskeletal (muscle).
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The body’s aging process speeds up between 45 and 55
After studying the proteins found in different systems, the researchers found that the most stark changes in the aging process occurred between the ages of 45 and 55. The greatest amount of changes happened in the aorta, the body’s main artery that runs that passes over the heart from the left ventricle and runs down the front of the backbone.
The researchers hope that their work will eventually lead to mapping of the entire body, where we can better understand the process on an organ-by-organ basis. That could lead to one day having different biological ages for various body parts based on proteins and lifestyle choices. One could have a liver that's 35 and an aorta in its 50s. "These insights may facilitate the development of targeted interventions for aging and age-related diseases, paving the way to improve the health of older adults," the authors concluded.
It may be a bit jarring for younger people to know that just like they may have enjoyed a growth spurt while in high school, they can also look forward to an aging spurt that happens at 50. The good news is that if you are past 55, then you are likely to be able to look forward to a phase where the aging process slows down a bit.
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