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The cool new DIY science movement that's changing everything from animals to agriculture.

"We're all here because we want to be the first humans able to fly."

"And we also want to live forever, see through walls, and shoot lasers from our eyeballs," the Ukrainian scientist tells me with a totally straight face. "But that's all science-fiction nonsense for now. So in the meantime, we're just making yogurt with an anti-aging protein, and things like that."

That must be Stamos' secret. GIF from Dannon Oikos/YouTube.

We're standing in the attic of a bicycle repair shop in Somerville, Massachusetts, where a group of local scientists and curious hobbyists have built a do-it-yourself laboratory for homegrown biology experiments.

The space is strewn with secondhand equipment, all scavenged and salvaged from the dumpsters of nearby universities and major pharmaceutical companies. Someone even found a way to use a breast pump to filter out bacteria samples. Yeah.

But as wild as this all may sound, it's hardly the most remarkable thing to come out of the life science revolution that's sweeping across the world.

"I cannot believe my eyes!" — Me, when I saw this stuff. GIF from "Dr. Horrible's Sing-Along Blog."

Recent advancements in biotech have made it easier than ever to manipulate and edit DNA with shocking accuracy.

At the forefront of this biological renaissance is a little thing scientists call CRISPR-Cas9, often shortened to just plain ol' CRISPR. It's a system that we pretty much stole from certain bacteria that uses enzymes and something called guide RNA to target and cut sequences of DNA.

But that's all kinds of confusing for non-science-y types, so think of it like this: DNA is full of information that tells a story, like a book. Previously, if we wanted to change any part of this DNA-book, we had to chop up random sections with our metaphorical scissors, or splash white-out on the pages, trying to scribble in new notes wherever we could. Sure, it got the job done sometimes. But it was also pretty messy and inefficient.

The CRISPR system offers a new kind of "find-and-replace" feature. Now we can take our DNA-book and say, "OK, CRISPR, please find that sentence that specifically says, 'Harry met Hagrid.'" Then we can tell it to cut out that particular sentence and either get rid of it entirely or add our own new, much cooler sentence in its place. (Like "Harry met Hagrid and then they high-fived and it was so epic that they destroyed Voldemort and everyone was awesome.")

Got that?

TL;DR: Everything is awesome with CRISPR. GIF from "The LEGO Movie."

Now imagine that instead of just rewriting their own derivative Harry Potter fanfic, scientists can use this "find-and-replace" feature to turn specific genes "on" or "off," or even add new sequences of base pairs into the genome. This makes it easier than ever to go in and splice, add, or change one little piece of genetic information and see what happens.

"It's like a toolkit, essentially," explained Joanne Kamens, executive director of Addgene. "It's like having just the right screwdriver we never had, and it's allowing scientists to create hundreds of new tools and making everything exponentially faster."

A much-more useful CRISPR explainer video. GIF from Desktop Genetics/YouTube.

This kind of super-accurate gene editing — and genetic synthesis in general — have become more accessible in the past few years.

CRISPR might be the prom queen of the biggest labs, but there are other similar versions of this kind of precision gene-editing technology — like the methods that my Ukrainian friend was using in that attic. And these tools are collectively changing the world as we know it, in attics and labs all over the world.

Let's go down the DNA rabbit hole... GIF from McGovern Institute for Brain Research at MIT/YouTube.

Here are five of the most fascinating inventions and discoveries we've seen in biotech to date:

1. Gene editing could help us limit, or maybe even destroy, diseases like malaria and cancer.

Now that we can slice into DNA with alarming accuracy, we can target exactly where diseases exist in the body and how drugs get delivered to kill those diseases. It's like a microbiological version of "Mission: Impossible" when you're trying to defuse a bomb — gene editing tells you exactly which wire to cut, without the risk of blowing up the building (which in this case is a human body).

Scientists at the University of California San Francisco, for example, have found a way to turn human T cells into hyper-efficient disease-killing machines. Similarly, at Temple University, researchers are using CRISPR to literally cut HIV out of live subjects. Pretty neat, huh?

As for those pesky mosquito-born illnesses plaguing our warming world, CRISPR has already made it easier to identify diseases such as Zika, malaria, and West Nile in patients and hosts alike — and some scientists hope to use gene editing to remove the disease-carrying capability from the mosquito genome entirely, destroying them at the source.

EXACTLY. GIF from "Adventure Time."

2. This same application is revolutionizing how we study mental health, too.

Scientists at MIT have already used gene editing to create lab mice with autism and OCD so they can better understand what causes those conditions and how best to treat them.

If they can create those conditions, they might be able to un-create them, too, by essentially flipping a switch on the problematic genes. (The only trick is figuring out with certainty which specific genes out of the billions in our body are causing the problems, which is easier said than done.)

I know, Krang. It's pretty mind-blowing. GIF from "Teenage Mutant Ninja Turtles."

3. It could also help us bring back the wooly mammoth or any other number of crazy chimera breeds.

Yup: Scientists at Harvard University successfully spliced wooly mammoth DNA into elephant cells. This is just on a cellular level so far, mind you; no one's prepared to go all "Jurassic Park" without looking into all the potential ramifications of such a project.

But, I mean, you knew this was coming, right? As cool and generally comforting as these other remarkable projects have been, we're still talking about genetic engineering, so of course there'd be some kind of super-powered kaiju-animal hybrids in the cards.

In China, scientists have already used CRISPR to breed dogs with twice the muscle mass by simply deleting one gene from their DNA. And in Boston, they've found a way to modify pig organs to make them compatible with human bodies in need of transplant donors.

And if you're wondering about the practical applications and ethical justifications of these kinds of projects, well ... those are totally valid things to be concerned about. But scientists are actively engaged in those discussions, and if it makes you feel any better, we're probably still a long way away from creating fully customizable mature synthetic humans. Probably.


My thoughts exactly, Doc Brown. GIF from "Back to the Future."

4. Gene editing could also help to revamp the entire agriculture industry — without the use of any off-putting genetic additives.

GMOs get a bad wrap. But gene editing is different from, say, adding a bit of flounder DNA into a tomato, which is why the FDA recently approved the first CRISPR-modified mushroom for human consumption.

These specially designed mushrooms have a greater resistance to browning — again, not because of any scary-sounding chemicals or foreign genes, but simply because biologists found a way to isolate and shut off the naturally occurring genes that caused the mushrooms to turn brown after you cut into them.

That's it. Really. Nothing scary about it.

Naturally occurring mushroom-hat parachutes are still in the early developmental stages. GIF from "Super Mario Bros. Super Show."

This method is also working to create disease-resistant plants, which is how a team at Seoul National University is trying to save the banana. Because why bother introducing pesticides or foreign genetic material when you can just poke at the DNA that the plant already has to improve its nutrient content and help it survive under less-than-ideal conditions? It's not quite "natural" in the traditional sense, but it's also not so different from the exchange and selective breeding of crops that's been going on for centuries.

Just, ya know — easier, and cooler-sounding.

So that's what Beaker's been meeping about all these years! GIF from "The Muppet Show."

5. But perhaps most importantly, gene editing is lowering the bar for scientific research and making it accessible to everyone.

Until recently, a lot of genetic and biotech data was protected behind intellectual property laws and institutional restrictions. But now? Anyone can buy an all-in-one CRISPR starter kit online or order a plasmid straight from a place like Addgene for a mere $65 and see what they can do with it ... just like those guys in the Somerville attic.

"It's like designing apps" for smartphones, said DeskGen's A.J. Ajetunmobi. DeskGen is a biotech startup that offers free open-source desktop gene-editing software, allowing anyone to design an experiment from anywhere in the world.

"People can focus on fixing problems instead of learning how to code," he said. "In life sciences, we're still stuck teaching people how to code. It's hard to teach that and still keep minds open."

GIF from "Dexter's Laboratory."

"Diversity of perspective makes everything better. People are so much more innovative when they're not coming at it from a specific overhead," Ajetunmobi added.

The possibilities for progress are endless as long as the opportunities are available to everyone — not just the pharmaceutical companies who can afford to pay millions for special equipment and data.

"The barriers to entry [in biotech] are significant," Ajetunmobi told me with an eyeroll and a laugh, before pointing out that it would be logistically difficult for an individual — say, a 30-year-old writer who is me — to obtain all the necessary plasmids and parts to breed a personal army of altruistic disease-resistant pig-human hybrid super-farmers with laser vision and flight capabilities.

"But now, there's nothing technically stopping anyone from experimenting and exploring."

Maybe you, too, can create your own web-shooters! ... Maybe. GIF from "The Amazing Spider-Man."

Personally, I decided to keep it simple and stick with the DIY bioluminescent yeast starter kit.

I'll leave the cool sci-fi-sounding progress to the pros (or to my new friends trying to find the fountain of youth in yogurt). But it's still nice to know that the opportunity is out there for anyone eager enough to give it a try.

Who knows? Maybe that 14-year-old kid next door will find a way to make pigs fly sooner than we think.

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Pop Culture

Parents who grew up in the '70s and '80s remember the experiences that blow their kids' minds

Kids were tougher then for a reason.

via Wikimedia Commons

Island School Class, circa 1970s.

Parents, do you think your child would be able to survive if they were transported back to the '70s or '80s? Could they live at a time before the digital revolution put a huge chunk of our lives online?

These days, everyone has a phone in their pocket, but before then, if you were in public and needed to call someone, you used a pay phone. Can you remember the last time you stuck 50 cents into one and grabbed the grubby handset?

According to the U.S. Federal Communications Commission, roughly 100,000 pay phones remain in the U.S., down from 2 million in 1999.

Do you think a 10-year-old kid would have any idea how to use a payphone in 2022? Would they be able to use a Thomas Guide map to find out how to get somewhere? If they stepped into a time warp and wound up in 1975, could they throw a Led Zeppelin album on the record player at a party?

Another big difference between now and life in the '70s and '80s has been public attitudes toward smoking cigarettes. In 1965, 42.4% of Americans smoked and now, it’s just 12.5%. This sea change in public opinion about smoking means there are fewer places where smoking is deemed acceptable.

But in the early '80s, you could smoke on a bus, on a plane, in a movie theater, in restaurants, in the classroom and even in hospitals. How would a child of today react if their third grade teacher lit up a heater in the middle of math class?

Dan Wuori, senior director of early learning at the Hunt Institute, tweeted that his high school had a smoking area “for the kids.” He then asked his followers to share “something you experienced as a kid that would blow your children’s minds.”


A lot of folks responded with stories of how ubiquitous smoking was when they were in school. While others explained that life was perilous for a kid, whether it was the school playground equipment or questionable car seats.

Here are a few responses that’ll show today’s kids just how crazy life used to be in the '70s and '80s.

First of all, let’s talk about smoking.

Want to call someone? Need to get picked up from baseball practice? You can’t text mom or dad, you’ll have to grab a quarter and use a pay phone.

People had little regard for their kids’ safety or health.

You could buy a soda in school.

Things were a lot different before the internet.

Remember pen pals?

A lot of people bemoan the fact that the children of today aren’t as tough as they were a few decades back. But that’s probably because the parents of today are better attuned to their kids’ needs so they don't have to cheat death to make it through the day.

But just imagine how easy parenting would be if all you had to do was throw your kids a bag of Doritos and a Coke for lunch and you never worried about strapping them into a car seat?


This article originally appeared on 06.08.22

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Pop Culture

Michael B. Jordan runs into his middle-school bully on the red carpet and calls her out

He didn't forget.

via Gage Skidmore/Wikimedia Commons

Michael B. Jordan speaking at the 2017 San Diego Comic Con International, for "Black Panther", at the San Diego Convention Center in San Diego, California.

As long as humans have endeavored to do anything great, there have been those who have tried to take them down. These are the opposite of the creators in life: the bullies, haters and naysayers who only want to bring people down to their level.

But when you have a dream and desire, its easy to tune out the voices of negativity. "It is not the critic who counts; not the man who points out how the strong man stumbles, or where the doer of deeds could have done them better,” Theodore Roosevelt once said. “The credit belongs to the man who is actually in the arena."

Some folks use the naysayers as fuel to push them to work even harder. Basketball legend Michael Jordan was infamous for letting his thirst for revenge drive him to even greater heights on the court.

Another Michael Jordan, "Black Panther" star, Michael B. Jordan, came face to face with someone who doubted that he could reach his dreams, and he wasn’t shy about letting her know that he remembered. What's Upworthy about the encounter is that he did so with class and confidence.

In 2023, Jordan was on the red carpet for the premiere of "Creed III," a film he starred in and directed. He was interviewed by “The Morning Hustle” radio show host Lore’l, who had recently admitted on the “Undressing Room” podcast that she used to make fun of him in school.

“You know what’s so crazy? I went to school with Michael B. Jordan at a point in life,” Lore’l said. “And to be honest with you, we teased him all the damn time because his name was Michael Jordan. Let’s start there, and he was no Michael Jordan.”

“He also would come to school with a headshot,” she added. “We lived in Newark. That’s the hood. We would make fun of him like, ‘What you gonna do with your stupid headshot?’ And now look at him!”

In addition, her co-host, Eva Marcille, referred to Jordan as “corny.”

Jordan had no problem discussing their past on the red carpet. “We go way back, all the way back to Chad Science [Academy] in Newark,” Lore’l told the actor. Oh yeah, I was the corny kid, right?” Jordan responded with a smirk.

“No, you did not hear me say that! I said we used to make fun of the name,” Lore’l said.

“I heard it,” Jordan said. “I heard it. It’s all good. What’s up?” he responded. “But yeah, [you are] obviously killing things out here…you’re not corny anymore,” Lore’l clarified.

After the exchange went viral, Lore’l admitted that she teased Jordan in school, but they were only classmates for one year.

“So the narrative that I bullied him all throughout high school—this was 7th grade. We were like 12 years old, and everyone made fun of each other,” Lore’l said. “That was school, you know. That was one year. And, again, I’ve never bullied him. That just sounds so outrageous to me.”

Jordan later shared some advice on how to deal with bullies.

"Just stay focused, just stay locked in,” he told a reporter from Complex. “You know, just follow your heart, try to block out the noise and distractions as much as possible and run your race. Don't compare yourself to anybody else. Just keep going."

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Science

A juice company dumped orange peels in a national park. Here's what it looks like now.

12,000 tons of food waste and 21 years later, this forest looks totally different.


In 1997, ecologists Daniel Janzen and Winnie Hallwachs approached an orange juice company in Costa Rica with an off-the-wall idea.

In exchange for donating a portion of unspoiled, forested land to the Área de Conservación Guanacaste — a nature preserve in the country's northwest — the park would allow the company to dump its discarded orange peels and pulp, free of charge, in a heavily grazed, largely deforested area nearby.

One year later, one thousand trucks poured into the national park, offloading over 12,000 metric tons of sticky, mealy, orange compost onto the worn-out plot.


The site was left untouched and largely unexamined for over a decade. A sign was placed to ensure future researchers could locate and study it.

16 years later, Janzen dispatched graduate student Timothy Treuer to look for the site where the food waste was dumped.

Treuer initially set out to locate the large placard that marked the plot — and failed.

The first deposit of orange peels in 1996.

Photo by Dan Janzen.

"It's a huge sign, bright yellow lettering. We should have been able to see it," Treuer says. After wandering around for half an hour with no luck, he consulted Janzen, who gave him more detailed instructions on how to find the plot.

When he returned a week later and confirmed he was in the right place, Treuer was floored. Compared to the adjacent barren former pastureland, the site of the food waste deposit was "like night and day."

The site of the orange peel deposit (L) and adjacent pastureland (R).

Photo by Leland Werden.

"It was just hard to believe that the only difference between the two areas was a bunch of orange peels. They look like completely different ecosystems," he explains.

The area was so thick with vegetation he still could not find the sign.

Treuer and a team of researchers from Princeton University studied the site over the course of the following three years.

The results, published in the journal "Restoration Ecology," highlight just how completely the discarded fruit parts assisted the area's turnaround.

The ecologists measured various qualities of the site against an area of former pastureland immediately across the access road used to dump the orange peels two decades prior. Compared to the adjacent plot, which was dominated by a single species of tree, the site of the orange peel deposit featured two dozen species of vegetation, most thriving.

Lab technician Erik Schilling explores the newly overgrown orange peel plot.

Photo by Tim Treuer.

In addition to greater biodiversity, richer soil, and a better-developed canopy, researchers discovered a tayra (a dog-sized weasel) and a giant fig tree three feet in diameter, on the plot.

"You could have had 20 people climbing in that tree at once and it would have supported the weight no problem," says Jon Choi, co-author of the paper, who conducted much of the soil analysis. "That thing was massive."

Recent evidence suggests that secondary tropical forests — those that grow after the original inhabitants are torn down — are essential to helping slow climate change.

In a 2016 study published in Nature, researchers found that such forests absorb and store atmospheric carbon at roughly 11 times the rate of old-growth forests.

Treuer believes better management of discarded produce — like orange peels — could be key to helping these forests regrow.

In many parts of the world, rates of deforestation are increasing dramatically, sapping local soil of much-needed nutrients and, with them, the ability of ecosystems to restore themselves.

Meanwhile, much of the world is awash in nutrient-rich food waste. In the United States, up to half of all produce in the United States is discarded. Most currently ends up in landfills.

The site after a deposit of orange peels in 1998.

Photo by Dan Janzen.

"We don't want companies to go out there will-nilly just dumping their waste all over the place, but if it's scientifically driven and restorationists are involved in addition to companies, this is something I think has really high potential," Treuer says.

The next step, he believes, is to examine whether other ecosystems — dry forests, cloud forests, tropical savannas — react the same way to similar deposits.

Two years after his initial survey, Treuer returned to once again try to locate the sign marking the site.

Since his first scouting mission in 2013, Treuer had visited the plot more than 15 times. Choi had visited more than 50. Neither had spotted the original sign.

In 2015, when Treuer, with the help of the paper's senior author, David Wilcove, and Princeton Professor Rob Pringle, finally found it under a thicket of vines, the scope of the area's transformation became truly clear.

The sign after clearing away the vines.

Photo by Tim Treuer.

"It's a big honking sign," Choi emphasizes.

19 years of waiting with crossed fingers had buried it, thanks to two scientists, a flash of inspiration, and the rind of an unassuming fruit.


This article originally appeared on 08.23.17

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Parenting

Mom creates a stir after refusing to drop her child off at a parent free birthday party

"I loved drop off parties. I didn't want to sit at some kids party."

Photos by Ivan Samkov and Gustavo Fring|Canva

Mom refuses to let kid go to "drop-off" birthday party

There are many Millennial moms that were raised on "Unsolved Mysteries" and "America's Most Wanted" during formative years, which may or may not have influenced the way they parent. It can be hard to think clearly when Robert Stack's voice is echoing in your head every time your child is out of eyesight. The jokes about what is responsible for the average Millennial's parenting style resembling more like a helicopter are endless. But sometimes additional caution is warranted where others may find it unnecessary.

At least that's what many folks on the internet believe after one mom seemingly split parents into two camps with her revelation about children's parties. Liv, who goes by the TikTok handle Liv SAHM, takes to social media to explain that her seven-year-old son was invited to a birthday party but when she went to RSVP, she noticed the invitation said, "drop off only."

The mom explains, "It's at someone's house. I don't know these parents. I don't know that there's actually going to be other adults besides this child's parents."

Liv states that she would not be dropping her young child off alone with strangers. To many parents this seems like a reasonable response. If you don't know the parents or any other adults then how can you ensure your child will be safe. Other parents felt like Liv was completely overreacting with a helicopter parenting style.

"Little kids have been going to peoples birthday parties without clingy parents for decades," one person declares.

"I'm a drop off kinda house. I want the parents to leave that is one less person I have to feed. I don't wanna have to make small talk with other parents," another says.

"That's a big no for me too! And I always try to take my kids to classmates parties because people never show up," someone writes.

"That's so worrisome. I completely agree with you mama bear, same with my son," a commenter says.

"Yeah, that would make me uncomfortable too! It's always a little interesting to me when parents drop off their kids at parties," someone else adds.

@livsahm

No thank you! I don’t feel comfortable with that. #mom #momsoftiktok #momlife #sahm #sahmlife #birthday #birthdayparty #celebration #controversial #parenting #parentingtips #parents #no

There's no right or wrong way to throw a party for a kid because there's no rulebook. Generally parents are accustomed to seeing invitations that say no siblings or the offer of parents staying or leaving. Many commenters pointed out that it seemed odd that the invitation was worded in a way that sounded like parents staying wasn't an option.

Some parents noted that the world has changed since they were children and wouldn't feel safe dropping their kids off either. Others found no issue with it and think fellow parents are overreacting. What do you say, odd or perfectly fine?

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Family

Dad shares what happens when you give your child books instead of a smartphone

The key to fostering healthy habits in children is to be wholly present and reject the “pressures of convenience”

via Armando Hart (used with permission)

Armando Hart and his son, Raya.

One of the most pressing dilemmas for parents these days is how much screen time they should allow their children. Research published by the Mayo Clinic shows that excessive screen time can lead to obesity, disrupted sleep, behavioral issues, poor academic performance, exposure to violence and a significant reduction in playtime.

The American Academy of Pediatrics recommends limiting screen time to 1 to 2 hours daily for children over 2. But American children spend far more time in front of screens than that and the situation is only worsening.

Before the pandemic, kids between the ages of 4 and 12 spent an average of 4.4 hours a day looking at screens, but since 2020, the average child’s daily screen time has increased by 1.75 hours.

A father in Long Beach, California, is getting some love for his TikTok video sharing what happens when you give your kid books instead of an iPhone. Armando Hart posted a video showing his 10-year-old son, Raya, reading a book in the back of a car and it’s been seen over 8 million times.

"Give them books instead of phones when they are little and this is the result," the caption reads. "Thank me later."

We’re so blessed with our son Raya. I think he’s read more books than I have.

@lifeinmotion08

We’re so blessed with our son Raya. I think he’s read more books than I have. #Books #Read #Fyp

Hart and his wife started reading to their son every night before bedtime, hoping to instill a love for books. "It was all about leading by example and creating a nurturing environment where reading was celebrated," Hart told Newsweek. These days, Raya is an avid reader who enjoys just about anything.

“My son likes novels, fiction, nonfiction, and realistic fiction,” Hart told Upworthy. “He also likes informative content, such as reading the almanac and other informative magazines. He loves to build, cook from recipes, and make art.”

For Hart, reading is all about creating a sense of balance in his son’s life.

“It's not about being against technology but about fostering a balanced approach that prioritizes meaningful experiences and hands-on learning,” he told Upworthy. “By instilling a love for reading, creativity, and exploration early on, we're equipping Raya with the skills and mindset he needs to thrive in an ever-changing world.”

Hart believes that the screen time discussion isn’t just about technology but a trend that goes deeper. “It speaks to a broader societal problem: our youth's lack of self-esteem, confidence and fundamental values. While screen time may exacerbate these issues, it is not the sole cause,” he told Upworthy.

“In contrast, physical activity, such as exercise, promotes joy and well-being. Spending hours scrolling on a phone can detract from genuine moments of happiness and fulfillment,” he continued. “Therefore, we must address the deeper underlying issues affecting our youth's mental and emotional health rather than solely attributing them to screen time.”

Hart believes the key to fostering healthy habits in children is to be wholly present and reject the “pressures of convenience” that encourage parental complacency.

“We prioritize quality time together, whether exploring nature, sharing meals with the best available foods, or engaging in meaningful conversations. In today's rapidly advancing technological world, staying grounded in our humanity and embodying integrity in everything we do is crucial,” he continued. “This means staying connected to our authentic selves and teaching our son the importance of honesty, kindness, and respect.”

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